Increasing evidence in recent years sug-gests homocysteine （Hcy） is involved in the pathogene-sis of Alzheimer’s disease （AD）, and that modifying this risk factor may be an alternative approach to delaying or pre...Increasing evidence in recent years sug-gests homocysteine （Hcy） is involved in the pathogene-sis of Alzheimer’s disease （AD）, and that modifying this risk factor may be an alternative approach to delaying or preventing onset of this disease. However, intervention studies uggest inconsistent effects of folic acid supple-mentation, with or without vitamin B12, on the prevention of incident AD. Studies with Hcy-lowering therapy show benefcial effects of B vitamins inpatients with mild cog-nitive impairment （MCI）, especially in those with high Hcy levels. Further studies are needed to confrm elevated Hcy levels as a potentially treatable risk factor for AD.展开更多
文摘Increasing evidence in recent years sug-gests homocysteine （Hcy） is involved in the pathogene-sis of Alzheimer’s disease （AD）, and that modifying this risk factor may be an alternative approach to delaying or preventing onset of this disease. However, intervention studies uggest inconsistent effects of folic acid supple-mentation, with or without vitamin B12, on the prevention of incident AD. Studies with Hcy-lowering therapy show benefcial effects of B vitamins inpatients with mild cog-nitive impairment （MCI）, especially in those with high Hcy levels. Further studies are needed to confrm elevated Hcy levels as a potentially treatable risk factor for AD.
