Objective: We explored the relationship between traditional Chinese constitution and risk factors for cardiovascular disease in subjects with high-normal blood pressure (BP). Methods: The traditional Chinese constitut...Objective: We explored the relationship between traditional Chinese constitution and risk factors for cardiovascular disease in subjects with high-normal blood pressure (BP). Methods: The traditional Chinese constitution of 80 subjects with high-normal BP was judged by questionnaires and interviews. Measurements of cardiovascular and metabolic health in- cluded BP, body weight, body mass index (BMI), low-density lipoprotein cholesterol (LDL-C), 2-hour oral glucose tolerance test (OGTT2h), and waist cir- cumference. Statistical relationships between cardiovascular disease risk factors and specific Chinese constitution were evaluated by univariate and multivariate analyses. Results: Ping He, Tan Shi, and Yin Xu were the dominant constitutions in subjects with high-normal blood pressure. There were significant differences in weight, LDL-C, BMI, OGTT2h, and waist circumference between Tan Shi and Ping He (P P < 0.05), and weight, BMI, waist circumference, SBP, and LDL-C between Tan Shi and Yin Xu constitutions (P < 0.01). Logistic regression found a strong association between the Tan Shi constitution and LDL-C in subjects with high-normal blood pressure. Conclusion: Ping He, Tan Shi, and Yin Xu are the principle traditional Chinese constitutions in subject with high-normal blood pressure. The Tan Shi constitution is associated with multiple risk factors for cardiovascular disease (LDL-C, BMI, body weight, and waist circumference), while OGTT2h is closely related to the Yin Xu constitution.展开更多
Ohjectire To examine the hypothesis of normal perjusion pressure breakthrough (NPPB). Methods A modified Spetzler carotid -jugular (CJ) fistula model was created to imitate NPPB. In 9 male adult Sprague- Dawley rats, ...Ohjectire To examine the hypothesis of normal perjusion pressure breakthrough (NPPB). Methods A modified Spetzler carotid -jugular (CJ) fistula model was created to imitate NPPB. In 9 male adult Sprague- Dawley rats, the ipsilateral vertebral artery and bilateral external carotid arteries were occluded. The period of hypoperfusion CJ fistula was extended to 14 weeks, as a modofcation of Spetzler model. The histological change were examtned under transmission electron microscope 14 weeks after creation of the listula. Results Ischemic histological changes such as increased pinocytosis, increased lucency of the basal lamina, and frank necrosis of the cerebral capillary were found in rats of CJ fistula group. Conclusion The findings in this study suggest that blood - braln barrier (BBB) was impaired by chronic hypoperfusion. The impaired BBB mny be one of the important causes of the NPPB phenomenon.展开更多
目的:系统评价中医健康管理改善高血压前期人群健康结局的有效性。方法:计算机检索中国知网、万方数据库、维普数据库、中国生物医学文献数据库、Cochrane Library、PubMed、Web of Science、CINAHL中有关中医“治未病”理论的健康管理...目的:系统评价中医健康管理改善高血压前期人群健康结局的有效性。方法:计算机检索中国知网、万方数据库、维普数据库、中国生物医学文献数据库、Cochrane Library、PubMed、Web of Science、CINAHL中有关中医“治未病”理论的健康管理改善高血压前期人群健康结局的随机对照试验及类实验研究,检索时限为建库至2023年8月10日。由2名研究者进行文献筛选、质量评价及提取资料工作,采用RevMan 5.4及Stata 17软件进行分析。结果:共纳入9项随机对照试验、2项实验研究。干预组收缩压[MD=-5.08,95%CI(-6.44,-3.72),P<0.00001]、舒张压[MD=-3.78,95%CI(-5.13,-2.44),P<0.00001]、头痛发生率[OR=0.35,95%CI(0.25,0.49),P<0.00001]、眩晕发生率[OR=-0.15,95%CI(-0.21,-0.08),P<0.00001]、全血黏度[MD=-1.05,95%CI(-1.14,-0.96),P<0.00001]、甘油三酯[MD=-0.67,95%CI(-0.75,-0.59),P<0.00001]均低于对照组,差异均有统计学意义。结论:基于中医“治未病”理论的健康管理能有效改善高血压前期人群的健康结局,但其模式仍需进一步规范。展开更多
临界性高血压是指血压在理想血压和确诊高血压之间的血压值,即收缩压(SBP)120~139 mm Hg和/或舒张压(DBP)80~89 mm Hg之间。代谢紊乱相关疾病包括高脂血症、糖尿病、高尿酸血症、超重肥胖等。当临界性高血压和代谢紊乱同时存在时,患者...临界性高血压是指血压在理想血压和确诊高血压之间的血压值,即收缩压(SBP)120~139 mm Hg和/或舒张压(DBP)80~89 mm Hg之间。代谢紊乱相关疾病包括高脂血症、糖尿病、高尿酸血症、超重肥胖等。当临界性高血压和代谢紊乱同时存在时,患者进展为高血压及发生心血管事件的危险性明显增加。痰湿为临界性高血压合并代谢紊乱的关键病理要素,该病可分为5种不同痰湿相关证型,并提出相应治则:脾虚湿盛证治宜健脾益气、燥湿化痰,湿阻热盛证治宜清热燥湿、化痰和中,湿瘀互结证治宜清痰化瘀、活血祛湿,湿阻气郁证治宜疏肝运脾、理气化痰,湿阻阴伤证治宜滋阴养血、清热除湿。附验案1则以佐证。展开更多
文摘Objective: We explored the relationship between traditional Chinese constitution and risk factors for cardiovascular disease in subjects with high-normal blood pressure (BP). Methods: The traditional Chinese constitution of 80 subjects with high-normal BP was judged by questionnaires and interviews. Measurements of cardiovascular and metabolic health in- cluded BP, body weight, body mass index (BMI), low-density lipoprotein cholesterol (LDL-C), 2-hour oral glucose tolerance test (OGTT2h), and waist cir- cumference. Statistical relationships between cardiovascular disease risk factors and specific Chinese constitution were evaluated by univariate and multivariate analyses. Results: Ping He, Tan Shi, and Yin Xu were the dominant constitutions in subjects with high-normal blood pressure. There were significant differences in weight, LDL-C, BMI, OGTT2h, and waist circumference between Tan Shi and Ping He (P P < 0.05), and weight, BMI, waist circumference, SBP, and LDL-C between Tan Shi and Yin Xu constitutions (P < 0.01). Logistic regression found a strong association between the Tan Shi constitution and LDL-C in subjects with high-normal blood pressure. Conclusion: Ping He, Tan Shi, and Yin Xu are the principle traditional Chinese constitutions in subject with high-normal blood pressure. The Tan Shi constitution is associated with multiple risk factors for cardiovascular disease (LDL-C, BMI, body weight, and waist circumference), while OGTT2h is closely related to the Yin Xu constitution.
文摘Ohjectire To examine the hypothesis of normal perjusion pressure breakthrough (NPPB). Methods A modified Spetzler carotid -jugular (CJ) fistula model was created to imitate NPPB. In 9 male adult Sprague- Dawley rats, the ipsilateral vertebral artery and bilateral external carotid arteries were occluded. The period of hypoperfusion CJ fistula was extended to 14 weeks, as a modofcation of Spetzler model. The histological change were examtned under transmission electron microscope 14 weeks after creation of the listula. Results Ischemic histological changes such as increased pinocytosis, increased lucency of the basal lamina, and frank necrosis of the cerebral capillary were found in rats of CJ fistula group. Conclusion The findings in this study suggest that blood - braln barrier (BBB) was impaired by chronic hypoperfusion. The impaired BBB mny be one of the important causes of the NPPB phenomenon.
文摘临界性高血压是指血压在理想血压和确诊高血压之间的血压值,即收缩压(SBP)120~139 mm Hg和/或舒张压(DBP)80~89 mm Hg之间。代谢紊乱相关疾病包括高脂血症、糖尿病、高尿酸血症、超重肥胖等。当临界性高血压和代谢紊乱同时存在时,患者进展为高血压及发生心血管事件的危险性明显增加。痰湿为临界性高血压合并代谢紊乱的关键病理要素,该病可分为5种不同痰湿相关证型,并提出相应治则:脾虚湿盛证治宜健脾益气、燥湿化痰,湿阻热盛证治宜清热燥湿、化痰和中,湿瘀互结证治宜清痰化瘀、活血祛湿,湿阻气郁证治宜疏肝运脾、理气化痰,湿阻阴伤证治宜滋阴养血、清热除湿。附验案1则以佐证。