Nowadays metabolic syndrome represents a real outbreak affecting society. Paradoxically, pediatricians must feel involved in fighting this condition because of the latest evidences of developmental origins of adult di...Nowadays metabolic syndrome represents a real outbreak affecting society. Paradoxically, pediatricians must feel involved in fighting this condition because of the latest evidences of developmental origins of adult diseases. Fetal programming occurs when the normal fetal development is disrupted by an abnormal insult applied to a critical point in intrauterine life. Placenta assumes a pivotal role in programming the fetal experience in utero due to the adaptive changes in structure and function. Pregnancy complications such as diabetes, intrauterine growth restriction, preeclampsia, and hypoxia are associated with placental dysfunction and programming. Many experimental studies have been conducted to explain the phenotypic consequences of fetal-placental perturbations that predispose to the genesis of metabolic syndrome, obesity, diabetes, hyperinsulinemia, hypertension, and cardiovascular disease in adulthood. In recent years, elucidating the mechanisms involved in such kind of process has become the challenge of scientific research. Oxidative stress may be the general underlying mechanism that links altered placental function to fetal programming. Maternal diabetes, prenatal hypoxic/ischaemic events, inflammatory/infective insults are specific triggers for an acute increase in free radicals generation. Early identification of fetuses and newborns at high risk of oxidative damage may be crucial to decrease infant and adult morbidity.展开更多
目的探讨巨大儿的高危因素及其并发症。方法将2010年2月~2013年12月期间在我院住院分娩的巨大儿259例作为观察组,随机收集同期正常分娩的单胎正常体重的新生儿259例对照组。分别记录两组孕妇年龄、孕次、产次、孕前体重、产前体重、身...目的探讨巨大儿的高危因素及其并发症。方法将2010年2月~2013年12月期间在我院住院分娩的巨大儿259例作为观察组,随机收集同期正常分娩的单胎正常体重的新生儿259例对照组。分别记录两组孕妇年龄、孕次、产次、孕前体重、产前体重、身高、宫高、腹围、胎儿性别、孕周、分娩方式、新生儿体重指标、胎儿双顶径及母婴并发症等情况,对比分析巨大儿的高危因素及其并发症。结果两组产妇孕周均在36~43周,观察组的妊娠天数、分娩前宫高、孕妇腹围、妊娠合并症,妊高症、GDM、胎膜早破、巨大儿经阴道分娩的新生儿窒息、锁骨骨折、臂丛神经损伤、产后出血、产道损伤等均明显高于对照组,两组差异均有统计学意义(P<0.05);观察组宫高+腹围≥140 cm 147例,占56.76%(147/259);胎儿双顶径≥9.5 cm 214例,占82.63%(214/259);胎儿股骨长≥7.5 cm217例,占83.78%(217/259)。结论妊娠天数、分娩前宫高、孕妇腹围、胎儿双顶径、股骨长是巨大儿发生的高危因素,巨大儿较正常体重儿的并发症明显增加,掌握巨大儿高危因素及并发症对产前诊断和围产期预防有一定的指导作用。展开更多
【目的】探讨高危儿6岁时智力发育的影响因素及其与早期原始反射和肌张力检查结果的关系,为早期干预提供依据。【方法】本院住院治疗的122例高危儿,12个月进行原始反射、肌张力检查;6岁时采用中国-韦氏儿童智力量表进行检查。【结果】1...【目的】探讨高危儿6岁时智力发育的影响因素及其与早期原始反射和肌张力检查结果的关系,为早期干预提供依据。【方法】本院住院治疗的122例高危儿,12个月进行原始反射、肌张力检查;6岁时采用中国-韦氏儿童智力量表进行检查。【结果】12个月时原始反射及肌张力检查异常为18例(18/105),6岁时智商测定低下或临界共34例(34/107)。影响6岁时智商的独立因素为父母文化程度、早产、新生儿低血糖和5 min Apgar评分。12个月原始反射、肌张力检查异常的儿童6岁时言语、操作及全量表智商均明显低于正常组(P均<0.001)。【结论】父母文化程度低、新生儿低血糖、早产(<32周)5、min Apgar评分低于6分及或12个月时原始反射及肌张力检查异常的儿童应监测其智力发育,以及时予以干预。展开更多
文摘Nowadays metabolic syndrome represents a real outbreak affecting society. Paradoxically, pediatricians must feel involved in fighting this condition because of the latest evidences of developmental origins of adult diseases. Fetal programming occurs when the normal fetal development is disrupted by an abnormal insult applied to a critical point in intrauterine life. Placenta assumes a pivotal role in programming the fetal experience in utero due to the adaptive changes in structure and function. Pregnancy complications such as diabetes, intrauterine growth restriction, preeclampsia, and hypoxia are associated with placental dysfunction and programming. Many experimental studies have been conducted to explain the phenotypic consequences of fetal-placental perturbations that predispose to the genesis of metabolic syndrome, obesity, diabetes, hyperinsulinemia, hypertension, and cardiovascular disease in adulthood. In recent years, elucidating the mechanisms involved in such kind of process has become the challenge of scientific research. Oxidative stress may be the general underlying mechanism that links altered placental function to fetal programming. Maternal diabetes, prenatal hypoxic/ischaemic events, inflammatory/infective insults are specific triggers for an acute increase in free radicals generation. Early identification of fetuses and newborns at high risk of oxidative damage may be crucial to decrease infant and adult morbidity.
文摘目的探讨巨大儿的高危因素及其并发症。方法将2010年2月~2013年12月期间在我院住院分娩的巨大儿259例作为观察组,随机收集同期正常分娩的单胎正常体重的新生儿259例对照组。分别记录两组孕妇年龄、孕次、产次、孕前体重、产前体重、身高、宫高、腹围、胎儿性别、孕周、分娩方式、新生儿体重指标、胎儿双顶径及母婴并发症等情况,对比分析巨大儿的高危因素及其并发症。结果两组产妇孕周均在36~43周,观察组的妊娠天数、分娩前宫高、孕妇腹围、妊娠合并症,妊高症、GDM、胎膜早破、巨大儿经阴道分娩的新生儿窒息、锁骨骨折、臂丛神经损伤、产后出血、产道损伤等均明显高于对照组,两组差异均有统计学意义(P<0.05);观察组宫高+腹围≥140 cm 147例,占56.76%(147/259);胎儿双顶径≥9.5 cm 214例,占82.63%(214/259);胎儿股骨长≥7.5 cm217例,占83.78%(217/259)。结论妊娠天数、分娩前宫高、孕妇腹围、胎儿双顶径、股骨长是巨大儿发生的高危因素,巨大儿较正常体重儿的并发症明显增加,掌握巨大儿高危因素及并发症对产前诊断和围产期预防有一定的指导作用。
文摘【目的】探讨高危儿6岁时智力发育的影响因素及其与早期原始反射和肌张力检查结果的关系,为早期干预提供依据。【方法】本院住院治疗的122例高危儿,12个月进行原始反射、肌张力检查;6岁时采用中国-韦氏儿童智力量表进行检查。【结果】12个月时原始反射及肌张力检查异常为18例(18/105),6岁时智商测定低下或临界共34例(34/107)。影响6岁时智商的独立因素为父母文化程度、早产、新生儿低血糖和5 min Apgar评分。12个月原始反射、肌张力检查异常的儿童6岁时言语、操作及全量表智商均明显低于正常组(P均<0.001)。【结论】父母文化程度低、新生儿低血糖、早产(<32周)5、min Apgar评分低于6分及或12个月时原始反射及肌张力检查异常的儿童应监测其智力发育,以及时予以干预。
