AIM： To investigate the effects of Danshao Huaxian （DSHX） capsules, a preparation of traditional Chinese medicine, on the expression of matrix metalloproteinase-1 （MMP-1）, and tissue inhibitor of metalloproteinas...AIM： To investigate the effects of Danshao Huaxian （DSHX） capsules, a preparation of traditional Chinese medicine, on the expression of matrix metalloproteinase-1 （MMP-1）, and tissue inhibitor of metalloproteinase-1 （TIMP-1） in the fibrous livers of rats. METHODS： Eighty male Wistar rats were randomly divided into normal control group （group A）, CCl4-induced hepatic fibrosis group （group B）, non-DSHX-treated group （group C）, low dose-treated group （group D）, and high dose-treated group （group E）. Fibrous liver models in rats were induced by subcutaneous injection of CCI4, oral administration of alcohol and high-lipid/low-protein diet for 8 wk. After the models were established, the rats in groups D and E were orally given a low dose （0.5 g/kg） and a high dose （1.0 g/kg） of DSHX daily for 8 wk, respectively. Then, the liver indexes, serum hyaluronic acid （HA） and alanine aminotransferase （ALT） were examined. The degree of hepatic fibrosis was evaluated by optical microscopy. Hydroxyproline （Hyp） in the urine was determined, and the expression of MMP-1 and TIMP-1 was detected by immunohistochemical techniques. RESULTS： In groups D and E, the liver indexes, levels of serum HA and ALT reduced and development of hepatic fibrosis weakened significantly. The urinary Hyp and expression of MMP-1 in the liver tissues elevated, but the expression of TIMP-1 decreased obviously, as compared to groups B and C.CONCLUSION： DSHX enhances the expression of MMP-1 but decreases that of TIMP-1 in liver tissues of CCI4-induced hepatic fibrotic rats, which may result in its elevated activity that contributes to fighting against hepatic fibrosis.展开更多
Accurate volume calculation of each individual landslide triggered by strong historical earthquakes can help understand the characteristics of the typical earthquake-induced landslides,thus providing significant infor...Accurate volume calculation of each individual landslide triggered by strong historical earthquakes can help understand the characteristics of the typical earthquake-induced landslides,thus providing significant information for the modification of the focal parameters of historical earthquakes.In this study,we select one rock fall and three loess landslides triggered by the 1556 AD Huaxian M8⅟earthquake,compute their volumes using the low-altitude high-precision Unmanned Aerial Vehicle(UAV)photogrammetry and landslide profile restoration methods.The results show that:①the whole influencing area of the Huangjiagou Rock Fall is approximately 3.03×105 m2 and the area of the collapsed rock accumulated at the slope foot is 3.33×104 m2,accounting for approximately 10%of the entire influencing range.However,the estimated volume of the collapsed rock is only 0.699×106 m3,indicating a rock fall with large influencing range but limited collapsed rock;②the geological form of thethree loess landslides are preserved intactly,with volumes of 0.283×108 m3,0.074×108 m3,and 0.377×108 m3.These important geological hazard relics reflect the strong vibrations and severe casualties in the meizoseismal area;③loess landslides are the key reason of the serious death toll in the hilly-gully loess area.Our new method can be used to estimate the influencing area and the actual volume of each individual landslide,and rationally evaluate the role of earthquake landslides in the disaster.In addition,quantitative research on secondary disasters triggered by strong historical earthquakes is beneficial for understanding the surface process and focal parameters of the earthquakes.展开更多
BACKGROUND: The prognosis of decompensated cirrhosis resulting from chronic hepatitis B is poor, and the benefits of treatment with interferon are ourweight serious sideeffects and the risk of fatal exacerbation of di...BACKGROUND: The prognosis of decompensated cirrhosis resulting from chronic hepatitis B is poor, and the benefits of treatment with interferon are ourweight serious sideeffects and the risk of fatal exacerbation of disease. Danshao Huaxian capsule rapidly reduces hepatitis B virus(HBV)-DNA in serum to undetectable levels. METHODS: A total of 35 patients with chronic hepatitis B and decompensated cirrhosis were treated with Danshao Huaxian 1.2g. po. tid daily. Before the treatment, HBVDNA in serum was positive in all patients. Ten patients had Child-Pugh class B and 25, class C hepatitis B. Seven patients underwent liver transplantation within 6 months of initial treatment. Of the 10 patients of class B, 5 died within 6 months, and the other 5 did not complete the treatment for some reasons; the 25 patients of class C were treated for at least 6 months (mean =19 months). RESULTS: In most of the 25 patients, liver function was improved slowly but markedly after 9 months of treatment, showing a decreased level of serum bilirubin from 67±13 to 30±4μmol/L (P<0.05, baseline vs.6 months), an increased level of serum albumin from 27±1 to 34±1 g/L(P<0.05) and a decreased level of Child-Pugh score from 10.3±0.4 to 7.5+0.5 (P<0.05). Three patients developed resistance to Danshao Huaxian because of a mutation in the YMDD motif, but liver function was not deteriorated. Inhibition of viral replication with Danshao Huaxian resulted in a significant improvement of liver function in patients with decompensated HBV cirrhosis, but the long-term results remain uncertain. CONCLUSION: Danshao Huaxian capsule is effective in inhibiting viral DNA replication in patients with decompensated cirrhosis and making clinical improvement.展开更多
In this paper, we focus on the characteristics of the landslides developed in the epicentral area of AD 1556 M^8.5 Huaxian Earthquake, and discuss their relations to the active normal faults in the SE Weihe Graben, Ce...In this paper, we focus on the characteristics of the landslides developed in the epicentral area of AD 1556 M^8.5 Huaxian Earthquake, and discuss their relations to the active normal faults in the SE Weihe Graben, Central China. The results from analyzing high-resolution remote-sensing imagery and digital elevation models（DEMs）, in combination with field survey, demonstrate that：（i） the landslides observed in the study area range from small-scale debris/rock falls to large-scale rock avalanches;（ii） the landslides are mostly developed upon steep slopes of ≥30°; and（iii） the step-like normal-fault scarps along the range-fronts of the Huashan Mountains as well as the thick loess sediments in the Weinan area may facilitate the occurrence of large landslides. The results presented in this study would be helpful to assess the potential landslide hazards in densely-populated areas affected by active normal faulting.展开更多
基金Supported by the Foundation of Traditional Chinese Medicine Modernization Project of Guizhou Province, No. 200409
文摘AIM： To investigate the effects of Danshao Huaxian （DSHX） capsules, a preparation of traditional Chinese medicine, on the expression of matrix metalloproteinase-1 （MMP-1）, and tissue inhibitor of metalloproteinase-1 （TIMP-1） in the fibrous livers of rats. METHODS： Eighty male Wistar rats were randomly divided into normal control group （group A）, CCl4-induced hepatic fibrosis group （group B）, non-DSHX-treated group （group C）, low dose-treated group （group D）, and high dose-treated group （group E）. Fibrous liver models in rats were induced by subcutaneous injection of CCI4, oral administration of alcohol and high-lipid/low-protein diet for 8 wk. After the models were established, the rats in groups D and E were orally given a low dose （0.5 g/kg） and a high dose （1.0 g/kg） of DSHX daily for 8 wk, respectively. Then, the liver indexes, serum hyaluronic acid （HA） and alanine aminotransferase （ALT） were examined. The degree of hepatic fibrosis was evaluated by optical microscopy. Hydroxyproline （Hyp） in the urine was determined, and the expression of MMP-1 and TIMP-1 was detected by immunohistochemical techniques. RESULTS： In groups D and E, the liver indexes, levels of serum HA and ALT reduced and development of hepatic fibrosis weakened significantly. The urinary Hyp and expression of MMP-1 in the liver tissues elevated, but the expression of TIMP-1 decreased obviously, as compared to groups B and C.CONCLUSION： DSHX enhances the expression of MMP-1 but decreases that of TIMP-1 in liver tissues of CCI4-induced hepatic fibrotic rats, which may result in its elevated activity that contributes to fighting against hepatic fibrosis.
基金Received on April 29th,2020revised on June 5th,2020.This project is sponsored by Fundamental Scientific Research Fund in the IEF,CEA(2017IES010102,2019IEF0201,2017IES010101,)+1 种基金the National Natural Science Foundation of China(42072248)the Seismic Active Fault Exploration Project based on Highresolution Remote Sensing Interpretation Technology by Department of Earthquake Damage Defense,CEA(15230003).
文摘Accurate volume calculation of each individual landslide triggered by strong historical earthquakes can help understand the characteristics of the typical earthquake-induced landslides,thus providing significant information for the modification of the focal parameters of historical earthquakes.In this study,we select one rock fall and three loess landslides triggered by the 1556 AD Huaxian M8⅟earthquake,compute their volumes using the low-altitude high-precision Unmanned Aerial Vehicle(UAV)photogrammetry and landslide profile restoration methods.The results show that:①the whole influencing area of the Huangjiagou Rock Fall is approximately 3.03×105 m2 and the area of the collapsed rock accumulated at the slope foot is 3.33×104 m2,accounting for approximately 10%of the entire influencing range.However,the estimated volume of the collapsed rock is only 0.699×106 m3,indicating a rock fall with large influencing range but limited collapsed rock;②the geological form of thethree loess landslides are preserved intactly,with volumes of 0.283×108 m3,0.074×108 m3,and 0.377×108 m3.These important geological hazard relics reflect the strong vibrations and severe casualties in the meizoseismal area;③loess landslides are the key reason of the serious death toll in the hilly-gully loess area.Our new method can be used to estimate the influencing area and the actual volume of each individual landslide,and rationally evaluate the role of earthquake landslides in the disaster.In addition,quantitative research on secondary disasters triggered by strong historical earthquakes is beneficial for understanding the surface process and focal parameters of the earthquakes.
基金This study is supported by a grant from the Primary Sciences and Technology Project of Guizhou Province, China (No. 961023).
文摘BACKGROUND: The prognosis of decompensated cirrhosis resulting from chronic hepatitis B is poor, and the benefits of treatment with interferon are ourweight serious sideeffects and the risk of fatal exacerbation of disease. Danshao Huaxian capsule rapidly reduces hepatitis B virus(HBV)-DNA in serum to undetectable levels. METHODS: A total of 35 patients with chronic hepatitis B and decompensated cirrhosis were treated with Danshao Huaxian 1.2g. po. tid daily. Before the treatment, HBVDNA in serum was positive in all patients. Ten patients had Child-Pugh class B and 25, class C hepatitis B. Seven patients underwent liver transplantation within 6 months of initial treatment. Of the 10 patients of class B, 5 died within 6 months, and the other 5 did not complete the treatment for some reasons; the 25 patients of class C were treated for at least 6 months (mean =19 months). RESULTS: In most of the 25 patients, liver function was improved slowly but markedly after 9 months of treatment, showing a decreased level of serum bilirubin from 67±13 to 30±4μmol/L (P<0.05, baseline vs.6 months), an increased level of serum albumin from 27±1 to 34±1 g/L(P<0.05) and a decreased level of Child-Pugh score from 10.3±0.4 to 7.5+0.5 (P<0.05). Three patients developed resistance to Danshao Huaxian because of a mutation in the YMDD motif, but liver function was not deteriorated. Inhibition of viral replication with Danshao Huaxian resulted in a significant improvement of liver function in patients with decompensated HBV cirrhosis, but the long-term results remain uncertain. CONCLUSION: Danshao Huaxian capsule is effective in inhibiting viral DNA replication in patients with decompensated cirrhosis and making clinical improvement.
基金supported by the National Natural Science Foundation of China (No. 41502203)the Scientific Research Foundation for Returned Overseas Scholars of China (awarded to G. Rao)+1 种基金the Natural Science Foundation of Zhejiang Province (No. LY15D02001)a Science Project (No. 23253002)from the Ministry of Education, Culture, Sports, Science and Technology of Japan
文摘In this paper, we focus on the characteristics of the landslides developed in the epicentral area of AD 1556 M^8.5 Huaxian Earthquake, and discuss their relations to the active normal faults in the SE Weihe Graben, Central China. The results from analyzing high-resolution remote-sensing imagery and digital elevation models（DEMs）, in combination with field survey, demonstrate that：（i） the landslides observed in the study area range from small-scale debris/rock falls to large-scale rock avalanches;（ii） the landslides are mostly developed upon steep slopes of ≥30°; and（iii） the step-like normal-fault scarps along the range-fronts of the Huashan Mountains as well as the thick loess sediments in the Weinan area may facilitate the occurrence of large landslides. The results presented in this study would be helpful to assess the potential landslide hazards in densely-populated areas affected by active normal faulting.
