Zinc(Zn)is considered a promising biodegradable metal for implant applications due to its appropriate degradability and favorable osteogenesis properties.In this work,laser powder bed fusion(LPBF)additive manufacturin...Zinc(Zn)is considered a promising biodegradable metal for implant applications due to its appropriate degradability and favorable osteogenesis properties.In this work,laser powder bed fusion(LPBF)additive manufacturing was employed to fabricate pure Zn with a heterogeneous microstructure and exceptional strength-ductility synergy.An optimized processing window of LPBF was established for printing Zn samples with relative densities greater than 99%using a laser power range of 80∼90 W and a scanning speed of 900 mm s−1.The Zn sample printed with a power of 80 W at a speed of 900 mm s−1 exhibited a hierarchical heterogeneous microstructure consisting of millimeter-scale molten pool boundaries,micrometer-scale bimodal grains,and nanometer-scale pre-existing dislocations,due to rapid cooling rates and significant thermal gradients formed in the molten pools.The printed sample exhibited the highest ductility of∼12.1%among all reported LPBF-printed pure Zn to date with appreciable ultimate tensile strength(∼128.7 MPa).Such superior strength-ductility synergy can be attributed to the presence of multiple deformation mechanisms that are primarily governed by heterogeneous deformation-induced hardening resulting from the alternative arrangement of bimodal Zn grains with pre-existing dislocations.Additionally,continuous strain hardening was facilitated through the interactions between deformation twins,grains and dislocations as strain accumulated,further contributing to the superior strength-ductility synergy.These findings provide valuable insights into the deformation behavior and mechanisms underlying exceptional mechanical properties of LPBF-printed Zn and its alloys for implant applications.展开更多
Heterogeneous photocatalysis,an advanced oxidation process,has garnered extensive attention in the field of environmental remediation because it involves the direct utilization of solar energy for the removal of numer...Heterogeneous photocatalysis,an advanced oxidation process,has garnered extensive attention in the field of environmental remediation because it involves the direct utilization of solar energy for the removal of numerous pollutants.However,the application of heterogeneous photocatalysis in environmental remediation has not achieved the expected consequences due to enormous challenges such as low photocatalytic efficiencies and high costs of heterogeneous photocatalysts in large-scale practical applications.Furthermore,pollutants in the natural environment,including water,air,and solid phases,are diverse and complex.Therefore,extensive efforts should be made to better understand and apply heterogeneous photocatalysis for environmental remediation.Herein,the fundamentals of heterogeneous photocatalysis for environmental remediation are introduced.Then,potential semiconductors and their modification strategies for environmental photocatalysis are systematically presented.Finally,conclusions and prospects are briefly summarized,and the direction for the future development of environmental photocatalysis is explored.This review may provide reference directions toward understanding,researching,and designing photocatalytic remediation systems for various environmental pollutants.展开更多
Although small cell offloading technology can alleviate the congestion in macrocell, aggressively offloading data traffic from macrocell to small cell can also degrade the performance of small cell due to the heavy lo...Although small cell offloading technology can alleviate the congestion in macrocell, aggressively offloading data traffic from macrocell to small cell can also degrade the performance of small cell due to the heavy load. Because of collision and backoff, the degradation is significant especially in network with contention-based channel access, and finally decreases throughput of the whole network. To find an optimal fraction of traffic to be offloaded in heterogeneous network, we combine Markov chain with the Poisson point process model to analyze contention-based throughput in irregularly deployment networks. Then we derive the close-form solution of the throughput and find that it is a function of the transmit power and density of base stations.Based on this, we propose the load-aware offloading strategies via power control and base station density adjustment. The numerical results verify our analysis and show a great performance gain compared with non-load-aware offloading.展开更多
Three-dimensional ocean subsurface temperature and salinity structures(OST/OSS)in the South China Sea(SCS)play crucial roles in oceanic climate research and disaster mitigation.Traditionally,real-time OST and OSS are ...Three-dimensional ocean subsurface temperature and salinity structures(OST/OSS)in the South China Sea(SCS)play crucial roles in oceanic climate research and disaster mitigation.Traditionally,real-time OST and OSS are mainly obtained through in-situ ocean observations and simulation by ocean circulation models,which are usually challenging and costly.Recently,dynamical,statistical,or machine learning models have been proposed to invert the OST/OSS from sea surface information;however,these models mainly focused on the inversion of monthly OST and OSS.To address this issue,we apply clustering algorithms and employ a stacking strategy to ensemble three models(XGBoost,Random Forest,and LightGBM)to invert the real-time OST/OSS based on satellite-derived data and the Argo dataset.Subsequently,a fusion of temperature and salinity is employed to reconstruct OST and OSS.In the validation dataset,the depth-averaged Correlation(Corr)of the estimated OST(OSS)is 0.919(0.83),and the average Root-Mean-Square Error(RMSE)is0.639°C(0.087 psu),with a depth-averaged coefficient of determination(R~2)of 0.84(0.68).Notably,at the thermocline where the base models exhibit their maximum error,the stacking-based fusion model exhibited significant performance enhancement,with a maximum enhancement in OST and OSS inversion exceeding 10%.We further found that the estimated OST and OSS exhibit good agreement with the HYbrid Coordinate Ocean Model(HYCOM)data and BOA_Argo dataset during the passage of a mesoscale eddy.This study shows that the proposed model can effectively invert the real-time OST and OSS,potentially enhancing the understanding of multi-scale oceanic processes in the SCS.展开更多
Maritime radar and automatic identification systems (AIS), which are essential auxiliary equipment for navigation safety in the shipping industry, have played significant roles in maritime safety supervision. However,...Maritime radar and automatic identification systems (AIS), which are essential auxiliary equipment for navigation safety in the shipping industry, have played significant roles in maritime safety supervision. However, in practical applications, the information obtained by a single device is limited, and it is necessary to integrate the information of maritime radar and AIS messages to achieve better recognition effects. In this study, the D-S evidence theory is used to fusion the two kinds of heterogeneous information: maritime radar images and AIS messages. Firstly, the radar image and AIS message are processed to get the targets of interest in the same coordinate system. Then, the coordinate position and heading of targets are chosen as the indicators for judging target similarity. Finally, a piece of D-S evidence theory based on the information fusion method is proposed to match the radar target and the AIS target of the same ship. Particularly, the effectiveness of the proposed method has been validated and evaluated through several experiments, which proves that such a method is practical in maritime safety supervision.展开更多
Urbanization changes have been widely examined and numerous urban growth models have been proposed. We introduce an alternative urban growth model specifically designed to incorporate spatial heterogeneity in urban gr...Urbanization changes have been widely examined and numerous urban growth models have been proposed. We introduce an alternative urban growth model specifically designed to incorporate spatial heterogeneity in urban growth models. Instead of applying a single method to the entire study area, we segment the study area into different regions and apply targeted algorithms in each subregion. The working hypothesis is that the integration of appropriately selected region-specific models will outperform a globally applied model as it will incorporate further spatial heterogeneity. We examine urban land use changes in Denver, Colorado. Two land use maps from different time snapshots (1977 and 1997) are used to detect the urban land use changes, and 23 explanatory factors are produced to model urbanization. The proposed Spatially Heterogeneous Expert Based (SHEB) model tested decision trees as the underlying modeling algorithm, applying them in different subregions. In this paper the segmentation tested is the division of the entire area into interior and exterior urban areas. Interior urban areas are those situated within dense urbanized structures, while exterior urban areas are outside of these structures. Obtained results on this model regionalization technique indicate that targeted local models produce improved results in terms of Kappa, accuracy percentage and multi-scale performance. The model superiority is also confirmed by model pairwise comparisons using t-tests. The segmentation criterion of interior/exterior selection may not only capture specific characteristics on spatial and morphological properties, but also socioeconomic factors which may implicitly be present in these spatial representations. The usage of interior and exterior subregions in the present study acts as a proof of concept. Other spatial heterogeneity indicators, for example landscape, socioeconomic and political boundaries could act as the basis for improved local segmentations.展开更多
Sulfate radical-advanced oxidation processes(SR-AOPs)are promising technologies for organic pollutants elimination.Heterogeneous metal-based catalysis has been widely studied and applied to activate peroxymonosulfate(...Sulfate radical-advanced oxidation processes(SR-AOPs)are promising technologies for organic pollutants elimination.Heterogeneous metal-based catalysis has been widely studied and applied to activate peroxymonosulfate(PMS)for producing sulfate radicals.Developing highly efficient catalysts is crucial for future extensive use.Importantly,the catalytic activity is mainly determined by mass and electron transfer.This paper aims to overview the recent enhancement strategies for developing heterogeneous metalbased catalysts as effective PMS activators.The main strategies,including surface engineering,structural engineering,electronic modulation,external energy assistance,and membrane filtration enhancement,are summarized.The potential mechanisms for improving catalytic activity are also introduced.Finally,the challenges and future research prospects of heterogenous metal-based catalysis in SR-AOPs are proposed.This work is hoped to guide the rational design of highly efficient heterogenous catalysts in SR-AOPs.展开更多
Hearing loss (HL) is the most common sensory disorder, affecting all age groups, ethnicities, and gen-ders. According to World Health Organization (WHO) estimates in 2005, 278 million people worldwide have moderate to...Hearing loss (HL) is the most common sensory disorder, affecting all age groups, ethnicities, and gen-ders. According to World Health Organization (WHO) estimates in 2005, 278 million people worldwide have moderate to profound HL in both ears. Results of the 2002 National Health Interview Survey indicate that nearly 31 million of all non-institutionalized adults (aged 18 and over) in the United States have trouble hearing. Epidemiological studies have estimated that approximately 50%of profound HL can be attributed to genetic causes. With over 60 genes implicated in nonsyndromic hearing loss, it is also an extremely het-erogeneous trait. Recent progress in identifying genes responsible for hearing loss enables otolaryngologists and other clinicians to apply molecular diagnosis by genetic testing. The advent of the $1000 genome has the potential to revolutionize the identification of genes and their mutations underlying genetic disorders. This is especially true for extremely heterogeneous Mendelian conditions such as deafness, where the muta-tion, and indeed the gene, may be private. The recent technological advances in target-enrichment methods and next generation sequencing offer a unique opportunity to break through the barriers of limitations im-posed by gene arrays. These approaches now allow for the complete analysis of all known deafness-causing genes and will result in a new wave of discoveries of the remaining genes for Mendelian disorders. This re-view focuses on describing genotype-phenotype correlations of the most frequent genes including GJB2, which is responsible for more than half of cases, followed by other common genes and on discussing the im-pact of genomic advances for comprehensive genetic testing and gene discovery in hereditary hearing loss.展开更多
Recently,multimodal sentiment analysis has increasingly attracted attention with the popularity of complementary data streams,which has great potential to surpass unimodal sentiment analysis.One challenge of multimoda...Recently,multimodal sentiment analysis has increasingly attracted attention with the popularity of complementary data streams,which has great potential to surpass unimodal sentiment analysis.One challenge of multimodal sentiment analysis is how to design an efficient multimodal feature fusion strategy.Unfortunately,existing work always considers feature-level fusion or decision-level fusion,and few research works focus on hybrid fusion strategies that contain feature-level fusion and decision-level fusion.To improve the performance of multimodal sentiment analysis,we present a novel multimodal sentiment analysis model using BiGRU and attention-based hybrid fusion strategy(BAHFS).Firstly,we apply BiGRU to learn the unimodal features of text,audio and video.Then we fuse the unimodal features into bimodal features using the bimodal attention fusion module.Next,BAHFS feeds the unimodal features and bimodal features into the trimodal attention fusion module and the trimodal concatenation fusion module simultaneously to get two sets of trimodal features.Finally,BAHFS makes a classification with the two sets of trimodal features respectively and gets the final analysis results with decision-level fusion.Based on the CMU-MOSI and CMU-MOSEI datasets,extensive experiments have been carried out to verify BAHFS’s superiority.展开更多
With the high-tech industrialization of earth observation satellite remote sensing and the implementation of digital earth strategy,the energy and natural resources have been decided to be the key research fields in C...With the high-tech industrialization of earth observation satellite remote sensing and the implementation of digital earth strategy,the energy and natural resources have been decided to be the key research fields in China.In these fields,from the model based on topology data,through simple feature data model to rule-based data model,the basic spatial analysis algorithms have been developed展开更多
In the realm of data privacy protection,federated learning aims to collaboratively train a global model.However,heterogeneous data between clients presents challenges,often resulting in slow convergence and inadequate...In the realm of data privacy protection,federated learning aims to collaboratively train a global model.However,heterogeneous data between clients presents challenges,often resulting in slow convergence and inadequate accuracy of the global model.Utilizing shared feature representations alongside customized classifiers for individual clients emerges as a promising personalized solution.Nonetheless,previous research has frequently neglected the integration of global knowledge into local representation learning and the synergy between global and local classifiers,thereby limiting model performance.To tackle these issues,this study proposes a hierarchical optimization method for federated learning with feature alignment and the fusion of classification decisions(FedFCD).FedFCD regularizes the relationship between global and local feature representations to achieve alignment and incorporates decision information from the global classifier,facilitating the late fusion of decision outputs from both global and local classifiers.Additionally,FedFCD employs a hierarchical optimization strategy to flexibly optimize model parameters.Through experiments on the Fashion-MNIST,CIFAR-10 and CIFAR-100 datasets,we demonstrate the effectiveness and superiority of FedFCD.For instance,on the CIFAR-100 dataset,FedFCD exhibited a significant improvement in average test accuracy by 6.83%compared to four outstanding personalized federated learning approaches.Furthermore,extended experiments confirm the robustness of FedFCD across various hyperparameter values.展开更多
Zirconium(Zr)emerges as the most effective grain refiner for magnesium(Mg)alloys incorporating Zr.Typically,Zr is introduced in the form of an Mg–Zr master alloy.However,within Mg–Zr master alloys,Zr predominantly e...Zirconium(Zr)emerges as the most effective grain refiner for magnesium(Mg)alloys incorporating Zr.Typically,Zr is introduced in the form of an Mg–Zr master alloy.However,within Mg–Zr master alloys,Zr predominantly exists in a particle form,which tends to aggregate due to attractive van der Waals forces.The clustered Zr is prone to settling,thereby reducing its refining impact on Mg alloys.In this work,a combined pretreatment process for Mg–Zr master alloys was proposed,encompassing the introduction of a physical field to intervene the agglomeration of particle Zr and the employ of high-temperature dissolution and peritectic reactions to promote the solid solution of Zr.The results demonstrate that the particle Zr within the pretreated Mg–Zr master alloy is effectively dispersed and refined,and greater solute Zr levels can be achieved.The subsequent grain refinement ability was studied on a typical Mg–6Zn–0.6Zr(wt%)alloy.The outcome highlights that an improvement in the grain refinement efficacy(32.4%)of Mg–Zr master alloys was obtained with a holding time of 60 min.The pretreated Mg–Zr master alloy significantly augments the efficiency of grain refinement for Mg alloys through a synergistic strategy involving heterogeneous nucleation and solute-driven growth restriction.The crucial factor in achieving effective grain refinement of Zr in Mg alloys lies in regulating the presence and morphology of Zr in the Mg–Zr master alloy,distinguishing between particle Zr and solute Zr.This study introduces a novel method for developing more efficient Mg–Zr refiners.展开更多
研究单转运系统分布式置换流水线调度问题,任一工厂内连续两台机器间有一台运输能力有限的转运机器人。基于此,提出一种多策略融合改进遗传算法以最小化最大完工时间。引入Logistic-tent混沌搜索、基于K-均值聚类的NEH算法和修正NEH算...研究单转运系统分布式置换流水线调度问题,任一工厂内连续两台机器间有一台运输能力有限的转运机器人。基于此,提出一种多策略融合改进遗传算法以最小化最大完工时间。引入Logistic-tent混沌搜索、基于K-均值聚类的NEH算法和修正NEH算法以改善初始工厂加工序列群的质量,运用结合均匀多点交叉和互换变异的自适应交叉变异算子或工厂内/间交叉变异算子进行解的调整,设计一种基于主工厂的邻域搜索(key-factory-based local search,KFLS)和半初始化策略进行再次优化。仿真结果表明了该算法的有效性。展开更多
基金National Natural Science Foundation of China (52305358)the Fundamental Research Funds for the Central Universities (2023ZYGXZR061)+3 种基金Guangdong Basic and Applied Basic Research Foundation (2022A1515010304)Science and Technology Program of Guangzhou (202201010362)Young Elite Scientists Sponsorship Program by CAST . (2023QNRC001)Young Talent Support Project of Guangzhou (QT-2023-001)
文摘Zinc(Zn)is considered a promising biodegradable metal for implant applications due to its appropriate degradability and favorable osteogenesis properties.In this work,laser powder bed fusion(LPBF)additive manufacturing was employed to fabricate pure Zn with a heterogeneous microstructure and exceptional strength-ductility synergy.An optimized processing window of LPBF was established for printing Zn samples with relative densities greater than 99%using a laser power range of 80∼90 W and a scanning speed of 900 mm s−1.The Zn sample printed with a power of 80 W at a speed of 900 mm s−1 exhibited a hierarchical heterogeneous microstructure consisting of millimeter-scale molten pool boundaries,micrometer-scale bimodal grains,and nanometer-scale pre-existing dislocations,due to rapid cooling rates and significant thermal gradients formed in the molten pools.The printed sample exhibited the highest ductility of∼12.1%among all reported LPBF-printed pure Zn to date with appreciable ultimate tensile strength(∼128.7 MPa).Such superior strength-ductility synergy can be attributed to the presence of multiple deformation mechanisms that are primarily governed by heterogeneous deformation-induced hardening resulting from the alternative arrangement of bimodal Zn grains with pre-existing dislocations.Additionally,continuous strain hardening was facilitated through the interactions between deformation twins,grains and dislocations as strain accumulated,further contributing to the superior strength-ductility synergy.These findings provide valuable insights into the deformation behavior and mechanisms underlying exceptional mechanical properties of LPBF-printed Zn and its alloys for implant applications.
文摘Heterogeneous photocatalysis,an advanced oxidation process,has garnered extensive attention in the field of environmental remediation because it involves the direct utilization of solar energy for the removal of numerous pollutants.However,the application of heterogeneous photocatalysis in environmental remediation has not achieved the expected consequences due to enormous challenges such as low photocatalytic efficiencies and high costs of heterogeneous photocatalysts in large-scale practical applications.Furthermore,pollutants in the natural environment,including water,air,and solid phases,are diverse and complex.Therefore,extensive efforts should be made to better understand and apply heterogeneous photocatalysis for environmental remediation.Herein,the fundamentals of heterogeneous photocatalysis for environmental remediation are introduced.Then,potential semiconductors and their modification strategies for environmental photocatalysis are systematically presented.Finally,conclusions and prospects are briefly summarized,and the direction for the future development of environmental photocatalysis is explored.This review may provide reference directions toward understanding,researching,and designing photocatalytic remediation systems for various environmental pollutants.
基金supported by the National High-Tech R&D Program (863 Program) under grant No. 2015AA01A705Beijing Municipal Science and Technology Commission research fund project under grant No. D151100000115002+1 种基金China Scholarship Council under grant No. 201406470038BUPT youth scientific research innovation program under grant No. 500401238
文摘Although small cell offloading technology can alleviate the congestion in macrocell, aggressively offloading data traffic from macrocell to small cell can also degrade the performance of small cell due to the heavy load. Because of collision and backoff, the degradation is significant especially in network with contention-based channel access, and finally decreases throughput of the whole network. To find an optimal fraction of traffic to be offloaded in heterogeneous network, we combine Markov chain with the Poisson point process model to analyze contention-based throughput in irregularly deployment networks. Then we derive the close-form solution of the throughput and find that it is a function of the transmit power and density of base stations.Based on this, we propose the load-aware offloading strategies via power control and base station density adjustment. The numerical results verify our analysis and show a great performance gain compared with non-load-aware offloading.
基金jointly supported by the National Key Research and Development Program of China(2022YFC3104304)the National Natural Science Foundation of China(Grant No.41876011)+1 种基金the 2022 Research Program of Sanya Yazhou Bay Science and Technology City(SKJC-2022-01-001)the Hainan Province Science and Technology Special Fund(ZDYF2021SHFZ265)。
文摘Three-dimensional ocean subsurface temperature and salinity structures(OST/OSS)in the South China Sea(SCS)play crucial roles in oceanic climate research and disaster mitigation.Traditionally,real-time OST and OSS are mainly obtained through in-situ ocean observations and simulation by ocean circulation models,which are usually challenging and costly.Recently,dynamical,statistical,or machine learning models have been proposed to invert the OST/OSS from sea surface information;however,these models mainly focused on the inversion of monthly OST and OSS.To address this issue,we apply clustering algorithms and employ a stacking strategy to ensemble three models(XGBoost,Random Forest,and LightGBM)to invert the real-time OST/OSS based on satellite-derived data and the Argo dataset.Subsequently,a fusion of temperature and salinity is employed to reconstruct OST and OSS.In the validation dataset,the depth-averaged Correlation(Corr)of the estimated OST(OSS)is 0.919(0.83),and the average Root-Mean-Square Error(RMSE)is0.639°C(0.087 psu),with a depth-averaged coefficient of determination(R~2)of 0.84(0.68).Notably,at the thermocline where the base models exhibit their maximum error,the stacking-based fusion model exhibited significant performance enhancement,with a maximum enhancement in OST and OSS inversion exceeding 10%.We further found that the estimated OST and OSS exhibit good agreement with the HYbrid Coordinate Ocean Model(HYCOM)data and BOA_Argo dataset during the passage of a mesoscale eddy.This study shows that the proposed model can effectively invert the real-time OST and OSS,potentially enhancing the understanding of multi-scale oceanic processes in the SCS.
文摘Maritime radar and automatic identification systems (AIS), which are essential auxiliary equipment for navigation safety in the shipping industry, have played significant roles in maritime safety supervision. However, in practical applications, the information obtained by a single device is limited, and it is necessary to integrate the information of maritime radar and AIS messages to achieve better recognition effects. In this study, the D-S evidence theory is used to fusion the two kinds of heterogeneous information: maritime radar images and AIS messages. Firstly, the radar image and AIS message are processed to get the targets of interest in the same coordinate system. Then, the coordinate position and heading of targets are chosen as the indicators for judging target similarity. Finally, a piece of D-S evidence theory based on the information fusion method is proposed to match the radar target and the AIS target of the same ship. Particularly, the effectiveness of the proposed method has been validated and evaluated through several experiments, which proves that such a method is practical in maritime safety supervision.
文摘Urbanization changes have been widely examined and numerous urban growth models have been proposed. We introduce an alternative urban growth model specifically designed to incorporate spatial heterogeneity in urban growth models. Instead of applying a single method to the entire study area, we segment the study area into different regions and apply targeted algorithms in each subregion. The working hypothesis is that the integration of appropriately selected region-specific models will outperform a globally applied model as it will incorporate further spatial heterogeneity. We examine urban land use changes in Denver, Colorado. Two land use maps from different time snapshots (1977 and 1997) are used to detect the urban land use changes, and 23 explanatory factors are produced to model urbanization. The proposed Spatially Heterogeneous Expert Based (SHEB) model tested decision trees as the underlying modeling algorithm, applying them in different subregions. In this paper the segmentation tested is the division of the entire area into interior and exterior urban areas. Interior urban areas are those situated within dense urbanized structures, while exterior urban areas are outside of these structures. Obtained results on this model regionalization technique indicate that targeted local models produce improved results in terms of Kappa, accuracy percentage and multi-scale performance. The model superiority is also confirmed by model pairwise comparisons using t-tests. The segmentation criterion of interior/exterior selection may not only capture specific characteristics on spatial and morphological properties, but also socioeconomic factors which may implicitly be present in these spatial representations. The usage of interior and exterior subregions in the present study acts as a proof of concept. Other spatial heterogeneity indicators, for example landscape, socioeconomic and political boundaries could act as the basis for improved local segmentations.
基金financially supported by the National Natural Science Foundation of China(21938009)。
文摘Sulfate radical-advanced oxidation processes(SR-AOPs)are promising technologies for organic pollutants elimination.Heterogeneous metal-based catalysis has been widely studied and applied to activate peroxymonosulfate(PMS)for producing sulfate radicals.Developing highly efficient catalysts is crucial for future extensive use.Importantly,the catalytic activity is mainly determined by mass and electron transfer.This paper aims to overview the recent enhancement strategies for developing heterogeneous metalbased catalysts as effective PMS activators.The main strategies,including surface engineering,structural engineering,electronic modulation,external energy assistance,and membrane filtration enhancement,are summarized.The potential mechanisms for improving catalytic activity are also introduced.Finally,the challenges and future research prospects of heterogenous metal-based catalysis in SR-AOPs are proposed.This work is hoped to guide the rational design of highly efficient heterogenous catalysts in SR-AOPs.
文摘Hearing loss (HL) is the most common sensory disorder, affecting all age groups, ethnicities, and gen-ders. According to World Health Organization (WHO) estimates in 2005, 278 million people worldwide have moderate to profound HL in both ears. Results of the 2002 National Health Interview Survey indicate that nearly 31 million of all non-institutionalized adults (aged 18 and over) in the United States have trouble hearing. Epidemiological studies have estimated that approximately 50%of profound HL can be attributed to genetic causes. With over 60 genes implicated in nonsyndromic hearing loss, it is also an extremely het-erogeneous trait. Recent progress in identifying genes responsible for hearing loss enables otolaryngologists and other clinicians to apply molecular diagnosis by genetic testing. The advent of the $1000 genome has the potential to revolutionize the identification of genes and their mutations underlying genetic disorders. This is especially true for extremely heterogeneous Mendelian conditions such as deafness, where the muta-tion, and indeed the gene, may be private. The recent technological advances in target-enrichment methods and next generation sequencing offer a unique opportunity to break through the barriers of limitations im-posed by gene arrays. These approaches now allow for the complete analysis of all known deafness-causing genes and will result in a new wave of discoveries of the remaining genes for Mendelian disorders. This re-view focuses on describing genotype-phenotype correlations of the most frequent genes including GJB2, which is responsible for more than half of cases, followed by other common genes and on discussing the im-pact of genomic advances for comprehensive genetic testing and gene discovery in hereditary hearing loss.
基金funded by the National Natural Science Foundation of China (Grant No.61872126,No.62273290)supported by the Key project of Natural Science Foundation of Shandong Province (Grant No.ZR2020KF019).
文摘Recently,multimodal sentiment analysis has increasingly attracted attention with the popularity of complementary data streams,which has great potential to surpass unimodal sentiment analysis.One challenge of multimodal sentiment analysis is how to design an efficient multimodal feature fusion strategy.Unfortunately,existing work always considers feature-level fusion or decision-level fusion,and few research works focus on hybrid fusion strategies that contain feature-level fusion and decision-level fusion.To improve the performance of multimodal sentiment analysis,we present a novel multimodal sentiment analysis model using BiGRU and attention-based hybrid fusion strategy(BAHFS).Firstly,we apply BiGRU to learn the unimodal features of text,audio and video.Then we fuse the unimodal features into bimodal features using the bimodal attention fusion module.Next,BAHFS feeds the unimodal features and bimodal features into the trimodal attention fusion module and the trimodal concatenation fusion module simultaneously to get two sets of trimodal features.Finally,BAHFS makes a classification with the two sets of trimodal features respectively and gets the final analysis results with decision-level fusion.Based on the CMU-MOSI and CMU-MOSEI datasets,extensive experiments have been carried out to verify BAHFS’s superiority.
文摘With the high-tech industrialization of earth observation satellite remote sensing and the implementation of digital earth strategy,the energy and natural resources have been decided to be the key research fields in China.In these fields,from the model based on topology data,through simple feature data model to rule-based data model,the basic spatial analysis algorithms have been developed
基金the National Natural Science Foundation of China(Grant No.62062001)Ningxia Youth Top Talent Project(2021).
文摘In the realm of data privacy protection,federated learning aims to collaboratively train a global model.However,heterogeneous data between clients presents challenges,often resulting in slow convergence and inadequate accuracy of the global model.Utilizing shared feature representations alongside customized classifiers for individual clients emerges as a promising personalized solution.Nonetheless,previous research has frequently neglected the integration of global knowledge into local representation learning and the synergy between global and local classifiers,thereby limiting model performance.To tackle these issues,this study proposes a hierarchical optimization method for federated learning with feature alignment and the fusion of classification decisions(FedFCD).FedFCD regularizes the relationship between global and local feature representations to achieve alignment and incorporates decision information from the global classifier,facilitating the late fusion of decision outputs from both global and local classifiers.Additionally,FedFCD employs a hierarchical optimization strategy to flexibly optimize model parameters.Through experiments on the Fashion-MNIST,CIFAR-10 and CIFAR-100 datasets,we demonstrate the effectiveness and superiority of FedFCD.For instance,on the CIFAR-100 dataset,FedFCD exhibited a significant improvement in average test accuracy by 6.83%compared to four outstanding personalized federated learning approaches.Furthermore,extended experiments confirm the robustness of FedFCD across various hyperparameter values.
基金supported by the National Key Research and Development Program of China(No.2021YFB3501001)the National Natural Science Foundation of China(No.52061028)the Major Research and Development Projects of Jiangxi Province(No.20223BBE51021).
文摘Zirconium(Zr)emerges as the most effective grain refiner for magnesium(Mg)alloys incorporating Zr.Typically,Zr is introduced in the form of an Mg–Zr master alloy.However,within Mg–Zr master alloys,Zr predominantly exists in a particle form,which tends to aggregate due to attractive van der Waals forces.The clustered Zr is prone to settling,thereby reducing its refining impact on Mg alloys.In this work,a combined pretreatment process for Mg–Zr master alloys was proposed,encompassing the introduction of a physical field to intervene the agglomeration of particle Zr and the employ of high-temperature dissolution and peritectic reactions to promote the solid solution of Zr.The results demonstrate that the particle Zr within the pretreated Mg–Zr master alloy is effectively dispersed and refined,and greater solute Zr levels can be achieved.The subsequent grain refinement ability was studied on a typical Mg–6Zn–0.6Zr(wt%)alloy.The outcome highlights that an improvement in the grain refinement efficacy(32.4%)of Mg–Zr master alloys was obtained with a holding time of 60 min.The pretreated Mg–Zr master alloy significantly augments the efficiency of grain refinement for Mg alloys through a synergistic strategy involving heterogeneous nucleation and solute-driven growth restriction.The crucial factor in achieving effective grain refinement of Zr in Mg alloys lies in regulating the presence and morphology of Zr in the Mg–Zr master alloy,distinguishing between particle Zr and solute Zr.This study introduces a novel method for developing more efficient Mg–Zr refiners.
文摘研究单转运系统分布式置换流水线调度问题,任一工厂内连续两台机器间有一台运输能力有限的转运机器人。基于此,提出一种多策略融合改进遗传算法以最小化最大完工时间。引入Logistic-tent混沌搜索、基于K-均值聚类的NEH算法和修正NEH算法以改善初始工厂加工序列群的质量,运用结合均匀多点交叉和互换变异的自适应交叉变异算子或工厂内/间交叉变异算子进行解的调整,设计一种基于主工厂的邻域搜索(key-factory-based local search,KFLS)和半初始化策略进行再次优化。仿真结果表明了该算法的有效性。