Deciphering the molecular mechanisms of Simiaowan in the treatment of hyperuricemia: in vivo and in silico approaches

Background:Simiaowan(SMW),a well-known traditional Chinese medicine,has been employed to treat hyperuricemia(HUA)and gout for centuries.However,the bioactive components and underlying mechanisms have not been elucidated.The objective of this study was to identify the active components and potential mechanisms of SMW by integrating pharmacological experimentation,serum pharmacochemistry,network pharmacology and molecular docking.Methods:HUA rats modelling by high-fat/high-sugar diet and potassium oxonate/adenine oral administration were used to evaluate the pharmacodynamic effects of SMW.UPLC-Q-Exactive-MS/MS was employed to detect the bioactive components present in SMW-containing serum.Network pharmacology and molecular docking were utilized to elucidate the potential targets and underlying mechanisms.Results:SMW effectively ameliorated HUA rats via the inhibition of uric acid(UA)production,promotion of UA excretion,improvement of lipid and glucose metabolic abnormalities,antioxidant,anti-inflammatory and anti-insulin resistance effects.A total of 73 compounds detected in SMW-containing serum were identified as potential active components,with alkaloids,flavonoids,organic acids,and terpenoids emerging as the primary active ingredients.Totally 203 corresponding targets were obtained as SMW anti-HUA/gout targets,which mainly participated in apoptosis,insulin resistance,TNF,PI3K-Akt,HIF-1,NF-κB,MAPK,IL-17 and TLR signaling pathways.Molecular docking indicated that active compounds(e.g.berberine,phellodendrine,quercetin,formononetin,ferulic acid)had superior binding abilities to the key targets(e.g.solute carrier family 22 member 12(URAT1),solute carrier family 22 member 6(OAT1),ATP-binding cassette sub-family G member 2(ABCG2),solute carrier family 2,facilitated glucose transporter member 9(GLUT9),xanthine dehydrogenase/oxidase(XDH),transcription factor p65(RELA),toll-like receptor 4(TLR4),prostaglandin G/H synthase 2(PTGS2),caspase-3(CASP3),insulin(INS)).Conclusion:SMW exerted regulatory influence over the disease network of HUA and gout through a multiplicity of components,targets,and pathways.Alkaloids,flavonoids,organic acids,and terpenoids were the primary active components,exerting anti-HUA/gout effects via antioxidant,anti-inflammatory,anti-insulin resistance,anti-apoptosis,inhibition of UA production,and promotion of UA excretion.This study revealed the active components and molecular mechanisms of SMW,providing insights into the development of natural products derived from SMW.

Leech Poecilobdella manillensis protein extract ameliorated hyperuricemia by restoring gut microbiota dysregulation and affecting serum metabolites

BACKGROUND Hyperuricemia(HUA)is a public health concern that needs to be solved urgently.The lyophilized powder of Poecilobdella manillensis has been shown to significantly alleviate HUA;however,its underlying metabolic regulation remains unclear.AIM To explore the underlying mechanisms of Poecilobdella manillensis in HUA based on modulation of the gut microbiota and host metabolism.METHODS A mouse model of rapid HUA was established using a high-purine diet and potassium oxonate injections.The mice received oral drugs or saline.Additionally,16S rRNA sequencing and ultra-high performance liquid chromatography with quadrupole time-of-flight mass spectrometry-based untargeted metabolomics were performed to identify changes in the microbiome and host metabolome,respectively.The levels of uric acid transporters and epithelial tight junction proteins in the renal and intestinal tissues were analyzed using an enzyme-linked immunosorbent assay.RESULTS The protein extract of Poecilobdella manillensis lyophilized powder(49 mg/kg)showed an enhanced anti-trioxypurine ability than that of allopurinol(5 mg/kg)(P<0.05).A total of nine bacterial genera were identified to be closely related to the anti-trioxypurine activity of Poecilobdella manillensis powder,which included the genera of Prevotella,Delftia,Dialister,Akkermansia,Lactococcus,Escherichia_Shigella,Enterococcus,and Bacteroides.Furthermore,22 metabolites in the serum were found to be closely related to the anti-trioxypurine activity of Poecilobdella manillensis powder,which correlated to the Kyoto Encyclopedia of Genes and Genomes pathways of cysteine and methionine metabolism,sphingolipid metabolism,galactose metabolism,and phenylalanine,tyrosine,and tryptophan biosynthesis.Correlation analysis found that changes in the gut microbiota were significantly related to these metabolites.CONCLUSION The proteins in Poecilobdella manillensis powder were effective for HUA.Mechanistically,they are associated with improvements in gut microbiota dysbiosis and the regulation of sphingolipid and galactose metabolism.

Andrias davidianus bone peptides alleviates hyperuricemia-induced kidney damage in vitro and in vivo

Hyperuricemia(HUA)is a vital risk factor for chronic kidney diseases(CKD)and development of functional foods capable of protecting CKD is of importance.This paper aimed to explore the amelioration effects and mechanism of Andrias davidianus bone peptides(ADBP)on HUA-induced kidney damage.In the present study,we generated the standard ADBP which contained high hydrophobic amino acid and low molecular peptide contents.In vitro results found that ADBP protected uric acid(UA)-induced HK-2 cells from damage by modulating urate transporters and antioxidant defense.In vivo results indicated that ADBP effectively ameliorated renal injury in HUA-induced CKD mice,evidenced by a remarkable decrease in serum UA,creatinine and blood urea nitrogen,improving kidney UA excretion,antioxidant defense and histological kidney deterioration.Metabolomic analysis highlighted 14 metabolites that could be selected as potential biomarkers and attributed to the amelioration effects of ADBP on CKD mice kidney dysfunction.Intriguingly,ADBP restored the gut microbiome homeostasis in CKD mice,especially with respect to the elevated helpful microbial abundance,and the decreased harmful bacterial abundance.This study demonstrated that ADBP displayed great nephroprotective effects,and has great promise as a food or functional food ingredient for the prevention and treatment of HUA-induced CKD.

A novel strain of Levilactobacillus brevis PDD-5 isolated from salty vegetables has beneficial effects on hyperuricemia through anti-inflammation and improvement of kidney damage

Hyperuricemia is a metabolic disorder caused by abnormal purine metabolism,resulting in abnormally high serum uric acid.In this study,a novel Levilactobacillus brevis PDD-5 isolated from salty vegetables was verified with the function of alleviating hyperuricemia.The relevant effects of L.brevis PDD-5 in lowering uric acid were analyzed by in vitro and in vivo experiments.The results showed that the L.brevis PDD-5 has(68.86±15.46)%of inosine uptake capacity and(95.75±3.30)%of guanosine uptake capacity in vitro.Oral administration of L.brevis PDD-5 to hyperuricemia rats reduced uric acid,creatinine,and urea nitrogen in serum,as well as decreased inosine and guanosine levels in the intestinal contents of rats.Analysis of relevant markers in the kidney by ELISA kits revealed that L.brevis PDD-5 alleviated oxidative stress and inflammation.Moreover,the gene expression of uric acid transporter 1(URAT1)and glucose transporter 9(GLUT9)was down-regulated,and the gene expression of organic anion transporter 1(OAT1)was up-regulated after treatment with L.brevis PDD-5.Western blot analysis showed that L.brevis PDD-5 alleviated hyperuricemia-induced kidney injury through the NLRP3 pathway.The se findings suggest that L.brevis PDD-5 can lower uric acid,repair kidney damage,and also has the potential to prevent uric acid nephropathy.

Elucidating the role of gut microbiota dysbiosis in hyperuricemia and gout:Insights and therapeutic strategies

Hyperuricemia(HUA)is a condition associated with a high concentration of uric acid(UA)in the bloodstream and can cause gout and chronic kidney disease.The gut microbiota of patients with gout and HUA is significantly altered compared to that of healthy people.This article focused on the complex interconnection between alterations in the gut microbiota and the development of this disorder.Some studies have suggested that changes in the composition,diversity,and activity of microbes play a key role in establishing and progressing HUA and gout pathogenesis.Therefore,we discussed how the gut microbiota contributes to HUA through purine metabolism,UA excretion,and intestinal inflammatory responses.We examined specific changes in the composition of the gut microbiota associated with gout and HUA,highlighting key bacterial taxa and the metabolic pathways involved.Additionally,we discussed the effect of conventional gout treatments on the gut microbiota composition,along with emerging therapeutic approaches that target the gut microbiome,such as the use of probiotics and prebiotics.We also provided insights into a study regarding the gut microbiota as a possible novel therapeutic intervention for gout treatment and dysbiosis-related diagnosis.

Food-derived bio-functional peptides for the management of hyperuricemia and associated mechanism

Hyperuricemia,a metabolic disorder related to uric acid metabolism dysregulation,has become a common metabolic disease worldwide,due to changes in lifestyle and dietary structure.In recent years,owing to their high activity and few adverse effects,food-derived active peptides used as functional foods against hyperuricemia have attracted increasing attention.This article aims to focus on the challenge associated with peptide-specific preparation methods development,functional components identification,action mechanism(s)clarification,and bioavailability improvement.The current review proposed recent advances in producing the food-derived peptides with high anti-hyperuricemia activity by protein source screening and matched enzymatic hydrolysis condition adjusting,increased the knowledge about strategies to search antihyperuricemia peptides with definite structure,and emphasized the necessity of combining computer-aided approaches and activity evaluations.In addition,novel action mechanism mediated by gut microbiota was discussed,providing different insights from classical mechanism.Moreover,considering that little attention was paid previously on the structure-activity relationships of anti-hyperuricemia peptides,we collected the sequences from published studies and make a preliminary summary about the structure-activity relationships,which in turn provided guides for enzymatic hydrolysis optimization and bioavailability improvement.Hopefully,this article could promote the development,application and commercialization of food-derived anti-hyperuricemia peptides in the future.

Lacticaseibacillus rhamnosus Fmb14 ameliorates hyperuricemia-induced hepatocyte pyroptosis via NLRP3 inflammasome cascade inhibition

Hyperuricemia is a high-risk factor for the development of gout and renal fibrosis,but the adverse effects of hyperuricemia on the liver have been seriously neglected.This research investigated the ameliorating effect of Lacticaseibacillus rhamnosus Fmb14 on hyperuricemia induced liver dysfunction both in vitro and in vivo.Cell free extracts of high dose L.rhamnosus Fmb14 treatment reduced the death rate of HepG2 cell lines from 24.1%to 14.9%by inhibiting NLRP3 recruitment,which was mainly activated by reactive oxygen species release and mitochondrial membrane potential disorder.In purine dietary induced hyperuricemia(PDIH)mice model,liver oedema and pyroptosis were ameliorated after L.rhamnosus Fmb14 administration through downregulating the expression levels of NLRP3,caspase-1 and gasdermin-D from 1.61 to 0.86,3.15 to 1.01 and 5.63 to 2.02,respectively.L.rhamnosus Fmb14 administration restored mitochondrial inner membrane protein(MPV17)and connexin 43 from 2.83 and 0.73 to 0.80 and 0.98 respectively in PDIH mice,indicating that dysbiosis of mitochondrial membrane potential was restored in liver.Intriguingly,PDIH pyroptosis stimulates the process of apoptosis,which leads to severe leakage of hepatocytes,and both of pyroptosis and apoptosis were decreased after L.rhamnosus Fmb14 treatment.Therefore,L.rhamnosus Fmb14 is a promising biological resource to maintain homeostasis of the liver in hyperuricemia and the prevention of subsequent complications.

Roles of traditional Chinese medicine extracts in hyperuricemia and gout treatment:Mechanisms and clinical applications

In this manuscript,we comment on the article by Liu et al published in the recent issue of the journal.Hyperuricemia(HUA)has become the second most common metabolic disease after type 2 diabetes mellitus and is the most important risk factor for gout.This discussion focuses on the targets and clinical application value of traditional Chinese medicine(TCM)extracts in the treatment of HUA and gout,emphasizing the role of gut microbiota.Liu et al’s study demonstrated that Poecilobdella manillensis protein extract alleviated HUA through multiple mechanisms,including inhibition of uric acid(UA)reabsorption,promotion of UA excretion,repair of intestinal barrier function,and regulation of gut microbiota and metabolome.Unlike the commonly used urate-lowering drugs such as allopurinol and febuxostat,which have clear and single targets,many TCMs have multi-target effects.However,the active components and mechanisms of TCMs are not fully understood,limiting their clinical application in the treatment of HUA and gout.Additionally,the role of gut microbiota in UA metabolic homeostasis needs to be further explored.

Efficacy and safety of Liqingtong granules in the treatment of hyperuricemia:A randomized double-blind placebo-controlled pilot clinical trial

Objective:To investigate the efficacy and safety of Liqingtong(LQT)granules in patients with dampness-heat hyperuricemia.Methods:A randomized,double-blind,placebo-controlled pilot trial was conducted at the 983rd Hos-pital of the Joint Logistic Support Force of the People's Liberation Army from March 15,2023,to August 10,2023.In total,119 participants were enrolled in this trial,and participants were given either LQT granules or placebo for 60 days based on a health education.The primary outcome was serum uric acid(SUA)level,and the secondary outcome was the traditional Chinese medicine(TCM)symptom score,measured on days 0,30,and 60.Safety indicators,including liver function,kidney function,blood routine,glucose,blood lipid,blood pressure,and heart rate were tested on days 0 and 60 of the trial.The data were analyzed using Prism 9 software,and the significance level was set at P<0.05.Results:Among 119 participants,six in the LQT granule group and seven in the placebo group dropped out,and 106 participants completed clinical observation.Baseline information,including SUA levels,TCM symptom scores,and other clinical characteristics,did not differ between the groups.At the end of the trial,compared with baseline values,the SUA levels in the LQT granule group decreased(P<0.001),and no significant change was observed in the placebo group(P=0.422);compared with the placebo group,the SUA levels decreased in the LQT granule group(P=0.001).Compared with baseline values,the total TCM symptom scores in the LQT granule group decreased(P<0.001),with no change in the placebo group(P=0.136).Safety indicators did not differ significantly between the two groups.Conclusion:The pilot trial demonstrated the potential of LQT granules to lower SUA levels and improve symptoms of dampness and heat.

Effect of dapagliflozin on uric acid in patients with chronic heart failure and hyperuricemia

BACKGROUND Patients with chronic heart failure(CHF)frequently develop hyperuricemia,an elevated serum uric acid level,associated with adverse outcomes.Dapagliflozin,a sodium-glucose cotransporter-2 inhibitor,demonstrates reduction in cardiovascular mortality and hospitalization in patients with CHF and ejection fraction(HFrEF),irrespective of diabetes.However,dapagliflozin’s effect on the uric acid levels in patients with CHF and hyperuricemia remain unclear.AIM To investigate the effects of dapagliflozin on uric acid levels in CHF patients with hyperuricemia.METHODS We conducted a randomized,double-blind,placebo-controlled trial in 200 patients with CHF and hyperuricemia,with HFrEF and serum uric acid levels≥7 mg/dL(≥416μmol/L).The participants were randomly assigned to receive a daily dose of 10 mg dapagliflozin or placebo for 24 months.The primary endpoint was the change in serum uric acid level from baseline to 24 months.Secondary endpoints included changes in left ventricular ejection fraction(LVEF),Nterminal pro-B-type natriuretic peptide(NT-proBNP),and quality of life(QoL)scores,as well as the incidence of cardiovascular death and hospitalization for heart failure.RESULTS At 24 months,dapagliflozin significantly reduced serum uric acid levels by 1.2 mg/dL(71μmol/L)compared with placebo(95%CI:-1.5 to-0.9;P<0.001).Dapagliflozin also significantly improved LVEF by 3.5%(95%CI:2.1-4.9;P<0.001),NT-proBNP by 25%(95%CI:18-32;P<0.001),and QoL scores by 10 points(95%CI:7-13;P<0.001)and reduced the risk of cardiovascular death and hospitalization for heart failure by 35%(95%CI:15–50;P=0.002)compared with the placebo.Adverse events were similar between the two groups,except for a higher rate of genital infections in the dapagliflozin group(10%vs 2%,P=0.01).CONCLUSION Dapagliflozin significantly lowered serum uric acid levels and improved the clinical outcomes in patients with CHF and hyperuricemia.Therefore,dapagliflozin may be a useful therapeutic option for this high-risk population.

Potential of traditional Chinese medicine lyophilized powder of Poecilobdella manillensis in the treatment of hyperuricemia

Traditional Chinese medicine has a long and illustrious history,and with the development of modern science and technology,the research and application of traditional Chinese medicines have continued to progress significantly.Many traditional Chinese medicinal herbs have undergone scientific validation,reinvi-gorating with new life and vitality,and contributing unique strengths to the advancement of human health.Recently,the discovery that leech total protein extracted from Poecilobdella manillensis lyophilized powder reduces blood uric acid(UA)levels by inhibiting the activity of xanthine oxidase to decrease UA synthesis and promotes UA excretion by regulating different UA transporters in the kidney and intestine has undoubtedly injected new vitality and hope into this field of research.The purpose of this editorial is to comment on this study,explore its strengths and weaknesses,and there is a hope to treat a range of metabolic-related syndromes,including hyperuricemia,by targeting the gut microbiota.

Study on the processing technology of Polygonatum cyrtonema Hua decoction pieces based on softening method and drying method

Background:To optimize the steaming processing technology of Polygonatum cyrtonema Hua(PC)decoction pieces.Methods:The softening method and drying method of PC decoction pieces were studied with Polygonatum Polysaccharide(PCP),diosgenin combined extract as quantitative indexes.The process parameters such as softening time,drying temperature and drying time were determined,and the best processing technology of PC decoction pieces was optimized.Results:Among the three softening methods of PC,the infiltration method had the highest ranking,with an average comprehensive index of 0.9496,and the softening effect was the best.Among the three drying methods,the drying effect of the hot air drying method was the best,and the average comprehensive index was 0.8233.Conclusion:The infiltration method is the best softening method for PC decoction pieces,and the hot air drying method is the best drying method for PC decoction pieces.

Effects of different processing methods on the quality of Polygonatum cyrtonema Hua

Background:In this study,we explored the effects of different processing methods on the quality of Polygonatum cyrtonema Hua(PC),and the role of Huangjiu in the processing procedure.Methods:The sensory characteristics of the crude product,steamed product,and wine-processed product of PC were described.The colorimeter was used to analyze the chromatic values of three different processed products on PC.At the same time,the contents of the water extract and alcohol extract were measured separately.The content of three different processing Polygonatum Polysaccharide(PCP)was determined using 0.2%anthrone-sulfuric acid.The correlation difference between the chromatic values and chemical composition of different PC products was analyzed using various analytical methods.Results:The surface colors gradually deepened,the sweetness increased,the viscosity strengthened,and the tongue-numbing sensation disappeared after PC processing.The contents of extract and L^(*) gradually decreased from the crude to the steamed to the wine-processed product,consistent with the pattern of surface color alteration.While,E^(*)ab gradually increased.The content of PCP was crude product>wine-processed product>steamed product.The results of multivariate statistical analysis showed that the samples processed for crude,steamed,and wine-processed product were clustered into three classes.The correlation analysis showed that L^(*)and E^(*)ab were highly significant positively correlated with the content of PCP,and a*was significantly negatively correlated with the content of PCP.Conclusion:The results showed that the wine-processed product had the best quality.The internal quality of the PC was correlated with its characteristics and chromatic value.In this study,we investigated the internal and external quality of three different products of PC in order to provide a reference for further research on the impact of different processing methods on PC quality,the standardization of PC processing,and the role of Huangjiu in the processing of PC.

一年生中林系号杨树全秆带皮材制浆造纸性能的研究——第一部分:KP法和KP+hua法蒸煮制漂白化学浆的研究

本文探讨了高密度超短轮伐期栽培的一年生中林系号杨树全秆带皮材的制浆造纸性能及经济利用价值,并对蒸煮条件的确定及KP法和KP+hua(磺化剂)蒸煮历程进行了研究。试验结果表明:可用一年生中林系号杨树全秆带皮材蒸煮制漂白化学浆;KP法和KP+hua法是适宜的蒸煮方法,而且后者好于前者;其漂白浆的质量达到生产文化用纸的要求。

第四类Hua结构的Bergman核函数

本文给出了第四类Hua结构的Bergman核函数及其全纯自同构群．

一类Hua Construction的Bergman核函数

给出了一类Hua constructin的Bergman核函数及其全纯自同构群.

2型糖尿病并发高尿酸血症患者血尿酸与粒淋比、γ-谷氨酰转肽酶的相关性及HUA发生的因素

目的研究2型糖尿病并发高尿酸血症患者血尿酸与粒淋比和γ-谷氨酰转肽酶的相关性及高尿血酸症发生的影响因素。方法选取江苏省常熟市第二人民医院内分泌代谢科门诊及住院的2型糖尿病患者270例,根据是否合并高尿酸血症,将患者分成仅糖尿病组和合并组;同时选择同期在本院行身体检查的60名健康志愿者为对照组。比较3组受试者血尿酸、粒淋比和γ-谷氨酰转肽酶的表达,Pearman法分析血尿酸与粒淋比和γ-谷氨酰转肽酶的相关性。单因素和非条件Logistic回归分析确定高尿酸血症发生的独立影响因素。结果3组受试者血尿酸、粒淋比和γ-谷氨酰转肽酶差异有统计学意义(F=451.351,78.706,314.433,P<0.001);合并组患者血尿酸、粒淋比和γ-谷氨酰转肽酶明显高于仅糖尿病组和对照组,仅糖尿病组患者血尿酸、粒淋比和γ-谷氨酰转肽酶明显高于对照组。血尿酸与粒淋比和γ-谷氨酰转肽酶均呈现正相关(r=0.423,0.730,P<0.001)。两组患者在高血压(χ^(2)=89.708,P<0.001)、高血脂(χ^(2)=5.575,P=0.018)、脂肪肝(χ^(2)=7.614,P=0.006)、视网膜病变(χ^(2)=110.174,P=0.000)、下肢血管病变(χ^(2)=14.110,P=0.000)、冠状动脉粥样硬化性心脏病(χ^(2)=35.042,P<0.001)、病程(t=8.242,P<0.001)、糖化血红蛋白(t=10.697,P<0.001)、空腹血糖(t=11.510,P<0.001)、三酰甘油(t=22.108,P<0.001)、高密度脂蛋白(t=4.488,P<0.001)、低密度脂蛋白(t=2.006,P=0.048)、血肌酐(t=5.691,P<0.001)、舒张压(t=7.835,P<0.001)等差异存在统计学意义。Logistic回归显示,年龄(OR=1.208,95%CI:1.013~1.441)、病程(OR=1.536,95%CI:1.188~1.985)、糖化血红蛋白(OR=2.184,95%CI:1.473~3.238)、粒淋比(OR=2.977,95%CI:1.889~4.691)和γ-谷氨酰转肽酶(OR=1.655,95%CI:1.363~2.010)是发生高尿血酸症的独立影响因素(P<0.05)。结论2型糖尿病并发高酸血症患者血尿酸与粒淋比和γ-谷氨酰转肽酶呈正相关,年龄、病程、糖化血红蛋白、粒淋比和γ-谷氨酰转肽酶是高尿血酸症发生的独立危险因素,值得临床进一步研究和推广。

痛风和高尿酸血症与眼部疾病的研究进展

痛风为一种系统性炎性疾病,是世界范围内最常见的关节炎之一,其中高尿酸血症是痛风发病的主要危险因素。痛风的发病机制包括尿酸盐结晶沉积继发炎症及氧化应激。而炎症及氧化应激正是多种眼病的发病机制。目前已有较多研究提示痛风和高尿酸血症与眼部疾病的相关性,包括尿酸盐结晶直接沉积在眼部结构、干眼、角膜内皮损伤、巩膜炎、葡萄膜炎、青光眼、年龄相关性黄斑变性、糖尿病视网膜病变,以及某些代谢性疾病如甲状腺相关眼病等。另外由于尿酸自身的抗氧化活性,尿酸水平还被认为与多种视神经病变如多发性硬化相关视神经炎、视神经脊髓炎等有关。尽管尿酸水平和眼部疾病的相关性已被报道,但仍存在许多问题亟待解决。为了更全面地了解痛风和高尿酸血症和眼部疾病的关系,文章将从发病机制、发病特点等逐一展开,以期提高对痛风和高尿酸血症的认识,并为将来相关研究提供参考。

体检人群中不同类型高尿酸血症(HUA)相关因素及中医体质的调查分析

目的:探讨体检人群中不同类型HUA患者相关因素及中医体质的调查结果。方法:选择2014年11月—2015年12月惠州市中医医院健康体检人群中发现的HUA 800例作为研究对象,根据流行病学调查的结果,完善高尿酸血症并高脂血症中医证候调查表,采用直接询问法进行。结果:不同类型HUA患者血压、年龄、BMI对比(P>0.05);生成过多型血脂、血糖指标高于排泄不良型、混合型(P<0.05);不同类型HUA与性别、饮酒、BMI呈正相关,与年龄呈负相关,与高血糖、高血压、高血脂呈明显正相关。结论:不同类型HUA与中医体质存在相关性,提前预防干预偏颇体质,能够降低HUA的发病率。

血管回声追踪技术评价T2DM及并发HUA病人颈动脉弹性功能

目的探讨应用血管回声追踪（ET）技术检测2型糖尿病（T2DM）及并发高尿酸血症（HUA）病人颈动脉弹性功能改变的临床意义。方法按照血尿酸水平将60例T2DM病人分为尿酸正常组（A组,30例）及HUA组（B组,30例）,应用ET技术检测颈动脉弹性功能指标,包括僵硬度指数（β）、颈动脉压力-应变弹性系数（Ep）、顺应性（AC）、扩张指数（AI）及脉搏波传导速度（PWVβ）,并与正常对照组（N组,30例）进行比较。结果与N组比较,A组及B组β、Ep、PWVβ均增高,AC减低（F=11.67~26.81,q=4.58~10.27,P〈0.05）;与A组比较,B组β、Ep、PWVβ均增高,AC减低（q=5.13~9.25,P〈0.05）。各组间AI比较差异无统计学意义（P〉0.05）。结论 ET技术能够发现T2DM及并发HUA病人早期颈动脉弹性改变,为临床早期干预和治疗T2DM病人动脉粥样硬化提供依据。