The serine protease HtrA2/Omi is released from the mitochondrial intermembrane space following apoptotic stimuli.Once in the cytosol,HtrA2/Omi has been implicated in promoting cell death in caspase-dependent or caspas...The serine protease HtrA2/Omi is released from the mitochondrial intermembrane space following apoptotic stimuli.Once in the cytosol,HtrA2/Omi has been implicated in promoting cell death in caspase-dependent or caspase-independent pathway.On the other hand,HtrA2/Omi can refold and degrade misfolded proteins in the mitochondria during cell stress.展开更多
目的:检测HtrA2/Omi,X染色体连锁凋亡抑制剂(X-linked inhibitor of apoptosis,XIAP)和半胱天冬酶-3(Caspase-3)在寻常型银屑病(PV)中的表达。方法:应用免疫组化SABC法检测30例PV皮损与10例正常人皮肤中HtrA2/Omi、XIAP和Caspase-3的表...目的:检测HtrA2/Omi,X染色体连锁凋亡抑制剂(X-linked inhibitor of apoptosis,XIAP)和半胱天冬酶-3(Caspase-3)在寻常型银屑病(PV)中的表达。方法:应用免疫组化SABC法检测30例PV皮损与10例正常人皮肤中HtrA2/Omi、XIAP和Caspase-3的表达,并分析HtrA2/Omi、XIAP和Caspase-3表达之间的相关性。结果:PV皮损中XIAP和Caspase-3阳性细胞数明显高于正常皮肤(P<0.01),HtrA2/Omi阳性细胞数与正常皮肤无明显差异(P>0.05)。Caspase-3阳性细胞数和XIAP呈正相关趋势(P<0.05),与HtrA2/Omi表达无明显相关性(P>0.05)。HtrA2/Omi和XIAP的表达无明显相关性(P>0.05)。结论:XIAP和Caspase-3可能在PV的发病中起重要作用。展开更多
文摘The serine protease HtrA2/Omi is released from the mitochondrial intermembrane space following apoptotic stimuli.Once in the cytosol,HtrA2/Omi has been implicated in promoting cell death in caspase-dependent or caspase-independent pathway.On the other hand,HtrA2/Omi can refold and degrade misfolded proteins in the mitochondria during cell stress.
文摘目的:检测HtrA2/Omi,X染色体连锁凋亡抑制剂(X-linked inhibitor of apoptosis,XIAP)和半胱天冬酶-3(Caspase-3)在寻常型银屑病(PV)中的表达。方法:应用免疫组化SABC法检测30例PV皮损与10例正常人皮肤中HtrA2/Omi、XIAP和Caspase-3的表达,并分析HtrA2/Omi、XIAP和Caspase-3表达之间的相关性。结果:PV皮损中XIAP和Caspase-3阳性细胞数明显高于正常皮肤(P<0.01),HtrA2/Omi阳性细胞数与正常皮肤无明显差异(P>0.05)。Caspase-3阳性细胞数和XIAP呈正相关趋势(P<0.05),与HtrA2/Omi表达无明显相关性(P>0.05)。HtrA2/Omi和XIAP的表达无明显相关性(P>0.05)。结论:XIAP和Caspase-3可能在PV的发病中起重要作用。