Model-Based Systems Engineering Approach to Design a Human Settlement to Better Serve Displaced People

The challenge of transitioning from temporary humanitarian settlements to more sustainable human settlements is due to a significant increase in the number of forcibly displaced people over recent decades, difficulties in providing social services that meet the required standards, and the prolongation of emergencies. Despite this challenging context, short-term considerations continue to guide their planning and management rather than more integrated, longer-term perspectives, thus preventing viable, sustainable development. Over the years, the design of humanitarian settlements has not been adapted to local contexts and perspectives, nor to the dynamics of urbanization and population growth and data. In addition, the current approach to temporary settlement harms the environment and can strain limited resources. Inefficient land use and ad hoc development models have compounded difficulties and generated new challenges. As a result, living conditions in settlements have deteriorated over the last few decades and continue to pose new challenges. The stakes are such that major shortcomings have emerged along the way, leading to disruption, budget overruns in a context marked by a steady decline in funding. However, some attempts have been made to shift towards more sustainable approaches, but these have mainly focused on vague, sector-oriented themes, failing to consider systematic and integration views. This study is a contribution in addressing these shortcomings by designing a model-driving solution, emphasizing an integrated system conceptualized as a system of systems. This paper proposes a new methodology for designing an integrated and sustainable human settlement model, based on Model-Based Systems Engineering and a Systems Modeling Language to provide valuable insights toward sustainable solutions for displaced populations aligning with the United Nations 2030 agenda for sustainable development.

An In-depth Interpretation of the Universal Declaration of Human Rights With the Common Values of Humanity As the Research Paradigm

Interpreting the Universal Declaration of Human Rights from political,juridical and philosophical perspectives is es-sential for promoting the guiding principles of the Declaration,build-ing consensus on human rights,and advancing human rights practice in the new historical context.To conduct an academic,systematic in-terpretation of the Declaration that conforms to the trends of the times and answers the fundamental questions of the world,it is necessary to find a new research paradigm.The common values of humanity,namely peace,development,equity,justice,democracy and freedom,put forward by Xi Jinping,general secretary of the Communist Party of China(CPC)Central Committee,provide the most explanatory and penetrating scientific paradigm for reaching the issue.This paper an-alyzes and reflects on the views,value foundation and principled(con-tractual)consensus of human rights in the Declaration,and narrates and foresees the far-reaching significance of the three global initia-tives(namely,the Global Development Initiative,the Global Security Initiative,and the Global Civilization Initiative)with the common val-ues of humanity as the soul in advancing the modernization of global human rights governance and building a new form of human rights civilization.

Study on the Correlation between Human Papillomavirus and Mycoplasma genitalium Combined with TCT Detection

Objective: This study aims to explore the correlation between human papillomavirus (HPV) and Mycoplasma genitalium (CT) combined with TCT detection in cervical cancer screening. Method: A cross-sectional study design was adopted, and a total of 609 women who came to seek medical treatment were recruited as the study subjects. Combination testing was evaluated on cervical cancer screening by testing the women for HPV, CT with TCT detection and analyzing the relationship of cervical lesions with HPV and CT infection. Results: The study results showed that 21.57% of the subjects were infected with both HPV and CT, and 48.42% of the cases had abnormal TCT results at the same time. Further data analysis showed that HPV infection was significantly associated with abnormal TCT outcomes (p < 0.05), suggesting a possible synergistic effect of the two infections in cervical lesions. The combined sensitivity and specificity of HPV, CT and TCT detection were 21.57% and 48.42%, respectively, which were significantly higher than that of single detection. Conclusion: In summary, the results of this study support the importance of combined HPV, CT, and TCT testing in cervical cancer screening, and propose the hypothesis that combined testing may improve screening effectiveness. However, further large sample studies are needed to confirm this conclusion and explore the prospects of combined testing in clinical practice.

Human induced pluripotent stem cell based in vitro models of the blood-brain barrier： the future standard？

There is an urgent and tremendous need for human dis- ease models in drug development in order to improve pre- clinical predictability. In the case of brain disorders drugs have to cross the blood-brain barrier （BBB） to enter the central nervous system （CNS）. It was estimated that more than 95% of the drugs cannot cross the BBB.

Continuously Performing the Consultation and Social Service Roles of Human Rights Bases

The Ministry of Education and the State Council Information Office have named Renmin University of China as one of the human rights national education and training bases. This shows the full affirmation and trust in the university＇s education, research and training work and also represents encouragement for its future work.

Construction of Human Rights Bases is a Daunting Task

In order to implement the National Human Rights Action Plan （2012-2015）, the Ministry of Education and the State Council Information Office named the Renmin University of China Human Rights Research Center, the Fudan University Human Rights Research Center, the Wuhan University Human Rights Research Academy, the Shandong University Human Rights Research Center and the Southwest University of Political Science and Law Human Rights Education and Research Center as national human rights education and training bases. This has a significant bearing on further improving hu- man rights training and theoretical research at universities in order to better serve the country＇s human rights cause.

Plasmid-based generation of neural cells from human fibroblasts using non-integrating episomal vectors

Differentiation of human fibroblasts into functional neurons depends on the introduction of viral-mediated transcription factors, which present risks of viral gene integration and tumorigenicity. In recent years, although some studies have been successful in directly inducing neurons through sustained expression of small molecule compounds, they have only been shown to be effective on mouse-derived cells. Thus, herein we delivered vectors containing Epstein-Barr virus-derived oriP/Epstein-Barr nuclear antigen 1 encoding the neuronal transcription factor, Ascl1, the neuron-specific microRNA, miR124, and a small hairpin directed against p53, into human fibroblasts. Cells were incubated in a neuron-inducing culture medium. Immunofluorescence staining was used to detect Tuj-1, microtubule-associated protein 2, neuron-specific nucleoprotein NeuN and nerve cell adhesion molecules in the induced cells. The proportion of Tuj1-positive cells was up to 36.7% after induction for 11 days. From day 21, these induced neurons showed neuron-specific expression patterns of microtubule-associated protein 2, NeuN and neural cell adhesion molecule. Our approach is a simple, plasmid-based process that enables direct reprogramming of human fibroblasts into neurons, and provides alternative avenues for disease modeling and neurodegenerative medicine.

Building National Level Human Rights Bases and Popularization Centers

Building national human rights education and train- ing bases is part of China＇s human rights development,which shows the strong will of the Chinese government for promoting human fights and strengthening hu- man rights protection. Such an action is not only a practical measure for implementing international human fights action plans, but also a practice of the Chinese government in re- specting and implementing relevant international obligations set by the United Nations.

Focusing on Building Bases,Improving Human Rights Work

Over the course of a whole day, all the candidate organizations introduced their work and respondedto inquiries from panel members. The selection meeting was smooth and successful.

Second Group of National Human Rights Education and Training Bases Established

The Ministry of Education and the State Council Information Office on July 22 announced the second group of national human rights education and training bases, in- cluding the Human Rights Research Center at Renmin University of China, the Human Rights Research Center at Fudan University, the Human Rights Research Academy at Wuhan University, the Human Rights Research Center at Shandong University and the Human Rights Education and Research Center at the Southwest University of Politica~ Science arid Law.

Responsibilities and Working Mechanism of National Human Rights Education and Training Bases

On July 22, 2014, the second group of national human rights education and train- ing bases was announced,increasing the number of national bases from the previous three to a total of eight, which reflects the advancement of human rights education and ~aining in China and has far-reaching significance.

Finite Element Method Computations of the Acoustics of the Human Head Based on the Projection Based Interpolation Data

In this paper we present the Projection Based Interpolation (PBI) technique for construction of continuous approximation of MRI scan data of the human head. We utilize the result of the PBI algorithm to perform three dimensional (3D) Finite Element Method (FEM) simulations of the acoustics of the human head. The computational problem is a multi-physics problem modeled as acoustics coupled with linear elasticity. The computational grid contains tetrahedral finite elements with the number of equations and polynomial orders of approximation varying locally on finite element edges, faces, and interiors. We utilize our own out-of-core parallel direct solver for the solution of this multi-physics problem. The solver minimizes the memory usage by dumping out all local systems from all nodes of the entire elimination tree during the elimination phase.

子宫颈癌十年研究回顾

子宫颈癌是一种病因明确且可防可控的恶性肿瘤。尽管人乳头瘤病毒(human papillomavirus,HPV)疫苗研发和子宫颈癌筛查已广泛开展,但其发病率仍逐年上升,并呈现低龄化的趋势,提示子宫颈癌防控仍有待优化。因此世界卫生组织提出加速消除子宫颈癌全球战略。随着对HPV致癌机制的深入研究,子宫颈癌筛查技术不断革新,出现HPV拓展分型、p16INK4a(p16)/Ki-67双重染色(双染)、基因甲基化和HPV整合检测等具有临床前景的新技术。另外,为改善子宫颈癌患者的预后,基于新辅助化疗、同步放化疗、免疫治疗和靶向治疗等不同治疗方式的联合方案成为临床研究热点。本文就子宫颈癌10年研究现状进行述评。

马克思“人化自然”对费尔巴哈“自在自然”的批判性超越

通过对观念论建制的颠覆和瓦解,费尔巴哈摧毁了德国形而上学的神秘基础,并将哲学从超感性的天国唤回到了感性的现实之中。他以直观中的自然和人作为“未来哲学”的出发点,并构建起了一种以自然主义为根基的人本学。然而,在马克思看来,费尔巴哈哲学的这一构想尽管恢复了感性自然的本体论意义,但同时却使人沦为非现实的抽象物:一方面,直观中的自然只是以自在存在的状态与人相对立;另一方面,人在“自在自然”中仅仅具有对自然的纯粹依附性。一言以蔽之,自然与人在本质上相分离而失却了彼此间的内在同一。与之相异,马克思从人与自然之间内在的同一性出发,在批判直观哲学范式的基础上将自然把握为与现实的人密切相关的“人化自然”,并揭示了其在人的感性活动中所体现出来的三重内在构境。据此,马克思实现了对费尔巴哈“自在自然”的批判性超越。

石墨烯纸基传感器在人体运动中的实验研究

随着可穿戴技术的飞速发展,柔性传感器因在定制医疗和人机互动中有应用前景而备受瞩目。受剪纸艺术启发,开发了一种新型剪纸结构的柔性纸基传感器。该传感器采用剪纸技术构建的石墨烯纸基材料,能够紧密贴合人体多个部位,旨在探索其在监测生理及运动信号方面的有效性。剪纸结构的设计不仅提高了传感器的敏感度和伸展性,还实现了其与皮肤的高度集成,为人体动态监测开辟了新途径。

运动监测柔性传感器中纸基材料的制备与应用

在现代科技飞速发展的背景下,可穿戴电子设备以其轻便、柔软、易于携带的特性,在医疗监测、康复治疗以及环境监控等多个领域展现出了巨大的应用潜力。这一趋势不仅促进了相关技术的进步,还对柔性储能材料与传感技术提出了更高的要求。因此,探索与开发成本低廉、性能卓越且易于集成的柔性充电电池和应变传感器成为研究的重点,这对推动可穿戴电子技术的发展具有深远的理论与实践意义。针对柔性摩擦电传感器在生产过程中存在的成本高、工艺复杂、环保性不佳等问题,提出了一种采用纸基导电银浆的柔性摩擦电传感器新方案。该传感器在监测人体运动状态方面表现出了优异的性能,能准确识别肘部和腕部的弯曲角度,区分不同的运动类型(如行走、快走、跑步)及健身动作(如踮脚、深蹲、抱腹跳),并能有效计算行走频率及健身次数。这些特性使其在人体运动监测领域展现出广阔的应用前景。

Construction of three-dimensional atlas of the lenticular nuclei and its subnucleus based on the cryosection images from Chinese visible human:a preliminary study

Objective To establish a 3D atlas of the lenticular nuclei and its subnucleus with the cryosection images of the male from "Atlas of Chinese Visible Human". Methods The lenticular nuclei and its subnucleus were segmented from the cryosection images and reconstructed with the software

Human Rights Connotations and Contemporary Values of Traditional Chinese People-Based Thinking

The time-honored traditional Chinese minben(people-based) thinking has rich implications for human rights. The concepts of min and minben are much in line with their contemporary counterparts of "human" and "people orientation". Upholding the belief of "people as the foundation of states", minben advocates the fundamental political status of the people, and requires leaders to implement "people-oriented" policies. Its encapsulation of the theoretical foundation and basic requirements for the protection of human rights enabled it to promote the protection of people’s livelihoods and civil rights in ancient China. Its sublimation in contemporary China has had, and will continue to have, a far-reaching impact on the development of human rights in China.

颍河源区径流变化特征及生态基流保障研究

为了探究人类活动引起的河川径流变化对生态基流的影响,基于颍河源区1965—2020年逐月径流资料,采用Mann-Kendall、R/S检验法、累积距平法和集中度、不均匀系数分析径流变化趋势、突变与持续特性,并据断面生态基流调控值,剖析径流变化对生态基流保障的影响。结果表明:源区年径流呈不显著减少态势,年内分配呈单峰型,主要集中于汛期;集中度与不均匀系数相关系数0.9460,变化趋势大体一致,均呈显著减少态势,且Hurst指数均>0.5,意味着源区径流年内不均匀分配状况将有所改观;受人类活动影响,源区径流在1990年发生了突变,且年、月径流Hurst指数均>0.5,表明未来一段时间径流量将呈减少态势,径流的突变与减少使生态基流得不到保障,甚至断流的月份增多。在开发利用河道水流资源时应保持适度,同时要开源节流、避免挤占生态基流,保障流域生态安全。

居家养老模式下室内空间适老化改造

为了提升老年人生活的安全性、舒适度,解决养老困难问题。通过居家养老模式的背景调研,表明居家养老是最适宜我国国情的养老模式。并结合室内空间适老化改造设计存在的问题,总结了室内空间适老化设计的策略和建议,归纳了室内通行空间、生活空间和辅助空间的适老化设计要点。为居家养老模式适老化改造设计提供了参考。