改良加固缝合方式在远端胃癌根治术毕Ⅱ联合Brown吻合中的应用价值探讨

探讨改良加固缝合方式在远端胃癌根治术毕Ⅱ联合Brown吻合中的应用价值。2019年10月至2022年10月,86例行腹腔镜远端胃癌根治术毕Ⅱ联合Brown吻合的患者,随机分为研究组和对照组。研究组45例采用改良加固缝合方式,对照组41例采用常规包埋加固缝合方式,对比两组患者手术时间、术后并发症、生存质量等指标。结果显示,两组患者手术时间、消化道重建时间、术中出血量、排气时间、首次进食流质时间比较差异无统计学意义(P>0.05);研究组和对照组术后1 d白细胞增加值分别为(5.14±0.92)×10^(9)/L、(7.08±0.98)×10^(9)/L,术后2 d镇痛药使用次数分别为(1.17±0.76)次、(1.63±1.18)次,住院时间分别为(9.22±1.49)d、(10.81±1.58)d,差异均具有统计学意义(P<0.05);两组患者术后7 d并发症发生率分别为6.67%、26.83%,术后6月总蛋白下降值分别为(2.842±0.465)g/L、(3.585±0.542)g/L,术后6月并发症发生率分别为13.33%、36.58%,差异均具有统计学意义(P<0.05);研究组术后6月Visick分级、生存质量指标优于对照组(P<0.05);两组PNI指数分别为(39.84±4.72)、(44.25±4.68),差异有统计学意义(P<0.05)。远端胃癌根治术毕Ⅱ联合Brown吻合中,改良加固缝合方式可明显降低并发症和胃肠道不良反应发生率,提高患者生活质量,促进患者身体功能恢复。

基于Hoek-Brown准则的底板破坏深度分析

为了研究煤层采动底板最大破坏深度,以1509工作面回风巷道为工程背景。利用半无限体理论建立力学模型,结合材料力学和Hoek-Brown准则,推导出最大破坏深度计算公式,并经过试验和现场监测进行验证。结果显示:底板最大破坏深度为20.3 m,且呈“水滴形”塑性区边界。底板破坏深度与岩体软硬程度呈负相关,与破碎程度呈正相关。现场监测结果显示,随底板埋深增加,采动应力影响减小;波速-垂深曲线表示底板最大破坏深度约为20 m,与理论计算基本吻合。研究成果对类似工作面有借鉴意义,有助于预测底板破坏深度,确保安全生产,并为相关领域研究提供参考。

基于Hoek-Brown准则的岩体高温-荷载耦合损伤模型及其验证

针对隧道岩体在高温和荷载共同作用下产生的耦合损伤问题,基于连续损伤力学理论,引入高温-荷载耦合损伤因子,建立了考虑高温作用的广义Hoek-Brown(H-B)准则的弹塑性损伤本构模型,解决了模型在数值积分过程中的奇异点问题,并利用Fortran语言编写了模型的有限元程序。结果表明:模型计算的应力-应变曲线与试验所得到的曲线趋势一致且计算结果误差在5%以内,温度作用下隧洞围岩损伤逐渐加剧,验证了模型的准确性和程序的稳健性,可为火灾作用下隧道围岩安全稳定性评价提供一种有效计算方法。

Effect of Daidzein on Ileum Microflora Biodiversity in Hy-Line Variety Brown Layers

Daidzein is always added into poultry feed to make the production performance and immunity of poultry better. In this study, a total of 600 40-week-old Hy-Line variety brown layers were randomized into five groups and fed with a corn-soybean-mixed basal diet supplement with 0, 10, 50, 100, and 500 mg · kg^-1 daidzein, respectively. Then, two PCR-based typing methods（RAPD-PCR and ERIC-PCR） were combined to analyze the ileum content and explore the changes of ileum microflora biodiversity. The results of RAPD-PCR and ERIC-PCR showed that bands under 10 mg · kg^-1 and 50 mg · kg^-1 were the most, and their similarity was the largest. Bands under 500 mg · kg^-1 were the least and similarity with other groups was the minimum. Ileum microflora biodiversity under 10 mg · kg^-1 or 50 mg · kg^-1 was richer than that under 500 mg · kg^-1. A corn-soybean-mixed basal diet supplement with 10 mg · kg^-1 to 50 mg · kg^-1 of daidzein might be beneficial to Hy-Line variety brown layers intestinal bacteria.

考虑中间主应力效应的修正Hoek-Brown真三轴强度准则

为改善Hoek-Brown强度准则未考虑中间主应力对岩石强度的影响,通过岩石真三轴试验结果分析了岩石强度的演化规律,引入中间主应力系数,量化分析主应力系数对岩石真三轴强度的影响,考虑Hoek-Brown强度准则中的参数和岩石应力水平间的关联性,提出了基于拉格朗日插值方法的修正岩石真三轴Hoek-Brown强度准则,分析了其空间包络特征。最后,利用7种岩石的真三轴试验数据与其它3种真三轴强度准则进行最优拟合误差分析,探讨了修正强度准则的合理性。研究结果表明:岩石强度随着最小主应力的增加逐渐增大,随着中间主应力的增加则呈现先增大后减小的变化规律,表现出显著的区间效应;修正强度准则不仅能够继承Hoek-Brown强度准则在子午面上的非线性优点,且能够表征岩石强度在应力空间中的基本特性;线性和非线性插值形式的修正强度准则空间包络面分别为非等边的六棱锥面以及能够满足拉压子午面区间连续光滑要求的圆锥面;修正强度准则能够较好地预测岩石真三轴试验强度,较为合理地反映中间主应力对岩石强度的影响;相比于线性插值形式强度准则,二次插值形式强度准则能够提高岩石强度的预测精度1.2~2.0倍;相较于其他真三轴强度准则,修正强度准则对不同硬脆性岩石的真三轴试验结果均具有良好的强度预测精度,体现了修正强度准则的适用性和可靠性。

基于Hoek-Brown强度准则的溶蚀作用下灰岩力学参数计算方法

Hoek-Brown强度准则广泛使用于岩石及岩体工程中,针对地下工程中灰岩围岩洞室受溶蚀作用其稳定性会降低的问题,提出一种相应的参数计算方法.基于Hoek-Brown强度准则中可描述溶蚀作用下灰岩的力学特性的地质强度指标G,构建其与卸载点值和溶蚀时间的函数方程.通过灰岩单轴压缩试验结果,并结合Flac3D软件数值模拟得出函数方程的参数.为验证计算方法的合理性,将试验结果和数值模拟结果进行对比,结果表明计算结果和试验结果吻合度高.最后归纳出G的变化率随卸载点、溶蚀时间的演化规律.上述研究成果可对溶蚀作用下的洞室围岩稳定性动态演化规律的相关计算与数值模拟提供理论支撑.

Effects of quantum noise on teleportation of arbitrary two-qubit state via five-particle Brown state

We propose a new protocol for quantum teleportation(QT)which adopts the Brown state as the quantum channel.This work focuses on the teleportation of a single unknown two-qubit state via a Brown state channel in an ideal environment.To validate the effectiveness of our proposed scheme,we conduct experiments by using the quantum circuit simulator Quirk.Furthermore,we investigate the effects of four noisy channels,namely,the phase damping noise,the bit-flip noise,the amplitude damping noise,and the phase-flip noise.Notably,we employ Monte Carlo simulation to elucidate the fidelity density under various noise parameters.Our analysis demonstrates that the fidelity of the protocol in a noisy environment is influenced significantly by the amplitude of the initial state and the noise factor.

Gapless Genome Assembly of ZH8015 and Preliminary Multi-Omics Analysis to Investigate ZH8015's Responses Against Brown Planthopper Infestation

Accurate genomic information is essential for advancing genetic breeding research in specific rice varieties.This study presented a gapless genome assembly of the indica rice cultivar Zhonghui 8015(ZH8015)using Pac Bio HiFi,Hi-C,and ONT(Oxford Nanopore Technologies)ultra-long sequencing technologies,annotating 43037 gene structures.Subsequently,utilizing this genome along with transcriptomic and metabolomic techniques,we explored ZH8015's response to brown planthopper(BPH)infestation.Continuous transcriptomic sampling indicated significant changes in gene expression levels around 48 h after BPH feeding.Enrichment analysis revealed particularly significant alterations in genes related to reactive oxygen species scavenging and cell wall formation.Metabolomic results demonstrated marked increases in levels of several monosaccharides,which are components of the cell wall and dramatic changes in flavonoid contents.Omics association analysis identified differentially expressed genes associated with key metabolites,shedding light on ZH8015's response to BPH infestation.In summary,this study constructed a reliable genome sequence resource for ZH8015,and the preliminary multi-omics results will guide future insect-resistant breeding research.

Global gene expression profiling of perirenal brown adipose tissue whitening in goat kids reveals novel genes linked to adipose remodeling

Background Brown adipose tissue(BAT)is known to be capable of non-shivering thermogenesis under cold stimulation,which is related to the mortality of animals.In the previous study,we observed that goat BAT is mainly located around the kidney at birth,and changes to white adipose tissue(WAT)in the perirenal adipose tissue of goats within one month after birth.However,the regulatory factors underlying this change is remain unclear.In this study,we systematically studied the perirenal adipose tissue of goat kids in histological,cytological,and accompanying molecular level changes from 0 to 28 d after birth.Results Our study found a higher mortality rate in winter-born goat kids,with goat birthing data statistics.Then we used thermal imaging revealing high temperature in goat hips at postnatal 0 d and gradually decrease during 28 d.This is consistent with the region of perirenal BAT deposition and highlights its critical role in energy expenditure and body temperature regulation in goat kids.Additionally,we found a series of changes of BAT during the first 28 d after birth,such as whitening,larger lipid droplets,decreased mitochondrial numbers,and down-regulation of key thermogenesis-related genes(UCP1,DIO2,UCP2,CIDEA,PPARGC1a,C/EBPb,and C/EBPa).Then,we used RNA-seq found specific marker genes for goat adipose tissue and identified 12 new marker genes for BAT and 10 new marker genes for WAT of goats.Furthermore,12 candidate genes were found to potentially regulate goat BAT thermogenesis.The mechanism of the change of this biological phenomenon does not involve a large-scale death of brown adipocytes and subsequent proliferation of white adipocytes.While apoptosis may play a limited role,it is largely not critical in this transition process.Conclusions We concluded that perirenal BAT plays a crucial role in thermoregulation in newborn goat kids,with notable species differences in the expression of adipose tissue marker genes,and we highlighted some potential marker genes for goat BAT and WAT.Additionally,the change from BAT to WAT does not involve a large-scale death of brown adipocytes and subsequent proliferation of white adipocytes.

Resistance index and browning mechanism of apple peel under high temperature stress

Apples are one of the most important economic crops worldwide.Because of global warming and an aggravation of environmental,abnormally high temperatures occur frequently in fruit-growing season and seriously affect normal fruit growth and reduce fruit quality and yield.We took five-year-old Ruixue’(Qinfu 1×Pink Lady;CNA20151469.1) fruits as test materials,and the ambient temperature during fruit development was monitored.The results showed that during the fruit-growing season,especially during the rapid growth stage (July to August),the maximum daily temperature exceeded 30℃ and lasted for more than 40 days.To determine the effects of high temperature stress on the apple fruit resistance,we treated expanding,veraison,and maturity-period fruits at different temperatures.It was found that the fruits of the expanding period showed strong resistance to high temperature stress,whereas during veraison and maturity,fruit resistance to high temperature stress decreased,and the fruit peel browning phenotype appeared.Meanwhile,the content of malonaldehyde (MDA),hydrogen peroxide (H_(2)O_(2)),and superoxide anion (O._(2)^(-)) in the peel gradually increased with increasing temperature.The content of total phenols,flavanol,and flavonoids in the peel decreased substantially at 45℃.Moreover,it was found that polyphenol oxidase gene (MdPPO1) was most sensitive to high temperature stress in apple.Furthermore,transient and stable MdPPO1 overexpression significantly promoted peel browning.The transgenic materials were more sensitive to high temperatures,and browning was more severe compared to non-genetically modified organism (WT).Stable MdPPO1 knockout calli obtained via clustered regularly interspersed short palindromic repeats (CRISPR/Cas9) gene knockout technology reduced the browning phenotype,and the resultant fruits were not sensitive to the effects of high temperature stress.Thus,MdPPO1 expression may be a key factor of high temperature-related changes observed in the browning phenotype that provides a scientific theoretical basis for the selection of high temperature-resistant varieties and apple cultivation and management in the future.

Evaluation of Resistance of Different Kiwifruit Varieties (Lines) to Canker Disease and Brown Spot Disease

Kiwifruit canker and brown spot are significant diseases affecting kiwis,caused by Pseudomonas syringae patho-genic variations(Pseudomonas syringae pv.Actinidiae(Psa))and Corynesporapolytica(Corynespora cassiicola).At present,the research on canker disease and brown spot disease mainly focuses on the isolation and identification of pathogenic bacteria,drug control,resistance gene mining and functional verification.Practice has proved that breeding disease resistant varieties are an effective method to control canker disease and brown spot disease.However,most existing cultivars lack genes for canker and brown spot resistance.Wild kiwifruit resources in nat-ure exhibit extensive genetic diversity due to prolonged natural selection,containing numerous resistance genes.But,due to insufficient understanding of the resistance of most kiwifruit varieties(lines)to canker disease and brown spot disease,some high-quality resources have not been fully utilized.The incidence of canker and brown spot of 18 kiwifruit cultivars(lines)was measured by inoculating isolated branches and leaves,and their resistance to canker and brown spot was analyzed according to the length,disease index,mean diameter,and systematic clustering.The results were as follows:Among 18 different kiwifruit varieties(lines)for canker disease,there were two highly resistant materials,eight disease-resistant materials,four disease-susceptible materials,and two highly susceptible materials.Moreover,regarding brown spot disease,there were one highly resistant material,five dis-ease-resistant materials,four susceptible materials,and three highly susceptible materials.Furthermore,four resources were resistant to both diseases.The outcomes provided a theoretical basis for breeding kiwifruit against canker and brown spot.

改良BillrothⅡ+Brown吻合与U-RY吻合在腹腔镜远端胃癌根治术中的应用效果比较

目的对比改良BillrothⅡ+Brown吻合与U-RY吻合在腹腔镜远端胃癌根治术中的临床效果。方法回顾性分析2022年3月至2023年4月于信阳市肿瘤医院肿瘤外科行腹腔镜远端胃癌根治术的123例胃癌患者临床资料,根据吻合术式分为两组,将61例采用U-RY吻合术的患者归为U-RY吻合组,62例采用改良BillrothⅡ+Brown吻合术的患者纳入改良BillrothⅡ+Brown吻合组。比较两组围手术期指标、胃肠功能恢复情况、复发率及并发症发生情况。结果改良BillrothⅡ+Brown吻合组住院时间及肠鸣音恢复时间较U-RY吻合组短(P<0.05)。两组患者术后1 a复发率比较,差异无统计学意义(P>0.05)。改良BillrothⅡ+Brown吻合组术后远期并发症发生率低于U-RY吻合组(P<0.05)。结论与U-RY吻合术相比,腹腔镜远端胃癌根治术中采用改良BillrothⅡ+Brown吻合的效果更好,可缩短患者住院时间及肠鸣音恢复时间,降低远期并发症发生风险。

Brown运动增量的小时间Chung重对数律

在本文中,我们研究了Brown运动增量的小时间参数泛函极限问题,得到了Brown运动增量的小时间Chung泛函重对数律.证明中的主要工具是Brown运动的大偏差和小偏差.

Impact of wetting-drying cycles and acidic conditions on the soil aggregate stability of yellow‒brown soil

Soil aggregate is the basic structural unit of soil,which is the foundation for supporting ecosystem functions,while its composition and stability is significantly affected by the external environment.This study was conducted to explore the effect of external environment(wetting-drying cycles and acidic conditions)on the soil aggregate distribution and stability and identify the key soil physicochemical factors that affect the soil aggregate stability.The yellow‒brown soil from the Three Gorges Reservoir area(TGRA)was used,and 8 wetting-drying conditions(0,1,2,3,4,5,10 and 15 cycles)were simulated under 4 acidic conditions(pH=3,4,5 and 7).The particle size distribution and soil aggregate stability were determined by wet sieving method,the contribution of environmental factors(acid condition,wetting-drying cycle and their combined action)to the soil aggregate stability was clarified and the key soil physicochemical factors that affect the soil aggregate stability under wetting-drying cycles and acidic conditions were determined by using the Pearson’s correlation analysis,Partial least squares path modeling(PLS‒PM)and multiple linear regression analysis.The results indicate that wetting-drying cycles and acidic conditions have significant effects on the stability of soil aggregates,the soil aggregate stability gradually decreases with increasing number of wetting-drying cycles and it obviously decreases with the increase of acidity.Moreover,the combination of wetting-drying cycles and acidic conditions aggravate the reduction in the soil aggregate stability.The wetting-drying cycles,acidic conditions and their combined effect imposes significant impact on the soil aggregate stability,and the wetting-drying cycles exert the greatest influence.The soil aggregate stability is significantly correlated with the pH,Ca^(2+),Mg^(2+),maximum disintegration index(MDI)and soil bulk density(SBD).The PLS‒PM and multiple linear regression analysis further reveal that the soil aggregate stability is primarily influenced by SBD,Ca^(2+),and MDI.These results offer a scientific basis for understanding the soil aggregate breakdown mechanism and are helpful for clarifying the coupled effect of wetting-drying cycles and acid rain on terrestrial ecosystems in the TGRA.

Expect the unexpected:Brown tumor of the mandible as the first manifestation of primary hyperparathyroidism

Hyperparathyroidism(HPT)is a condition in which one or more parathyroid glands produce increased levels of parathyroid hormone(PTH),causing disturbances in calcium homeostasis.Most commonly HPT presents with asymptomatic hypercalcemia but the clinical spectrum may include disturbances reflecting the combined effects of increased PTH secretion and hypercalcemia.Brown tumors are rare,benign,tumor-like bone lesions,occurring in 1.5%to 4.5%of patients with HPT,as a complication of an uncontrolled disease pathway,and are nowadays rarely seen in clinical practice.The tumor can appear either as a solitary or multifocal lesion and usually presents as an asymptomatic swelling or a painful exophytic mass.Furthermore,it can cause a pathological fracture or skeletal pain and be radiologically described as a lytic bone lesion.The diagnosis of a brown tumor in HPT is typically confirmed by assessing the levels of serum calcium,phosphorus,and PTH.Although when present,brown tumor is quite pathognomonic for HPT,the histologic finding often suggests a giant cell tumor,while clinical presentation might suggest other more frequent pathologies such as metastatic tumors.Treatment of brown tumors frequently focuses on managing the underlying HPT,which can often lead to regression and resolution of the lesion,without the need for surgical intervention.However,in refractory cases or when dealing with large symptomatic lesions,surgical treatment may be necessary.

Ekphrasis in Robert Browning’s “Fra Lippo Lippi”

As an ekphrastic poem re-created from the painting Coronation of the Virgin,“Fra Lippo Lippi”lacks adequate scrutiny from the perspective of interart poetics.With regards to the core concept of ekphrasis,this paper makes an in-depth analysis of the features and functions of ekphrasis in the poem.The former lie in the poet’s identification with the painter,and his imaginative supplementation in“the verbal representation of visual representation”.The latter are embodied in the revelation of the invisible in the painting,namely,the desires and value of human beings,as well as the power of beauty and truth.Browning enriches the poem with both philosophical and artistic contemplation,thus strongly conveying the thematic implications of“know thyself”and the persistent pursuit of beauty and truth.It is hoped that this study can shed some light on the studies of Robert Browning and the poem itself,and contribute to the development of the interart poetics.

一种改进的真三轴Hoek–Brown强度准则

Hoek–Brown强度准则已经广泛应用于岩石与岩体力学分析、岩石边坡稳定性分析、岩石隧道设计等领域,但常规Hoek–Brown强度准则未考虑中间主应力对岩石强度的影响,应用上不能反映岩石的真三轴力学性能,因此有必要对Hoek–Brown强度准则进行改进。通过分析岩石的真三轴试验结果,明确了岩石中间主应力对岩石强度的影响存在增强和抑制两种特征,当中间主应力大于临界值σ*2时,岩石强度被增强;当中间主应力小于临界值σ*2时,岩石强度被减弱。基于中间主应力的临界应力状态,引入中间主应力系数β,将一种2维Hoek–Brown强度准则改进为真三轴Hoek–Brown强度准则。采用非线性拟合方法确定了模型中的参数,通过对比8种岩石类型的真三轴试验数据,对改进后强度准则的精确性和普适性进行验证,并与其他3种真三轴强度准则做对比。结果表明:改进的真三轴强度准则的最佳参数m取值均能落在Hoek和Brown建议的取值区间,能够继承Hoek–Brown强度准则的优点。改进后的强度准则对8种岩石类型的均方根差(RMSE)均低于另外3种准则,能够准确预测岩石强度,且适用于大多数岩石类型,较好地体现了中间主应力对岩石强度的影响;Pan–Hudson准则总是在低σ2条件下高估岩石强度值,在高σ2条件下低估岩石强度值;Zhang–Zhu和Priest准则对岩石类型具有较强依赖性,描述精度较差。因此,改进的真三轴Hoek–Brown强度准则具有重要的应用推广价值。

基于约束收敛法的Hoek-Brown岩体巷道大变形分析

轴对称圆形巷道的弹塑性理论分析是深部软岩巷道施工过程的基础问题和重要问题。基于约束收敛法、有限变形次弹塑性理论、Hoek-Brown破坏准则、应变软化本构模型等基本理论,开展了深埋软弱围岩圆形巷道开挖诱致挤压大变形现象的基础研究。在相关大变形研究的基础上,以巷道开挖后围岩脆塑性解析解来表征岩体应变软化区划分圆环岩体响应解析解的方法,简述Hoek-Brown岩体深埋软岩巷道围岩各分区应力与变形解析解求解思路。通过现场监测数据和不同力学模型的计算结果分别进行模型有效性对比验证,并对m、s、a等岩体强度相关参数进行了影响分析。基于大变形和小变形理论下围岩特征曲线差别,提出软弱破碎岩体的支护建议,为深部不利赋存条件下软弱围岩支护工程设计提供理论分析手段和指导。

西澳大利亚新元古代Browne组-Hussar组旋回地层学研究

旋回地层学研究目前主要集中在显生宙,对于占据地球历史绝大部分时期的前寒武纪,相关研究较为薄弱。西澳大利亚的Officer盆地具有新元古代中期(约800 Ma)良好的地层沉积记录。Lancer 1井位于Officer盆地的西部,岩心底部包含新元古代Browne组—Hussar组约750 m的连续沉积地层,岩性以砂岩和泥岩互层为主,偶见白云岩夹层,是开展前寒武纪旋回地层学研究的理想材料。本文以自然伽马测井数据作为古气候替代性指标,通过频谱分析等方法进行了旋回地层学分析,结果表明Hussar组940~1200 m泥岩段的伽马测井数据记录了完整的米兰科维奇旋回,长偏心率、短偏心率、斜率和岁差控制的地层旋回厚度分别为34、8~10、1.8~2.7和1.2~1.4 m。以构建的长偏心率周期(405 ka)标准曲线对该泥岩段进行天文年代校准,建立了浮动天文年代标尺,估计了约800 Ma的长偏心率、短偏心率、斜率和岁差周期分别为405、127、27~34和15.2~18.1 ka。此外,根据斜率周期(27±0.7)ka计算出当时的地月距离为(362935±1495)km,日长为(20.56±0.2)h。这一研究将填补新元古代早—中期(约800 Ma时期)旋回地层学研究的空白,为前寒武纪地月系统演化提供数据支持。

基于Hoek-Brown准则的岩体力学参数确定

国内外岩体力学参数测定的方法多不胜数,其中室内岩石力学参数试验法能较准确地确定岩体各类参数。以昆阳某磷矿为工程背景,进行现场采样并制备标准试件,分别对顶板、磷矿层以及底板岩样进行室内岩石物理力学参数试验。为提高参数结果的准确性,以及使数据更接近工程实际情况,将采用Hoek-Brown准则对参数计算结果进行折减,并进一步对经验准则中引入的扰动系数D、地质强度指标GSI以及完整岩石材料常数mi的取值进行分析。经过折减后,其结果表明,经折减后的力学参数综合考虑了更多的现场因素,使试验结果更准确,提高了后续现场相关工作的准确性。