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Identification of a gene engineering antibody against cystic echinococcosis in liver
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作者 Xin-Hua Chen Hao Wen +3 位作者 Yao-Xin Zhang Xiao-Hui Feng Xiao-Mei Lu Dong Ma the Xinjiang Hydatid Clinical Research Institute and the Department of Infectious Diseases First Teaching Hospital, Xinjiang Medical University, Urumqi 830054, China 《Hepatobiliary & Pancreatic Diseases International》 SCIE CAS 2003年第3期383-386,共4页
OBJECTIVE: To identify a gene engineering antibody against cystic echinococcosis in liver. METHODS: A single chain of variable fragment of human antibodies (ScFvs) was selected from the library by using affinity selec... OBJECTIVE: To identify a gene engineering antibody against cystic echinococcosis in liver. METHODS: A single chain of variable fragment of human antibodies (ScFvs) was selected from the library by using affinity selection technique with the recombinant antigen on solid surface. The positive clones were demonstrated by ELISA and their DNA sequences were also determined. RESULTS: The DNA sequence data showed that the antibody gene is composed of 768bp. In addition, a specific combination capacity with recombinant Echinococcus granulosus antigen B (r-EgB) was demonstrated by ELISA. CONCLUSION: The obtained gene engineering antibody against r-EgB may have potential implications in immunological treatment and drug targeting delivery. 展开更多
关键词 cystic echinococcosis in liver gene engineering antibody phage display single chain of varlable fragment of human antibody recombinant Echinococcus granulosus antigen B
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