A novel hemodynamic model has been recently introduced,which provides analytical relation-ships between the changes in cerebral blood volume(CBV),cerebral blood flow(CBF),andcerebral metabolic rate of oxy gen(CMRO2),a...A novel hemodynamic model has been recently introduced,which provides analytical relation-ships between the changes in cerebral blood volume(CBV),cerebral blood flow(CBF),andcerebral metabolic rate of oxy gen(CMRO2),and associat ed changes in the tissue concentrationsof oxy-and deoxy-hemoglobin(AO and AD)measured with near-infrared,spectroscopy(NIRS)[S.Fantini,Neuroimage 85,202-221(2014)].This novel model can be applied tomeasurements of the amplit ude and phase of induced hemodynamic oscillations as a function ofthe frequency of oscillation,realizing the novel technique of coherent hemodynamics spectroscopy(CHS)[S.Fantini,Neuroimage 85,202-221(2014);M.L.Pierro et al.,Neuroimage 85,222-233(2014)]:In a previous work,,we have demonstrated an in vivo application of CiHS on hunanSubjects during paced breat hing[M.L.Pierro et al,Neuroimage 85,222-233(2014)].In thiswork,we present a new analysis of the collected data duringpaced breat hing based on a slightlyrevised formulation of the hemodynamic model and ann efficient fitting procedure.While we haveinitially treated all 12 model parameindeependent,we have found that,in this new in-plementation of CHS,the number of independent is eight.In this article,we identifythe eight independent model parameters and,we show that our previous results are consistentwith the new formulation,once the individual parameters of the earlier analysis are combinedinto the new set of independent parameters.展开更多
The dynamics indexes, playing an important role in the cerebral circulation, will be changed significantly compared with their normal range in many cerebrovas-cular disease. The geometrical parameters of cerebrovascul...The dynamics indexes, playing an important role in the cerebral circulation, will be changed significantly compared with their normal range in many cerebrovas-cular disease. The geometrical parameters of cerebrovascular may be detected by DSA or MRA scan, but the hemodynamic parameters, such as, blood flow, artery resistance and compliance must be calculated by building hemodynamics model.The cerebral circular system that has four entrances for blood flow (two carotid and two vertebral arteries) and three communicating arteries is much different from the systematic ststem which has only one entrance, ie. , the aortic. The purpose of this study is to set up a hemodynamics model with lumped parameters to describe the cerebral circulation. From this model, we get its governing equations and present a new method to calculate the hemodynamics indexes in clinical application.展开更多
基金supported by the National Institutes of Health(Grant No.R01-CA154774)by the National Science Foundation(Award No.IIs-1065154).
文摘A novel hemodynamic model has been recently introduced,which provides analytical relation-ships between the changes in cerebral blood volume(CBV),cerebral blood flow(CBF),andcerebral metabolic rate of oxy gen(CMRO2),and associat ed changes in the tissue concentrationsof oxy-and deoxy-hemoglobin(AO and AD)measured with near-infrared,spectroscopy(NIRS)[S.Fantini,Neuroimage 85,202-221(2014)].This novel model can be applied tomeasurements of the amplit ude and phase of induced hemodynamic oscillations as a function ofthe frequency of oscillation,realizing the novel technique of coherent hemodynamics spectroscopy(CHS)[S.Fantini,Neuroimage 85,202-221(2014);M.L.Pierro et al.,Neuroimage 85,222-233(2014)]:In a previous work,,we have demonstrated an in vivo application of CiHS on hunanSubjects during paced breat hing[M.L.Pierro et al,Neuroimage 85,222-233(2014)].In thiswork,we present a new analysis of the collected data duringpaced breat hing based on a slightlyrevised formulation of the hemodynamic model and ann efficient fitting procedure.While we haveinitially treated all 12 model parameindeependent,we have found that,in this new in-plementation of CHS,the number of independent is eight.In this article,we identifythe eight independent model parameters and,we show that our previous results are consistentwith the new formulation,once the individual parameters of the earlier analysis are combinedinto the new set of independent parameters.
文摘The dynamics indexes, playing an important role in the cerebral circulation, will be changed significantly compared with their normal range in many cerebrovas-cular disease. The geometrical parameters of cerebrovascular may be detected by DSA or MRA scan, but the hemodynamic parameters, such as, blood flow, artery resistance and compliance must be calculated by building hemodynamics model.The cerebral circular system that has four entrances for blood flow (two carotid and two vertebral arteries) and three communicating arteries is much different from the systematic ststem which has only one entrance, ie. , the aortic. The purpose of this study is to set up a hemodynamics model with lumped parameters to describe the cerebral circulation. From this model, we get its governing equations and present a new method to calculate the hemodynamics indexes in clinical application.
