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Design and Implementation of a High-Sensitivity Magnetic Sensing System Based on GMI Effect
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作者 Wenzhu Wu Ming Xu +4 位作者 Changlin Han Junquan Tang Jia Xu Lin Xu Mingxin Qin 《Journal of Beijing Institute of Technology》 EI CAS 2024年第3期237-247,共11页
A high-sensitivity magnetic sensing system based on giant magneto-impedance(GMI)effect is designed and fabricated.The system comprises a GMI sensor equipped with a gradient probe and an signal acquisition and processi... A high-sensitivity magnetic sensing system based on giant magneto-impedance(GMI)effect is designed and fabricated.The system comprises a GMI sensor equipped with a gradient probe and an signal acquisition and processing module.A segmented superposition algorithm is used to increase target signal and reduce the random noise.The results show that under unshielded,room temperature conditions,the system achieves successful detection of weak magnetic fields down to 2 pT with a notable sensitivity of 1.84×10^(8)V/T(G=1000).By applying 17 overlays,the segmented superposition algorithm increases the power proportion of the target signal at 31 Hz from6.89%to 45.91%,surpassing the power proportion of the 2 Hz low-frequency interference signal.Simultaneously,it reduces the power proportion of the 20 Hz random noise.The segmented superposition process effectively cancels out certain random noise elements,leading to a reduction in their respective power proportions.This high-sensitivity magnetic sensing system features a simple structure,and is easy to operate,making it highly valuable for both practical applications and broader dissemination. 展开更多
关键词 high-sensitivity magnetic field sensing system GMI effect segmented superposition algorithm
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Value of N-Terminal Pro B-Type Natriuretic Peptide,High-Sensitivity C-Reactive Protein,and Homocysteine Levels in Predicting Cardiovascular Events in Chronic Heart Failure Patients After Discharge
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作者 Qian Yu Linya Zhao +1 位作者 Yinyin Chen Qing Zhao 《Proceedings of Anticancer Research》 2023年第2期22-27,共6页
Objective:To investigate the value of N-terminal pro B-type natriuretic peptide(NT-proBNP),high-sensitivity C-reactive protein(hs-CRP),and homocysteine(Hcy)levels in predicting cardiovascular events(CV)in patients wit... Objective:To investigate the value of N-terminal pro B-type natriuretic peptide(NT-proBNP),high-sensitivity C-reactive protein(hs-CRP),and homocysteine(Hcy)levels in predicting cardiovascular events(CV)in patients with chronic heart failure(CHF).Methods:A total of 63 patients with CHF admitted to our hospital between June 2019 and July 2021 were selected.Their NT-proBNP,hs-CRP,and Hcy levels were detected at discharge,and a 12-month follow-up was done after their discharge to collect clinical data.The collected data were inclusive of data from 21 CHF patients with cardiovascular disease and 42 CHF patients without cardiovascular disease.The effect of NT-proBNP,hs-CRP,and Hcy levels on the occurrence of CV was analyzed.Results:The levels of NT-proBNP,hs-CRP,and Hcy in the group with cardiovascular disease were significantly higher than those in the group without cardiovascular disease(P<0.05);the levels of serum NT-proBNP,hs-CRP,and Hcy at discharge had certain value in predicting short-term CV in CHF patients(P<0.05).Conclusion:NT-proBNP,hs-CRP,and Hcy levels can be used to predict CV in CHF patients,thus having clinical application value. 展开更多
关键词 Chronic heart failure N-terminal pro B-type natriuretic peptide HOMOCYSTEINE high-sensitivity C-reactive protein
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Concept and Design of a Novel High-Bandwidth,High-Sensitivity Differential Receiver for Optical Interconnections 被引量:1
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作者 余长亮 毛陆虹 +1 位作者 宋瑞良 肖新东 《Journal of Semiconductors》 EI CAS CSCD 北大核心 2008年第5期903-907,共5页
A novel high-bandwidth, high-sensitivity differential optical receiver without any additional cost compared to general optical receivers, is proposed for high-speed optical communications and interconnections. High ba... A novel high-bandwidth, high-sensitivity differential optical receiver without any additional cost compared to general optical receivers, is proposed for high-speed optical communications and interconnections. High bandwidth and high sensitivity are achieved through a fully differential transimpedance amplifier with balanced input loads and two photodetectors to convert the incident light into a pair of differential photogenerated currents,respectively. In addition,a corresponding 0.35μm standard CMOS optoelectronic integrated receiver with two 60μm × 30μm, 1. 483pF fingered p^+/n- well/p-substrate photodiodes is also presented. The simulation results demonstrate that it achieves a 1.37GHz bandwidth and a 81.9dBΩ transimpedance gain,supporting data rates up to at least 2Gbit/s. The device consumes a core area of 0. 198mm^2 and the optical sensitivity is at least - 13dBm for a 10^-12 bit error rate under a 2^15 - 1 PRBS input signal. 展开更多
关键词 high-bandwidth high-sensitivity CMOS optical receiver
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Partial frequency band match filtering based on high-sensitivity data: method and applications 被引量:1
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作者 沈洪垒 田钢 石战结 《Applied Geophysics》 SCIE CSCD 2013年第1期15-24,117,共11页
During seismic data acquisition, a high-sensitivity geophone with a high inherent frequency can increase high frequency energy by suppressing low frequency signals. This could cause a worse response at low frequencies... During seismic data acquisition, a high-sensitivity geophone with a high inherent frequency can increase high frequency energy by suppressing low frequency signals. This could cause a worse response at low frequencies. If the advantages of high-sensitivity data and conventional data are combined, the effective bandwidth will be broadened. Considering this, we propose a partial frequency band match filtering method which can combine the advantages of both high frequency and conventional frequency ranges. By introducing Ricker wavelets with different dominant frequencies and amplitudes, we established a theoretical model which possesses characteristics of both types of seismic data and demonstrates the feasibility of the partial frequency band match filtering method. A test using single shot records shows the effectiveness of this method for widening the effective frequency band. 展开更多
关键词 high-sensitivity effective bandwidth partial frequency band match RESOLUTION
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High-sensitivity cardiac troponins in everyday clinical practice 被引量:4
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作者 Johannes Mair 《World Journal of Cardiology》 CAS 2014年第4期175-182,共8页
High-sensitivity cardiac troponin(hs-cTn) assays are increasingly being used in many countries worldwide,however,a generally accepted definition of high-sen-sitivity is still pending.These assays enable cTn mea-sureme... High-sensitivity cardiac troponin(hs-cTn) assays are increasingly being used in many countries worldwide,however,a generally accepted definition of high-sen-sitivity is still pending.These assays enable cTn mea-surement with a high degree of analytical sensitivity with a low analytical imprecision at the low measuring range of cTn assays(coefficient of variation of < 10% at the 99th percentile upper reference limit).One of the most important advantages of these new assays is that they allow novel,more rapid approaches to rule in or rule out acute coronary syndromes(ACSs) than with previous cTn assay generations which are still more commonly used in practice worldwide.hs-cTn is also more sensitive for the detection of myocardial damage unrelated to acute myocardial ischemia.Therefore,the increase in early diagnostic sensitivity of hs-cTn assays for ACS comes at the cost of a reduced ACS specificity,because more patients with other causes of acute or chronic myocardial injury without overt myocardial isch-emia are detected than with previous cTn assays.As hs-cTn assays are increasingly being adopted in clinical practice and more hs-cTn assays are being developed,this review attempts to synthesize the available clinical data to make recommendations for their everyday clini-cal routine use. 展开更多
关键词 Cardiac TROPONIN high-sensitivity Diagno-sis ACUTE MYOCARDIAL INFARCTION ACUTE coronary syn-drome Review
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Distribution of High-sensitivity C-reactive Protein Status in an Urban Population in China 被引量:2
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作者 TANG Yan Bin HUO Jun Sheng +4 位作者 HUANG Jian LI Hong PIAO Jian Hua SUN Jing WANG Li Juan 《Biomedical and Environmental Sciences》 SCIE CAS CSCD 2020年第6期396-402,共7页
Objectives To evaluate the distribution by age and sex of serum high-sensitivity C-reactive protein(hsCRP)in an urban Chinese population and to provide a profile prediction for the risk of bacterial infection,inflamma... Objectives To evaluate the distribution by age and sex of serum high-sensitivity C-reactive protein(hsCRP)in an urban Chinese population and to provide a profile prediction for the risk of bacterial infection,inflammatory diseases,or tissue damages in the body.Methods Serum hsCRP was determined using the Roche Tina-quant immuno-turbidimetric assay on a Hitachi 7600–010 automatic biochemical analyzer(Roche Diagnostics)in 1,572 males and 1,800 females,including 78 pregnant women,who were derived from the National Health and Nutrition Survey in2010–2012.Results The average hsCRP concentration in urban China was 0.68 mg/L for males and 0.65 mg/L for females.Significant differences in hsCRP were found among different age groups(P<0.05).Monitoring results showed no significant differences among the 6–11,45–59,and≥60-year-old groups in the comparison of hsCRP between males and females in large cities.However,hsCRP concentration was significantly higher in men aged 12–17 and 18–44 years than in women.Conclusion The distribution of the hsCRP status of residents in large cities in China was influenced by age and gender,and the hsCRP levels of both sexes increased gradually with age.In addition,hsCRP concentration was higher in healthy pregnant women than in non-pregnant women.Basing on our results,we recommend that this parameter be included in future national and international screening for early detection of various illnesses. 展开更多
关键词 high-sensitivity C-reactive protein Urban population INFLAMMATION DISTRIBUTION
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Elevated levels of inflammatory cytokines and high-sensitivity C-reactive protein in periodontitis patients in Kosovo: A pilot study 被引量:7
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作者 Zana Sllamniku-Dalipi Hasan Mehmeti +5 位作者 Fatmir Dragidella Ferit Ko?ani Metush Disha Kastriot Meqa Luljeta Begolli Gramos Begolli 《Open Journal of Stomatology》 2013年第1期32-38,共7页
The following article has been retracted due to the investigation of complaints received against it. The Editorial Board found that the same contents have been published in another journal at the same time. The scient... The following article has been retracted due to the investigation of complaints received against it. The Editorial Board found that the same contents have been published in another journal at the same time. The scientific community takes a very strong view on this matter, and the Open Journal of Stomatology treats all unethical behavior such as plagiarism seriously. This paper published in Vol.3 No.1 32-38, 2013 has been removed from this site. Title: Elevated levels of inflammatory cytokines and high-sensitivity C-reactive protein in periodontitis patients in Kosovo: A pilot study Authors: Zana Sllamniku-Dalipi, Hasan Mehmeti, Fatmir Dragidella, Ferit Kocani, Metush Disha, Kastriot Meqa, Luljeta Begolli, Gramos 展开更多
关键词 Periodontal Disease Interleukin-1beta INTERLEUKIN-6 Tumour Necrosis Factor Alpha high-sensitivity C Reactive Protein
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Responses of serum inflammatory factor high-sensitivity C-reactive protein, interleukin-6, and tumor necrosis factor-alpha in elderly males with cerebral infarction Non-randomized concurrent control 被引量:1
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作者 Guiping Jiao Xinjie Tan Zhiliu Yuan Chunling Li Jing Wang Wen Mo 《Neural Regeneration Research》 SCIE CAS CSCD 2008年第5期498-500,共3页
BACKGROUND: Cerebral infarction is poorly treated due to neuronal necrosis and secondary pathophysiological changes; for example, free radical production and inflammatory reactions. OBJECTIVE: To detect the levels o... BACKGROUND: Cerebral infarction is poorly treated due to neuronal necrosis and secondary pathophysiological changes; for example, free radical production and inflammatory reactions. OBJECTIVE: To detect the levels of high-sensitivity C-reactive protein (hs-CRP), interleukin-6 (IL-6), and tumor necrosis factor- a (TNF- α ) in elderly males with cerebral infarction. DESIGN: Non-randomized current control study. SETTING: Cadre Medical Department, Guizhou Provincial People's Hospital. PARTICIPANTS: Forty elderly males (65-89 years old) with cerebral infarction were selected from Cadre Medical Department, Guizhou Provincial People's Hospital from February 2004 to December 2006. All patients met the diagnostic criteria of cerebral infarction modified at the 4th National Cerebrovascular Disease Academic Meeting, and were diagnosed on the basis of CT or MRI tests. Furthermore, 35 elderly male inpatients (65-87 years old) without cerebral infarction were selected as the control group. Included subjects provided confirmed consent and did not have heart disease, diabetes mellitus, lipid disorder, acute trauma, infection, rheumatism, or other inflammatory diseases. The study was approved by the local ethics committee. There were no significant differences in age, blood pressure, and lipid levels between the cerebral infarction group and the control group (P 〉 0.05), and this suggested that the baseline data of both groups were comparable. METHODS: Fasting venous blood was drawn from cerebral infarction patients 24 hours after cerebral infarction attack and from control subjects 24 hours after hospitalization. A latex-enhanced immunoturbidimetric assay and an enzyme-linked immunosorbent assay were used to detect the levels of hs-CRP, IL-6, and TNF- α in the serum. MAIN OUTCOME MEASURES: The levels of hs-CRP, 1L-6, and TNF- α in the serum in both groups. RESULTS: Forty cerebral infarction patients and thirty-five control subjects were included in the final analysis without any loss. Levels of hs-CRP, IL-6, and TNF-α in the cerebral infarction group were significantly higher than those in the control group (P 〈 0.01 ). CONCLUSION: Levels of serum inflammatory reactive factors are increased in elderly males with cerebral infarction. 展开更多
关键词 high-sensitivity C-reactive protein INTERLEUKIN tumor necrosis factor-alpha: elderly males cerebral infarction
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A dual-axis, high-sensitivity atomic magnetometer 被引量:1
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作者 李茹杰 全伟 +4 位作者 范文峰 邢力 王卓 翟跃阳 房建成 《Chinese Physics B》 SCIE EI CAS CSCD 2017年第12期196-200,共5页
Atomic magnetometer (AM) operated in a spin-exchange relaxation-free (SERF) regime features superior sensitivity and non-cryogenic operation, and thus is competitive with the best superconducting quantum interfere... Atomic magnetometer (AM) operated in a spin-exchange relaxation-free (SERF) regime features superior sensitivity and non-cryogenic operation, and thus is competitive with the best superconducting quantum interference devices. Previously, SERF AM with fT/Hz1/2 level sensitivity commonly acted as a single-axis sensor. Here we demonstrate a dual-axis SERF AM capable of simultaneously and independently detecting x-and y-field components with a sensitivity of 20 fT/Hz1/2. As there is no necessity to worry about the cross-talk effects arising from field modulations, the dual-axis scheme proposed here is of particular interest to AM array and hence the biomagnetic applications. 展开更多
关键词 optically pumped magnetometers multi-axis field measurements high-sensitivity field measurements polarized atoms
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N-terminal pro-brain natriuretic peptide but not high-sensitivity C-reactive protein is related to severity of coronary artery stenosis in patients with acute coronary syndrome 被引量:1
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作者 Shi-Jun Li Zhi-Jun Sun +3 位作者 Dan-Dan Li Geng Qian Ting-Shu Yang Xiao-Ying Li 《Journal of Geriatric Cardiology》 SCIE CAS CSCD 2010年第2期101-105,共5页
Objective Biochemical indicators such as N-terminal pro-brain type natriuretic peptide(NT pro-BNP)and high-sensitivity Creactive protein(hsCRP)predict mortality in acute coronary syndrome(ACS).However,little is ... Objective Biochemical indicators such as N-terminal pro-brain type natriuretic peptide(NT pro-BNP)and high-sensitivity Creactive protein(hsCRP)predict mortality in acute coronary syndrome(ACS).However,little is known about the relationship of these factors with severity of coronary artery stenosis in patients with.Methods Three hundred and thirty-one subjects including 246 unstable angina pectoris patients and 85 myocardial infarction patients were recruited and classified into two groups:single-vessel disease group(1-vessel disease,n=93)and multiple-vessel disease group(≥2-vessels disease,n=238)according to selective coronary angiography.Plasma levels of NT pro-BNP and hsCRP were measured and severity of coronary stenosis was determined by Gensini score.Results NT pro-BNP but not hsCRP level was higher in patients with myocardial infarction than in patients with unstable angina pectoris.The patients with multiple-vessel disease had significantly higher NT pro-BNP level but not hsCRP compared with those with single-vessel disease.NT pro-BNP levels increased significantly as left ventricle(LV)function decreased,and only NT proBNP but not hsCRP level was related to Gensini score of severity of coronary stenosis in ACS.Conclusion NT proBNP but not hsCRP level is related to severity of coronary artery stenosis in patients in ACS. 展开更多
关键词 N-terminal pro-brain natriuretic peptide high-sensitivity C-reactive protein coronary artery stenosis acute coronary syndrome
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High-Sensitivity Magnetization Measurements
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作者 C.D. Graham (Dept. of Materials Science, University of Pennsylvania, Philadelphia, PA 19104, USA) 《Journal of Materials Science & Technology》 SCIE EI CAS CSCD 2000年第2期97-101,共5页
The three most common instruments for high-sensitivity magnetization measurements (the vibrating-sampie magnetometer, the alternating gradient magnetometer, and the SQUID magnetometer) are described and their limiting... The three most common instruments for high-sensitivity magnetization measurements (the vibrating-sampie magnetometer, the alternating gradient magnetometer, and the SQUID magnetometer) are described and their limiting sensitivities are discussed. The advantages and disadvantages of each are described. Magnetometers using micro-machined force detectors are briefly mentioned. 展开更多
关键词 VSM high-sensitivity Magnetization Measurements
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A High-Sensitivity Refractive-Index Sensor Based on Plasmonic Waveguides Asymmetrically Coupled with a Nanodisk Resonator
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作者 肖丽萍 王发强 +2 位作者 梁瑞生 邹世伟 胡淼 《Chinese Physics Letters》 SCIE CAS CSCD 2015年第7期13-16,共4页
A high-sensitivity plasmonic refractive-index sensor based on the asymmetrical coupling of two metal-insulator- metal waveguides with a nanodisk resonator is proposed and simulated in the finite-difference time domain... A high-sensitivity plasmonic refractive-index sensor based on the asymmetrical coupling of two metal-insulator- metal waveguides with a nanodisk resonator is proposed and simulated in the finite-difference time domain. Both analytic and simulated results show that the resonance wavelengths of the sensor have an approximate linear relationship with the refractive index of the materials which are filled into the slit waveguides and the disk- shaped resonator. The working mechanism of this sensor is exactly due to the linear relationship, based on which tile refractive index of the materials unknown can be obtained from the detection of the resonance wavelength. The measurement sensitivity can reach as high as 6.45 × 10-7, which is nearly five times higher than the results reported in the recent literature [Opt. Commun. 300 (2013) 265]. With an optimum design, the sensing value can be further improved, and it can be widely applied into the biological sensing. Tile sensor working for temperature sensing is also analyzed. 展开更多
关键词 A high-sensitivity Refractive-Index Sensor Based on Plasmonic Waveguides Asymmetrically Coupled with a Nanodisk Resonator
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An electrochemiluminescent magneto-immunosensor for ultrasensitive detection of hs-cTnI on a microfluidic chip
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作者 Yun Hui Zhen Zhao +7 位作者 Weiliang Shu Fengshan Shen Weijun Kong Shengyong Geng Zhen Xu Tianzhun Wu Wenhua Zhou Xuefeng Yu 《Nanotechnology and Precision Engineering》 EI CAS CSCD 2024年第3期13-23,共11页
Sensitive detection and precise quantitation of trace-level crucial biomarkers in a complex sample matrix has become an important area of research.For example,the detection of high-sensitivity cardiac troponin I(hs-cT... Sensitive detection and precise quantitation of trace-level crucial biomarkers in a complex sample matrix has become an important area of research.For example,the detection of high-sensitivity cardiac troponin I(hs-cTnI)is strongly recommended in clinical guidelines for early diagnosis of acute myocardial infarction.Based on the use of an electrode modified by single-walled carbon nanotubes(SWCNTs)and a Ru(bpy)32+-doped silica nanoparticle(Ru@SiO2)/tripropylamine(TPA)system,a novel type of electrochemiluminescent(ECL)magneto-immunosensor is developed for ultrasensitive detection of hs-cTnI.In this approach,a large amount of[Ru(bpy)3]2+is loaded in SiO2(silica nanoparticles)as luminophores with high luminescent efficiency and SWCNTs as electrode surface modification material with excellent elec-trooxidation ability for TPA.Subsequently,a hierarchical micropillar array of microstructures is fabricated with a magnet placed at each end to efficiently confine a single layer of immunomagnetic microbeads on the surface of the electrode and enable 7.5-fold signal enhancement.In particular,the use of transparent SWCNTs to modify a transparent ITO electrode provides a two-order-of-magnitude ECL signal amplifi-cation.A good linear calibration curve is developed for hs-cTnI concentrations over a wide range from 10 fg/ml to 10 ng/ml,with the limit of detection calculated as 8.720 fg/ml(S/N 3).This ultrasensitive immunosensor exhibits superior detection performance with remarkable sta-=bility,reproducibility,and selectivity.Satisfactory recoveries are obtained in the detection of hs-cTnI in human serum,providing a potential analysis protocol for clinical applications. 展开更多
关键词 Electrochemiluminescent magneto-immunosensor Microfluidic chip high-sensitivity cardiac troponin I Single-walled carbon nanotube [Ru(bpy)3]2+-doped silica nanoparticle
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High-sensitive terahertz detection by parametric up-conversion using nanosecond pulsed laser 被引量:1
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作者 Yuye Wang Gang Nie +6 位作者 Changhao Hu Kai Chen Chao Yan Bin Wu Junfeng Zhu Degang Xu Jianquan Yao 《Chinese Physics B》 SCIE EI CAS CSCD 2022年第2期336-341,共6页
A high-sensitive terahertz detector operating at room temperature was demonstrated based on parametric upconversion.A nanosecond 1064-nm Nd:YAG laser was used to pump the parametric up-conversion detector and the upco... A high-sensitive terahertz detector operating at room temperature was demonstrated based on parametric upconversion.A nanosecond 1064-nm Nd:YAG laser was used to pump the parametric up-conversion detector and the upconversion from terahertz wave to NIR laser was realized in a lithium niobate crystal.The minimum detectable terahertz energy of 9 p J was realized with the detection dynamic range of 54 d B,which was three orders of magnitude higher than that of commercial Golay cell.The detectable terahertz frequency range of the detection system was 0.90 Thz–1.83 THz.Besides,the effects of pump energy and effective gain length on the detection sensitivity were studied in experiment.The results showed that higher pump energy and longer effective gain length are helpful for improving the detection sensitivity of parametric up-conversion detector. 展开更多
关键词 terahertz wave high-sensitive detection room temperature operation parametric up-conversion
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High-sensitive phototransistor based on vertical HfSe_(2)/MoS_(2) heterostructure with broad-spectral response 被引量:1
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作者 Wen Deng Li-Sheng Wang +2 位作者 Jia-Ning Liu Tao Xiang Feng-Xiang Chen 《Chinese Physics B》 SCIE EI CAS CSCD 2022年第12期662-669,共8页
Van der Waals heterostructures based on the two-dimensional(2D)semiconductor materials have attracted increasing attention due to their attractive properties.In this work,we demonstrate a high-sensitive back-gated pho... Van der Waals heterostructures based on the two-dimensional(2D)semiconductor materials have attracted increasing attention due to their attractive properties.In this work,we demonstrate a high-sensitive back-gated phototransistor based on the vertical HfSe_(2)/MoS_(2)heterostructure with a broad-spectral response from near-ultraviolet to near-infrared and an efficient gate tunability for photoresponse.Under bias,the phototransistor exhibits high responsivity of up to 1.42×103A/W,and ultrahigh specific detectivity of up to 1.39×1015cm·Hz^(1/2)·W^(-1).Moreover,it can also operate under zero bias with remarkable responsivity of 10.2 A/W,relatively high specific detectivity of 1.43×1014cm·Hz^(1/2)·W^(-1),ultralow dark current of 1.22 f A,and high on/off ratio of above 105.These results should be attributed to the fact that the vertical HfSe_(2)/MoS_(2)heterostructure not only improves the broadband photoresponse of the phototransistor but also greatly enhances its sensitivity.Therefore,the heterostructure provides a promising candidate for next generation high performance phototransistors. 展开更多
关键词 HfSe_(2)/MoS_(2)heterostructure PHOTOTRANSISTOR high-sensitive broad-spectral response
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Facile fabrication of microstructured surface using laser speckle for high-sensitivity capacitive pressure sensors 被引量:2
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作者 TONG ZhaoMin SUN ChangYuan +3 位作者 MA YiFei WANG Mei JIA SuoTang CHEN XuYuan 《Science China(Technological Sciences)》 SCIE EI CAS CSCD 2023年第1期155-164,共10页
The design of a maskless exposure system for fabricating the microstructured surface based on the grainy light illumination generated by laser speckle is reported. Upon combining with soft lithography, we obtained mic... The design of a maskless exposure system for fabricating the microstructured surface based on the grainy light illumination generated by laser speckle is reported. Upon combining with soft lithography, we obtained microstructured polydimethylsiloxane electrodes with microstructure sizes of 20 μm and 40 μm and microstructure fill factors ranging from 10% to 90%. The feasibility of using this method in fabricating high-sensitivity capacitive pressure sensors was demonstrated. The sensor shows the highest sensitivity of 2.14 k Pa-1under 0–100 Pa pressures, the low detection limit of 4.9 Pa, and the excellent stability and durability of 10000 cycles. The method of employing laser speckle in fabricating microstructures with different morphologies is simple and robust, which is superior to other methods such as traditional photolithography. 展开更多
关键词 maskless exposure system MICROSTRUCTURE laser speckle high-sensitivity capacitive pressure sensor
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Ultrasensitive and Highly Stretchable Multiple‑Crosslinked Ionic Hydrogel Sensors with Long‑Term Stability 被引量:1
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作者 Jin‑Young Yu Seung Eon Moon +1 位作者 Jeong Hun Kim Seong Min Kang 《Nano-Micro Letters》 SCIE EI CAS CSCD 2023年第4期85-96,共12页
Flexible hydrogels are receiving significant attention for their application in wearable sensors.However,most hydrogel materials exhibit weak and one-time adhesion,low sensitivity,ice crystallization,water evaporation... Flexible hydrogels are receiving significant attention for their application in wearable sensors.However,most hydrogel materials exhibit weak and one-time adhesion,low sensitivity,ice crystallization,water evaporation,and poor self-recovery,thereby limiting their application as sensors.These issues are only partly addressed in previous studies.Herein,a multiplecrosslinked poly(2-(methacryloyloxy)ethyl)dimethyl-(3-sulfopropyl)ammonium hydroxide-co-acrylamide)(P(SBMA-co-AAm))multifunctional hydrogel is prepared via a one-pot synthesis method to overcome the aforementioned limitations.Specifically,ions,glycerol,and 2-(methacryloyloxy)ethyl)dimethyl-(3-sulfopropyl)ammonium hydroxide are incorporated to reduce the freezing point and improve the moisture retention ability.The proposed hydrogel is superior to existing hydrogels because it exhibits good stretchability(a strain of 2900%),self-healing properties,and transparency through effective energy dissipation in its dynamic crosslinked network.Further,2-(methacryloyloxy)ethyl)dimethyl-(3-sulfopropyl)ammonium hydroxide as a zwitterion monomer results in an excellent gauge factor of 43.4 at strains of 1300-1600%by improving the ion transportability and achieving a strong adhesion of 20.9 kPa owing to the dipole-dipole moment.The proposed hydrogel is promising for next-generation biomedical applications,such as soft robots,and health monitoring. 展开更多
关键词 Hydrogel sensors Biocompatibility MULTIFUNCTION high-sensitivity sensors Multiple-crosslink association
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Enhanced Fano resonance for high-sensitivity sensing based on bound states in the continuum 被引量:1
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作者 冯光 陈智辉 +6 位作者 王扬 刘欣 刘寅山 刘啸 孙非 杨毅彪 陈树琪 《Chinese Optics Letters》 SCIE EI CAS CSCD 2023年第3期54-59,共6页
Although previously reported terahertz absorbers can achieve high-sensitivity refractive index sensing,the resonant peak is too broad,which leads to a low figure of merit[FOM].Transmissive sensors based on bound state... Although previously reported terahertz absorbers can achieve high-sensitivity refractive index sensing,the resonant peak is too broad,which leads to a low figure of merit[FOM].Transmissive sensors based on bound states in the continuum[BIC]can achieve high FOM,but they have some limitations in high sensitivity.Herein,we propose a periodic triple parallel metal bars structure to obtain high quality,a strong field,and multiple hot spots by the Friedrich-Wintgen BIC.Numerical results show the sensitivity and FOM can reach 1877 GHz/RIU and 665,respectively.Compared to the previously reported transmissive sensors based on BIC,the sensitivity has been greatly improved. 展开更多
关键词 Fano resonance bound states in the continuum TERAHERTZ high-sensitivity sensing
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Elevated level of high-sensitivity cardiac troponin I as a predictor of adverse cardiovascular events in patients with heart failure with preserved ejection fraction
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作者 Hongyu Hu Jingjin Li +2 位作者 Xin Wei Jia Zhang Jiayu Wang 《Chinese Medical Journal》 SCIE CAS CSCD 2023年第18期2195-2202,共8页
Background:The relationship between the elevation of cardiac troponin and the increase of mortality and hospitalization rate in patients with heart failure with reduced ejection fraction is clear.This study investigat... Background:The relationship between the elevation of cardiac troponin and the increase of mortality and hospitalization rate in patients with heart failure with reduced ejection fraction is clear.This study investigated the association between the extent of elevated levels of high-sensitivity cardiac troponin I(hs-cTnI)and the prognosis in heart failure with preserved ejection fraction patients.Methods:A retrospective cohort study consecutively enrolled 470 patients with heart failure with preserved ejection fraction from September 2014 to August 2017.According to the level of hs-cTnI,the patients were divided into the elevated level group(hs-cTnI>0.034 ng/mL in male and hs-cTnI>0.016 ng/mL in female)and the normal level group.All of the patients were followed up once every 6 months.Adverse cardiovascular events were cardiogenic death and heart failure hospitalization.Results:The mean follow-up period was 36.2±7.9 months.Cardiogenic mortality(18.6%[26/140]vs.1.5%[5/330],P<0.001)and heart failure(HF)hospitalization rate(74.3%[104/140]vs.43.6%[144/330],P<0.001)were significantly higher in the elevated level group.The Cox regression analysis showed that the elevated level of hs-cTnI was a predictor of cardiogenic death(hazard ratio[HR]:5.578,95%confidence interval[CI]:2.995-10.386,P<0.001)and HF hospitalization(HR:3.254,95%CI:2.698-3.923,P<0.001).The receiver operating characteristic curve demonstrated that a sensitivity of 72.6%and specificity of 88.8%for correct prediction of adverse cardiovascular events when a level of hs-cTnI of 0.1305 ng/mL in male and a sensitivity of 70.6%and specificity of 90.2%when a level of hs-cTnI of 0.0755 ng/mL in female were used as the cut-off value.Conclusion:Significant elevation of hs-cTnI(≥0.1305 ng/mL in male and≥0.0755 ng/mL in female)is an effective indicator of the increased risk of cardiogenic death and HF hospitalization in heart failure with preserved ejection fraction patients. 展开更多
关键词 Heart failure with preserved ejection fraction high-sensitivity cardiac troponin I Cardiogenic mortality Heart failure hospitalization
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A high-sensitive and self-selective humanoid mechanoreceptor for spatiotemporal tactile stimuli cognition
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作者 Shuxin Bi Xuan Zhao +6 位作者 Fangfang Gao Xiaochen Xun Bin Zhao Liangxu Xu Tian Ouyang Qingliang Liao Yue Zhang 《Nano Research》 SCIE EI CSCD 2024年第5期4400-4409,共10页
The cognition of spatiotemporal tactile stimuli,including fine spatial stimuli and static/dynamic temporal stimuli,is paramount for intelligent robots to feel their surroundings and complete manipulation tasks.However... The cognition of spatiotemporal tactile stimuli,including fine spatial stimuli and static/dynamic temporal stimuli,is paramount for intelligent robots to feel their surroundings and complete manipulation tasks.However,current tactile sensors have restrictions on simultaneously demonstrating high sensitivity and performing selective responses to static/dynamic stimuli,making it a challenge to effectively cognize spatiotemporal tactile stimuli.Here,we report a high-sensitive and self-selective humanoid mechanoreceptor(HMR)that can precisely respond to spatiotemporal tactile stimuli.The HMR with PDMS/chitosan@CNTs(PDMS:polydimethylsiloxane;CNT:carbon nanotube)graded microstructures and polyurethane hierarchical porous spacer exhibits high sensitivity of 3790.8 kPa^(-1).The HMR demonstrates self-selective responses to static and dynamic stimuli with mono signal through the hybrid of piezoresistive and triboelectric mechanisms.Consequently,it can respond to spatiotemporal tactile stimuli and generate distinguishable and multi-type characteristic signals.With the assistance of the convolutional neural network,multiple target objects can be easily identified with a high accuracy of 99.1%.This work shows great potential in object precise identification and dexterous manipulation,which is the basis of intelligent robots and natural human-machine interactions. 展开更多
关键词 mechanoreceptors self-selective high-sensitive spatiotemporal tactile stimuli cognition sensors
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