There are three ports in this poper.Part I is involved in discussion of threeessential soft factors acting at development of high-tech industry-location,nctworkand comptehensive factors.It strobes the role of brains a...There are three ports in this poper.Part I is involved in discussion of threeessential soft factors acting at development of high-tech industry-location,nctworkand comptehensive factors.It strobes the role of brains and practical capeity inhigh-tech development,clarifying the same importance of qualified personnel networkas information network,elucidating both intemal and external impetus Part II dealswith locatkinal comparison among high-tech industrial zones in Ch;. for which anAnalysis of Hierarchy Process (AHP) method is used. Upe esults, Chinesehigh-tech industrial zones are divided into four grades. The las. p proposes four aspects as implementation measures for high-tech industrial zone in China.展开更多
BACKGROUND Diabetic intracerebral hemorrhage(ICH)is a serious complication of diabetes.The role and mechanism of bone marrow mesenchymal stem cell(BMSC)-derived exosomes(BMSC-exo)in neuroinflammation post-ICH in patie...BACKGROUND Diabetic intracerebral hemorrhage(ICH)is a serious complication of diabetes.The role and mechanism of bone marrow mesenchymal stem cell(BMSC)-derived exosomes(BMSC-exo)in neuroinflammation post-ICH in patients with diabetes are unknown.In this study,we investigated the regulation of BMSC-exo on hyperglycemia-induced neuroinflammation.AIM To study the mechanism of BMSC-exo on nerve function damage after diabetes complicated with cerebral hemorrhage.METHODS BMSC-exo were isolated from mouse BMSC media.This was followed by transfection with microRNA-129-5p(miR-129-5p).BMSC-exo or miR-129-5poverexpressing BMSC-exo were intravitreally injected into a diabetes mouse model with ICH for in vivo analyses and were cocultured with high glucoseaffected BV2 cells for in vitro analyses.The dual luciferase test and RNA immunoprecipitation test verified the targeted binding relationship between miR-129-5p and high-mobility group box 1(HMGB1).Quantitative polymerase chain reaction,western blotting,and enzyme-linked immunosorbent assay were conducted to assess the levels of some inflammation factors,such as HMGB1,interleukin 6,interleukin 1β,toll-like receptor 4,and tumor necrosis factorα.Brain water content,neural function deficit score,and Evans blue were used to measure the neural function of mice.RESULTS Our findings indicated that BMSC-exo can promote neuroinflammation and functional recovery.MicroRNA chip analysis of BMSC-exo identified miR-129-5p as the specific microRNA with a protective role in neuroinflammation.Overexpression of miR-129-5p in BMSC-exo reduced the inflammatory response and neurological impairment in comorbid diabetes and ICH cases.Furthermore,we found that miR-129-5p had a targeted binding relationship with HMGB1 mRNA.CONCLUSION We demonstrated that BMSC-exo can reduce the inflammatory response after ICH with diabetes,thereby improving the neurological function of the brain.展开更多
To examine whether there is a co-alignment relationship between environment risk, capital structure, growth and high-tech firm performance, the environment risk was measured from the viewpoint of environment change, t...To examine whether there is a co-alignment relationship between environment risk, capital structure, growth and high-tech firm performance, the environment risk was measured from the viewpoint of environment change, the long-term debt ratio was adopted as the measure of the capital structure, and the total asset growth and sales growth were chosen to measure the growth of high-tech firms. Regression analysis shows that there is a significant relationship between environment risk, growth and performance of hightech firms measured by the return on equity and cash flow, respectively.展开更多
Representing the appeals of its industry,the high-tech interest group has recently become an emerging political force in the United States.With abundant financial resources and proficiency in political communication,t...Representing the appeals of its industry,the high-tech interest group has recently become an emerging political force in the United States.With abundant financial resources and proficiency in political communication,the group rapidly grows to be a significant force in the American political sphere.It has started to affect the internal and foreign affairs of the U.S.and played a proactive role in the latest presidential election.Since the high-tech interest group has already become and will continue to be a big player in Sino-U.S.relations,China should carefully deal with its appeals and conflict of interests,and try to develop this group into a stabilizer between the two countries.展开更多
This paper illustrates the current situation and problems concerning the industrial structure in Huazhong Agricultural High-tech Industrial Development Zone,and analyzes the internal contradictions that exist in indus...This paper illustrates the current situation and problems concerning the industrial structure in Huazhong Agricultural High-tech Industrial Development Zone,and analyzes the internal contradictions that exist in industry: small-scale land operation has become an inherent obstacle to the industrial development in Agricultural High-tech Zone; farmers are always in a passive position in industrial restructuring optimization; government's policy failures and rent-seeking behaviors have hindered industrial development; the research,popularization and application of agricultural science and technology is not suited to industrial development requirements. Finally,this paper makes the corresponding recommendations for industrial development in Huazhong Agricultural High-tech Industrial Development Zone.展开更多
This study, with the shake table experiments in the National Earthquake Engineering Research Center, investigated the seismic behavior of automation stocker system. The automation stocker system provided a fast and ef...This study, with the shake table experiments in the National Earthquake Engineering Research Center, investigated the seismic behavior of automation stocker system. The automation stocker system provided a fast and effective method for stocking products in the high-tech facilities. Firstly, the original machine tests for testing common stocker system were to investigate the seismic capacity and failing modes. Secondly, the team completed 2 kinds of reinforcement tests to investigate the seismic behavior: 1) the installation of bracing to improve overall stiffness;2) the installation of the viscous dampers to improve the overall damping ratio. In comparing the results and performance of the three experiments, we learned from the results of the top-layer acceleration: the installation of bracing had the largest acceleration value, the original machine the second acceleration value and the damper the lowest acceleration value;the best effect was the installation of the damper. The result of the comparison of the top floor displacement meter showed that the highest data was the original machine;the second data was with the damper, the lowest data was the installation of the bracing. Based on the preliminary assessment on the best seismic retrofit ways of the storage system, we further examined the feasibility and applicability of automatic storage seismic retrofit in the high-tech factory.展开更多
High-tech industry has become the strategic and leading industry of the national economic and social development, and it is also the main driving force for economic growth and social progress in China. It is necessary...High-tech industry has become the strategic and leading industry of the national economic and social development, and it is also the main driving force for economic growth and social progress in China. It is necessary to redefine the composition of high-tech enterprises'value and thus find the ways to maximize their value. This paper attempted to address the following set of questions: 1. What are the value drivers and how do they affect high-tech enterprises'value? 2. How to establish the value appraisal measure system of high-tech enterprise?展开更多
Product innovation is an important strategy for high-tech firms, especially for small and medium enterprises. This paper proposes that the technological strategies for SMEs are dynamic and during different phase, ther...Product innovation is an important strategy for high-tech firms, especially for small and medium enterprises. This paper proposes that the technological strategies for SMEs are dynamic and during different phase, there is different innovation strategy which leads to various market performances. In particular, through the case study of Weili Electronics Co., Ltd, we fred that organizational learning abilities play a fundamental role in strategic decision. In addition, the frameworks for the determinants of technological strategies in three stages are established to illustrate the evolutionary processes of product innovation in Weili Electronics Co., Ltd.展开更多
The Chinese Government hasearmarked 15 billion yuan(US$1.8 billion) for the nextphase of its national high-tech re-search and development program, aspart of the 10th Five-Year Plan forthe period 2001-05, three times
High-resolution atomic-beam laser spectroscopy has been performed to study Stark effect of Ba atom. Stark spectra have been observed at various electric fields for Ba highly excited states. The scalar polarizability o...High-resolution atomic-beam laser spectroscopy has been performed to study Stark effect of Ba atom. Stark spectra have been observed at various electric fields for Ba highly excited states. The scalar polarizability of the transition from 6s5d3D2 to 5d6p3F3 at 728.0 nm and the tensor polarizability of the 3F3 level have been determined for the first time, to be αs = -89.8 (12) kHz/(kV/cm)2 and αt = -133.7 (20) kHz/(kV/cm)2, respectively.展开更多
Extreme high temperature(EHT)events are among the most impact-related consequences related to climate change,especially for China,a nation with a large population that is vulnerable to the climate warming.Based on the...Extreme high temperature(EHT)events are among the most impact-related consequences related to climate change,especially for China,a nation with a large population that is vulnerable to the climate warming.Based on the latest Coupled Model Intercomparison Project Phase 6(CMIP6),this study assesses future EHT changes across China at five specific global warming thresholds(1.5℃-5℃).The results indicate that global mean temperature will increase by 1.5℃/2℃ before 2030/2050 relative to pre-industrial levels(1861-1900)under three future scenarios(SSP1-2.6,SSP2-4.5,and SSP5-8.5),and warming will occur faster under SSP5-8.5 compared to SSP1-2.6 and SSP2-4.5.Under SSP5-8.5,global warming will eventually exceed 5℃ by 2100,while under SSP1-2.6,it will stabilize around 2℃ after 2050.In China,most of the areas where warming exceeds global average levels will be located in Tibet and northern China(Northwest China,North China and Northeast China),covering 50%-70%of the country.Furthermore,about 0.19-0.44 billion people(accounting for 16%-41%of the national population)will experience warming above the global average.Compared to present-day(1995-2014),the warmest day(TXx)will increase most notably in northern China,while the number of warm days(TX90p)and warm spell duration indicator(WSDI)will increase most profoundly in southern China.For example,relative to the present-day,TXx will increase by 1℃-5℃ in northern China,and TX90p(WSDI)will increase by 25-150(10-80)days in southern China at 1.5℃-5℃ global warming.Compared to 2℃-5℃,limiting global warming to 1.5℃ will help avoid about 36%-87%of the EHT increases in China.展开更多
AIM To elucidate how high diet-induced endoplasmic reticulum-stress upregulates thioredoxin interacting protein expression in Müller cells leading to retinal inflammation. METHODS Male C57Bl/J mice were fed eithe...AIM To elucidate how high diet-induced endoplasmic reticulum-stress upregulates thioredoxin interacting protein expression in Müller cells leading to retinal inflammation. METHODS Male C57Bl/J mice were fed either normal diet or 60% high fat diet for 4-8 wk. During the 4 wk study, mice received phenyl-butyric acid(PBA); endoplasmic reticulum-stress inhibitor; for 2 wk. Insulin resistance was assessed by oral glucose tolerance. Effects of palmitate-bovine serum albumin(BSA)(400 μmol/L) were examined in retinal Müller glial cell line and primary Müller cells isolated from wild type and thioredoxin interacting protein knock-out mice. Expression of thioredoxin interacting protein, endoplasmic reticulum-stress markers, mi R-17-5p m RNA, as well as nucleotide-binding oligomerization domain-like receptor protein(NLRP3) and IL1β protein was determined.RESULTS High fat diet for 8 wk induced obesity and insulin resistance evident by increases in body weight and impaired glucose tolerance. By performing quantitative real-time polymerase chain reaction, we found that high fat diet triggered the expression of retinal endoplasmic reticulum-stress markers(P < 0.05). These effects were associated with increased thioredoxin interacting protein and decreased mi R-17-5p expression, whichwere restored by inhibiting endoplasmic reticulumstress with PBA(P < 0.05). In vitro, palmitate-BSA triggered endoplasmic reticulum-stress markers, which was accompanied with reduced mi R-17-5p and induced thioredoxin interacting protein m RNA in retinal Müller glial cell line(P < 0.05). Palmitate upregulated NLRP3 and IL1β expression in primary Müller cells isolated from wild type. However, using primary Müller cells isolated from thioredoxin interacting protein knock-out mice abolished palmitate-mediated increase in NLRP3 and IL1β.CONCLUSION Our work suggests that targeting endoplasmic reticulumstress or thioredoxin interacting protein are potential therapeutic strategies for early intervention of obesityinduced retinal inflammation.展开更多
A series of perovskite-like mixed oxides La2-xSrxMO4±λ(M =Cu, Co,Ni; x=0,1 ) was prepared and characterized using X-ray powder diffraction. The catalytic properties of these catalysts in NO decompositiori were t...A series of perovskite-like mixed oxides La2-xSrxMO4±λ(M =Cu, Co,Ni; x=0,1 ) was prepared and characterized using X-ray powder diffraction. The catalytic properties of these catalysts in NO decompositiori were tested. The results showed that LaSrNiO4-λ with K2NiF4 structure is very active and stable for the decomposition of NO.展开更多
文摘There are three ports in this poper.Part I is involved in discussion of threeessential soft factors acting at development of high-tech industry-location,nctworkand comptehensive factors.It strobes the role of brains and practical capeity inhigh-tech development,clarifying the same importance of qualified personnel networkas information network,elucidating both intemal and external impetus Part II dealswith locatkinal comparison among high-tech industrial zones in Ch;. for which anAnalysis of Hierarchy Process (AHP) method is used. Upe esults, Chinesehigh-tech industrial zones are divided into four grades. The las. p proposes four aspects as implementation measures for high-tech industrial zone in China.
基金Supported by the National Natural Science Foundation of China,No.81900743Heilongjiang Province Outstanding Young Medical Talents Training Grant Project,China,No.HYD2020YQ0007.
文摘BACKGROUND Diabetic intracerebral hemorrhage(ICH)is a serious complication of diabetes.The role and mechanism of bone marrow mesenchymal stem cell(BMSC)-derived exosomes(BMSC-exo)in neuroinflammation post-ICH in patients with diabetes are unknown.In this study,we investigated the regulation of BMSC-exo on hyperglycemia-induced neuroinflammation.AIM To study the mechanism of BMSC-exo on nerve function damage after diabetes complicated with cerebral hemorrhage.METHODS BMSC-exo were isolated from mouse BMSC media.This was followed by transfection with microRNA-129-5p(miR-129-5p).BMSC-exo or miR-129-5poverexpressing BMSC-exo were intravitreally injected into a diabetes mouse model with ICH for in vivo analyses and were cocultured with high glucoseaffected BV2 cells for in vitro analyses.The dual luciferase test and RNA immunoprecipitation test verified the targeted binding relationship between miR-129-5p and high-mobility group box 1(HMGB1).Quantitative polymerase chain reaction,western blotting,and enzyme-linked immunosorbent assay were conducted to assess the levels of some inflammation factors,such as HMGB1,interleukin 6,interleukin 1β,toll-like receptor 4,and tumor necrosis factorα.Brain water content,neural function deficit score,and Evans blue were used to measure the neural function of mice.RESULTS Our findings indicated that BMSC-exo can promote neuroinflammation and functional recovery.MicroRNA chip analysis of BMSC-exo identified miR-129-5p as the specific microRNA with a protective role in neuroinflammation.Overexpression of miR-129-5p in BMSC-exo reduced the inflammatory response and neurological impairment in comorbid diabetes and ICH cases.Furthermore,we found that miR-129-5p had a targeted binding relationship with HMGB1 mRNA.CONCLUSION We demonstrated that BMSC-exo can reduce the inflammatory response after ICH with diabetes,thereby improving the neurological function of the brain.
基金The Fok Ying-Tong Education Founda-tion for Young Teachers in the Higher Education Institutions of China (No101084)Science and Technology Foundationof Liaoning Province (No1051354)
文摘To examine whether there is a co-alignment relationship between environment risk, capital structure, growth and high-tech firm performance, the environment risk was measured from the viewpoint of environment change, the long-term debt ratio was adopted as the measure of the capital structure, and the total asset growth and sales growth were chosen to measure the growth of high-tech firms. Regression analysis shows that there is a significant relationship between environment risk, growth and performance of hightech firms measured by the return on equity and cash flow, respectively.
文摘Representing the appeals of its industry,the high-tech interest group has recently become an emerging political force in the United States.With abundant financial resources and proficiency in political communication,the group rapidly grows to be a significant force in the American political sphere.It has started to affect the internal and foreign affairs of the U.S.and played a proactive role in the latest presidential election.Since the high-tech interest group has already become and will continue to be a big player in Sino-U.S.relations,China should carefully deal with its appeals and conflict of interests,and try to develop this group into a stabilizer between the two countries.
基金Supported by Fund Project of Hubei Provincial Institute of New Rural Development Study
文摘This paper illustrates the current situation and problems concerning the industrial structure in Huazhong Agricultural High-tech Industrial Development Zone,and analyzes the internal contradictions that exist in industry: small-scale land operation has become an inherent obstacle to the industrial development in Agricultural High-tech Zone; farmers are always in a passive position in industrial restructuring optimization; government's policy failures and rent-seeking behaviors have hindered industrial development; the research,popularization and application of agricultural science and technology is not suited to industrial development requirements. Finally,this paper makes the corresponding recommendations for industrial development in Huazhong Agricultural High-tech Industrial Development Zone.
文摘This study, with the shake table experiments in the National Earthquake Engineering Research Center, investigated the seismic behavior of automation stocker system. The automation stocker system provided a fast and effective method for stocking products in the high-tech facilities. Firstly, the original machine tests for testing common stocker system were to investigate the seismic capacity and failing modes. Secondly, the team completed 2 kinds of reinforcement tests to investigate the seismic behavior: 1) the installation of bracing to improve overall stiffness;2) the installation of the viscous dampers to improve the overall damping ratio. In comparing the results and performance of the three experiments, we learned from the results of the top-layer acceleration: the installation of bracing had the largest acceleration value, the original machine the second acceleration value and the damper the lowest acceleration value;the best effect was the installation of the damper. The result of the comparison of the top floor displacement meter showed that the highest data was the original machine;the second data was with the damper, the lowest data was the installation of the bracing. Based on the preliminary assessment on the best seismic retrofit ways of the storage system, we further examined the feasibility and applicability of automatic storage seismic retrofit in the high-tech factory.
文摘High-tech industry has become the strategic and leading industry of the national economic and social development, and it is also the main driving force for economic growth and social progress in China. It is necessary to redefine the composition of high-tech enterprises'value and thus find the ways to maximize their value. This paper attempted to address the following set of questions: 1. What are the value drivers and how do they affect high-tech enterprises'value? 2. How to establish the value appraisal measure system of high-tech enterprise?
文摘Product innovation is an important strategy for high-tech firms, especially for small and medium enterprises. This paper proposes that the technological strategies for SMEs are dynamic and during different phase, there is different innovation strategy which leads to various market performances. In particular, through the case study of Weili Electronics Co., Ltd, we fred that organizational learning abilities play a fundamental role in strategic decision. In addition, the frameworks for the determinants of technological strategies in three stages are established to illustrate the evolutionary processes of product innovation in Weili Electronics Co., Ltd.
文摘The Chinese Government hasearmarked 15 billion yuan(US$1.8 billion) for the nextphase of its national high-tech re-search and development program, aspart of the 10th Five-Year Plan forthe period 2001-05, three times
文摘High-resolution atomic-beam laser spectroscopy has been performed to study Stark effect of Ba atom. Stark spectra have been observed at various electric fields for Ba highly excited states. The scalar polarizability of the transition from 6s5d3D2 to 5d6p3F3 at 728.0 nm and the tensor polarizability of the 3F3 level have been determined for the first time, to be αs = -89.8 (12) kHz/(kV/cm)2 and αt = -133.7 (20) kHz/(kV/cm)2, respectively.
基金supported by the National Key Research and Development Program of China(2017YFA0603804)the National Natural Science Foundation of China(41831174 and 41430528)+1 种基金the Postgraduate Research&Practice Innovation Program of Jiangsu Province(KYCX19_1026)Guwei ZHANG was supported by the China Scholarship Council(NO.201908320503)。
文摘Extreme high temperature(EHT)events are among the most impact-related consequences related to climate change,especially for China,a nation with a large population that is vulnerable to the climate warming.Based on the latest Coupled Model Intercomparison Project Phase 6(CMIP6),this study assesses future EHT changes across China at five specific global warming thresholds(1.5℃-5℃).The results indicate that global mean temperature will increase by 1.5℃/2℃ before 2030/2050 relative to pre-industrial levels(1861-1900)under three future scenarios(SSP1-2.6,SSP2-4.5,and SSP5-8.5),and warming will occur faster under SSP5-8.5 compared to SSP1-2.6 and SSP2-4.5.Under SSP5-8.5,global warming will eventually exceed 5℃ by 2100,while under SSP1-2.6,it will stabilize around 2℃ after 2050.In China,most of the areas where warming exceeds global average levels will be located in Tibet and northern China(Northwest China,North China and Northeast China),covering 50%-70%of the country.Furthermore,about 0.19-0.44 billion people(accounting for 16%-41%of the national population)will experience warming above the global average.Compared to present-day(1995-2014),the warmest day(TXx)will increase most notably in northern China,while the number of warm days(TX90p)and warm spell duration indicator(WSDI)will increase most profoundly in southern China.For example,relative to the present-day,TXx will increase by 1℃-5℃ in northern China,and TX90p(WSDI)will increase by 25-150(10-80)days in southern China at 1.5℃-5℃ global warming.Compared to 2℃-5℃,limiting global warming to 1.5℃ will help avoid about 36%-87%of the EHT increases in China.
文摘AIM To elucidate how high diet-induced endoplasmic reticulum-stress upregulates thioredoxin interacting protein expression in Müller cells leading to retinal inflammation. METHODS Male C57Bl/J mice were fed either normal diet or 60% high fat diet for 4-8 wk. During the 4 wk study, mice received phenyl-butyric acid(PBA); endoplasmic reticulum-stress inhibitor; for 2 wk. Insulin resistance was assessed by oral glucose tolerance. Effects of palmitate-bovine serum albumin(BSA)(400 μmol/L) were examined in retinal Müller glial cell line and primary Müller cells isolated from wild type and thioredoxin interacting protein knock-out mice. Expression of thioredoxin interacting protein, endoplasmic reticulum-stress markers, mi R-17-5p m RNA, as well as nucleotide-binding oligomerization domain-like receptor protein(NLRP3) and IL1β protein was determined.RESULTS High fat diet for 8 wk induced obesity and insulin resistance evident by increases in body weight and impaired glucose tolerance. By performing quantitative real-time polymerase chain reaction, we found that high fat diet triggered the expression of retinal endoplasmic reticulum-stress markers(P < 0.05). These effects were associated with increased thioredoxin interacting protein and decreased mi R-17-5p expression, whichwere restored by inhibiting endoplasmic reticulumstress with PBA(P < 0.05). In vitro, palmitate-BSA triggered endoplasmic reticulum-stress markers, which was accompanied with reduced mi R-17-5p and induced thioredoxin interacting protein m RNA in retinal Müller glial cell line(P < 0.05). Palmitate upregulated NLRP3 and IL1β expression in primary Müller cells isolated from wild type. However, using primary Müller cells isolated from thioredoxin interacting protein knock-out mice abolished palmitate-mediated increase in NLRP3 and IL1β.CONCLUSION Our work suggests that targeting endoplasmic reticulumstress or thioredoxin interacting protein are potential therapeutic strategies for early intervention of obesityinduced retinal inflammation.
文摘A series of perovskite-like mixed oxides La2-xSrxMO4±λ(M =Cu, Co,Ni; x=0,1 ) was prepared and characterized using X-ray powder diffraction. The catalytic properties of these catalysts in NO decompositiori were tested. The results showed that LaSrNiO4-λ with K2NiF4 structure is very active and stable for the decomposition of NO.
