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基于Hotelling T2-BiLSTM的同步调相机故障诊断方法
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作者 李俊卿 张承志 +3 位作者 韩小平 黄涛 何玉灵 孔凡春 《智慧电力》 北大核心 2024年第7期96-102,127,共8页
同步调相机故障会严重影响特高压直流输电工程的稳定性。针对特高压电网中不对称电压条件下同步调相机励磁绕组匝间短路故障难以识别问题,提出基于霍特林T2-双向长短期记忆网络(Hotelling T2-BiLSTM)的同步调相机故障诊断方法。首先,从... 同步调相机故障会严重影响特高压直流输电工程的稳定性。针对特高压电网中不对称电压条件下同步调相机励磁绕组匝间短路故障难以识别问题,提出基于霍特林T2-双向长短期记忆网络(Hotelling T2-BiLSTM)的同步调相机故障诊断方法。首先,从三相电压、三相电流、励磁电流、转子振动和无功功率中提取故障特征,计算Hotelling T2统计量以构建故障检测指标;然后,采用BiLSTM模型对特征进行分类,并利用逻辑回归层进行故障诊断;最后,在动模实验室中进行实验验证其有效性。实验结果表明,所提方法具有较高的故障诊断精度。 展开更多
关键词 同步调相机 不对称电压 励磁绕组匝间短路 hotelling T2 BiLSTM 故障诊断
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基于Hotelling模型的铁路保价运输与铁路货运保险协同发展策略分析
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作者 冯芬玲 梁瑷兰 +1 位作者 黄启营 战映辰 《铁道科学与工程学报》 EI CAS CSCD 北大核心 2023年第1期356-363,共8页
加强运输风险防控、提高服务质量是我国铁路货运高质量发展的必然要求。2015年中国铁路财产保险自保有限公司正式成立并逐步推出了铁路货运保险产品,新产品与铁路保价运输存在竞合关系,如何确定铁路保价运输、铁路货运保险以及商业货运... 加强运输风险防控、提高服务质量是我国铁路货运高质量发展的必然要求。2015年中国铁路财产保险自保有限公司正式成立并逐步推出了铁路货运保险产品,新产品与铁路保价运输存在竞合关系,如何确定铁路保价运输、铁路货运保险以及商业货运保险的关系成为保障铁路货物运输安全、提高铁路运输服务质量的关键问题之一。基于Hotelling模型,构建铁路保价运输与国内货运保险竞争、铁路保价运输与铁路货运保险协同后再与商业货运保险竞争2种情况下的竞合模型并对比收益情况。研究表明,铁路保价运输与铁路货运保险协同发展并推出一体化协同产品能增加铁路运输企业收益,协同后铁路保价运输的收益与一体化协同产品利润分配比、铁路保价运输成本、铁路货运保险成本、铁路保价和铁路货运保险的产品替代率有关。同时,提出加快铁路保价保险协同发展进程、推出一体化协同产品、探索铁路保价运输与铁路货运保险协同发展平衡点、提高铁路货运保险在国内货运保险市场中的份额4条协同发展策略。 展开更多
关键词 铁路保价运输 铁路货运保险 竞争协同 hotelling模型
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基于Hotelling模型的电机以旧换新模式及定价策略研究
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作者 马汉武 李苏皖 《物流工程与管理》 2023年第7期61-67,共7页
为了提高电机迭代,吸引消费者主动参与逆向物流,文中基于Hotelling模型,构建由零售商和第三方平台组成的双渠道供应链,同时引入消费者价格敏感度,研究不同供应链主导者模式下最优以旧换新价格及消费者的渠道偏好。研究表明:单位距离成... 为了提高电机迭代,吸引消费者主动参与逆向物流,文中基于Hotelling模型,构建由零售商和第三方平台组成的双渠道供应链,同时引入消费者价格敏感度,研究不同供应链主导者模式下最优以旧换新价格及消费者的渠道偏好。研究表明:单位距离成本增加,零售商和第三方平台与消费者博弈选择提高以旧换新价格,单位距离成本对消费者零售商渠道选择具有负影响,因此零售商还需考虑选址问题;只有当消费者价格敏感度之差较小,单位距离成本较大时,消费者偏好才会处于双方均衡的状态,反之,消费者会明显偏好于零售商渠道;零售商作为供应链主导者时,供应链总体利润最高,此时消费者对零售商和第三方平台偏好相当,市场处于稳定状态。文中的研究结论对电机迭代供应链具有一定的指导意义。 展开更多
关键词 hotelling模型 以旧换新 闭环供应链 供应链结构
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基于Hotelling模型品牌效应视域下传统在位企业和跨界数字企业的竞争策略研究
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作者 叶春森 陈芳 《西安航空学院学报》 2023年第6期28-38,共11页
针对数字经济对传统经济的冲击,构建了一个传统在位企业和一个跨界数字企业之间的竞争模型,并讨论在位企业和数字企业的博弈均衡策略。研究发现,品牌延伸是数字企业跨界入市的占优策略。面对跨界入市的数字企业,传统在位企业议价能力较... 针对数字经济对传统经济的冲击,构建了一个传统在位企业和一个跨界数字企业之间的竞争模型,并讨论在位企业和数字企业的博弈均衡策略。研究发现,品牌延伸是数字企业跨界入市的占优策略。面对跨界入市的数字企业,传统在位企业议价能力较低时,应根据新产品价值、与原产品和数字企业产品的相似度选择以品牌延伸或新品牌方式推出新产品参与竞争;否则应根据数字企业产品价值的高、低水平依次选择并存式、冷藏式的收购策略更优。 展开更多
关键词 数字经济 传统在位企业 跨界数字企业 新产品开发 收购 hotelling模型
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采用STAMP-24Model的多组织事故分析
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作者 曾明荣 秦永莹 +2 位作者 刘小航 栗婧 尚长岭 《安全与环境学报》 CAS CSCD 北大核心 2024年第7期2741-2750,共10页
安全生产事故往往由多组织交互、多因素耦合造成,事故原因涉及多个组织。为预防和遏制多组织生产安全事故的发生,基于系统理论事故建模与过程模型(Systems-Theory Accident Modeling and Process,STAMP)、24Model,构建一种用于多组织事... 安全生产事故往往由多组织交互、多因素耦合造成,事故原因涉及多个组织。为预防和遏制多组织生产安全事故的发生,基于系统理论事故建模与过程模型(Systems-Theory Accident Modeling and Process,STAMP)、24Model,构建一种用于多组织事故分析的方法,并以青岛石油爆炸事故为例进行事故原因分析。结果显示:STAMP-24Model可以分组织,分层次且有效、全面、详细地分析涉及多个组织的事故原因,探究多组织之间的交互关系;对事故进行动态演化分析,可得到各组织不安全动作耦合关系与形成的事故失效链及管控失效路径,进而为预防多组织事故提供思路和参考。 展开更多
关键词 安全工程 系统理论事故建模与过程模型(STAMP) 24model 多组织事故 原因分析
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基于改进24Model-ISM-SNA建筑工人不安全行为关联路径研究
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作者 赵平 刘钰 +1 位作者 靳丽艳 王佳慧 《工业安全与环保》 2024年第7期37-40,共4页
建筑施工现场环境复杂,为有效控制不安全行为发生,基于行为安全“2-4”模型对360份具有代表性的建筑安全事故调查报告进行分析,提取出22个不安全行为的主要影响因素。利用灰色关联分析方法(GRA)改进的集成ISM-SNA模型,将不安全行为风险... 建筑施工现场环境复杂,为有效控制不安全行为发生,基于行为安全“2-4”模型对360份具有代表性的建筑安全事故调查报告进行分析,提取出22个不安全行为的主要影响因素。利用灰色关联分析方法(GRA)改进的集成ISM-SNA模型,将不安全行为风险因素划分为表层、过渡层与深层,然后对风险因素进行可视化分析、中心度分析及凝聚子群分析,揭示了各致因因素间的关联关系和传导路径。结果表明,建筑工人不安全行为影响因素可划分成7级3阶的多级递阶结构,安全意识、现场监管、外部环境是建筑工人不安全行为的关键影响因素,同时现场监管和隐患排查到位能有效降低不安全行为的发生。 展开更多
关键词 建筑工人 不安全行为 24model 解释结构模型(ISM) 社会网络分析(SNA)
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基于24Model-D-ISM的地铁站火灾疏散影响因素研究
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作者 孙世梅 张家严 《中国安全科学学报》 CAS CSCD 北大核心 2024年第4期153-159,共7页
为预防地铁站火灾事故,深入了解地铁站火灾人员疏散影响因素间的内在联系与层次结构,基于第6版“2-4”模型(24Model)分析63起地铁站火灾疏散事故,充分考虑各个因素之间的交互作用,提取19个影响地铁站人员疏散的关键因素,建立地铁站火灾... 为预防地铁站火灾事故,深入了解地铁站火灾人员疏散影响因素间的内在联系与层次结构,基于第6版“2-4”模型(24Model)分析63起地铁站火灾疏散事故,充分考虑各个因素之间的交互作用,提取19个影响地铁站人员疏散的关键因素,建立地铁站火灾人员疏散影响因素指标体系;采用算子客观赋权法(C-OWA)改进决策试验与评价实验法(DEMATEL),确定地铁站火灾人员疏散的重要影响因素;在此基础上,采用解释结构模型(ISM)分析各个因素间的层次结构及相互作用路径,构建地铁站火灾人员疏散影响因素的多级递阶结构模型。研究结果表明:疏散引导、恐慌从众行为、人员拥挤为地铁站火灾人员疏散的关键影响因素;地铁站火灾人员疏散受表层因素、中间层因素、深层因素共同作用的影响,其中,疏散教育与培训、设施维护与检查、疏散预案等因素是根源影响因素,重视根源影响因素的改善有利于从本质上预防和控制事故的发生。 展开更多
关键词 “2-4”模型(24model) 决策试验与评价实验法(DEMATEL) 解释结构模型(ISM) 地铁站 火灾疏散 影响因素
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基于改进Hotelling模型的新运输通道定价和补贴策略:以西部陆海新通道为例 被引量:4
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作者 吕靖 乔冠瑛 蒋永雷 《上海海事大学学报》 北大核心 2023年第1期38-45,共8页
在既定的区域货运市场内,为快速扩大新运输通道的受众范围,与既有运输通道形成合理的区域货运格局,考虑不同货物时间价值差异及政府补贴的重要作用,构建改进Hotelling模型分析新运输通道与既有运输通道之间的博弈关系,讨论新运输通道运... 在既定的区域货运市场内,为快速扩大新运输通道的受众范围,与既有运输通道形成合理的区域货运格局,考虑不同货物时间价值差异及政府补贴的重要作用,构建改进Hotelling模型分析新运输通道与既有运输通道之间的博弈关系,讨论新运输通道运营商的最优定价策略和地方政府的最佳补贴策略。以西部陆海新通道中重庆至新加坡及重庆至汉堡的运输通道为例进行实证分析,结果表明:在重庆至新加坡的货运市场中,政府以市场份额为目标时应对电子元件等高时间价值货物提供补贴,政府以社会福利最大为目标时应对橡胶塑料制品等低时间价值货物提供补贴;在重庆至汉堡的货运市场中,政府对笔记本电脑等高时间价值货物提供补贴会带来最佳收益。 展开更多
关键词 西部陆海新通道 政府补贴 hotelling模型 货物时间价值 海铁联运
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耦合优化蚁群算法与P-Median model的选址模型设计
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作者 顾梓程 胡新玲 《现代电子技术》 北大核心 2024年第3期109-114,共6页
为节省城建部门对于公共体育设施的投入成本以及提高城市人民生活质量,以运动场所优化选址为例,提出一种新型设施选址模型。该模型主要基于P-Median model(最小化阻抗模型)根据需求点数量从全部候选设施选址中选择设施空间位置,让用户... 为节省城建部门对于公共体育设施的投入成本以及提高城市人民生活质量,以运动场所优化选址为例,提出一种新型设施选址模型。该模型主要基于P-Median model(最小化阻抗模型)根据需求点数量从全部候选设施选址中选择设施空间位置,让用户达到离自己最近设施距离成本总和最小的目的,对选址的基本原则和实际情况提出要求,构造目标函数用于优化后蚁群算法求解进行选址工作。优化蚁群算法实现基于Python语言模块,通过改进蚁群原始信息素,提升原有算法的收敛速度,求出目标函数最优解,可以很好地模拟对于运动场所的选址。用二者耦合进行优势互补所设计的选址模型来搜寻研究区蚁群信息素浓度残留最大的栅格像元,从而确定未被已有设施点服务半径覆盖的最佳设施点建立位置。实验结果表明,该新型选址模型相较于最小化阻抗模型与最大化覆盖模型,新增优化设施点使整体服务半径覆盖率分别高出10.42%和6.95%,适合求解较为精确且小规模空间下的选址问题。 展开更多
关键词 蚁群算法 P-Median model 选址模型 GIS 运动场所 位置分配 PYTHON
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Anisotropic time-dependent behaviors of shale under direct shearing and associated empirical creep models 被引量:1
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作者 Yachen Xie Michael Z.Hou +1 位作者 Hejuan Liu Cunbao Li 《Journal of Rock Mechanics and Geotechnical Engineering》 SCIE CSCD 2024年第4期1262-1279,共18页
Understanding the anisotropic creep behaviors of shale under direct shearing is a challenging issue.In this context,we conducted shear-creep and steady-creep tests on shale with five bedding orientations (i.e.0°,... Understanding the anisotropic creep behaviors of shale under direct shearing is a challenging issue.In this context,we conducted shear-creep and steady-creep tests on shale with five bedding orientations (i.e.0°,30°,45°,60°,and 90°),under multiple levels of direct shearing for the first time.The results show that the anisotropic creep of shale exhibits a significant stress-dependent behavior.Under a low shear stress,the creep compliance of shale increases linearly with the logarithm of time at all bedding orientations,and the increase depends on the bedding orientation and creep time.Under high shear stress conditions,the creep compliance of shale is minimal when the bedding orientation is 0°,and the steady-creep rate of shale increases significantly with increasing bedding orientations of 30°,45°,60°,and 90°.The stress-strain values corresponding to the inception of the accelerated creep stage show an increasing and then decreasing trend with the bedding orientation.A semilogarithmic model that could reflect the stress dependence of the steady-creep rate while considering the hardening and damage process is proposed.The model minimizes the deviation of the calculated steady-state creep rate from the observed value and reveals the behavior of the bedding orientation's influence on the steady-creep rate.The applicability of the five classical empirical creep models is quantitatively evaluated.It shows that the logarithmic model can well explain the experimental creep strain and creep rate,and it can accurately predict long-term shear creep deformation.Based on an improved logarithmic model,the variations in creep parameters with shear stress and bedding orientations are discussed.With abovementioned findings,a mathematical method for constructing an anisotropic shear creep model of shale is proposed,which can characterize the nonlinear dependence of the anisotropic shear creep behavior of shale on the bedding orientation. 展开更多
关键词 Rock anisotropy Direct shear creep Creep compliance Steady-creep rate Empirical model Creep constitutive model
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Mshpy23:a user-friendly,parameterized model of magnetosheath conditions 被引量:1
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作者 Jaewoong Jung Hyunju Connor +3 位作者 Andrew Dimmock Steve Sembay Andrew Read Jan Soucek 《Earth and Planetary Physics》 EI CSCD 2024年第1期89-104,共16页
Lunar Environment heliospheric X-ray Imager(LEXI)and Solar wind−Magnetosphere−Ionosphere Link Explorer(SMILE)will observe magnetosheath and its boundary motion in soft X-rays for understanding magnetopause reconnectio... Lunar Environment heliospheric X-ray Imager(LEXI)and Solar wind−Magnetosphere−Ionosphere Link Explorer(SMILE)will observe magnetosheath and its boundary motion in soft X-rays for understanding magnetopause reconnection modes under various solar wind conditions after their respective launches in 2024 and 2025.Magnetosheath conditions,namely,plasma density,velocity,and temperature,are key parameters for predicting and analyzing soft X-ray images from the LEXI and SMILE missions.We developed a userfriendly model of magnetosheath that parameterizes number density,velocity,temperature,and magnetic field by utilizing the global Magnetohydrodynamics(MHD)model as well as the pre-existing gas-dynamic and analytic models.Using this parameterized magnetosheath model,scientists can easily reconstruct expected soft X-ray images and utilize them for analysis of observed images of LEXI and SMILE without simulating the complicated global magnetosphere models.First,we created an MHD-based magnetosheath model by running a total of 14 OpenGGCM global MHD simulations under 7 solar wind densities(1,5,10,15,20,25,and 30 cm)and 2 interplanetary magnetic field Bz components(±4 nT),and then parameterizing the results in new magnetosheath conditions.We compared the magnetosheath model result with THEMIS statistical data and it showed good agreement with a weighted Pearson correlation coefficient greater than 0.77,especially for plasma density and plasma velocity.Second,we compiled a suite of magnetosheath models incorporating previous magnetosheath models(gas-dynamic,analytic),and did two case studies to test the performance.The MHD-based model was comparable to or better than the previous models while providing self-consistency among the magnetosheath parameters.Third,we constructed a tool to calculate a soft X-ray image from any given vantage point,which can support the planning and data analysis of the aforementioned LEXI and SMILE missions.A release of the code has been uploaded to a Github repository. 展开更多
关键词 MAGNETOSHEATH PYTHON modelING
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Development and validation of a prediction model for early screening of people at high risk for colorectal cancer 被引量:1
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作者 Ling-Li Xu Yi Lin +3 位作者 Li-Yuan Han Yue Wang Jian-Jiong Li Xiao-Yu Dai 《World Journal of Gastroenterology》 SCIE CAS 2024年第5期450-461,共12页
BACKGROUND Colorectal cancer(CRC)is a serious threat worldwide.Although early screening is suggested to be the most effective method to prevent and control CRC,the current situation of early screening for CRC is still... BACKGROUND Colorectal cancer(CRC)is a serious threat worldwide.Although early screening is suggested to be the most effective method to prevent and control CRC,the current situation of early screening for CRC is still not optimistic.In China,the incidence of CRC in the Yangtze River Delta region is increasing dramatically,but few studies have been conducted.Therefore,it is necessary to develop a simple and efficient early screening model for CRC.AIM To develop and validate an early-screening nomogram model to identify individuals at high risk of CRC.METHODS Data of 64448 participants obtained from Ningbo Hospital,China between 2014 and 2017 were retrospectively analyzed.The cohort comprised 64448 individuals,of which,530 were excluded due to missing or incorrect data.Of 63918,7607(11.9%)individuals were considered to be high risk for CRC,and 56311(88.1%)were not.The participants were randomly allocated to a training set(44743)or validation set(19175).The discriminatory ability,predictive accuracy,and clinical utility of the model were evaluated by constructing and analyzing receiver operating characteristic(ROC)curves and calibration curves and by decision curve analysis.Finally,the model was validated internally using a bootstrap resampling technique.RESULTS Seven variables,including demographic,lifestyle,and family history information,were examined.Multifactorial logistic regression analysis revealed that age[odds ratio(OR):1.03,95%confidence interval(CI):1.02-1.03,P<0.001],body mass index(BMI)(OR:1.07,95%CI:1.06-1.08,P<0.001),waist circumference(WC)(OR:1.03,95%CI:1.02-1.03 P<0.001),lifestyle(OR:0.45,95%CI:0.42-0.48,P<0.001),and family history(OR:4.28,95%CI:4.04-4.54,P<0.001)were the most significant predictors of high-risk CRC.Healthy lifestyle was a protective factor,whereas family history was the most significant risk factor.The area under the curve was 0.734(95%CI:0.723-0.745)for the final validation set ROC curve and 0.735(95%CI:0.728-0.742)for the training set ROC curve.The calibration curve demonstrated a high correlation between the CRC high-risk population predicted by the nomogram model and the actual CRC high-risk population.CONCLUSION The early-screening nomogram model for CRC prediction in high-risk populations developed in this study based on age,BMI,WC,lifestyle,and family history exhibited high accuracy. 展开更多
关键词 Colorectal cancer Early screening model High-risk population Nomogram model Questionnaire survey Dietary habit Living habit
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24Model与LCM原因因素定义对比研究
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作者 袁晨辉 傅贵 +1 位作者 吴治蓉 赵金坤 《中国安全科学学报》 CAS CSCD 北大核心 2024年第1期27-34,共8页
为探究损失致因模型(LCM)原因因素定义与事故致因“2-4”模型(24Model)存在的异同和优缺点,梳理2个模型各层面原因和结果的定义,对比定义内容及其对事故原因分析等安全实务的指导作用,并以一起瓦斯爆炸事故为例加以实证分析,获得二者分... 为探究损失致因模型(LCM)原因因素定义与事故致因“2-4”模型(24Model)存在的异同和优缺点,梳理2个模型各层面原因和结果的定义,对比定义内容及其对事故原因分析等安全实务的指导作用,并以一起瓦斯爆炸事故为例加以实证分析,获得二者分析结果之间的差异。研究结果表明:LCM是首个将管理因素纳入事故致因分析的一维事件序列模型,可明确各层面原因因素的定义和因素间的逻辑关系,但部分定义存在交叉重复的问题,并没有揭示安全工作指导思想等深层次事故致因因素;24Model作为系统性事故致因模型,对各类因素的定义均以组织为主体,描述事件、事故、安全的概念内涵,划分个体安全动作、安全能力和组织安全管理体系的类别并给出含义解析,探究组织安全文化层面的问题并以32个元素体现;2个模型的事故原因分析方法均建立在对各层级原因因素定义的基础上,并适用于模型理论体系本身。 展开更多
关键词 “2-4”模型(24model) 损失致因模型(LCM) 事故致因模型 原因因素定义 对比研究
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The Effects of Job Insecurity, Emotional Exhaustion, and Met Expectations on Hotel Employees’ Pro-Environmental Behaviors: Test of a Serial Mediation Model
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作者 Osman M.Karatepe Raheleh Hassannia +2 位作者 Tuna Karatepe Constanţa Enea Hamed Rezapouraghdam 《International Journal of Mental Health Promotion》 2023年第2期287-307,共21页
There are a plethora of empirical pieces about employees’pro-environmental behaviors.However,the extant literature has either ignored or not fully examined various factors(e.g.,negative or positive non-green workplac... There are a plethora of empirical pieces about employees’pro-environmental behaviors.However,the extant literature has either ignored or not fully examined various factors(e.g.,negative or positive non-green workplace factors)that might affect employees’pro-environmental behaviors.Realizing these voids,the present paper proposes and tests a serial mediation model that examines the interrelationships of job insecurity,emotional exhaustion,met expectations,and proactive pro-environmental behavior.We used data gathered from hotel customer-contact employees with a time lag of one week and their direct supervisors in China.After presenting support for the psychometric properties of the measures via confirmatory analysis in LISREL 8.30,the abovementioned linkages were gauged using the PROCESS plug-in for statistical package for social sciences.The findings delineated support for the hypothesized associations.Specifically,emotional exhaustion and met expectations partly mediated the effect of job insecurity on proactive pro-environmental behavior.More importantly,emotional exhaustion and met expectations serially mediated the influence of job insecurity on proactive pro-environmental behavior.These findings have important theoretical implications as well as significant implications for diminishing job insecurity,managing emotional exhaustion,increasing met expectations,and enhancing ecofriendly behaviors. 展开更多
关键词 Emotional exhaustion hotel customer-contact employees job insecurity met expectations pro-environmental behavior
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Oxygen tension modulates cell function in an in vitro three-dimensional glioblastoma tumor model 被引量:1
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作者 Sen Wang Siqi Yao +8 位作者 Na Pei Luge Bai Zhiyan Hao Dichen Li Jiankang He J.Miguel Oliveira Xiaoyan Xue Ling Wang Xinggang Mao 《Bio-Design and Manufacturing》 SCIE EI CAS CSCD 2024年第3期307-319,共13页
Hypoxia is a typical feature of the tumor microenvironment,one of the most critical factors affecting cell behavior and tumor progression.However,the lack of tumor models able to precisely emulate natural brain tumor ... Hypoxia is a typical feature of the tumor microenvironment,one of the most critical factors affecting cell behavior and tumor progression.However,the lack of tumor models able to precisely emulate natural brain tumor tissue has impeded the study of the effects of hypoxia on the progression and growth of tumor cells.This study reports a three-dimensional(3D)brain tumor model obtained by encapsulating U87MG(U87)cells in a hydrogel containing type I collagen.It also documents the effect of various oxygen concentrations(1%,7%,and 21%)in the culture environment on U87 cell morphology,proliferation,viability,cell cycle,apoptosis rate,and migration.Finally,it compares two-dimensional(2D)and 3D cultures.For comparison purposes,cells cultured in flat culture dishes were used as the control(2D model).Cells cultured in the 3D model proliferated more slowly but had a higher apoptosis rate and proportion of cells in the resting phase(G0 phase)/gap I phase(G1 phase)than those cultured in the 2D model.Besides,the two models yielded significantly different cell morphologies.Finally,hypoxia(e.g.,1%O2)affected cell morphology,slowed cell growth,reduced cell viability,and increased the apoptosis rate in the 3D model.These results indicate that the constructed 3D model is effective for investigating the effects of biological and chemical factors on cell morphology and function,and can be more representative of the tumor microenvironment than 2D culture systems.The developed 3D glioblastoma tumor model is equally applicable to other studies in pharmacology and pathology. 展开更多
关键词 HYPOXIA GLIOMA Three-dimensional glioma model In vitro
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Effects of mesenchymal stem cell on dopaminergic neurons,motor and memory functions in animal models of Parkinson's disease:a systematic review and meta-analysis 被引量:3
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作者 Jong Mi Park Masoud Rahmati +2 位作者 Sang Chul Lee Jae Il Shin Yong Wook Kim 《Neural Regeneration Research》 SCIE CAS CSCD 2024年第7期1584-1592,共9页
Parkinson’s disease is chara cterized by the loss of dopaminergic neurons in the substantia nigra pars com pacta,and although restoring striatal dopamine levels may improve symptoms,no treatment can cure or reve rse ... Parkinson’s disease is chara cterized by the loss of dopaminergic neurons in the substantia nigra pars com pacta,and although restoring striatal dopamine levels may improve symptoms,no treatment can cure or reve rse the disease itself.Stem cell therapy has a regenerative effect and is being actively studied as a candidate for the treatment of Parkinson’s disease.Mesenchymal stem cells are considered a promising option due to fewer ethical concerns,a lower risk of immune rejection,and a lower risk of teratogenicity.We performed a meta-analysis to evaluate the therapeutic effects of mesenchymal stem cells and their derivatives on motor function,memory,and preservation of dopamine rgic neurons in a Parkinson’s disease animal model.We searched bibliographic databases(PubMed/MEDLINE,Embase,CENTRAL,Scopus,and Web of Science)to identify articles and included only pee r-reviewed in vivo interve ntional animal studies published in any language through J une 28,2023.The study utilized the random-effect model to estimate the 95%confidence intervals(CI)of the standard mean differences(SMD)between the treatment and control groups.We use the systematic review center for laboratory animal expe rimentation’s risk of bias tool and the collaborative approach to meta-analysis and review of animal studies checklist for study quality assessment.A total of 33studies with data from 840 Parkinson’s disease model animals were included in the meta-analysis.Treatment with mesenchymal stem cells significantly improved motor function as assessed by the amphetamine-induced rotational test.Among the stem cell types,the bone marrow MSCs with neurotrophic factor group showed la rgest effect size(SMD[95%CI]=-6.21[-9.50 to-2.93],P=0.0001,I^(2)=0.0%).The stem cell treatment group had significantly more tyrosine hydroxylase positive dopamine rgic neurons in the striatum([95%CI]=1.04[0.59 to 1.49],P=0.0001,I^(2)=65.1%)and substantia nigra(SMD[95%CI]=1.38[0.89 to 1.87],P=0.0001,I^(2)=75.3%),indicating a protective effect on dopaminergic neurons.Subgroup analysis of the amphetamine-induced rotation test showed a significant reduction only in the intracranial-striatum route(SMD[95%CI]=-2.59[-3.25 to-1.94],P=0.0001,I^(2)=74.4%).The memory test showed significant improvement only in the intravenous route(SMD[95%CI]=4.80[1.84 to 7.76],P=0.027,I^(2)=79.6%).Mesenchymal stem cells have been shown to positively impact motor function and memory function and protect dopaminergic neurons in preclinical models of Parkinson’s disease.Further research is required to determine the optimal stem cell types,modifications,transplanted cell numbe rs,and delivery methods for these protocols. 展开更多
关键词 ANIMAL animal experimentation mesenchymal stem cells models Parkinson’s disease stem cell transplantation
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Assessing the Performance of CMIP6 Models in Simulating Droughts across Global Drylands 被引量:1
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作者 Xiaojing YU Lixia ZHANG +1 位作者 Tianjun ZHOU Jianghua ZHENG 《Advances in Atmospheric Sciences》 SCIE CAS CSCD 2024年第2期193-208,共16页
Both the attribution of historical change and future projections of droughts rely heavily on climate modeling. However,reasonable drought simulations have remained a challenge, and the related performances of the curr... Both the attribution of historical change and future projections of droughts rely heavily on climate modeling. However,reasonable drought simulations have remained a challenge, and the related performances of the current state-of-the-art Coupled Model Intercomparison Project phase 6(CMIP6) models remain unknown. Here, both the strengths and weaknesses of CMIP6 models in simulating droughts and corresponding hydrothermal conditions in drylands are assessed.While the general patterns of simulated meteorological elements in drylands resemble the observations, the annual precipitation is overestimated by ~33%(with a model spread of 2.3%–77.2%), along with an underestimation of potential evapotranspiration(PET) by ~32%(17.5%–47.2%). The water deficit condition, measured by the difference between precipitation and PET, is 50%(29.1%–71.7%) weaker than observations. The CMIP6 models show weaknesses in capturing the climate mean drought characteristics in drylands, particularly with the occurrence and duration largely underestimated in the hyperarid Afro-Asian areas. Nonetheless, the drought-associated meteorological anomalies, including reduced precipitation, warmer temperatures, higher evaporative demand, and increased water deficit conditions, are reasonably reproduced. The simulated magnitude of precipitation(water deficit) associated with dryland droughts is overestimated by 28%(24%) compared to observations. The observed increasing trends in drought fractional area,occurrence, and corresponding meteorological anomalies during 1980–2014 are reasonably reproduced. Still, the increase in drought characteristics, associated precipitation and water deficit are obviously underestimated after the late 1990s,especially for mild and moderate droughts, indicative of a weaker response of dryland drought changes to global warming in CMIP6 models. Our results suggest that it is imperative to employ bias correction approaches in drought-related studies over drylands by using CMIP6 outputs. 展开更多
关键词 DROUGHTS hydrothermal conditions DRYLANDS CMIP6 model evaluation
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Cellular interplay to 3D in vitro microphysiological disease model:cell patterning microbiota-gut-brain axis 被引量:1
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作者 Kamare Alam Lakshmi Nair +6 位作者 Souvik Mukherjee Kulwinder Kaur Manjari Singh Santanu Kaity Velayutham Ravichandiran Sugato Banerjee Subhadeep Roy 《Bio-Design and Manufacturing》 SCIE EI CAS CSCD 2024年第3期320-357,共38页
The microbiota-gut-brain axis(MGBA)has emerged as a key prospect in the bidirectional communication between two major organ systems:the brain and the gut.Homeostasis between the two organ systems allows the body to fu... The microbiota-gut-brain axis(MGBA)has emerged as a key prospect in the bidirectional communication between two major organ systems:the brain and the gut.Homeostasis between the two organ systems allows the body to function without disease,whereas dysbiosis has long-standing evidence of etiopathological conditions.The most common communication paths are the microbial release of metabolites,soluble neurotransmitters,and immune cells.However,each pathway is intertwined with a complex one.With the emergence of in vitro models and the popularity of three-dimensional(3D)cultures and Transwells,engineering has become easier for the scientific understanding of neurodegenerative diseases.This paper briefly retraces the possible communication pathways between the gut microbiome and the brain.It further elaborates on three major diseases:autism spectrum disorder,Parkinson’s disease,and Alzheimer’s disease,which are prevalent in children and the elderly.These diseases also decrease patients’quality of life.Hence,understanding them more deeply with respect to current advances in in vitro modeling is crucial for understanding the diseases.Remodeling of MGBA in the laboratory uses many molecular technologies and biomaterial advances.Spheroids and organoids provide a more realistic picture of the cell and tissue structure than monolayers.Combining them with the Transwell system offers the advantage of compartmentalizing the two systems(apical and basal)while allowing physical and chemical cues between them.Cutting-edge technologies,such as bioprinting and microfluidic chips,might be the future of in vitro modeling,as they provide dynamicity. 展开更多
关键词 Microbiota-gut-brain axis Neurodegeneration 3D disease model Organoid Transwell system
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Genetically modified non-human primate models for research on neurodegenerative diseases 被引量:1
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作者 Ming-Tian Pan Han Zhang +1 位作者 Xiao-Jiang Li Xiang-Yu Guo 《Zoological Research》 SCIE CSCD 2024年第2期263-274,共12页
Neurodegenerative diseases(NDs)are a group of debilitating neurological disorders that primarily affect elderly populations and include Alzheimer's disease(AD),Parkinson's disease(PD),Huntington's disease(... Neurodegenerative diseases(NDs)are a group of debilitating neurological disorders that primarily affect elderly populations and include Alzheimer's disease(AD),Parkinson's disease(PD),Huntington's disease(HD),and amyotrophic lateral sclerosis(ALS).Currently,there are no therapies available that can delay,stop,or reverse the pathological progression of NDs in clinical settings.As the population ages,NDs are imposing a huge burden on public health systems and affected families.Animal models are important tools for preclinical investigations to understand disease pathogenesis and test potential treatments.While numerous rodent models of NDs have been developed to enhance our understanding of disease mechanisms,the limited success of translating findings from animal models to clinical practice suggests that there is still a need to bridge this translation gap.Old World nonhuman primates(NHPs),such as rhesus,cynomolgus,and vervet monkeys,are phylogenetically,physiologically,biochemically,and behaviorally most relevant to humans.This is particularly evident in the similarity of the structure and function of their central nervous systems,rendering such species uniquely valuable for neuroscience research.Recently,the development of several genetically modified NHP models of NDs has successfully recapitulated key pathologies and revealed novel mechanisms.This review focuses on the efficacy of NHPs in modeling NDs and the novel pathological insights gained,as well as the challenges associated with the generation of such models and the complexities involved in their subsequent analysis. 展开更多
关键词 NEURODEGENERATION Non-human primate Macaque monkey Animal model Gene modification
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High-speed penetration of ogive-nose projectiles into thick concrete targets:Tests and a projectile nose evolution model 被引量:1
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作者 Xu Li Yan Liu +4 位作者 Junbo Yan Zhenqing Shi Hongfu Wang Yingliang Xu Fenglei Huang 《Defence Technology(防务技术)》 SCIE EI CAS CSCD 2024年第2期553-571,共19页
The majority of the projectiles used in the hypersonic penetration study are solid flat-nosed cylindrical projectiles with a diameter of less than 20 mm.This study aims to fill the gap in the experimental and analytic... The majority of the projectiles used in the hypersonic penetration study are solid flat-nosed cylindrical projectiles with a diameter of less than 20 mm.This study aims to fill the gap in the experimental and analytical study of the evolution of the nose shape of larger hollow projectiles under hypersonic penetration.In the hypersonic penetration test,eight ogive-nose AerMet100 steel projectiles with a diameter of 40 mm were launched to hit concrete targets with impact velocities that ranged from 1351 to 1877 m/s.Severe erosion of the projectiles was observed during high-speed penetration of heterogeneous targets,and apparent localized mushrooming occurred in the front nose of recovered projectiles.By examining the damage to projectiles,a linear relationship was found between the relative length reduction rate and the initial kinetic energy of projectiles in different penetration tests.Furthermore,microscopic analysis revealed the forming mechanism of the localized mushrooming phenomenon for eroding penetration,i.e.,material spall erosion abrasion mechanism,material flow and redistribution abrasion mechanism and localized radial upsetting deformation mechanism.Finally,a model of highspeed penetration that included erosion was established on the basis of a model of the evolution of the projectile nose that considers radial upsetting;the model was validated by test data from the literature and the present study.Depending upon the impact velocity,v0,the projectile nose may behave as undistorted,radially distorted or hemispherical.Due to the effects of abrasion of the projectile and enhancement of radial upsetting on the duration and amplitude of the secondary rising segment in the pulse shape of projectile deceleration,the predicted DOP had an upper limit. 展开更多
关键词 High-speed penetration Concrete target EROSION Projectile nose evolution model
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