Association of accelerometer-measured sleep duration and different intensities of physical activity with incident type 2 diabetes in a population-based cohort study

Purpose:The aim of the current study was to investigate the association of accelerometer-measured sleep duration and different intensities of physical activity(PA)with the risk of incident type 2 diabetes in a population-based prospective cohort study.Methods:Altogether,88,000 participants(mean age=62.2±7.9 years,mean±SD)were included from the UK Biobank.Sleep duration(short:<6 h/day;normal:6-8 h/day;long:>8 h/day)and PA of different intensities were measured using a wrist-won accelerometer over a 7-day period between 2013 and 2015.PA was classified according to the median or World Health Organization-recommendation:total volume of PA(high,low),moderate-to-vigorous PA(MVPA)(recommended,not recommended),and light-intensity PA(high,low).Incidence of type 2diabetes was ascertained using hospital records or death registries.Results:During a median follow-up of 7.0 years,1615 incident type 2 diabetes cases were documented.Compared with normal sleep duration,short(hazard ratio(HR)=1.21,95%confidence interval(95%CI):1.03-1.41)but not long sleep duration(HR=1.01,95%CI:0.89-1.15)was associated with excessive type 2 diabetes risk.This increased risk among short sleepers seems to be protected against by PA.Compared with normal sleepers with high or recommended PA,short sleepers with low volume of PA(HR=1.81,95%CI:1.46-2.25),not recommended(below the World Health Organization-recommended level of)MVPA(HR=1.92,95%CI:1.55-2.36),or low light-intensity PA(HR=1.49,95%CI:1.13-1.90)had a higher risk of type 2 diabetes,while short sleepers with a high volume of PA(HR=1.14,95%CI:0.88-1.49),recommended MVPA(HR=1.02,95%CI:0.71-1.48),or high light-intensity PA(HR=1.14,95%CI:0.92-1.41)did not.Conclusion:Accelerometer-measured short but not long sleep duration was associated with a higher risk of incident type 2 diabetes.A higher level of PA,regardless of intensity,potentially ameliorates this excessive risk.

Verification and Validation of High-Resolution Inviscid and Viscous Conical Nozzle Flows

Capturing elaborated flow structures and phenomena is required for well-solved numerical flows.The finite difference methods allow simple discretization of mesh and model equations.However,they need simpler meshes,e.g.,rectangular.The inverse Lax-Wendroff(ILW)procedure can handle complex geometries for rectangular meshes.High-resolution and high-order methods can capture elaborated flow structures and phenomena.They also have strong mathematical and physical backgrounds,such as positivity-preserving,jump conditions,and wave propagation concepts.We perceive an effort toward direct numerical simulation,for instance,regarding weighted essentially non-oscillatory(WENO)schemes.Thus,we propose to solve a challenging engineering application without turbulence models.We aim to verify and validate recent high-resolution and high-order methods.To check the solver accuracy,we solved vortex and Couette flows.Then,we solved inviscid and viscous nozzle flows for a conical profile.We employed the finite difference method,positivity-preserving Lax-Friedrichs splitting,high-resolution viscous terms discretization,fifth-order multi-resolution WENO,ILW,and third-order strong stability preserving Runge-Kutta.We showed the solver is high-order and captured elaborated flow structures and phenomena.One can see oblique shocks in both nozzle flows.In the viscous flow,we also captured a free-shock separation,recirculation,entrainment region,Mach disk,and the diamond-shaped pattern of nozzle flows.

Design and simulation of an accelerometer based on NV center spin–strain coupling

The nitrogen-vacancy (NV) center quantum systems have emerged as versatile tools in the field of precision measurement because of their high sensitivity in spin state detection and miniaturization potential as solid-state platforms.In this paper,an acceleration sensing scheme based on NV spin–strain coupling is proposed,which can effectively eliminate the influence of the stray noise field introduced by traditional mechanical schemes.Through the finite element simulation,it is found that the measurement bandwidth of this ensemble NV spin system ranges from 3 kHz to hundreds of kHz with structure√optimization.The required power is at the sub-μW level,corresponding to a noise-limited sensitivity of 6.7×10^(-5) /√Hz.Compared with other types of accelerometers,this micro-sized diamond sensor proposed here has low power consumption,exquisite sensitivity,and integration potential.This research opens a fresh perspective to realize an accelerometer with appealing comprehensive performance applied in biomechanics and inertial measurement fields.

Accurate Source-Receiver Positioning Method for a High-Resolution Deep-Towed Multichannel Seismic Exploration System

The near-seabed multichannel seismic exploration systems have yielded remarkable successes in marine geological disaster assessment,marine gas hydrate investigation,and deep-sea mineral exploration owing to their high vertical and horizontal resolution.However,the quality of deep-towed seismic imaging hinges on accurate source-receiver positioning information.In light of existing technical problems,we propose a novel array geometry inversion method tailored for high-resolution deep-towed multichannel seismic exploration systems.This method is independent of the attitude and depth sensors along a deep-towed seismic streamer,accounting for variations in seawater velocity and seabed slope angle.Our approach decomposes the towed line array into multiline segments and characterizes its geometric shape using the line segment distance and pitch angle.Introducing optimization parameters for seawater velocity and seabed slope angle,we establish an objective function based on the model,yielding results that align with objective reality.Employing the particle swarm optimization algorithm enables synchronous acquisition of optimized inversion results for array geometry and seawater velocity.Experimental validation using theoretical models and practical data verifies that our approach effectively enhances source and receiver positioning inversion accuracy.The algorithm exhibits robust stability and reliability,addressing uncertainties in seismic traveltime picking and complex seabed topography conditions.

Investigating the relationship between intracranial atherosclerotic plaque remodelling and diabetes using high-resolution vessel wall imaging

BACKGROUND Intracranial atherosclerosis,a leading cause of stroke,involves arterial plaque formation.This study explores the link between plaque remodelling patterns and diabetes using high-resolution vessel wall imaging(HR-VWI).AIM To investigate the factors of intracranial atherosclerotic remodelling patterns and the relationship between intracranial atherosclerotic remodelling and diabetes mellitus using HR-VWI.METHODS Ninety-four patients diagnosed with middle cerebral artery or basilar artery INTRODUCTION Intracranial atherosclerotic disease is one of the main causes of ischaemic stroke in the world,accounting for approx-imately 10%of transient ischaemic attacks and 30%-50%of ischaemic strokes[1].It is the most common factor among Asian people[2].The adaptive changes in the structure and function of blood vessels that can adapt to changes in the internal and external environment are called vascular remodelling,which is a common and important pathological mechanism in atherosclerotic diseases,and the remodelling mode of atherosclerotic plaques is closely related to the occurrence of stroke.Positive remodelling(PR)is an outwards compensatory remodelling where the arterial wall grows outwards in an attempt to maintain a constant lumen diameter.For a long time,it was believed that the degree of stenosis can accurately reflect the risk of ischaemic stroke[3-5].Previous studies have revealed that lesions without significant luminal stenosis can also lead to acute events[6,7],as summarized in a recent meta-analysis study in which approximately 50%of acute/subacute ischaemic events were due to this type of lesion[6].Research[8,9]has pointed out that the PR of plaques is more dangerous and more likely to cause acute ischaemic stroke.Previous studies[10-13]have found that there are specific vascular remodelling phenomena in the coronary and carotid arteries of diabetic patients.However,due to the deep location and small lumen of intracranial arteries and limitations of imaging techniques,the relationship between intracranial arterial remodelling and diabetes is still unclear.In recent years,with the development of magnetic resonance technology and the emergence of high-resolution(HR)vascular wall imaging,a clear and multidimensional display of the intracranial vascular wall has been achieved.Therefore,in this study,HR wall imaging(HR-VWI)was used to display the remodelling characteristics of bilateral middle cerebral arteries and basilar arteries and to explore the factors of intracranial vascular remodelling and its relationship with diabetes.

In vivo pilot study into superficial microcirculatory characteristics of colorectal adenomas using novel high-resolution magnifying endoscopy with blue laser imaging

BACKGROUND No studies have yet been conducted on changes in microcirculatory hemody-namics of colorectal adenomas in vivo under endoscopy.The microcirculation of the colorectal adenoma could be observed in vivo by a novel high-resolution magnification endoscopy with blue laser imaging(BLI),thus providing a new insight into the microcirculation of early colon tumors.AIM To observe the superficial microcirculation of colorectal adenomas using the novel magnifying colonoscope with BLI and quantitatively analyzed the changes in hemodynamic parameters.METHODS From October 2019 to January 2020,11 patients were screened for colon adenomas with the novel high-resolution magnification endoscope with BLI.Video images were recorded and processed with Adobe Premiere,Adobe Photoshop and Image-pro Plus software.Four microcirculation parameters:Microcirculation vessel density(MVD),mean vessel width(MVW)with width standard deviation(WSD),and blood flow velocity(BFV),were calculated for adenomas and the surrounding normal mucosa.RESULTS A total of 16 adenomas were identified.Compared with the normal surrounding mucosa,the superficial vessel density in the adenomas was decreased(MVD:0.95±0.18 vs 1.17±0.28μm/μm2,P<0.05).MVW(5.11±1.19 vs 4.16±0.76μm,P<0.05)and WSD(11.94±3.44 vs 9.04±3.74,P<0.05)were both increased.BFV slowed in the adenomas(709.74±213.28 vs 1256.51±383.31μm/s,P<0.05).CONCLUSION The novel high-resolution magnification endoscope with BLI can be used for in vivo study of adenoma superficial microcirculation.Superficial vessel density was decreased,more irregular,with slower blood flow.

High-resolution magnetic resonance imaging in the diagnosis and management of vertebral artery dissection:A case report

BACKGROUND Vertebral artery dissection(VAD)is a rare but life-threatening condition characterized by tearing of the intimal layer of the vertebral artery,leading to stenosis,occlusion or rupture.The clinical presentation of VAD can be heterogeneous,with common symptoms including headache,dizziness and balance problems.Timely diagnosis and treatment are crucial for favorable outcomes;however,VAD is often missed due to its variable clinical presentation and lack of robust diagnostic guidelines.High-resolution magnetic resonance imaging(HRMRI)has emerged as a reliable diagnostic tool for VAD,providing detailed visualization of vessel wall abnormalities.CASE SUMMARY A young male patient presented with an acute onset of severe headache,vomiting,and seizures,followed by altered consciousness.Imaging studies revealed bilateral VAD,basilar artery thrombosis,multiple brainstem and cerebellar infarcts,and subarachnoid hemorrhage.Digital subtraction angiography(DSA)revealed vertebral artery stenosis but failed to detect the dissection,potentially because intramural thrombosis obscured the VAD.In contrast,HRMRI confirmed the diagnosis by revealing specific signs of dissection.The patient was managed conservatively with antiplatelet therapy and other supportive measures,such as blood pressure control and pain management.After 5 mo of rehabilitation,the patient showed significant improvement in swallowing and limb strength.CONCLUSION HR-MRI can provide precise evidence for the identification of VAD.

Trajectory of Walking Function in Late-Stage Older Individuals Managed with a Regular Exercise Program: A 5-Year Longitudinal Tracking with an IoT Gait Analysis System Using Accelerometers

Purpose: This study focused on maintaining and improving the walking function of late-stage older individuals while longitudinally tracking the effects of regular exercise programs in a day-care service specialized for preventive care over 5 years, using detailed gait function measurements with an accelerometer-based system. Methods: Seventy individuals (17 male and 53 female) of a daycare service in Tokyo participated in a weekly exercise program, meeting 1 - 2 times. The average age of the participants at the start of the program was 81.4 years. Gait function, including gait speed, stride length, root mean square (RMS) of acceleration, gait cycle time and its standard deviation, and left-right difference in stance time, was evaluated every 6 months. Results: Gait speed and stride length improved considerably within six months of starting the exercise program, confirming an initial improvement in gait function. This suggests that regular exercise programs can maintain or improve gait function even age groups that predictably have a gradual decline in gait ability due to enhanced age. In the long term, many indicators tended to approach baseline values. However, the exercise program seemingly counteracts age-related changes in gait function and maintains a certain level of function. Conclusions: While a decline in gait ability with aging is inevitable, establishing appropriate exercise habits in late-stage older individuals may contribute to long-term maintenance of gait function.

Evaluation of Tianji and ECMWF high-resolution precipitation forecasts for extreme rainfall event in Henan in July 2021

The extreme rainfall event of July 17 to 22, 2021 in Henan Province, China, led to severe urban waterlogging and flood disasters. This study investigated the performance of high-resolution weather forecasts in predicting this extreme event and the feasibility of weather forecast-based hydrological forecasts. To achieve this goal, high-resolution precipitation forecasts from the Tianji weather system and the forecast system of the European Centre for Medium-Range Weather Forecasts (ECMWF) were evaluated with the spatial verification metrics of structure, amplitude, and location. The results showed that Tianji weather forecasts accurately predicted the amplitude of 12-h accumulated precipitation with a lead time of 12 h. The location and structure of the rainfall areas in Tianji forecasts were closer to the observations than ECMWF forecasts. Tianji hourly precipitation forecasts were also more accurate than ECMWF hourly forecasts, especially at lead times shorter than 8 h. The precipitation forecasts were used as the inputs to a hydrological model to evaluate their hydrological applications. The results showed that the runoff forecasts driven by Tianji weather forecasts could effectively predict the extreme flood event. The runoff forecasts driven by Tianji forecasts were more accurate than those driven by ECMWF forecasts in terms of amplitude and location. This study demonstrates that high-resolution weather forecasts and corresponding hydrological forecasts can provide valuable information in advance for disaster warnings and leave time for people to act on the event. The results encourage further hydrological applications of high-resolution weather forecasts, such as Tianji weather forecasts, in the future.

Few-Shot Object Detection Based on the Transformer and High-Resolution Network

Now object detection based on deep learning tries different strategies.It uses fewer data training networks to achieve the effect of large dataset training.However,the existing methods usually do not achieve the balance between network parameters and training data.It makes the information provided by a small amount of picture data insufficient to optimize model parameters,resulting in unsatisfactory detection results.To improve the accuracy of few shot object detection,this paper proposes a network based on the transformer and high-resolution feature extraction(THR).High-resolution feature extractionmaintains the resolution representation of the image.Channels and spatial attention are used to make the network focus on features that are more useful to the object.In addition,the recently popular transformer is used to fuse the features of the existing object.This compensates for the previous network failure by making full use of existing object features.Experiments on the Pascal VOC and MS-COCO datasets prove that the THR network has achieved better results than previous mainstream few shot object detection.

Vector fiber Bragg gratings accelerometer based on silicone compliant cylinder for low frequency vibration monitoring

Vector accelerometer has attracted much attention for its great application potential in underground seismic signal measurement. We propose and demonstrate a novel vector accelerometer based on the three fiber Bragg gratings(FBGs)embedded in a silicone rubber compliant cylinder at 120° distributed uniformly. The accelerometer is capable of detecting the orientation of vibration with a range of 0°–360° and the acceleration through monitoring the central wavelength shifts of three FBGs simultaneously. The experimental results show that the natural frequency of the accelerometer is about 85 Hz, and the sensitivity is 84.21 pm/g in the flat range of 20 Hz–60 Hz. Through experimental calibration, the designed accelerometer can accurately obtain vibration vector information, including vibration orientation and acceleration. In addition, the range of resonant frequency and sensitivity can be expanded by adjusting the hardness of the silicone rubber materials. Due to the characteristics of small size and orientation recognition, the accelerometer can be applied to low-frequency vibration acceleration vector measurement in narrow spaces.

Full Scale-Aware Balanced High-Resolution Network for Multi-Person Pose Estimation

Scale variation is amajor challenge inmulti-person pose estimation.In scenes where persons are present at various distances,models tend to perform better on larger-scale persons,while the performance for smaller-scale persons often falls short of expectations.Therefore,effectively balancing the persons of different scales poses a significant challenge.So this paper proposes a newmulti-person pose estimation model called FSANet to improve themodel’s performance in complex scenes.Our model utilizes High-Resolution Network(HRNet)as the backbone and feeds the outputs of the last stage’s four branches into the DCB module.The dilated convolution-based(DCB)module employs a parallel structure that incorporates dilated convolutions with different rates to expand the receptive field of each branch.Subsequently,the attention operation-based(AOB)module performs attention operations at both branch and channel levels to enhance high-frequency features and reduce the influence of noise.Finally,predictions are made using the heatmap representation.The model can recognize images with diverse scales and more complex semantic information.Experimental results demonstrate that FSA Net achieves competitive results on the MSCOCO and MPII datasets,validating the effectiveness of our proposed approach.

High-Resolution Mass Spectroscopy for Revealing the Charge Storage Mechanism in Batteries: Oxamide Materials as an Example

The pursuit of high-performance electrode materials is highly desired to meet the demand of batteries with high energy and power density.However,a deep understanding of the charge storage mechanism is always challenging,which limits the development of advanced electrode materials.Herein,high-resolution mass spectroscopy(HR-MS)is employed to detect the evolution of organic electrode materials during the redox process and reveal the charge storage mechanism,by using small molecular oxamides as an example,which have ortho-carbonyls and are therefore potential electrochemical active materials for batteries.The HR-MS results adequately proved that the oxamides could reversibly store lithium ions in the voltage window of 1.5–3.8 V.Upon deeper reduction,the oxamides would decompose due to the cleavage of the C–N bonds in oxamide structures,which could be proved by the fragments detected by HR-MS,^(1)H NMR,and the generation of NH_(3)after the reduction of oxamide by Li.This work provides a strategy to deeply understand the charge storage mechanism of organic electrode materials and will stimulate the further development of characterization techniques to reveal the charge storage mechanism for developing high-performance electrode materials.

A systematic printability study of direct ink writing towards high-resolution rapid manufacturing

Direct ink writing(DIW)holds enormous potential in fabricating multiscale and multi-functional architectures by virtue of its wide range of printable materials,simple operation,and ease of rapid prototyping.Although it is well known that ink rheology and processing parameters have a direct impact on the resolution and shape of the printed objects,the underlying mechanisms of these key factors on the printability and quality of DIW technique remain poorly understood.To tackle this issue,we systematically analyzed the printability and quality through extrusion mechanism modeling and experimental validating.Hybrid non-Newtonian fluid inks were first prepared,and their rheological properties were measured.Then,finite element analysis of the whole DIW process was conducted to reveal the flow dynamics of these inks.The obtained optimal process parameters(ink rheology,applied pressure,printing speed,etc)were also validated by experiments where high-resolution(<100μm)patterns were fabricated rapidly(>70 mm s^(-1)).Finally,as a process research demonstration,we printed a series of microstructures and circuit systems with hybrid inks and silver inks,showing the suitability of the printable process parameters.This study provides a strong quantitative illustration of the use of DIW for the high-speed preparation of high-resolution,high-precision samples.

On High-Resolution Entropy-Consistent Flux with Slope Limiter for Hyperbolic Conservation Laws

This paper proposes a new version of the high-resolution entropy-consistent(EC-Limited)flux for hyperbolic conservation laws based on a new minmod-type slope limiter.Firstly,we identify the numerical entropy production,a third-order differential term deduced from the previous work of Ismail and Roe[11].The corresponding dissipation term is added to the original Roe flux to achieve entropy consistency.The new,resultant entropy-consistent(EC)flux has a general and explicit analytical form without any corrective factor,making it easy to compute and a less-expensive method.The inequality constraints are imposed on the standard piece-wise quadratic reconstruction to enforce the pointwise values of bounded-type numerical solutions.We design the new minmod slope limiter as combining two separate limiters for left and right states.We propose the EC-Limited flux by adding this reconstruction data method to the primitive variables rather than to the conservative variables of the EC flux to preserve the equilibrium of the primitive variables.These resulting fluxes are easily applied to general hyperbolic conservation laws while having attractive features:entropy-stable,robust,and non-oscillatory.To illustrate the potential of these proposed fluxes,we show the applications to the Burgers equation and the Euler equations.

Calculation,Simulation,and Testing for the Natural Frequency of a Micro Accelerometer

A calculation and test method for the natural frequency of a high-g micro accelerometer with complex structures is presented. A universal formula for natural frequency, which can significantly simplify the structural design process, is deduced and confirmed by experiment. A simplified analytical model is established to describe the accelerometer＇s mechanical behavior and deduce the formula for the natural frequency. Finite element modeling is also conducted to evaluate the natural frequency of the micro-accelerometer and verify the formula. The results obtained from the analytical model and the finite element simulation show good agreement. Finally, a shock comparison method designed for acquiring the high frequency characteristics of the accelerometer is introduced to verify the formula by testing its actual natural frequency.

ATTITUDE MEASUREMENT ON HIGH-SPINNING PROJECTILE USING MAGNETIC SENSORS AND ACCELEROMETERS

In allusion to the limitations of the traditional attitude measurement system consisting of a three-axis magnetic sensor and two accelerometers on high-spinning projectile, a new scheme comprised of two magnetic sensors and two accelerometers installed in a particular way is given. The configuration of the sensors is described. The calculation method and the mathematical model of the projectile attitude based on the sensor configuration are discussed. The basic calculation method including the Magsonde Window, the proof of the ratios of maximums and minimums and the calculation of the attitude angles are analyzed in theory. Finally, the system is simulated under the given conditions. The simulation result indicates that the estimated attitude angles are in agreement with the true attitude angles.

Bulk-Silicon Resonant Accelerometer

Resonant accelerometer is designed,which includes two double-ended tuning forks,a proof mass,four-leverage system amplifying inertial force,and drive/sense combs.Each tuning fork is electrostatically actuated and sensed at resonance using comb electrodes.The device is fabricated using MEMS bulk-silicon technology,whose sensitive degree is 27 3Hz/g,and the resolution is 167 8μg.

Fabrication and Characterization of Tunneling Current of Anodic Bonded Dry-Etched MEMS Tunneling Accelerometer

A tunneling accelerometer is fabricated and characterized based on the extension of the silicon-glass anodic-bonding and deep etching releasing process provided by Peking University.The tunneling current under open loop operation is tested in the air by HP4145B semiconductor analyzer,which verifies the presence of tunneling current and the exponential relationship between tunneling gap and tunneling current.The tunneling barrier is extrapolated to be from 1.182 to 2.177eV.The threshold voltages are tested to be 14～16V for most of the devices.The threshold voltages under -1,0,and +1g are tested,respectively,which shows the sensitivity of the accelerometer is about 87mV/g.

A Novel Capacitive Biaxial Microaccelerometer Based on the Slide-Film Damping Effect

A novel capacitive biaxial microaccelerometer with a highly symmetrical microstructure is developed. The sensor is composed of a single seismic mass, grid strip, supporting beam, joint beam, and damping adjusting combs. The sensing method of changing capacitance area is used in the design,which depresses the requirement of the DRIE process, and de- creases electronic noise by increasing sensing voltage to improve the resolution. The parameters and characteristics of the biaxial microaccelerometer are discussed with the FEM tool ANSYS. The simulated results show that the transverse sensitivity of the sensor is equal to zero. The testing devices based on the slide-film damping effect are fabricated, and the testing quality factor is 514, which shows that the designed structure can improve the resolution and proves the feasibility of the designed process.