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Cemented vertebra and adjacent vertebra refractured in a chronic kidney disease-mineral and bone disorder patient: A case report
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作者 Ti-Dong Zhang Shuai Cao +2 位作者 Hui-Yong Ren Yu-Min Li Yi-Ming Yuan 《World Journal of Clinical Cases》 SCIE 2024年第10期1804-1809,共6页
BACKGROUND Although percutaneous vertebral augmentation(PVA)is a commonly used procedure for treating vertebral compression fracture(VCF),the risk of vertebral refracture should be considered.Chronic kidney disease-mi... BACKGROUND Although percutaneous vertebral augmentation(PVA)is a commonly used procedure for treating vertebral compression fracture(VCF),the risk of vertebral refracture should be considered.Chronic kidney disease-mineral and bone disorder(CKD-MBD)is a systemic disease of mineral and bone metabolism.It is associated with an increased risk of fracture.Few studies have reported the use of PVA in patients with CKD-MBD.We herein report a rare case wherein the cemented vertebra and the adjacent vertebra refractured simultaneously in a CKD-MBD patient after PVA.CASE SUMMARY A 74-year-old man suffered from low back pain after taking a fall about 3 wk ago.According to physical examination,imaging and laboratory findings,diagnoses of T12 VCF,CKD-MBD,and chronic kidney disease stage 5 were established.He then received percutaneous vertebroplasty at T12 vertebra.Fourteen weeks later,he presented with T12 and L1 vertebral refractures caused by lumbar sprain.Once again,he was given PVA which was optimized for the refractured vertebrae.Although the short-term postoperative effect was satisfactory,he reported chronic low back pain again at the 3-month follow-up.CONCLUSION It is necessary that patients with CKD-MBD who have received PVA are aware of the adverse effects of CKD-MBD.It may increase the risk of vertebral refracture.Furthermore,the PVA surgical technique needs to be optimized according to the condition of the patient.The medium-and long-term effects of PVA remain uncertain in patients with CKD-MBD. 展开更多
关键词 Chronic kidney disease-mineral and bone disorder Percutaneous vertebral augmentation Vertebral compression fracture Vertebral refracture cemented vertebra Adjacent vertebra Case report
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Polymethylmethacrylate bone cements and additives: A review of the literature 被引量:11
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作者 Manit Arora Edward KS Chan +1 位作者 Sunil Gupta Ashish D Diwan 《World Journal of Orthopedics》 2013年第2期67-74,共8页
Polymethylmethacrylate(PMMA) bone cement technology has progressed from industrial Plexiglass administration in the 1950 s to the recent advent of nanoparticle additives. Additives have been trialed to address problem... Polymethylmethacrylate(PMMA) bone cement technology has progressed from industrial Plexiglass administration in the 1950 s to the recent advent of nanoparticle additives. Additives have been trialed to address problems with modern bone cements such as the loosening of prosthesis, high post-operative infection rates, and inflammatory reduction in interface integrity. This review aims to assess current additives used in PMMA bone cements and offer an insight regarding future directions for this biomaterial. Low index(< 15%) vitamin E and low index(< 5 g) antibiotic impregnated additives significantly address infection and inflammatory problems, with only modest reductions in mechanical strength. Chitosan(15% w/w PMMA) and silver(1% w/w PMMA) nanoparticles have strong antibacterial activity with no significant reduction in mechanical strength. Future work on PMMA bone cements should focus on trialing combinations of these additives as this may enhance favourable properties. 展开更多
关键词 POLYMETHYLMETHACRYLATE bone cement cement nanoparticle Vitamin E ADDITIVE ARTHROPLASTY Artificial joint fixation POST-OPERATIVE infection Mechanical WEAKNESS Fat ADDITIVE Antibiotics
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Synthesis of Chitosan-Hydroxyapatite Composites and Its Effect on the Properties of Bioglass Bone Cement 被引量:3
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作者 Jingxiao Liu Fei Shi Ling Yu Liting Niu Shanshan Gao 《Journal of Materials Science & Technology》 SCIE EI CAS CSCD 2009年第4期551-555,共5页
Chitosan-hydroxyapatite (CS-HA) composite powders were synthesized via in situ co-precipitation method, through the reaction of Ca(NO3)2 and H3PO4 in the simulated body fluid (SBF) containing appropri- ate amoun... Chitosan-hydroxyapatite (CS-HA) composite powders were synthesized via in situ co-precipitation method, through the reaction of Ca(NO3)2 and H3PO4 in the simulated body fluid (SBF) containing appropri- ate amount of chitosan. The thermal evolution, microstructure and morphology were studied by TG-DTA (thermogravimetry-differential thermal analysis), XRD (X-ray diffraction), FTIR (Fourier transform infrared spectroscopy) and TEM (transmission electron microscopy). The in vitro bioactivity test showed that the obtained CS-HA composites had higher capability of inducing calcium ions deposition. Effects of CS-HA com- posites on the bioactivity and compressive strength of bioglass bone cement were investigated. The results indicated that the bioactivity of bioglass bone cement could be improved further when CS-HA composite pow- ders were added into the cement, and appropriate amount of CS-HA additive was favorable for compressive strength improvement of bioglass bone cement. 展开更多
关键词 HYDROXYAPATITE CHITOSAN COMPOSITES bone cement
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Calcium phosphate cements for bone engineering and their biological properties 被引量:16
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作者 Hockin HK Xu Ping Wang +7 位作者 Lin Wang Chongyun Bao Qianming Chen Michael D Weir Laurence C Chow Liang Zhao Xuedong Zhou Mark A Reynolds 《Bone Research》 SCIE CAS CSCD 2017年第4期286-304,共19页
Calcium phosphate cements (CPCs) are frequently used to repair bone defects. Since their discovery in the 1980s, extensive research has been conducted to improve their properties, and emerging evidence supports thei... Calcium phosphate cements (CPCs) are frequently used to repair bone defects. Since their discovery in the 1980s, extensive research has been conducted to improve their properties, and emerging evidence supports their increased application in bone tissue engineering. Much effort has been made to enhance the biological performance of CPCs, including their biocompatibility, osteoconductivity, osteoinductivity, biodegradability, bioactivity, and interactions with cells. This review article focuses on the major recent developments in CPCs, including 3D printing, injectability, stem cell delivery, growth factor and drug delivery, and pre- vascularization of CPC scaffolds via co-culture and tri-culture techniques to enhance angiogenesis and osteogenesis. 展开更多
关键词 CPC BMSCS Calcium phosphate cements for bone engineering and their biological properties
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Influences of IL-6R Antibody on PMMA Bone Cement-mediated Expression of OPG and RANKL in Synovial Fibroblasts 被引量:4
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作者 陶可 曾晖 +3 位作者 肖德明 熊奡 翁鉴 康斌 《Journal of Huazhong University of Science and Technology(Medical Sciences)》 SCIE CAS 2014年第2期241-246,共6页
Effect of interleukin-6 receptor (IL-6R) antibody on polymethyl methacrylate (PMMA) bone cement-mediated expression of osteoprotegerin (OPG) and :receptor activator of nuclear fac- tor-kappaB ligand (RANKL) i... Effect of interleukin-6 receptor (IL-6R) antibody on polymethyl methacrylate (PMMA) bone cement-mediated expression of osteoprotegerin (OPG) and :receptor activator of nuclear fac- tor-kappaB ligand (RANKL) in synovial fibroblasts was investigated. Synovial tissue obtained from to- tal knee arthroplasty was digested and cultured. Inverted microscope was employed to observe the synovial cells and immunocytochemistry (SABC method) staining was used to identify synovial fibro- blasts. This experiment was divided into three groups according to different culture media: PMMA group (75μg/mL PMMA bone cement particles), IL-6R antibody group (10 ng/mL IL-6R antibody+75 μg/mL PMMA bone cement particles), and control group (no IL-6R antibody or PMMA bone cement particles). Influence of IL-6R antibody and PMMA on proliferation of synovial fibroblasts was meas- ured by cell counting kit-8 (CCK-8). ELISA method was used to measure OPG and RANKL levels in culture solution. Fluorescence quantitative real-time PCR (FQ-PCR) was used to detect the expression of OPG and RANKL mRNA. After three consecutive passages, more than 95% of the primary synovial cells became long spindle fibroblast-like cells. SABC staining results showed that the fibroblast-like cells were negative for anti-CD68 antibody and positive for anti-vimentin antibody, with brown madder stained. CCK-8 test demonstrated that the absorbance (A) value at 450 nm was significantly lower in IL-6R antibody group than in PMMA group and control group (P〈0.01), but there was no statistically significant difference in A value at 450 nm between the control group and PMMA group (P〉0.05). Re- suits of ELISA indicated that the expression of OPG was significantly higher in IL-6R antibody group than in PMMA group and control group (P〈0.01). The expression of RANKL was inhibited (P〈0.05), and the ratio of OPG/RANKL was significantly increased in IL-6R antibody group as compared with PMMA group and control group. There was no significant difference in the expression of OPG between control group and PMMA group (P〉0.05), but the expression of RANKL was higher in PMMA group than in control group (P〈0.05), and there was a significant difference in the ratio of OPG/RANKL be- tween them (P〈0.05). Results of FQ-PCR revealed the expression of RANKL mRNA was significantly inhibited (P〈0.01) and the expression of OPG mRNA was significantly increased (P〈0.01) in IL-6R an- tibody group as compared with PMMA group and control group. The expression of RANKL mRNA was higher in PMMA group than in control group (P〈0.05), but the expression of OPG mRNA had no sig- nificant difference between them (P〉0.05). IL-6R antibody could significantly increase the expression of OPC~ but inhibit the expression of RANKL, which might provide a theoretical basis of molecular bi- ology for the prevention and treatment of aseptic loosening of prosthesis. 展开更多
关键词 interleukin-6 receptor polymethyl methacrylate bone cement synovial fibroblasts osteo-protegerin receptor activator of nuclear factor-kappaB ligand
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Injectable bioactive polymethyl methacrylate-hydrogel hybrid bone cement loaded with BMP-2 to improve osteogenesis for percutaneous vertebroplasty and kyphoplasty 被引量:4
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作者 Xin Sun Xin Zhang +8 位作者 Xin Jiao Jie Ma Xingzhen Liu Han Yang Kangping Shen Yaokai Gan Jinwu Wang Haiyan Li Wenjie Jin 《Bio-Design and Manufacturing》 SCIE EI CAS CSCD 2022年第2期318-332,共15页
Poly methyl methacrylate(PMMA)bone cement is used in augmenting and stabilizing fractured vertebral bodies through percutaneous vertebroplasty(PVP)and percutaneous kyphoplasty(PKP).However,applications of PMMA bone ce... Poly methyl methacrylate(PMMA)bone cement is used in augmenting and stabilizing fractured vertebral bodies through percutaneous vertebroplasty(PVP)and percutaneous kyphoplasty(PKP).However,applications of PMMA bone cement are limited by the high elasticity modulus of PMMA,its low biodegradability,and its limited ability to regenerate bone.To improve PMMA bio activity and biodegradability and to modify its elasticity modulus,we mixed PMMA bone cement with oxidized hyaluronic acid and carboxymethyl chitosan in situ cross-linking hydrogel loaded with bone morphogenetic protein-2(BMP-2)to achieve novel hybrid cement.These fabric ated PMMA-hydrogel hybrid cements exhibited lower setting temperatures,a lower elasticity modulus,and better biodegradability and biocompatibility than that of pure PMMA cement,while retaining acceptable setting times,mechanical strength,and inj ectability.In addition,we detected release of BMP-2 from the PMMA-hydrogel hybrid cements,significantly enhancing in vitro osteogenesis of bone marrow mesenchymal stem cells by up-regulating the gene expression of Runx2,Coll,and OPN.Use of PMMA-hydrogel hybrid cements loaded with BMP-2 on rabbit femoral condyle bone-defect models revealed their biodegradability and enhanced bone formation.Our study demonstrated the favorable mechanical properties,biocompatibility,and biodegradability of fabricated PMMA-hydrogel hybrid cements loaded with BMP-2,as well as their ability to improve osteogenesis,making them a promising material for use in PKP and PVP. 展开更多
关键词 Polymethyl methacrylate bone cement HYDROGEL bone morphogenetic protein-2 OSTEOGENESIS Percutaneous vertebroplasty
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Treatment of Kümmell’s disease with sequential infusion of bone cement:A retrospective study 被引量:6
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作者 Xing Zhang Yong-Chao Li +2 位作者 Hong-Peng Liu Bing Zhou Hui-Lin Yang 《World Journal of Clinical Cases》 SCIE 2020年第23期5887-5893,共7页
BACKGROUND Percutaneous vertebroplasty(PVP)is an effective method for the treatment of neurologically intact Kümmell’s disease,but bone cement leakage during surgery is a problem that deserves attention.AIM To r... BACKGROUND Percutaneous vertebroplasty(PVP)is an effective method for the treatment of neurologically intact Kümmell’s disease,but bone cement leakage during surgery is a problem that deserves attention.AIM To reduce bone cement leakage and evaluate the effect of the sequential infusion of bone cement during PVP for the treatment of stage I or II Kümmell’s disease.METHODS Patients with Kümmell’s disease treated in our hospital from September 2015 to September 2018 were retrospectively analyzed.Patients meeting the inclusion and exclusion criteria were divided into two groups:Traditional single infusion and sequential infusion(SI).The visual analog scale(VAS)and Oswestry disability index(ODI)were evaluated and compared,and duration of operation,bone cement content and complications were recorded.RESULTS Forty-five patients were included in this study;there were 24 in the traditional single infusion group and 21 in the SI group.The VAS and ODI were significantly different for both groups when compared pre-and postoperatively,whereas the differences between 1 wk postoperatively and at the final follow-up were not statistically.When the VAS and ODI of the two groups were compared,there were no significant differences at any time point.The leakage rate of bone cement was significantly lower in the SI group(14.3%,3 of 21)than that in the traditional single infusion group(41.7%,10 of 24).CONCLUSION SI in unipedicular PVP is a safe and effective procedure for neurologically intact Kümmell’s disease,and this technique could decrease the incidence of bone cement leakage. 展开更多
关键词 Kümmell’s Disease Percutaneous vertebroplasty bone cement leakage Back pain OSTEOPOROSIS Intravertebral vacuum cleft
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Drug Release Characteristics of Hydroxyapatite Bone Cement 被引量:1
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作者 陈德敏 《Journal of Wuhan University of Technology(Materials Science)》 SCIE EI CAS 2005年第B12期16-18,共3页
To discuss the feasibility of bydroxyapatite bone cement (HAC) used as a drug delivery carrier and observe the bacteriostatic activity of HAC/ Norvancomycin( HAC/ NVCM ) composite in vitro and its release charac... To discuss the feasibility of bydroxyapatite bone cement (HAC) used as a drug delivery carrier and observe the bacteriostatic activity of HAC/ Norvancomycin( HAC/ NVCM ) composite in vitro and its release characteristics in vivo. Bacteriostatic zone and cycle of composite containing 1.5wt% of NVCM were measured in vitro studies. In vivo stndies , the composite was implanted into the top of rabbit' s tibia as the local medication group, HAC without NVCM being composed was also implanted and NVCM was injected into auricular vein as the systemic medication group. Cnncentrations of NVCM in blood and local bone were measured in both groups at different time points. The experimental results showed that HAC did not influence the bacteriostatic activity of NVCM otviously, and NVCM exist in the porosities of HAC in the pattern of amorphism. The blood coueemrations of NVCM in local medication group were always lower than those in systemic medication group at any time point, while the bone concentrations of NVCM in local medication group were much higher than those of systemic medication group,which remained to be 3.96μg/mg/mL after 2 weeks. And HAC has good release characteristics as a drug delivery earricr. 展开更多
关键词 hydroxyapatite bone cement NORVANCOMYCIN drug carrier slow-release
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The Behavior of New Hydrophilic Composite Bone Cements for Immediate Loading of Dental Implant 被引量:1
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作者 马毅慧 WANG Ruoli +2 位作者 程祥荣 LIU Zhilan ZHANG Yufeng 《Journal of Wuhan University of Technology(Materials Science)》 SCIE EI CAS 2013年第3期627-633,共7页
We introduced the hydrophilic groups to acrylic bone cement to improve compliance and achieve more interdigitation between the bone and the acrylic bone cement in order to create better substrates for immediate loadin... We introduced the hydrophilic groups to acrylic bone cement to improve compliance and achieve more interdigitation between the bone and the acrylic bone cement in order to create better substrates for immediate loading. FTIR-ATR, contact angle, and maximum breach torque were employed for measurement. The results reveal that the introduction of hydrophilic functional groups has increased PMMA's surface hydrophilicity after contact angle test. FTIR-ATR results suggest the hydrophilic groups participate in the polymerization reactions, and maximum breach torque of the hydrophilic acrylic bone cements is near 110 Ncm torque. Those effects make it possible for conventional acrylic bone cement application in immediate loading of dental implant. 展开更多
关键词 immediate loading hydrophilic acrylic bone cement tooth implant
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Bone cement implantation syndrome during hip replacement in a patient with pemphigus and Parkinson’s disease: A case report 被引量:2
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作者 Wei Zhou Wen-Jing Zhang +1 位作者 Guo-Qing Zhao Kai Li 《World Journal of Clinical Cases》 SCIE 2021年第14期3342-3349,共8页
BACKGROUND Bone cement implantation syndrome(BCIS)is characterized by hypotension,arrhythmia,diffuse pulmonary microvascular embolism,shock,cardiac arrest,any combination of these factors,or even death following bone ... BACKGROUND Bone cement implantation syndrome(BCIS)is characterized by hypotension,arrhythmia,diffuse pulmonary microvascular embolism,shock,cardiac arrest,any combination of these factors,or even death following bone cement implantation.CASE SUMMARY An 80-year-old patient with pemphigus and Parkinson’s disease underwent total hip replacement under spinal subarachnoid block and developed acute pulmonary embolism after bone cement implantation.The patient received mask mechanical ventilation with a continuous intravenous infusion of adrenaline(2μg/mL)at a rate of 30 mL/h.Subsequently,the symptoms of BCIS were markedly alleviated,and the infusion rate of adrenaline was gradually reduced until the infusion was completely stopped 45 min later.The patient was then transferred to the Department of Orthopedics,and anticoagulation therapy began at 12 h postoperatively.No other complications were observed.CONCLUSION This is a rare case of BCIS in a high-risk patient with pemphigus and Parkinson’s disease. 展开更多
关键词 bone cement implantation syndrome PEMPHIGUS Parkinson’s disease Pulmonary embolism Case report
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Dual antibiotic loaded bone cement in patients at high infection risks in arthroplasty: Rationale of use for prophylaxis and scientific evidence 被引量:1
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作者 Christof Ernst Berberich Jérome Josse +1 位作者 Frédéric Laurent Tristan Ferry 《World Journal of Orthopedics》 2021年第3期119-128,共10页
In view of the demographic changes and projected increase of arthroplasty procedures worldwide,the number of prosthetic joint infection cases will naturally grow.Therefore,in order to counteract this trend more rigid ... In view of the demographic changes and projected increase of arthroplasty procedures worldwide,the number of prosthetic joint infection cases will naturally grow.Therefore,in order to counteract this trend more rigid rules and a stricter implementation of effective preventive strategies is of highest importance.In the absence of a"miracle weapon"priorities should lie in evidence-based measures including preoperative optimization of patients at higher infection risks,the fulfilment of strict hygiene rules in the operating theatre and an effective antibiotic prophylaxis regimen.Instead of a"one size fits all"philosophy,it has been proposed to adjust the antibiotic prophylaxis protocol to major infection risks taking into account important patient-and procedure-related risk factors.A stronger focus on the local application mode via use of high dose dual antibioticloaded bone cement in such risk situations may have its advantages and is easy to apply in the theatre.The more potent antimicrobial growth inhibition in vitro and the strong reduction of the prosthetic joint infection rate in risk for infection patients with aid of dual antibiotic-loaded bone cement in clinical studies align with this hypothesis. 展开更多
关键词 Prosthetic joint infection Antibiotic-loaded bone cement Single low dose antibiotic-loaded bone cement Dual high dose antibiotic-loaded bone cement Antibiotic prophylaxis Risk-for-infection patients
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Antibiotic-free antimicrobial poly (methyl methacrylate) bone cements:A state-of-the-art review 被引量:1
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作者 Gladius Lewis 《World Journal of Orthopedics》 2022年第4期339-353,共15页
Prosthetic joint infection(PJI)is the most serious complication following total joint arthroplasty,this being because it is associated with,among other things,high morbidity and low quality of life,is difficult to pre... Prosthetic joint infection(PJI)is the most serious complication following total joint arthroplasty,this being because it is associated with,among other things,high morbidity and low quality of life,is difficult to prevent,and is very challenging to treat/manage.The many shortcomings of antibiotic-loaded poly(methyl methacrylate)(PMMA)bone cement(ALBC)as an agent for preventing and treating/managing PJI are well-known.One is that microorganisms responsible for most PJI cases,such as methicillin-resistant S.aureus,have developed or are developing resistance to gentamicin sulfate,which is the antibiotic in the vast majority of approved ALBC brands.This has led to many research efforts to develop cements that do not contain gentamicin(or,for that matter,any antibiotic)but demonstrate excellent antimicrobial efficacy.There is a sizeable body of literature on these socalled“antibiotic-free antimicrobial”PMMA bone cements(AFAMBCs).The present work is a comprehensive and critical review of this body.In addition to summaries of key trends in results of characterization studies of AFAMBCs,the attractive features and shortcomings of the literature are highlighted.Shortcomings provide motivation for future work,with some ideas being formulation of a new generation of AFAMBCs by,example,adding a nanostructured material and/or an extract from a natural product to the powder and/or liquid of the basis cement,respectively. 展开更多
关键词 Periprosthetic joint infection Poly(methyl methacrylate)bone cement Antibiotic-loaded poly(methyl methacrylate)bone cement bone cement Antibiotic-free antimicrobial poly(methyl methacrylate)bone cement bone cement
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A Finite Element Study of Crack Behavior for Carbon Na-notube Reinforced Bone Cement 被引量:1
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作者 Kaveh PourAkbar Saffar Ahmad Raeisi Najafi +1 位作者 Manssour H. Moeinzadeh Leszek J. Sudak 《World Journal of Mechanics》 2013年第5期13-21,共9页
Polymethylmethacrylate (PMMA) bone cement is a polymeric material that is widely used as a structural orthopedic material. However, it is not an ideal material for bone grafting due to its fragility. Carbon nanotubes ... Polymethylmethacrylate (PMMA) bone cement is a polymeric material that is widely used as a structural orthopedic material. However, it is not an ideal material for bone grafting due to its fragility. Carbon nanotubes (CNTs) have been introduced in order to reinforce PMMA resulting in a composite material which exhibits improved tensile properties, increased fatigue resistance and fracture toughness. This improvement is potentially due to bridging and arresting cracks as well as absorption of energy. In this study, a two-dimensional finite element model is presented for the fracture analysis of PMMA-CNT composite material. Instead of the classical single fiber model, the present work considers an ensemble of CNTs interacting with a pre-existing crack. Casca is used to produce a two dimensional mesh and the fracture analysis is performed using Franc 2D. The model is subjected to uni-axial loading in the transverse plane and the interaction between the crack and CNTs is evaluated by determining the stress intensity factor in the vicinity of the crack tips. The effects of geometric parameters of the CNTs and the material structural heterogeneity on crack propagation trajectory are investigated. Furthermore, the effects of CNT diameter, wall thickness and elastic mismatch between the matrix and the nanotubes on crack growth are studied. The results illustrate that the CNTs repel cracks during loading as they act as barriers to crack growth. As a result, the incorporation of CNTs into PMMA reduces crack growth but more importantly increases the fracture resistance of bone cement. 展开更多
关键词 bone cement CARBON NANOTUBE Finite Element CRACK Propagation Stress INTENSITY Factor
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Capacity of bone induction of compound material of decalcified bone matrix combined with rhBMP-2 and impregnated with bone cement 被引量:3
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作者 周勇 董玉霞 +1 位作者 范清宇 文艳华 《中国临床康复》 CSCD 2003年第6期1010-1011,共2页
AIM:To analyze bone inductive capacity of the compound material of decalcified bone matrix combined with rhBMP 2 and impregnated with bone cement.METHODS:To assess the experimental study, histological and Masson’s me... AIM:To analyze bone inductive capacity of the compound material of decalcified bone matrix combined with rhBMP 2 and impregnated with bone cement.METHODS:To assess the experimental study, histological and Masson’s methods were used.RESULTS:The effects of compound material on the induction of bone formation were investigated in NIH mouse models.It was observed that in the with rhBMP 2 group, mesenchymal cells gathered in the implanted material at the 7th day postoperation,chondrogenesis were found at 14 to 21 days after implantation,new bone formation were observed at about 21 to 28 days after surgery and the DBM particles were absorbed by the new generated tissues gradually.CONCLUSIONS:The compound material of DBM combined with rhBMP 2 and impregnated with bone cement could induce the proliferation and migration of mesenchymal tissues that could be differentiated into cartilage and formed new bone finally.The new bone could absorb DBM particles gradually.The compound material had fair capacity of bone induction. 展开更多
关键词 异体脱钙骨 基质骨粒 骨水泥 骨形态发生蛋白 复合材料 诱导活性
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Bond strength analysis of the bone cement-stem interface of hip arthroplasties
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作者 Lan-Feng Zhang Shi-Rong Ge +3 位作者 Hong-Tao Liu Kai-Jin Guo Shu-Yang Han Jun-Yan Qi 《Asian Pacific Journal of Tropical Medicine》 SCIE CAS 2014年第2期153-159,共7页
Objective:To study and establish the preliminary linear and modified models for the interface shear mechanics performance between implant and bone cement and to explore its damage significantce.Method:The loosening re... Objective:To study and establish the preliminary linear and modified models for the interface shear mechanics performance between implant and bone cement and to explore its damage significantce.Method:The loosening research between artificial hip joint prosthesis stem and bone cement interface performance can be evaluated by the push-in test.Based on the debondittg perforntance test,the analytical expressions of the average load and displacement from the debottdiftg failure and splitting failure process were deduced and determined.The correlations of the expressions of the average load-displacement and statistical experimental data were analyzed.Results:It demonstrated that the interface debonding failure mechanical model could be characterisied as interface bond strength mechanical performance.Based on analysis of models and experimental data by the three statistical analysis methods,the results indicated the modified model could be better represented by the interfacial debonding strength properties.The bond stress(?)and relative sliding s distribution along the embedment regional were coupling affected by both pressure arch effect and shear lag effect in bone cement.Two stress peaks of implant have been found at the distance from 0.175L_0 loading tip to 0.325L_0 free tip,which also verified the early loosening clinical reports for the proximal and latter region.As the bone cement arch effect,the bond stress peak tend to move to the free tip when the debonding failure would be changed into the splitting failure,which presents a preliminary study on the mechanism of early delmnding failure for the stem-cement interface.Conclusions:Functional models of the stembone cement interfacial debonding failure are developed lo analyze the relevant mechanism.The different lotcational titanium alloy stress,and the interfacial bond stress and the relative slides are evaluated to acquire a guide of the different positions of interfacial damage.The coupling;effect which is original from the pressure arch and the interfacial shear hysteresis cumulative effect has influence on the interfacial debonding and damage process. 展开更多
关键词 bone cement MANTLE Stem-cement DEBONDING Titanium Total HIP ARTHROPLASTY
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Formation and Characterization of Bone-like Nanoscale Hydroxyapatite in Glass Bone Cement
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作者 Qiang FU, Nai ZHOU, Wenhai HUANG, Deping WANG and Liying ZHANGSchool of Materials Science and Engineering, Tongji University, Shanghai 200092, China 《Journal of Materials Science & Technology》 SCIE EI CAS CSCD 2004年第6期772-774,共3页
Glass based bone cement (GBC) was synthesized by mixing CaO-SiO2-P2O5 based glass powder with ammonium phosphate liquid medium. Bone-like hydroxyapatite (HAP, Ca10(PO4)6(OH)2) was found to form after GBC was immersed ... Glass based bone cement (GBC) was synthesized by mixing CaO-SiO2-P2O5 based glass powder with ammonium phosphate liquid medium. Bone-like hydroxyapatite (HAP, Ca10(PO4)6(OH)2) was found to form after GBC was immersed in simulated body fluid (SBF). HAP crystal grew with an increasing time along c axle and reached about 200 nm in length after 30 days, however, the end plane granularity remained 30-50 nm. The chemical composition, crystal structure and morphology of HAP formed from GBC were proved to have great resemblance with living HAP. It is believed that GBC was a desirabie biomedicai material with high bioactivity. Furthermore, the high compressive strength guaranteed the possibility of GBC in clinical application. 展开更多
关键词 Bioactivity bone cement HYDROXYAPATITE Microstructure
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Biological Evaluation of α-TCP/TTCP Composite Bone Cement
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作者 戴红莲 《Journal of Wuhan University of Technology(Materials Science)》 SCIE EI CAS 2002年第3期35-38,共4页
tricalcium phosphate(α TCP)/tetracalcium phosphate(TTCP) composite bone cement had good hydration characteristic.In our system,α TCP/TTCP powder mixture was mixed with water at a powder/liquid (P/L) ratio of 1.50g... tricalcium phosphate(α TCP)/tetracalcium phosphate(TTCP) composite bone cement had good hydration characteristic.In our system,α TCP/TTCP powder mixture was mixed with water at a powder/liquid (P/L) ratio of 1.50g·mL -1 .The setting time could be adjusted,the maximum compressive strength was 45.36MPa,and the hydration product was hydroxyapatite (HAP).In vitro biological simulated experiments indicate that α TCP/TTCP bone cement has α certain dissolubility.The hardened product is mainly HAP after soaking in simulated body fluid (SBF) for 10 weeks.The results of in vitro test and animal experiments and SEM analyses show that no local or general toxicity response,no muscle stimulation,no haemolysis,no cruor,no inflammatory reaction and no exclusion response are caused by α TCP/TTCP cement, which can be contributed to bone tissue spreading and impinging.α TCP/TTCP cement hydrated and hardened continually in vivo.The materials fused with host bone together with implanting time prolonging.Therefore,it is believed that α TCP/TTCP composite bone cement has a high biocompatibility and bioactivity,a certain biodegradation and good osteogenesis as well. 展开更多
关键词 α-TCP/TTCP bone cement BIOCOMPATIBILITY bioactivity
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Mechanical Behaviour of Composite Bioactive Bone Cements Consisting of Two Different Types of Surface Treated Hydroxyapatite as Filler
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作者 S Deb JA Roether 《Journal of Wuhan University of Technology(Materials Science)》 SCIE EI CAS 2005年第B12期10-12,共3页
Bioactive bone cements based on a paste-paste system for orthopaedic applications were developed consisting of hydroxyapatite ( HA ) filler panicles in a methacrylate matrix comprising urethane dimethacrylate ( UD... Bioactive bone cements based on a paste-paste system for orthopaedic applications were developed consisting of hydroxyapatite ( HA ) filler panicles in a methacrylate matrix comprising urethane dimethacrylate ( UDMA ) and triethylene glycol dimethacrylate ( TEGDMA ). To improve the interface between inorganic filler and organic matrix the HA panicles were subjected to two different surface treatment methods, using polyacrylic acid (PAA) and γ-methacryloxy propyl trimethoxy silane (γMPS). The aim of the present study was to determine the influence of surface treatment and the inclusion of multifunctional methacrylates on the mechanical properties, namely 3-point flexural strength (FS) and fracture toughness of the cements and the effect of ageing in simulated body fluid. Comparing the mechanical properties of the two cements, the γMPS- HA cement showed that the fracture toughness of the experimental bone cements were significantly greater ( p 〈 0.001) compared to that of the PMMA cement, whereas PAA-HA containing cement had strength vollues around 20% lower. Interestingly, PAA was found to be more effective in improving the interface as the PAA treated HA cement ( UTHAPPA ) maintained its strength on immersion in SBF, suggesting that PAA provided a coupling, which was less sensitive to moisture, a similar trend was also observed with the inclusion of the carboxyl containing multifunctional methacrylates. 展开更多
关键词 bioactive bone cements coupling agents COMPOSITES polyacrylic acid
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Antibiotic bone cement's effect on infection rates in primary and revision total knee arthroplasties
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作者 Donald Kleppel Jacob Stirton +1 位作者 Jiayong Liu Nabil A Ebraheim 《World Journal of Orthopedics》 2017年第12期946-955,共10页
AIM To compare infection rates in primary and revision total knee arthroplasty(TKA) procedures using antibiotic impregnated bone cement(AIBC) to those rates in procedures not using AIBC.METHODS A systematic review and... AIM To compare infection rates in primary and revision total knee arthroplasty(TKA) procedures using antibiotic impregnated bone cement(AIBC) to those rates in procedures not using AIBC.METHODS A systematic review and meta-analysis was conducted in search for randomized controlled trials/studies(RCTs) pertaining to the field of antibiotic AIBC vs non-AIBC groups in both primary and revision TKA procedures. The primary literature search performed was to identify all RCTs that assessed AIBC in primary and revision TKA procedures. This search was done strictly through the Pub Med database using the article "filters" setting that identified and separated all RCTs from the overall search. The original search was "Primary/revision total knee arthroplasty using AIBC". Other key terms and phrases were included in the search as well. Eligible articles that were used in the "results" of this review met the following criteria:(1) Involved primary or revision TKA procedures(for any reason);(2) included TKA outcome infection rate information;(3) analyzed an AIBC group vs a non-AIBC control group;(4) were found through the RCT filter or hand search in Pub Med; and(5) published 1985-2017. Exclusion criteria was as follows:(1) Patients that were not undergoing primary or revision TKA procedures;(2) articles that did not separate total hip arthroplasity(THA) vs TKA results if both hip and knee revisions were evaluated;(3) papers that did not follow up on clinical outcomes of the procedure;(4) extrapolation of data was not possible given published results;(5) knee revisions not done on human patients;(6) studies that were strictly done on THAs;(7) articles that were not found through the RCT filter or through hand search in Pub Med;(8) articles that did not evaluate AIBC used in a prosthesis or a spacer during revision;(9) articles that did not compare an AIBC group vs a non-AIBC control group; and(10) articles that were published before 1985.RESULTS In total, 11 articles were deemed eligible for this analysis. Nine of the 11 studies dealt with primary TKA procedures comparing AIBC to non-AIBC treatment. The other two studies dealt with revision TKA procedures that compared such groups. From these papers, 4092 TKA procedures were found. 3903 of these were primary TKAs, while 189 were revision TKAs. Of the 3903 primary TKAs, 1979 of these used some form of AIBC while 1924 were part of a non-AIBC control group. Of the 189 revision TKAs, 96 of these used some form of AIBC while 93 were part of a non-AIBC control group. Average followup times of 47.2 mo and 62.5 mo were found in primary and revision groups respectively. A two-tailed Fisher's exact test was done to check if infection rates differed significantly between the groups. In the primary TKA group, a statistically significant difference between AIBC and non-AIBC groups was not found(AIBC infection rate = 23/1979, non-AIBC infection rate = 35/1924, P = 0.1132). In the revision TKA group, a statistically significant difference between the groups was found(AIBC infection rate = 0/96, non-AIBC infection rate = 7/93, P = 0.0062). No statistically significant differences existed in Knee Society Scores, Hospital for Special Surgery Scores, or Loosening Rates.CONCLUSION AIBC did not have a significant effect on primary TKA infection rates. AIBC did have a significant effect on revision TKA infection rates. 展开更多
关键词 TOTAL KNEE ARTHROPLASTY KNEE REVISION Antibiotic impregnated/laden/infused bone cement bone cement KNEE ARTHROPLASTY Primary/revision TOTAL KNEE arthroplasties infection
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Effect on Hydration and Hardening of Tricalcium Phosphate Bone Cement
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作者 戴红莲 《Journal of Wuhan University of Technology(Materials Science)》 SCIE EI CAS 2005年第B12期274-277,共4页
The bioactive α-Ca3( PO4 )2 bone cement was studied by XRD , SEM and isothermal calorimetric measurements. The results showed that a mixed pattern of TCP and hydroxylapatite were obtained after hydration and harden... The bioactive α-Ca3( PO4 )2 bone cement was studied by XRD , SEM and isothermal calorimetric measurements. The results showed that a mixed pattern of TCP and hydroxylapatite were obtained after hydration and hardening. The mechanism of hydration and hardening of the α-Ca3 ( PO4)2 was dissolution-precipitation, ( NH4 ) 112 PO4 was the best set accelerator to the α-Ca3 ( PO4)2 cement, and the HAP powers and the ( NH4)H2 PO4 concentration had a great effect on the hydration rate of a-Ca3( PO4)2. 展开更多
关键词 tricalcium phosphate bone cement hydration and hardening EFFECT
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