BACKGROUND The incidence of pulmonary embolism(PE) in children is low, but its mortality is high. Hypereosinophilic syndrome(HES) is a group of diseases caused by an abnormal increase in eosinophilic granulocytes resu...BACKGROUND The incidence of pulmonary embolism(PE) in children is low, but its mortality is high. Hypereosinophilic syndrome(HES) is a group of diseases caused by an abnormal increase in eosinophilic granulocytes resulting in multiple-organ dysfunction. The urgent event of thromboembolism in the pulmonary region provoked by eosinophils in idiopathic HES(IHES) is relatively unusual. This article reports a case of IHES with multiple PEs and left leg venous thrombosis as the first manifestation. One month later, the patient developed Henoch-Schonlein purpura(HSP), which is very rare.CASE SUMMARY We report the case of a 12-year-old boy who was admitted to the hospital with dyspnea, left leg pain, and aggravation. He had bilateral PE and left leg venous embolism with mild eosinophilia. Low-molecular-weight heparin and urokinase were given. At the same time, the interventional department was contacted about filter implantation, followed by urokinase thrombolysis. The left leg thrombus was aspirated under ultrasound guidance. He was discharged from the hospital on rivaroxaban. One month later, he developed a rash on both legs and ankle pain consistent with HSP, with severe eosinophilia and motor and sensory disturbances. The patient was diagnosed with IHES with multiple embolisms complicated by HSP after excluding other causes of the eosinophil elevation. After glucocorticoid treatment, the symptoms were relieved, but the patient later developed purpura nephritis.CONCLUSION We report a rare and life-threatening case of IHES with multiple embolisms associated with HSP.A mild elevation of eosinophils early in the disease leads to difficulties in diagnosis and delayed treatment.展开更多
Objective:To study the effect of Helicobacter pylori infection on renal function and immune response in children with Henoch-Sch?oenlein purpura (HSP).Methods: Children diagnosed with Henoch-Sch?oenlein purpura in Zho...Objective:To study the effect of Helicobacter pylori infection on renal function and immune response in children with Henoch-Sch?oenlein purpura (HSP).Methods: Children diagnosed with Henoch-Sch?oenlein purpura in Zhognshan Chenxinghai Hospital and Huizhou Third People's Hospital between May 2013 and July 2016 were selected and divided into Hp(﹢) and Hp(-) HSP group according to Helicobacter pylori infection condition. Then renal function and immune response were determined.Results: Scr, BUN, CysC, TM, vWF, sVCAM-1, CTGF, MMP9, IL-17 and IL-23 contents in serum as well as Th17 cell content in peripheral blood of Hp(﹢) HSP group were significantly higher than those of Hp(-) HSP group, Treg cell content in peripheral blood as well as TGF-β1 and IL-10 contents in serum of Hp(﹢) HSP group were significantly lower than those of Hp(-) HSP group, SOCS1 and Tim1 mRNA expression in peripheral blood mononuclear cells of Hp(﹢) HSP group were significantly higher than those of Hp(-) HSP group, and SOCS3 and Tim3 mRNA expression were not significantly different from those of Hp(-) HSP group.Conclusion:Helicobacter pylori infection in children with Henoch-Sch?oenlein purpura can aggravate the damage of renal function and the disorder of autoimmune response.展开更多
目的探讨细胞因子信号转导抑制蛋白1(SOCS1)和SOCS3在儿童过敏性紫癜中的表达情况和作用。方法应用逆转录—聚合酶链反应检测20例过敏性紫癜患儿和15例正常健康对照儿童的外周血单个核细胞中SOCS1/SOCS3m RNA表达水平。结果过敏性紫癜患...目的探讨细胞因子信号转导抑制蛋白1(SOCS1)和SOCS3在儿童过敏性紫癜中的表达情况和作用。方法应用逆转录—聚合酶链反应检测20例过敏性紫癜患儿和15例正常健康对照儿童的外周血单个核细胞中SOCS1/SOCS3m RNA表达水平。结果过敏性紫癜患儿SOCS1、SOCS3 m RNA相对表达水平分别为(1.37±0.38)、(1.87±0.53),高于对照儿童的(0.85±0.12)、(0.77±0.13),差异均有统计学意义(P均<0.001);SOCS3 m RNA表达增高更为明显。结论过敏性紫癜患儿有SOCS3的高表达。展开更多
文摘BACKGROUND The incidence of pulmonary embolism(PE) in children is low, but its mortality is high. Hypereosinophilic syndrome(HES) is a group of diseases caused by an abnormal increase in eosinophilic granulocytes resulting in multiple-organ dysfunction. The urgent event of thromboembolism in the pulmonary region provoked by eosinophils in idiopathic HES(IHES) is relatively unusual. This article reports a case of IHES with multiple PEs and left leg venous thrombosis as the first manifestation. One month later, the patient developed Henoch-Schonlein purpura(HSP), which is very rare.CASE SUMMARY We report the case of a 12-year-old boy who was admitted to the hospital with dyspnea, left leg pain, and aggravation. He had bilateral PE and left leg venous embolism with mild eosinophilia. Low-molecular-weight heparin and urokinase were given. At the same time, the interventional department was contacted about filter implantation, followed by urokinase thrombolysis. The left leg thrombus was aspirated under ultrasound guidance. He was discharged from the hospital on rivaroxaban. One month later, he developed a rash on both legs and ankle pain consistent with HSP, with severe eosinophilia and motor and sensory disturbances. The patient was diagnosed with IHES with multiple embolisms complicated by HSP after excluding other causes of the eosinophil elevation. After glucocorticoid treatment, the symptoms were relieved, but the patient later developed purpura nephritis.CONCLUSION We report a rare and life-threatening case of IHES with multiple embolisms associated with HSP.A mild elevation of eosinophils early in the disease leads to difficulties in diagnosis and delayed treatment.
基金Zhongshan Science and Technology Plan Project No:20122A065
文摘Objective:To study the effect of Helicobacter pylori infection on renal function and immune response in children with Henoch-Sch?oenlein purpura (HSP).Methods: Children diagnosed with Henoch-Sch?oenlein purpura in Zhognshan Chenxinghai Hospital and Huizhou Third People's Hospital between May 2013 and July 2016 were selected and divided into Hp(﹢) and Hp(-) HSP group according to Helicobacter pylori infection condition. Then renal function and immune response were determined.Results: Scr, BUN, CysC, TM, vWF, sVCAM-1, CTGF, MMP9, IL-17 and IL-23 contents in serum as well as Th17 cell content in peripheral blood of Hp(﹢) HSP group were significantly higher than those of Hp(-) HSP group, Treg cell content in peripheral blood as well as TGF-β1 and IL-10 contents in serum of Hp(﹢) HSP group were significantly lower than those of Hp(-) HSP group, SOCS1 and Tim1 mRNA expression in peripheral blood mononuclear cells of Hp(﹢) HSP group were significantly higher than those of Hp(-) HSP group, and SOCS3 and Tim3 mRNA expression were not significantly different from those of Hp(-) HSP group.Conclusion:Helicobacter pylori infection in children with Henoch-Sch?oenlein purpura can aggravate the damage of renal function and the disorder of autoimmune response.
文摘目的探讨细胞因子信号转导抑制蛋白1(SOCS1)和SOCS3在儿童过敏性紫癜中的表达情况和作用。方法应用逆转录—聚合酶链反应检测20例过敏性紫癜患儿和15例正常健康对照儿童的外周血单个核细胞中SOCS1/SOCS3m RNA表达水平。结果过敏性紫癜患儿SOCS1、SOCS3 m RNA相对表达水平分别为(1.37±0.38)、(1.87±0.53),高于对照儿童的(0.85±0.12)、(0.77±0.13),差异均有统计学意义(P均<0.001);SOCS3 m RNA表达增高更为明显。结论过敏性紫癜患儿有SOCS3的高表达。
