The aim of this paper is to detect, prevent and resolve DRP （drug-related problems） and NOM （negative outcomes associated with medication） in hospitalized patients with DM2 （type 2 diabetes） with HTN （hypertens...The aim of this paper is to detect, prevent and resolve DRP （drug-related problems） and NOM （negative outcomes associated with medication） in hospitalized patients with DM2 （type 2 diabetes） with HTN （hypertension） in a tertiary care clinic. Descriptive cross-sectional interventional study is used. DTM （drug therapy monitoring） was conducted in 73 patients using data obtained from clinical histories and interviews. NOM were detected based on symptoms and laboratory test results. The statistical significance was 0.05. It can be found that 23 DRP were detected, primarily in the category ＂likelihood of adverse effects＂ （30.43%） causing NOM in the ＂non-quantitative safety problem＂ category. The NOM detected were related to safety （62%）, effectiveness （24.5%） and necessity （13.5%）. Of the 68.57% of pharmacist interventions accepted, 48.57% were resolved and 20% were not resolved. A simple linear correlation （r = -0.34） analysis indicated a weak association between patient age and severity ofNOM. DTM made it＇possible to detect suspected DRP and NOM, which were then prevented or resolved, improving the control of HTN and DM2 and helping ensure better drug therapy outcomes for patients.展开更多
Objective: To analyze the inductive agents, post-surgical managements and precautions of the serious complications caused by transcatheter arterial chemoembolization (TACE) for the treatment of hepatocellular carcinom...Objective: To analyze the inductive agents, post-surgical managements and precautions of the serious complications caused by transcatheter arterial chemoembolization (TACE) for the treatment of hepatocellular carcinoma. Methods: Clinical data of 2 375 cases of TACE for 832 patients with middle-stage or advanced hepatocellular carcinoma from January 1994 to December 2002 were analyzed. Results: There were 7 cases of serious complications, one of which was liver carcinoma rupture and another was acute renal failure. Totally there were 4 cases of paraplegia and one case of conduit knotted. Conclusion: Deadly complications may happen after TACE and it needs close surveillance and management in time.展开更多
目的 评价药物联合康复治疗对高血压性脑出血的疗效。方法 目的选取滕州市工人医院神经内科于2022年4月—2023年4月收治的76例高血压性脑出血患者为研究对象,按照治疗方式不同,分为药物组和康复组,每组28例。药物组接受药物治疗,康复组...目的 评价药物联合康复治疗对高血压性脑出血的疗效。方法 目的选取滕州市工人医院神经内科于2022年4月—2023年4月收治的76例高血压性脑出血患者为研究对象,按照治疗方式不同,分为药物组和康复组,每组28例。药物组接受药物治疗,康复组接受药物联合康复治疗,比较两组的神经系统功能评分和日常生活能力评分,以及并发症的发生率的差异。结果 康复组治疗后的美国国立卫生研究院卒中量表评分(National Institute of Health Stroke Scale,NIHSS)小于药物组,差异有统计学意义(P<0.05);日常生活能力量表(Activity of Daily Living Scale,ADL)评分大于药物组,差异有统计学意义(P<0.05);康复组无并发症发生,药物组的并发症发生率为15.79%(6/38),差异有统计学意义(χ^(2)=4.607,P=0.031)。结论 药物联合康复治疗下的高血压性脑出血患者,神经功能得到改善,日常生活能力较好,并且发生并发症的概率较小。药物联合康复治疗对于高血压性脑出血的患者较适用。展开更多
目的:分析凝血功能、纤溶指标在妊娠高血压中的表达及给予联合用药后的变化。方法:选择本院2021年8月至2022年8月收治的妊娠期高血压患者84例为观察组,在同一时期选择于本院就诊的健康孕妇84例为对照组,检测并对比观察组及对照组的凝血...目的:分析凝血功能、纤溶指标在妊娠高血压中的表达及给予联合用药后的变化。方法:选择本院2021年8月至2022年8月收治的妊娠期高血压患者84例为观察组,在同一时期选择于本院就诊的健康孕妇84例为对照组,检测并对比观察组及对照组的凝血功能、纤溶指标,之后根据患者高血压严重程度将观察组划分为轻度高血压(n=28)、中度高血压(n=28)以及子痫前期(n=28),对比不同高血压严重程度患者的凝血功能以及纤溶指标,最后给予观察组药物治疗,对比联合用药前、后观察组患者凝血功能、纤溶指标变化情况,借助受试者工作(receiver operating characteristic,ROC)曲线评估诊断效能。结果:两组受试者凝血功能、纤溶指标对比差异有统计学意义(P<0.05)。与治疗前相比,治疗后三组高血压患者的凝血功能、纤溶指标均有所下降,三组高血压患者凝血功能以及纤溶指标对比差异有统计学意义(P<0.05)。ROC曲线分析结果显示,PT的曲线下面积(area under curve,AUC)为1.000,其灵敏度以及特异度分别为100.00%、100.00%,高于其他指标检测的水平。结论:凝血、纤溶指标与妊娠期高血压发病之间存在密切关系,能够为早期妊娠期高血压患者的诊断、治疗提供数据参考,并在治疗后期起到评估预后的作用。展开更多
BACKGROUND： Patients with hypertension coupled with metabolic syndrome （MetS） are among the high risk population in cardiovascular and cerebrovascular diseases. To reduce the prevalence of cardiovascular and cerebr...BACKGROUND： Patients with hypertension coupled with metabolic syndrome （MetS） are among the high risk population in cardiovascular and cerebrovascular diseases. To reduce the prevalence of cardiovascular and cerebrovascular diseases, it is essential to appropriately control b^ood pressure together with other cardiovascular risk factors. OBJECTIVE： The current study was designed to investigate the therapeutic effects on blood pressure, blood pressure variability and other cardiovascular risk factors by giving Yiqi Huaju Formula, a compound traditional Chinese herbal medicine, in addition to routine treatment to hypertensive patients coupled with MetS. DESIGN, SETTING, PARTICIPANTS AND INTERVENTIONS： A total of 43 patients with hypertension coupled with MetS were recruited into this study. The enrolled patients were randomly divided into the Chinese herbal formula group （anti-hypertensive drugs plus Yiqi Huaju Formula, CHF） and the control group （anti-hypertensive drugs plus placebo）. The CHF group enrolled 22 patients while the control group received 21 cases. Treatments were given for 12 weeks in both groups. MAIN OUTCOME MEASURES： Parameters examined include 24-hour ambulatory blood pressure monitoring, body mass index, waist circumference, waist-to-hip ratio, homeostatic model assessment for insulin resistance （HOMA-IR）, fasting glycosylated hemoglobin （HbAlc）, fasting plasma glucose, 2-hour postprandial plasma glucose （PPG）, fasting plasma insulin, serum lipid, etc. RESULTS： Compared with the control group, the CHF group had significant improvement （P〈0.01） in anthropometric parameters, FPG, HOMA-IR, blood pressure amplitude, blood pressure variability and blood pressure load. CONCLUSION： This study showed that integrated traditional Chinese and Western medicine treatment can achieve better results in controlling blood pressure as well as other cardiovascular risk factors. The mechanism of controlling of blood pressure may be associated with the improvement of insulin sensitivity due to the Yiqi Huaju intervention. TRIAL REGISTRATION IDENTIFIER： ChiCTR-TRC-11001633.展开更多
文摘The aim of this paper is to detect, prevent and resolve DRP （drug-related problems） and NOM （negative outcomes associated with medication） in hospitalized patients with DM2 （type 2 diabetes） with HTN （hypertension） in a tertiary care clinic. Descriptive cross-sectional interventional study is used. DTM （drug therapy monitoring） was conducted in 73 patients using data obtained from clinical histories and interviews. NOM were detected based on symptoms and laboratory test results. The statistical significance was 0.05. It can be found that 23 DRP were detected, primarily in the category ＂likelihood of adverse effects＂ （30.43%） causing NOM in the ＂non-quantitative safety problem＂ category. The NOM detected were related to safety （62%）, effectiveness （24.5%） and necessity （13.5%）. Of the 68.57% of pharmacist interventions accepted, 48.57% were resolved and 20% were not resolved. A simple linear correlation （r = -0.34） analysis indicated a weak association between patient age and severity ofNOM. DTM made it＇possible to detect suspected DRP and NOM, which were then prevented or resolved, improving the control of HTN and DM2 and helping ensure better drug therapy outcomes for patients.
文摘Objective: To analyze the inductive agents, post-surgical managements and precautions of the serious complications caused by transcatheter arterial chemoembolization (TACE) for the treatment of hepatocellular carcinoma. Methods: Clinical data of 2 375 cases of TACE for 832 patients with middle-stage or advanced hepatocellular carcinoma from January 1994 to December 2002 were analyzed. Results: There were 7 cases of serious complications, one of which was liver carcinoma rupture and another was acute renal failure. Totally there were 4 cases of paraplegia and one case of conduit knotted. Conclusion: Deadly complications may happen after TACE and it needs close surveillance and management in time.
文摘目的 评价药物联合康复治疗对高血压性脑出血的疗效。方法 目的选取滕州市工人医院神经内科于2022年4月—2023年4月收治的76例高血压性脑出血患者为研究对象,按照治疗方式不同,分为药物组和康复组,每组28例。药物组接受药物治疗,康复组接受药物联合康复治疗,比较两组的神经系统功能评分和日常生活能力评分,以及并发症的发生率的差异。结果 康复组治疗后的美国国立卫生研究院卒中量表评分(National Institute of Health Stroke Scale,NIHSS)小于药物组,差异有统计学意义(P<0.05);日常生活能力量表(Activity of Daily Living Scale,ADL)评分大于药物组,差异有统计学意义(P<0.05);康复组无并发症发生,药物组的并发症发生率为15.79%(6/38),差异有统计学意义(χ^(2)=4.607,P=0.031)。结论 药物联合康复治疗下的高血压性脑出血患者,神经功能得到改善,日常生活能力较好,并且发生并发症的概率较小。药物联合康复治疗对于高血压性脑出血的患者较适用。
文摘目的:分析凝血功能、纤溶指标在妊娠高血压中的表达及给予联合用药后的变化。方法:选择本院2021年8月至2022年8月收治的妊娠期高血压患者84例为观察组,在同一时期选择于本院就诊的健康孕妇84例为对照组,检测并对比观察组及对照组的凝血功能、纤溶指标,之后根据患者高血压严重程度将观察组划分为轻度高血压(n=28)、中度高血压(n=28)以及子痫前期(n=28),对比不同高血压严重程度患者的凝血功能以及纤溶指标,最后给予观察组药物治疗,对比联合用药前、后观察组患者凝血功能、纤溶指标变化情况,借助受试者工作(receiver operating characteristic,ROC)曲线评估诊断效能。结果:两组受试者凝血功能、纤溶指标对比差异有统计学意义(P<0.05)。与治疗前相比,治疗后三组高血压患者的凝血功能、纤溶指标均有所下降,三组高血压患者凝血功能以及纤溶指标对比差异有统计学意义(P<0.05)。ROC曲线分析结果显示,PT的曲线下面积(area under curve,AUC)为1.000,其灵敏度以及特异度分别为100.00%、100.00%,高于其他指标检测的水平。结论:凝血、纤溶指标与妊娠期高血压发病之间存在密切关系,能够为早期妊娠期高血压患者的诊断、治疗提供数据参考,并在治疗后期起到评估预后的作用。
基金supported by grants from the National Traditional Chinese Medicine Administration Bureau, Chinathe project of Science and Technology Commission of Shanghai Municipality(No.08dj 1400600),Shanghaithe National Natural Science Foundation(No.81001574)
文摘BACKGROUND： Patients with hypertension coupled with metabolic syndrome （MetS） are among the high risk population in cardiovascular and cerebrovascular diseases. To reduce the prevalence of cardiovascular and cerebrovascular diseases, it is essential to appropriately control b^ood pressure together with other cardiovascular risk factors. OBJECTIVE： The current study was designed to investigate the therapeutic effects on blood pressure, blood pressure variability and other cardiovascular risk factors by giving Yiqi Huaju Formula, a compound traditional Chinese herbal medicine, in addition to routine treatment to hypertensive patients coupled with MetS. DESIGN, SETTING, PARTICIPANTS AND INTERVENTIONS： A total of 43 patients with hypertension coupled with MetS were recruited into this study. The enrolled patients were randomly divided into the Chinese herbal formula group （anti-hypertensive drugs plus Yiqi Huaju Formula, CHF） and the control group （anti-hypertensive drugs plus placebo）. The CHF group enrolled 22 patients while the control group received 21 cases. Treatments were given for 12 weeks in both groups. MAIN OUTCOME MEASURES： Parameters examined include 24-hour ambulatory blood pressure monitoring, body mass index, waist circumference, waist-to-hip ratio, homeostatic model assessment for insulin resistance （HOMA-IR）, fasting glycosylated hemoglobin （HbAlc）, fasting plasma glucose, 2-hour postprandial plasma glucose （PPG）, fasting plasma insulin, serum lipid, etc. RESULTS： Compared with the control group, the CHF group had significant improvement （P〈0.01） in anthropometric parameters, FPG, HOMA-IR, blood pressure amplitude, blood pressure variability and blood pressure load. CONCLUSION： This study showed that integrated traditional Chinese and Western medicine treatment can achieve better results in controlling blood pressure as well as other cardiovascular risk factors. The mechanism of controlling of blood pressure may be associated with the improvement of insulin sensitivity due to the Yiqi Huaju intervention. TRIAL REGISTRATION IDENTIFIER： ChiCTR-TRC-11001633.
