Peptide analogs of salmon calcitonin (sCT) were synthesized by using Fmoc-based chemistry on MBHA resins. Salmon calcitonin was modified by 1) cysteines at positions 1 and 7 were replaced by valine and alanine respect...Peptide analogs of salmon calcitonin (sCT) were synthesized by using Fmoc-based chemistry on MBHA resins. Salmon calcitonin was modified by 1) cysteines at positions 1 and 7 were replaced by valine and alanine respectively to result in open chain analogs, 2) the glycine at position 30 was replaced by alanine, D-alanine and sarcosine respectively, and 3) some residues were deleted besides the above two modifications. A modified two-step deprotection / cleavage procedure, in which a solvent of TFA / TMSBr / thioanisole / EDT / m-cresol combines with HF cleavage, was adopted in SPPS.展开更多
In this paper,we consider the statistical inferences in a partially linear model when the model error follows an autoregressive process.A two-step procedure is proposed for estimating the unknown parameters by taking ...In this paper,we consider the statistical inferences in a partially linear model when the model error follows an autoregressive process.A two-step procedure is proposed for estimating the unknown parameters by taking into account of the special structure in error.Since the asymptotic matrix of the estimator for the parametric part has a complex structure,an empirical likelihood function is also developed.We derive the asymptotic properties of the related statistics under mild conditions.Some simulations,as well as a real data example,are conducted to illustrate the finite sample performance.展开更多
Cointegration analysis is often of special interest in the analysis of nonstationary vector valued time series, especially for the vector with higher order integrated components. In this paper we present the represen...Cointegration analysis is often of special interest in the analysis of nonstationary vector valued time series, especially for the vector with higher order integrated components. In this paper we present the representation theorem for a generalized cointegrated system, and formulate the generalized error correction model(GECM). We also provide the modified EG two step procedure to estimate the parameters in a GECM. The paper extends some important results of cointegration into the analysis of generalized cointegration, and is of great importance in the analysis of nonstationary time series.展开更多
文摘Peptide analogs of salmon calcitonin (sCT) were synthesized by using Fmoc-based chemistry on MBHA resins. Salmon calcitonin was modified by 1) cysteines at positions 1 and 7 were replaced by valine and alanine respectively to result in open chain analogs, 2) the glycine at position 30 was replaced by alanine, D-alanine and sarcosine respectively, and 3) some residues were deleted besides the above two modifications. A modified two-step deprotection / cleavage procedure, in which a solvent of TFA / TMSBr / thioanisole / EDT / m-cresol combines with HF cleavage, was adopted in SPPS.
基金supported by the NSF of China(Nos.11971208,11601197)the NSSF of China(Grant No.21&ZD152)+2 种基金the China Postdoctoral Science Foundation(Nos.2016M600511,2017T100475)the NSF of Jiangxi Province(Nos.2018ACB21002,20171ACB21030)the Post graduate Innovation Project of Jiangxi Province(No.YC2021CB124)。
文摘In this paper,we consider the statistical inferences in a partially linear model when the model error follows an autoregressive process.A two-step procedure is proposed for estimating the unknown parameters by taking into account of the special structure in error.Since the asymptotic matrix of the estimator for the parametric part has a complex structure,an empirical likelihood function is also developed.We derive the asymptotic properties of the related statistics under mild conditions.Some simulations,as well as a real data example,are conducted to illustrate the finite sample performance.
文摘Cointegration analysis is often of special interest in the analysis of nonstationary vector valued time series, especially for the vector with higher order integrated components. In this paper we present the representation theorem for a generalized cointegrated system, and formulate the generalized error correction model(GECM). We also provide the modified EG two step procedure to estimate the parameters in a GECM. The paper extends some important results of cointegration into the analysis of generalized cointegration, and is of great importance in the analysis of nonstationary time series.
