Accuracy of FreeStyle Libre flash glucose monitoring in patients with type 2 diabetes who migrated from highlands to plains

BACKGROUND The FreeStyle Libre flash glucose monitoring(FGM)system entered the Chinese market in 2017 to complement the self-monitoring of blood glucose.Due to its increased usage in clinics,the number of studies investigating its accuracy has increased.However,its accuracy has not been investigated in highland populations in China.AIM To evaluate measurements recorded using the FreeStyle Libre FGM system compared with capillary blood glucose measured using the enzyme electrode method in patients with type 2 diabetes(T2D)who had migrated within 3 mo from highlands to plains.METHODS Overall,68 patients with T2D,selected from those who had recently migrated from highlands to plains(within 3 mo),were hospitalized at the Department of Endocrinology from August to October 2017 and underwent continuous glucose monitoring(CGM)with the FreeStyle Libre FGM system for 14 d.Throughout the study period,fingertip capillary blood glucose was measured daily using the enzyme electrode method(Super GL,China),and blood glucose levels were read from the scanning probe during fasting and 2 h after all three meals.Moreover,the time interval between reading the data from the scanning probe and collecting fingertip capillary blood was controlled to<5 min.The accuracy of the FGM system was evaluated according to the CGM guidelines.Subsequently,the factors influencing the mean absolute relative difference(MARD)of this system were analyzed by a multiple linear regression method.RESULTS Pearson’s correlation analysis showed that the fingertip and scanned glucose levels were positively correlated(R=0.86,P=0.00).The aggregated MARD of scanned glucose was 14.28±13.40%.Parker's error analysis showed that 99.30%of the data pairs were located in areas A and B.According to the probe wear time of the FreeStyle Libre FGM system,MARD_(1 d) and MARD_(2-14 d) were 16.55%and 14.35%,respectively(t=1.23,P=0.22).Multiple stepwise regression analysis showed that MARD did not correlate with blood glucose when the largest amplitude of glycemic excursion(LAGE)was<5.80 mmol/L but negatively correlated with blood glucose when the LAGE was≥5.80 mmol/L.CONCLUSION The FreeStyle Libre FGM system has good accuracy in patients with T2D who had recently migrated from highlands to plains.This system might be ideal for avoiding the effects of high hematocrit on blood glucose monitoring in populations that recently migrated to plains.MARD is mainly influenced by glucose levels and fluctuations,and the accuracy of the system is higher when the blood glucose fluctuation is small.In case of higher blood glucose level fluctuations,deviation in the scanned glucose levels is the highest at extremely low blood glucose levels.

Warhead fragments motion trajectories tracking and spatio-temporal distribution reconstruction method based on high-speed stereo photography

High speed photography technique is potentially the most effective way to measure the motion parameter of warhead fragment benefiting from its advantages of high accuracy,high resolution and high efficiency.However,it faces challenge in dense objects tracking and 3D trajectories reconstruction due to the characteristics of small size and dense distribution of fragment swarm.To address these challenges,this work presents a warhead fragments motion trajectories tracking and spatio-temporal distribution reconstruction method based on high-speed stereo photography.Firstly,background difference algorithm is utilized to extract the center and area of each fragment in the image sequence.Subsequently,a multi-object tracking(MOT)algorithm using Kalman filtering and Hungarian optimal assignment is developed to realize real-time and robust trajectories tracking of fragment swarm.To reconstruct 3D motion trajectories,a global stereo trajectories matching strategy is presented,which takes advantages of epipolar constraint and continuity constraint to correctly retrieve stereo correspondence followed by 3D trajectories refinement using polynomial fitting.Finally,the simulation and experimental results demonstrate that the proposed method can accurately track the motion trajectories and reconstruct the spatio-temporal distribution of 1.0×10^(3)fragments in a field of view(FOV)of 3.2 m×2.5 m,and the accuracy of the velocity estimation can achieve 98.6%.

Switching Frequency Improvement of a High Speed on/off Valve Based on Pre-excitation Control Algorithm

The high-speed on/off valve(HSV)serves as the fundamental component responsible for generating discrete fluids within digital hydraulic systems.As the switching frequency of the HSV increases,the properties of the generated discrete fluid approach those of continuous fluids.Therefore,a higher frequency response characteristic of HSV is the key to ensure the control accuracy of digital hydraulic systems.However,the current research mainly focuses on its dynamic performance,but neglect its FRC.This paper presents a theoretical analysis demonstrating that the FRC of the HSV can be enhanced by minimizing its switching time.The maximum switching frequency(MSF)is mainly determined by opening dynamic performance when HSV operates with low switching duty ratio(SDR),whereas the closing dynamic performance limits the MSF when HSV operates with high SDR.Building upon these findings,the pre-excitation control algorithm(PECA)is proposed to reduce the switching time of the HSV,and consequently enhance its FRC.Experimental results demonstrate that PECA shortens the opening delay time of HSV by 1.12 ms,the closing delay time by 2.54 ms,and the closing moving time by 0.47 ms in comparison to the existing advanced control algorithms.As a result,a larger MSF of 417 Hz and a wider controllable SDR range from 20%to 70%were achieved at a switching frequency of 250 Hz.Thus,the proposed PFCA in this paper has been verified as an effective and promising approach for enhancing the control performance of digital hydraulic systems.

Time-Domain Higher-Order Boundary Element Method for Simulating High Forward-Speed Ship Motions in Waves

The hydrodynamic performance of a high forward-speed ship in obliquely propagating waves is numerically examined to assess both free motions and wave field in comparison with a low forward-speed ship.This numerical model is based on the time-domain potential flow theory and higher-order boundary element method,where an analytical expression is completely expanded to determine the base-unsteady coupling flow imposed on the moving condition of the ship.The ship in the numerical model may possess different advancing speeds,i.e.stationary,low speed,and high speed.The role of the water depth,wave height,wave period,and incident wave angle is analyzed by means of the accurate numerical model.It is found that the resonant motions of the high forward-speed ship are triggered by comparison with the stationary one.More specifically,a higher forward speed generates a V-shaped wave region with a larger elevation,which induces stronger resonant motions corresponding to larger wave periods.The shoaling effect is adverse to the motion of the low-speed ship,but is beneficial to the resonant motion of the high-speed ship.When waves obliquely propagate toward the ship,the V-shaped wave region would be broken due to the coupling effect between roll and pitch motions.It is also demonstrated that the maximum heave motion occurs in beam seas for stationary cases but occurs in head waves for high speeds.However,the variation of the pitch motion with period is hardly affected by wave incident angles.

Determining future high speed rail review topics through bibliometric analysis

As High Speed Rail(HSR)has proliferated globally,so has a related research field dedicated to exploring and addressing its unique issues.Yet,studies to understand and classify the HSR research domain are limited.This paper addresses the gap,using bibliometric analysis to identify future research areas and 20 candidate topics for literature review based on keyword analysis through VOSviewer.Article and review papers related to HSR published in the last 20 years(2003-2022)were retrieved from Scopus,and then analyzed to determine the split in knowledge between languages,the collaboration between countries and institutions,highly productive and cited journals,and research topics which have and have not been reviewed.Approximately 30%of the search results were published exclusively in Chinese,highlighting the importance of extending the evaluation to cover both languages.This is a novel aspect of the work,which has enabled the recognition of potential knowledge gaps.It is recommended that future reviews incorporate works in both languages,possibly through international collaboration.Institutions in China and other countries that are strong collaborators have been identified,as well as relevant,highly cited journals.

Study on the pattern of train arrival headway time in high-speed railway

Purpose-The design goal for the tracking interval of high-speed railway trains in China is 3 min,but it is difficult to achieve,and it is widely believed that it is mainly limited by the tracking interval of train arrivals.If the train arrival tracking interval can be compressed,it will be beneficial for China's high-speed railway to achieve a 3-min train tracking interval.The goal of this article is to study how to compress the train arrival tracking interval.Design/methodologylapproach-By simulating the process of dense train groups arriving at the station and stopping,the headway between train arrivals at the station was calculated,and the pattern of train arrival headway was obtained,changing the traditional understanding that the train arrival headway is considered the main factor limiting the headway of trains.Findings-When the running speed of trains is high,the headway between trains is short,the length of the station approach throat area is considerable and frequent train arrivals at the station,the arrival headway for the first group or several groups of trains will exceed the headway,but the subsequent sets of trains will havea headway equal to the arrival headway.This convergence characteristic is obtained by appropriately increasing the running time.Originality/value-According to this pattern,there is no need to overly emphasize the impact of train arrival headway on the headway.This plays an important role in compressing train headway and improving high-speedrailwaycapacity.

Key technologies of earthquake early warning system for China’s high-speed railway

Purpose–The purpose of this study is to introduce the top-level design ideas and the overall architecture of earthquake early-warning system for high speed railways in China,which is based on P-wave earthquake early-warning and multiple ways of rapid treatment.Design/methodology/approach–The paper describes the key technologies that are involved in the development of the system,such as P-wave identification and earthquake early-warning,multi-source seismic information fusion and earthquake emergency treatment technologies.The paper also presents the test results of the system,which show that it has complete functions and its major performance indicators meet the design requirements.Findings–The study demonstrates that the high speed railways earthquake early-warning system serves as an important technical tool for high speed railways to cope with the threat of earthquake to the operation safety.The key technical indicators of the system have excellent performance:The first report time of the P-wave is less than three seconds.From the first arrival of P-wave to the beginning of train braking,the total delay of onboard emergency treatment is 3.63 seconds under 95%probability.The average total delay for power failures triggered by substations is 3.3 seconds.Originality/value–The paper provides a valuable reference for the research and development of earthquake early-warning system for high speed railways in other countries and regions.It also contributes to the earthquake prevention and disaster reduction efforts.

Corrosion Test of the Steel Plate in a WJ-8 Fastener for High Speed Rail

It was found that the steel plate in the composite plate in the WJ-8 fastener used in high speed rail is rusty. The objective of this study is to test the zinc coating of the steel plate. A literature review was conducted to identify the zinc coating techniques, and the companies that can provide different coating service was identified. A salt fog chamber was built that was in compliance with the ANSI B117 code, and the steel plates that were coated by the identified companies were tested using the salt fog chamber. The results indicated that the coating technique that had the best performance in preventing corrosion was the Greenkote plates with passivation. The galvanized option had the roughest coating layer, and it was the most reactive in the salt water solution. This makes it non-ideal for the dynamic rail environment because the increased friction of the plate could damage the supports, especially during extreme temperatures that would cause the rail to expand or contract. Greenkote with Phosphate and ArmorGalv also provided increased corrosion prevention with a smooth, strong finish, but it had more rust on the surface area than the Greenkote with ELU passivation. The ArmorGalv sample had more rust on the surface area than the Greenkote samples. This may not be a weakness in the ArmorGalv process;rather, it likely was the result of this particular sample not having the added protection of a colored coating.

Research on fault time prediction method for high speed rail BTM unit based on multi method interactive validation

The Balise Transmission Module(BTM)unit of the on-board train control system is a crucial component.Due to its unique installation position and complex environment,this unit has a higher fault rate within the on-board train control system.To conduct fault prediction for the BTM unit based on actual fault data,this study proposes a prediction method combining reliability statistics and machine learning,and achieves the fusion of prediction results from different dimensions through multi-method interactive validation.Firstly,a method for predicting equipment fault time targeting batch equipment is introduced.This method utilizes reliability statistics to construct a model of the remaining faultless operating time distribution considering uncertainty,thereby predicting the remaining faultless operating probability of the BTM unit.Secondly,considering the complexity of the BTM unit’s fault mechanism,the small sample size of fault cases,and the potential presence of multiple fault features in fault text records,an individual-oriented fault prediction method based on Bayesian-optimized Gradient Boosting Regression Tree(Bayes-GBRT)is proposed.This method achieves better prediction results compared to linear regression algorithms and random forest regression algorithms,with an average absolute error of only 0.224 years for predicting the fault time of this type of equipment.Finally,a multi-method interactive validation approach is proposed,enabling the fusion and validation of multi-dimensional results.The results indicate that the predicted fault time and the actual fault time conform to a log-normal distribution,and the parameter estimation results are basically consistent,verifying the accuracy and effectiveness of the prediction results.The above research findings can provide technical support for the maintenance and modification of BTM units,effectively reducing maintenance costs and ensuring the safe operation of high-speed railway,thus having practical engineering value for preventive maintenance.

The Application of China's High Speed Railway Earthquake Early Warning System in Jakarta-Bandung HSR

Earthquake has a significant impact on operation safety of the high speed railway,and for Jakarta-Bandung High Speed Railway(HSR)in Indonesia where it is earthquake-prone,it is necessary to establish an earthquake early warning system to strengthen its earthquake resistance.Based on the principle and technical characteristics of China's high speed railway earthquake early warning system and combining the actual situations of Jakarta-Bandung HSR in Indonesia,this paper describes how to implement China's high speed railway earthquake early warning system in Jakarta-Bandung HSR.It focuses on optimizations in environmental adaptation design and seismic network interface design,earthquake attenuation model parameter adjustment and terminal software interface adjustment,so as to make the system better suit the local situations,and meet operation requirements and guarantee safe operation of Jakarta-Bandung HSR.

Model of Rotation Accuracy of High-Speed Spindles on Ball Bearings

For the purpose to improve a design quality of high-speed spindle units, we have developed mathematical models and software to simulate a rotation accuracy of spindles running on ball bearings. In order to better understand the mechanics of ball bearings, the dynamic interaction of ball bearings and spindle unit, and the influence of the bearing imperfections on the spindle rotation accuracy, we have carried out computer aided analysis and experimental studies. When doing this, we have found that the spindle rotation accuracy can vary drastically with rotational speed. The influence of bearing preload has a secondary importance. Comparison of the results of these studies has demonstrated adequacy of the models developed to the real spindle units.

Analysis of Accuracy of a High-speed Mobile Platform Control System

The efficient manufacture technique involves a high-speed control of platform mobile system. A linear acutor is presented in this paper. The linear acutor is constructed as a linear stepper motor. However, to sustain both high accuracy and high speed for the position and speed control, A single-stack computer system is constructed and a special control algorithm is prescribed to controled the linear actuator continuously. In this paper, the nonlinear errors resulted from the magnetic saturation and the hysteresis is anaysis and discussed. In the view of electromagnetic propotional control, the actuator is a stage proportional magnet, because the driving current to the linear acuator changes for a number of cycles and a series of reset points will occur as the current undergoes cyclic changes. At each reset point the original starting characteristics of the system are re-established. A large number of reset points across the full stroke of the platform results in a significant reduction in the nonlinear behavior. The stage control is first discussed. Experiments carried out to obtain the characteristics of the mobile platform control system. It is demonstrated that with the introduction of stage control, nonlinearities, such as saturation and hysteresis, are greatly reduced, system stiffness is increased, and the positioning accuracy and resolution are improved. The effect of dither due to a "digital fragment" signal is also examined and found to be crucial in reducing the hysteresis and in improving the resolution accuracy.

ANALYSIS ON SURFACE INTEGRITY DURING HIGH SPEED MILLING FOR NEW DAMAGE-TOLERANT TITANIUM ALLOY

Surface integrity of a new damage-tolerant titanium alloy （TC21）, including surface roughness, microhardness and metallurgical structure is investigated when normal and high speed milling are used at different tool wear status. Results show that good surface integrity of TC21 can be obtained in high speed milling. In addition, even in acutely worn stages, there is no so-called serious hardening layer （or white layer） according to the studies on microhardness and metallurgical structure.

CUTTING FORCES IN HIGH SPEED TAPPING CAST IRON BY TUNGSTEN CARBIDE TAPS

The engineblock production lines need high speed tapping with tungsten carbide taps. In the tapping process, the machining precision and the tool life of taps are directly influenced by tapping forces. And the parameter optimization of tap structures is also correlated with the variation of tapping forces. Therefore, the study of tapping forces is necessary in developing new style taps. Several experiments about some novel carbide taps are performed on a vertical machining center by a Kistler dynamometer system in blind tapping both gray cast iron and ductile cast iron. And the variations of tapping forces are analyzed in tapping-in and tapping-out periods. It indicates that cutting forces hardly vary with the tap wear in tapping cast iron. Contrarily, tapping forces are closely correlated with the holding method. Besides, it also depends on the helix angle, the flute numbers and the plasticity of the work material to some extent.

Investigating Jet Appearance in Different Background Lights with High-Speed Frame Photography

Shaped charge jet formation process is studied under the conditions of different background lights by means of high speed frame photography. In order to shoot true jet appearance, the glass tube in which jet moves is vacuumized. The experiment results show that observing jet appearance with the double reflecting mirrors system is feasible as long as the vacuum of the glass tube can meet the requirement of experiment.

Multiplexer Design Applied to High-Speed Signal Transmission

A multiplexer with a low-distortion high-bandwidth analog switch is presented. The gate-to-source voltage of the switch is set by the combined on-voltage of a pMOS and an nMOS,and the difference between its gate-source voltage and the threshold voltage （VGST） is guaranteed to be constant with input variation. Thus, the body effect is nearly canceled. Implemented in a TSMC 0.18μm CMOS process, results from HSPICE simulation show that the VGST is nearly constant with an input range from 0.3 to 1.7V,and the - 3dB bandwidth is larger than 10GHz;the SFDR （spurious free dynamic range） of the output is 67. lldB with 1GHz input frequency; the turn-on time is 2.98ns,and the turn-off time is 1.35ns, which indicates a break-before-make action of the multiplexer. The proposed structure can be applied to high speed signal transmission.

Carbide refinement in M42 high speed steel by rare earth metals and spheroidizing treatment

The influence of rare earth metals and heat treatment on the microstructure and performance of M42 steel has been investigated by means of an optical microscope OM scanning electron microscope SEM energy dispersive spectroscopy EDS transmission electron microscope TEM electron back-scatter diffraction EBSD and X-ray diffraction XRD . The results show that M2 C is the prevailing type of eutectic carbides in M42 steel. After modification with rare earth metals M2 C eutectic carbides change from the ordered lamellar structure into a circular structure.Despite different morphologies the two carbides present the same characteristics of microstructure and growth orientation.Compared with lamellar carbides M2 C carbides with the circular structure are much easier to decompose and spheroidize after heating which remarkably refines the carbide dimensions.The refined carbides improve the supersaturation of alloying elements in martensite and increase the hardness of M42 steel by 1.5 HRC.

PRECISION OF HSK TOOLING SYSTEM IN HIGH SPEED MACHINING

Based on the theory of elastic mechanics and material mechanics, the orientation precision of the hohl schaft kegel（HSK） tooling system in static and dynamic states is theoretically and experimentally studied. The relation between the clamping force and the shank taper is obtained. And a proper clamping force is found to be essential to assure the axial and radial orientation precisions of the HSK tooling system in high speed machining （HSM）. Analytical results show that the reason why the HSK tooling system can keep high precision at the high rotational speed is that the actual axial clamping force keeps the two surfaces of the shank and the spindle in contact all the time.

An Explicit Difference Scheme with High Accuracy and Branching Stability for Solving Parabolic Partial Differential Equation

This paper presents an explicit difference scheme with accuracy and branching stability for solving onedimensional parabolic type equation by the method of undetermined parameters and its truncation error is O(△t4+△x4). The stability condition is r=a△t/△x2<1/2.

STRATEGY AND IMPLEMENTATION FOR HIGH-SPEED TORQUE ENHANCEMENT OF BRUSHLESS DC MOTOR

Serious commutation lag occurs when a Brushless DC Motor(BLDCM) operates at high speeds,and this leads to torque decline with ripple.In this paper,an advanced conduction control scheme is proposed which can accelerate the commutation and enhance the torque production remarkably.Besides,an on line adjusting algorithm based on the Golden Section Method is adopted to search the optimal advanced conduction angle.Simulation and experimental results verify the feasibility and effectivity of the scheme proposed.