OBJECTIVE: To explore the clinical effect of Huangqi and Zeling granule combined with Zhushui No.l paste plus conventional therapy on patients with cirrhosi.METHODS: Totally 90 patients with liver cirrhosis were rando...OBJECTIVE: To explore the clinical effect of Huangqi and Zeling granule combined with Zhushui No.l paste plus conventional therapy on patients with cirrhosi.METHODS: Totally 90 patients with liver cirrhosis were randomly assigned into two groups: control group and study group. They all met the inclusion criteria. The patients in the control group were treated by conventional treatment; the patients in the study group received Huangqi and Zeling granule and Zhushui No. 1 paste along with the conventional therapy.The paste was applied on the acupoint of shenque. The levels of LPS, ET-1, NO and AM ON were all measured before and after treatment. The depth of ascites, the change of diameter portal and size of spleen were performed by abdominal ultrasonography Adverse events were observed and documented.RESULTS: The levels of AMON, LPS, ET-1 and NO were all reduced after treatment which were more obviously in study group(P<0.05). The depth decreased in both study group and control group after treatment. However, the decrease was more in the study group than in the control group(P<0.05).CONCLUSION: The effect of Huangqi and Zeling granule plus Zhushui No. 1 paste combined with routine conventional therapy on cirrhosis was better than that of using the routine conventional therapy alone.展开更多
基金Project Supported by Science and Technology Program of Henan Province(Grant No.:132102310154)
文摘OBJECTIVE: To explore the clinical effect of Huangqi and Zeling granule combined with Zhushui No.l paste plus conventional therapy on patients with cirrhosi.METHODS: Totally 90 patients with liver cirrhosis were randomly assigned into two groups: control group and study group. They all met the inclusion criteria. The patients in the control group were treated by conventional treatment; the patients in the study group received Huangqi and Zeling granule and Zhushui No. 1 paste along with the conventional therapy.The paste was applied on the acupoint of shenque. The levels of LPS, ET-1, NO and AM ON were all measured before and after treatment. The depth of ascites, the change of diameter portal and size of spleen were performed by abdominal ultrasonography Adverse events were observed and documented.RESULTS: The levels of AMON, LPS, ET-1 and NO were all reduced after treatment which were more obviously in study group(P<0.05). The depth decreased in both study group and control group after treatment. However, the decrease was more in the study group than in the control group(P<0.05).CONCLUSION: The effect of Huangqi and Zeling granule plus Zhushui No. 1 paste combined with routine conventional therapy on cirrhosis was better than that of using the routine conventional therapy alone.
