Effect of sintering temperature and holding time on structure and properties of Li_(1.5)Ga_(0.5)Ti_(1.5)(PO_4)_(3)electrolyte with fast ionic conductivity

Li_(1.5)Ga_(0.5)Ti_(1.5)PO_(4))_(3)(LGTP)is recognized as a promising solid electrolyte material for lithium ions.In this work,LGTP solid electrolyte materials were prepared under different process conditions to explore the effects of sintering temperature and holding time on relative density,phase composition,microstructure,bulk conductivity,and total conductivity.In the impedance test under frequency of 1-10^(6) Hz,the bulk conductivity of the samples increased with increasing sintering temperature,and the total conductivity first increased and then decreased.SEM results showed that the average grain size in the ceramics was controlled by the sintering temperature,which increased from(0.54±0.01)μm to(1.21±0.01)μm when the temperature changed from 750 to 950°C.The relative density of the ceramics increased and then decreased with increasing temperature as the porosity increased.The holding time had little effect on the grain size growth or sample density,but an extended holding time resulted in crack generation that served to reduce the conductivity of the solid electrolyte.

Characterization of Hydroxyapatite Extracted from Crab Shell Using the Hydrothermal Method with Varying Holding Times

Hydroxyapatite(HA)is a bio ceramic commonly utilized in bone tissue engineering due to its bioactive and osteoconductive properties.Crab shells are usually disregarded as waste material despite their significant CaCO_(3) content,and have not been widely utilized in the synthesis of HA.This study aims to synthesize and analyze HA derived from crab shells using the hydrothermal method with different durations of holding time.This study utilized precipitated calcium carbonate(PCC)derived from crab shells.With a hydrothermal reactor set at 160℃ and varying holding times of 14(HA_14),16(HA_16),and 18(HA_18)h,a PCC and(NH4)2HPO4 mixture was used to synthesize HA.The synthesis results were analyzed using scanning electron microscopy(SEM),fourier transform infrared spectroscopy(FTIR),and X-ray diffraction(XRD)tests.This study has accomplished the synthesis of HA from crab shells.Nonetheless,the final product of synthesis still contained CaCO_(3) as an impurity.The prolonged hydrothermal holding time of 14 to 18 h resulted in a reduction of impurities while increasing the percentage of crystal weight and crystallite size of HA.Specimen CH_18 is the best-quality product generated in this study.This specimen produced HA with the highest percentage of crystal weight and crystallite size compared to the other specimens.Furthermore,specimen CH_18 exhibited the lowest concentration of impurities.The Ca/P ratio in this specimen was also the closest to 1.67.The Ca/P ratio,crystallite size,and crystal weight percentage of this specimen are 1.54,19.06 nm,and 99.1%,respectively.

Inter-Fraction Analysis of One Week Hypo-Fractionation of Deep Inspiration Breath Hold (DIBH) Technique for Left Sided Breast Cancer Radiation Treatment

The aim of this study was to investigate the inter-fraction variations, patient comfort and knowledge at Charlotte Maxeke Johannesburg Academic Hospital (CMJAH). The differences in set-up that occurred between treatment sessions for the left sided breast patients were observed and recorded. Measurements of routine set-up variation for 24 patients were performed by matching the cone beam computed tomography (CBCT) and the planning computed tomography (CT). Scans of all five fractions per patient were used to quantify the setup variations with standard deviation (SD) in all the three directions (anterior posterior, left right, and superior inferior). The patients DIBH comfort and knowledge was also evaluated. The average translational errors for the anterior posterior (AP, z), left-right (LR, x), and Superior-inferior (SI, y) directions were 0.40 cm, 0.40 cm, and 0.40 cm, respectively. The translation variation of the three directions showed statistical significance (P < 0.05). On comfort and knowledge investigation, among all participants, 80% moderately agreed that the therapist’s instructions for operating the deep inspiration breath hold (DIBH) technique were easy to understand, and 63.33% indicated that their comfort with the DIBH technique was neutral or average. The inter-fraction variations in patients with left-sided breast cancer were qualitatively analyzed. Significant shifts between CBCT and planning CT images were observed. The daily treatment verification could assist accurate dose delivery.

Application of a 2 Parameter Weibull Distribution in Modeling of State Holding Time in HIV/AIDS Transition Dynamics

This study investigates the application of the two-parameter Weibull distribution in modeling state holding times within HIV/AIDS progression dynamics. By comparing the performance of the Weibull-based Accelerated Failure Time (AFT) model, Cox Proportional Hazards model, and Survival model, we assess the effectiveness of these models in capturing survival rates across varying gender, age groups, and treatment categories. Simulated data was used to fit the models, with model identification criteria (AIC, BIC, and R2) applied for evaluation. Results indicate that the AFT model is particularly sensitive to interaction terms, showing significant effects for older age groups (50 - 60 years) and treatment interaction, while the Cox model provides a more stable fit across all age groups. The Survival model displayed variability, with its performance diminishing when interaction terms were introduced, particularly in older age groups. Overall, while the AFT model captures the complexities of interactions in the data, the Cox model’s stability suggests it may be better suited for general analyses without strong interaction effects. The findings highlight the importance of model selection in survival analysis, especially in complex disease progression scenarios like HIV/AIDS.

Down syndrome child with multiple heart diseases: A case report

BACKGROUND Down syndrome,also known as trisomy 21 syndrome,is commonly associated with congenital heart disease,and can often result in early formation of pulmonary hypertension.The development of pulmonary hypertension can result from factors such as intracardiac and macrovascular shunts,and upper airway obstruction or hypoplasia of lung tissue.Individuals with Down syndrome and congenital heart disease have a significantly lower average life expectancy,with surgical intervention being the most viable treatment option to improve longevity.CASE SUMMARY We report the case of a 13-year-old boy with Down syndrome presenting with atrial septal defect and patent ductus arteriosus along with severe pulmonary hypertension.The electrocardiogram shows sinus rhythm and right ventricular hypertrophy.The echocardiogram shows an atrial septal defect with interrupted echo in the interatrial septum,measuring 0.813 cm in length.The patient was initially refused to be offered surgical treatment by many hospitals due to the high surgical risk and pulmonary artery resistance.After discussing the patient’s diagnosis and treatment options,we ultimately recommended surgical treatment.However,the patient and their family declined this recommendation and chose to be discharged.During the follow-up period of 6 mo,there were no significant improvements or deteriorations in the patient’s condition.CONCLUSION In conclusion,this case highlights the challenges faced by individuals with Down syndrome and congenital heart disease complicated by severe pulmonary hypertension.Timely intervention and a multidisciplinary approach are crucial for improving prognosis and life expectancy.Further research is needed to enhance our understanding and develop effective interventions for this popula-tion.Core Tip:This case study presents a 13-year-old boy diagnosed with Down syndrome alongside atrial septal defect,patent ductus arteriosus,and severe pulmonary hypertension.A complex condition initially met with surgical treatment denial due to high risks,highlights the significant challenges faced by individuals with Down syndrome and congenital heart disease.This case highlights the discussion and educational value surrounding the decision to undergo surgery in complex congenital heart diseases.The educational value lies in the diagnostic and therapeutic approaches demonstrated by our team.Due to the relatively common occurrence of this case in the field of cardiology,our decision-making process holds significant value and applicability.

自升式钻井平台HOLDDOWN协调性设计与安装

自升式钻井平台在正常作业时，需要将自身的悬臂梁与连接井架一同伸出主船体之外。当悬臂梁及钻井井架装置的重心伸出主船体后，HOLDDOWN是将悬臂梁固定在平台上的强结构构件。结合南通中远船务工程有限公司交付的自升式钻井平台“凯旋一号”，介绍保证HOLDDOWN与主船体、悬臂梁的协调性的设计、安装要点。

Nail Holding Performance of Self-Tapping Screws on Masson Pine and Chinese Fir Dimension Lumbers

Screw connection is a type most commonly applied to timber structures.As important commercial tree species in China,Masson pine and Chinese fir have the potential to prepare wood structures.In this study,the effects of the diameter of the self-tapping screw and the guiding bores on the nail holding performance on different sections of Masson pine and Chinese fir dimension lumbers were mainly explored.The results showed that:(1)The nail holding strength of the tangential section was the maximum,followed by that of the radial section,and that of the cross section was the minimum.(2)The nail holding strength of Masson pine was higher than that of Chinese fir.(3)The nail holding strength grew with the increase in the diameter of self-tapping screws,but a large diameter would lead to plastic cracking of the timber,thus further affecting the nail holding strength.Masson pine and Chinese fir reached the maximum nail holding strength when the diameter of self-tapping screws was 3.5 mm.(4)Under a large diameter of screws,prefabricated guiding bores could mitigate timber cracking and improve its nail holding strength.(5)Prefabricated guiding bores were more necessary for the screw connection of Masson pine.The results obtained could provide a scientific basis for the screw connection design of Masson pine and Chinese fir timber structures.

CAFIU holds a Webinar on the New Vision of China-Bosnia and Herzegovina Cooperation and Role of Civil Society

On January 17,the Chinese Association for International Understanding(CAFIU)and the Association of Bosnia-China Friendship co-hosted the webinar themed New Vision of China-Bosnia and Herzegovina Cooperation and Role of Civil Society.

China holds the secretariat of ISO/TC 341 on heat supply network

The inauguration of the secretariat of ISO/TC 341,Heat supply net work,was held in Beijing on April 11.China Urban Construction Design&Research Institute,a subordinate enterprise of China Construction Technology Consulting Co.,Ltd.(CCTC),holds the secret ariat,which is China’s first ISO secretariat for standardization in the field of housing and urban-rural development.

Application of Deep Inspiration Breath Hold Technique in Radiotherapy After Breast- Conserving Surgery for Left Breast Cancer and Its Improvement on Cardiac Dose

Objective:To analyze the application of deep inspiration breath hold technique in radiotherapy after breast-conserving surgery for left breast cancer and the improvement of cardiac dose.Methods:A total of 45 patients with left breast cancer treated in our hospital after breast-conserving surgery were selected,and the selection time was set from January 2020 to August 2022.All patients received radiotherapy.The right breast,heart,and lung volumes,and dose parameters of the heart,lungs,right breast,and left anterior descending coronary artery were compared under free breathing(FB)and deep inspiration breath hold(DIBH)technical modes.Results:The heart volume of the DIBH group was smaller than that of the FB group,and the left and right lung volumes were significantly larger than those of the FB group.In the DIBH group,the heart dose parameters V5,proper lung dose parameters,and left anterior descending coronary artery dose parameters were found lower than that of the FB group,and the differences were statistically significant(P<0.05).Conclusion:Compared with FB,the DIBH technique can reduce the heart’s size and increase the lung volume when used for radiotherapy after breast-conserving surgery for left breast cancer.It also reduces the dose to the heart,right lung,and left anterior descending coronary artery,thus protecting the heart and lungs.

核反应堆堆芯吊篮压紧弹簧松弛特性

核反应堆中堆芯吊篮的稳定性是反应堆正常运行的保障和前提.压紧弹簧作为堆芯吊篮的约束与支撑直接影响堆芯吊篮的振动特性.在高温、辐射等恶劣工况下,压紧弹簧力学性能会发生如应力松弛的退化,影响堆芯吊篮振动以及反应堆运行安全,因此需要对堆芯吊篮压紧弹簧松弛特性展开研究.首先,建立堆芯吊篮及压紧弹簧在内的装配体有限元模型,利用湿模态法分析并获得压紧弹簧松弛情况下的堆芯吊篮梁式模态振动频率的变化.然后,开展堆芯吊篮压紧弹簧松弛试验,试验结果验证了模型的有效性.进一步利用仿真模型生成更多压紧弹簧松弛影响下的堆芯吊篮梁式模态频率数据,结合试验数据建立堆芯吊篮压紧弹簧松弛程度识别的数学模型,为反应堆堆芯吊篮压紧弹簧松弛劣化监测奠定了技术基础.

基于排队论模型的蓝牙Hold模式再利用研究

文章调查了蓝牙技术在低速率的网络应用中存在的问题,以排队论模型为基础,对蓝牙低能耗保持模式(Hold)进行了深入的分析和再利用研究。研究表明,蓝牙运行在低速率时,重复性使用Hold模式可减少系统的通信时间,提高系统利用率。仿真和结果验证表明,当Hold时间参数不变和采用较大的基带数据分组类型,例如3-DH5,将减少蓝牙通信时间,提高系统利用率。此外,根据应用速率特点,结合Hold模式再利用的传输方式,合理地设置Hold时间、通信时间和硬件缓存大小等参数,可优化整个系统的成本和运行时的功率消耗。

从“hold住”看网络流行语中的汉英语码混用现象

随着网络的飞速发展,网络流行语也日益丰富,不但成为网上使用的交流常用语,而且也逐渐来到网下,成为人们频繁使用的社会流行语,网络流行语的影响必将越来越大。近年来,网络流行语更是引起了语言学界的诸多关注,成为语言学家的热门研究对象。从最近流行的"hold住"一词出发,着重探讨网络流行语中的汉英语码混用现象,并通过实例分析语码混用的类型特点和现实意义。在积极肯定网络流行语作为语言形式的新发展的同时,也指出其存在的缺陷以及使用中需要注意之处。

Perspectives for delivery of therapeutics by extravasation of biodegradable microspheres in the brain

Development of therapeutics for brain diseases has remained challenging,in particular due to the difficulty of passing the blood-brain barrier.As a result,the current arsenal of therapeutics targeting the brain is limited to small,lipid-soluble drugs and there is a lack of options for treating neuroblastomas,Alzheimer’s disease,and many other devastating pathologies.Despite the advances in strategies for crossing the blood-brain barrier such as the use of nanoparticles(Hersh et al.,2022;Duan et al.,2023),such delivery systems have not yet reached clinical practice.Therefore,novel platforms for the transport of therapeutics across the blood-brain barrier remain highly desired.This specifically holds for large molecules such as monoclonal antibodies and recombinant proteins,as well as nucleotide-based therapeutics and cell therapies.Research efforts in this field are increasing exponentially,with thousands of publications in the last few years.

Advancing sustainability:Magnesium-based solutions for environmental challenges and high-performance technologies in superconductivity

The Journal of Magnesium and Alloys(JMA)is actively dedicated to addressing crucial issues related to energy con-servation,emission reduction,energy crises,and sustainable development[1].Magnesium,recognized as the lightest com-mercial structural metal and a promising energy storage ma-terial,holds immense potential in contributing to strategic objectives such as achieving“carbon neutrality”and the“emission peak”,thus mitigating the ongoing energy cri-sis[2].JMA diligently reports on various research fronts,including magnesium-based structural materials,magnesium batteries,magnesium-based hydrogen storage materials,and magnesium-based superconducting super magnets[3].

Mott Gap Filling by Doping Electrons through Depositing One Sub-Monolayer Thin Film of Rb on Ca_(2)CuO_(2)Cl_(2)

Understanding the doping evolution from a Mott insulator to a superconductor probably holds the key to resolve the mystery of unconventional superconductivity in copper oxides. To elucidate the evolution of the electronic state starting from the Mott insulator, we dose the surface of the parent phase Ca_(2)CuO_(2)Cl_(2) by depositing Rb atoms, which are supposed to donate electrons to the CuO_(2) planes underneath. We successfully achieved the Rb sub-monolayer thin films in forming the square lattice. The scanning tunneling microscopy or spectroscopy measurements on the surface show that the Fermi energy is pinned within the Mott gap but close to the edge of the charge transfer band. In addition, an in-gap state appears at the bottom of the upper Hubbard band(UHB), and the Mott gap will be significantly diminished. Combined with the Cl defect and the Rb adatom/cluster results, the electron doping is likely to increase the spectra weight of the UHB for the double occupancy. Our results provide information to understand the electron doping to the parent compound of cuprates.

Omics for deciphering oral microecology

The human oral microbiome harbors one of the most diverse microbial communities in the human body,playing critical roles in oral and systemic health.Recent technological innovations are propelling the characterization and manipulation of oral microbiota.High-throughput sequencing enables comprehensive taxonomic and functional profiling of oral microbiomes.New long-read platforms improve genome assembly from complex samples.Single-cell genomics provides insights into uncultured taxa.Advanced imaging modalities including fluorescence,mass spectrometry,and Raman spectroscopy have enabled the visualization of the spatial organization and interactions of oral microbes with increasing resolution.Fluorescence techniques link phylogenetic identity with localization.Mass spectrometry imaging reveals metabolic niches and activities while Raman spectroscopy generates rapid biomolecular fingerprints for classification.Culturomics facilitates the isolation and cultivation of novel fastidious oral taxa using high-throughput approaches.Ongoing integration of these technologies holds the promise of transforming our understanding of oral microbiome assembly,gene expression,metabolites,microenvironments,virulence mechanisms,and microbe-host interfaces in the context of health and disease.However,significant knowledge gaps persist regarding community origins,developmental trajectories,homeostasis versus dysbiosis triggers,functional biomarkers,and strategies to deliberately reshape the oral microbiome for therapeutic benefit.The convergence of sequencing,imaging,cultureomics,synthetic systems,and biomimetic models will provide unprecedented insights into the oral microbiome and offer opportunities to predict,prevent,diagnose,and treat associated oral diseases.

Nonadiabatic Holonomic Quantum Computation Based on Rydberg Ground State Blockade

Quantum gates are crucial for quantum computation and quantum information processing. However, their effectiveness is often hindered by systematic errors and decoherence. Therefore, achieving resilient quantum gates to these factors is of great significance. We present a method to construct nonadiabatic holonomic single-and two-qubit gates in a Rydberg ground-state-blockade regime. Our approach utilizes a far-off-resonant technique for the single-qubit gate and a modified Rydberg antiblockade for the two-qubit gate. The reduction of the population of single-and two-excitation Rydberg states and the nonadiabatic holonomic process during the construction of the gates ensure robustness to decoherence and systematic errors, respectively. Numerical results demonstrate the fidelity and robustness of our scheme. The proposed scheme holds promise for future applications in quantum computation and quantum information processing tasks.

Pressure-Tuned Intrinsic Anomalous Hall Conductivity in Kagome Magnets RV_(6)Sn_(6)(R=Gd,Tb)

Exploration of exotic phenomena in magnetic topological systems is at the frontier of condensed matter physics,holding a significant promise for applications in topological spintronics.However,complex magnetic structures carrying nontrivial topological properties hinder its progresses.Here,we investigate the pressure effect on the novel topological kagome magnets GdV_(6)Sn_(6) and TbV_(6)Sn_(6) to dig out the interplay between magnetic Gd/Tb layers and nonmagnetic V-based kagome sublattice.The pressure-tuned magnetic transition temperature Tm in both the compounds exhibit a turning point at the critical pressure P_(c),accompanied with a sign reversal in anomalous Hall effect(AHE).The separation of intrinsic and extrinsic contributions using the Tian-Ye-Jin scaling model suggests that the intrinsic mechanism originating from the electronic Berry curvature holds the priority in the competition with extrinsic mechanism in AHE.The above-mentioned findings can be attributed to the combined effect of pressure-tuned band topology and magnetic interaction in segregated layers.Our results provide a practical route to design and manipulate the intrinsic AHE in magnetic topological materials.

Current-Induced Magnetization Switching Behavior in Perpendicular Magnetized L1_(0)-MnAl/B2-CoGa Bilayer

Rare-earth-free Mn-based binary alloy L1_(0)-MnAl with bulk perpendicular magnetic anisotropy(PMA) holds promise for high-performance magnetic random access memory(MRAM) devices driven by spin-orbit torque(SOT). However, the lattice-mismatch issue makes it challenging to place conventional spin current sources, such as heavy metals, between L1_(0)-MnAl layers and substrates. In this work, we propose a solution by using the B2-CoGa alloy as the spin current source. The lattice-matching enables high-quality epitaxial growth of 2-nm-thick L1_(0)-MnAl on B2-CoGa, and the L1_(0)-MnAl exhibits a large PMA constant of 1.04 × 10^(6)J/m^(3). Subsequently, the considerable spin Hall effect in B2-CoGa enables the achievement of SOT-induced deterministic magnetization switching. Moreover, we quantitatively determine the SOT efficiency in the bilayer. Furthermore, we design an L1_(0)-MnAl/B2-CoGa/Co_(2)MnGa structure to achieve field-free magnetic switching. Our results provide valuable insights for achieving high-performance SOT-MRAM devices based on L1_(0)-MnAl alloy.