Unraveling the precise mineralization age is vital to understand the geodynamic setting and ore-forming mechanism of the sediment-hosted Pb-Zn deposit;this has long been a challenge.The Sichuan-Yunnan-Guizhou(SYG)tria...Unraveling the precise mineralization age is vital to understand the geodynamic setting and ore-forming mechanism of the sediment-hosted Pb-Zn deposit;this has long been a challenge.The Sichuan-Yunnan-Guizhou(SYG)triangle in the southwestern margin of the Yangtze Block is a globally recognized carbonate-hosted Pb-Zn metallogenic province and also an essential part of the South China low-temperature metallogenic domain.This region has>30 million tons(Mt)Zn and Pb resources and shows the enrichment of dispersed metals,such as Ga,Ge,Cd,Se,and Tl.During the past 2 decades,abundant data on mineralization ages of Pb-Zn deposits within the SYG triangle have been documented based on various radioisotopic dating methods,resulting in significant progress in understanding the geodynamic background and ore formation of Pb-Zn deposits hosted in sedimentary rocks at SYG triangle.This paper provides a comprehensive summary of the geochronological results and Pb-Sr isotopic data regarding Pb-Zn deposits in the SYG triangle,which identified two distinct Pb-Zn mineralization periods influencing the dynamic processes associated with the expansion and closure of the Paleo-Tethys Ocean in the western margin of the Yangtze Block.The predominant phase of Pb-Zn mineralization at SYG triangle spanned from the Middle Triassic to Early Jurassic(226-191 Ma),which was intensely correlated with the large-scale basin fluid transport triggered by the closure of the Paleo-Tethys Ocean and Indosinian orogeny.The secondary Pb-Zn mineralization phase occurred during the Late Devonian to Late Carboniferous and was controlled by extensional structures associated with the expansion of the Paleo-Tethys Ocean.Further investigation is necessary to clarify the occurrence and potential factors involved in the Pb-Zn mineralization events during the Late Devonian to Late Carboniferous.展开更多
AIM:To explore the effect of co-host non-coding RNA(ncRNA)MIR503HG/miR-503-5p on the angiogenesis of pterygium.METHODS:MIR503HG/miR-503-5p/fibroblast growth factor 2(FGF2)expression levels in pterygium tissues,control...AIM:To explore the effect of co-host non-coding RNA(ncRNA)MIR503HG/miR-503-5p on the angiogenesis of pterygium.METHODS:MIR503HG/miR-503-5p/fibroblast growth factor 2(FGF2)expression levels in pterygium tissues,control conjunctival tissues,and human pterygium fibroblasts(HPF)were examined by reverse transcription-polymerase chain reaction(qRT-PCR)and immunohistochemical methods.Effects of MIR503HG/miR-503-5p on low molecular weight FGF2(LWM FGF2),migration and angiogenesis of human retinal microvascular endothelial cells(HRMEC)were determined in an HPF and HRMEC co-culture model using Western blots,wound healing assay,Matrigel-based tube formation assay,and Transwell assay.RESULTS:MIR503HG/miR-503-5p/FGF2 pathway was actively increased in pterygium tissue and there was a negative correlation between the expression of the two ncRNAs.FGF2 expression level was positively correlated with MIR503HG and negatively correlated with miR-503-5p.Overexpressed MIR503HG/miR-503-5p did not affect the migration and angiogenesis of HRMECs cultured separately,but significantly affected migration and angiogenesis of HRMEC in HPF and HRMEC co-culture models.Western blotting revealed that MIR503HG/miR-503-5p overexpression significantly increased LMW FGF2 expression in HPF.CONCLUSION:MIR503HG/miR-503-5p inhibits HRMEC migration and angiogenic function by interfering with the interaction between HPF and endothelial cells via reducing LMW FGF2 in HPF.展开更多
建立了一种在温和条件下,用可见光催化合成一系列3,4-二氢异喹啉-1(2H)-酮及其衍生物的方法。该方法在室温条件下,以2-烯丙基-N-甲氧基苯甲酰胺为模板底物,以碘化钾作为光催化剂,25 W 460 nm的蓝色LED灯照射下,合成一系列3,4-二氢异喹啉...建立了一种在温和条件下,用可见光催化合成一系列3,4-二氢异喹啉-1(2H)-酮及其衍生物的方法。该方法在室温条件下,以2-烯丙基-N-甲氧基苯甲酰胺为模板底物,以碘化钾作为光催化剂,25 W 460 nm的蓝色LED灯照射下,合成一系列3,4-二氢异喹啉-1(2H)-酮衍生物,最高产率可达到83%。该合成路径具有底物适用范围广、经济实用等特点,为3,4-二氢异喹啉-1(2H)-酮衍生物合成提供了一种经济简便的方法。展开更多
基金supported by the National Natural Science Foundation of China(92162218,42302101,42202099)the Guizhou Provincial Natural Science Foundation(ZK[2023]477)。
文摘Unraveling the precise mineralization age is vital to understand the geodynamic setting and ore-forming mechanism of the sediment-hosted Pb-Zn deposit;this has long been a challenge.The Sichuan-Yunnan-Guizhou(SYG)triangle in the southwestern margin of the Yangtze Block is a globally recognized carbonate-hosted Pb-Zn metallogenic province and also an essential part of the South China low-temperature metallogenic domain.This region has>30 million tons(Mt)Zn and Pb resources and shows the enrichment of dispersed metals,such as Ga,Ge,Cd,Se,and Tl.During the past 2 decades,abundant data on mineralization ages of Pb-Zn deposits within the SYG triangle have been documented based on various radioisotopic dating methods,resulting in significant progress in understanding the geodynamic background and ore formation of Pb-Zn deposits hosted in sedimentary rocks at SYG triangle.This paper provides a comprehensive summary of the geochronological results and Pb-Sr isotopic data regarding Pb-Zn deposits in the SYG triangle,which identified two distinct Pb-Zn mineralization periods influencing the dynamic processes associated with the expansion and closure of the Paleo-Tethys Ocean in the western margin of the Yangtze Block.The predominant phase of Pb-Zn mineralization at SYG triangle spanned from the Middle Triassic to Early Jurassic(226-191 Ma),which was intensely correlated with the large-scale basin fluid transport triggered by the closure of the Paleo-Tethys Ocean and Indosinian orogeny.The secondary Pb-Zn mineralization phase occurred during the Late Devonian to Late Carboniferous and was controlled by extensional structures associated with the expansion of the Paleo-Tethys Ocean.Further investigation is necessary to clarify the occurrence and potential factors involved in the Pb-Zn mineralization events during the Late Devonian to Late Carboniferous.
基金Supported by the National Natural Science Foundation of China(No.81770898).
文摘AIM:To explore the effect of co-host non-coding RNA(ncRNA)MIR503HG/miR-503-5p on the angiogenesis of pterygium.METHODS:MIR503HG/miR-503-5p/fibroblast growth factor 2(FGF2)expression levels in pterygium tissues,control conjunctival tissues,and human pterygium fibroblasts(HPF)were examined by reverse transcription-polymerase chain reaction(qRT-PCR)and immunohistochemical methods.Effects of MIR503HG/miR-503-5p on low molecular weight FGF2(LWM FGF2),migration and angiogenesis of human retinal microvascular endothelial cells(HRMEC)were determined in an HPF and HRMEC co-culture model using Western blots,wound healing assay,Matrigel-based tube formation assay,and Transwell assay.RESULTS:MIR503HG/miR-503-5p/FGF2 pathway was actively increased in pterygium tissue and there was a negative correlation between the expression of the two ncRNAs.FGF2 expression level was positively correlated with MIR503HG and negatively correlated with miR-503-5p.Overexpressed MIR503HG/miR-503-5p did not affect the migration and angiogenesis of HRMECs cultured separately,but significantly affected migration and angiogenesis of HRMEC in HPF and HRMEC co-culture models.Western blotting revealed that MIR503HG/miR-503-5p overexpression significantly increased LMW FGF2 expression in HPF.CONCLUSION:MIR503HG/miR-503-5p inhibits HRMEC migration and angiogenic function by interfering with the interaction between HPF and endothelial cells via reducing LMW FGF2 in HPF.
文摘建立了一种在温和条件下,用可见光催化合成一系列3,4-二氢异喹啉-1(2H)-酮及其衍生物的方法。该方法在室温条件下,以2-烯丙基-N-甲氧基苯甲酰胺为模板底物,以碘化钾作为光催化剂,25 W 460 nm的蓝色LED灯照射下,合成一系列3,4-二氢异喹啉-1(2H)-酮衍生物,最高产率可达到83%。该合成路径具有底物适用范围广、经济实用等特点,为3,4-二氢异喹啉-1(2H)-酮衍生物合成提供了一种经济简便的方法。
