BACKGROUND Hypopharyngeal lipoma is a rare disease that can lead to asphyxiation after aspiration.Sclerotic lipoma in the hypopharynx is an extremely rare histological type.Hypopharyngeal lipoma should be resected in ...BACKGROUND Hypopharyngeal lipoma is a rare disease that can lead to asphyxiation after aspiration.Sclerotic lipoma in the hypopharynx is an extremely rare histological type.Hypopharyngeal lipoma should be resected in time after diagnosis.CASE SUMMARY An 86-year-old female patient presented to our department with a long pedunculated mass protruding from her mouth.Until this time,the patient had no dyspnea,dysphagia,or throat discomfort.Physical examination showed stable vital signs and clear consciousness.The pedicel was derived from the posterior wall of the hypopharynx.The tumor was smooth,hyperemic and dark red,about 10 cm long,and 4 cm wide.In order to prevent airway obstruction,the hypopharyngeal tumor was excised in emergent operation.The pharyngeal cavity was exposed by a mouth gag during the operation.A disposable plasma knife was used to completely remove the tumor along the base of the new organism,and no active bleeding occurred.The postoperative pathological results were sclerotic lipoma.CONCLUSION Lipoma in the pharynx is relatively rare.Patients with this condition must be referred immediately to Ear-Nose-Throat specialists and complete surgical excision should be performed as soon as possible to prevent serious complications,such as airway obstruction and death.展开更多
Celiac disease is a gluten-related malabsorption in small intestine occurring in genetically susceptible patients. In this disease the risk of many malignancies is increased the most important of which being non-Hodgk...Celiac disease is a gluten-related malabsorption in small intestine occurring in genetically susceptible patients. In this disease the risk of many malignancies is increased the most important of which being non-Hodgkin lymphoma of small intestine. Other malignancies include adenocarcinoma of small intestine and squamous cell carcinoma of esophagus and melanoma. As to our knowledge so far only one case of ceJiac disease associated with hypopharyngeaJ squamous ceil car- cinoma has been reported. In this article we presented a patient suffering from celiac disease with squamous cell carcinoma of hypopharynx. She underwent chemotherapy and radiation therapy, unfortunately however she died because of progress of disease. So, in patients with celiac disease we should pay attention to various malignancies and when cases of cancers are accompanied by malabsorption we must think of celiac disease involvement.展开更多
Fibrovascular polyp of the hypopharynx and esophagus, a rare, benign, intraluminal and submucosal tumor, is most commonly originated from the proximal esophagus. We discussed four cases with regurgitation, respiratory...Fibrovascular polyp of the hypopharynx and esophagus, a rare, benign, intraluminal and submucosal tumor, is most commonly originated from the proximal esophagus. We discussed four cases with regurgitation, respiratory symptom or the feeling of a mass in the throat. All the patients were examined with laryngoscope under general anesthesia. A transverse cervical incision was performed in one patient and the polyps were excised under laryngoscope with CO2 laser in the other three patients. All the lesions were removed successfully. Diagnostic and therapeutic principles involved in these cases are presented and discussed. The recognition of fibrovascular polyp of the hypopharynx and esophagus as a potential cause of regurgitation is paramount. Surgical excision is recommended because of the satisfactory outcome.展开更多
Reconstruction of the hypopharynx and upper esophagus after resection of advanced pyriform sinus cancer. is usually complicated and time-consuming. Laryngotracheal flap was used in hypopharyngaesophageal reconstructio...Reconstruction of the hypopharynx and upper esophagus after resection of advanced pyriform sinus cancer. is usually complicated and time-consuming. Laryngotracheal flap was used in hypopharyngaesophageal reconstruction for 26 elderly patients with advanced pyriform sinus cancer Pharyngocutaneous fistula developed in 5 patients and healed spontaneously without further surgery. Full diet was resumed in all the patients. The surgical technique and its advantages and disadvantages are discussed. The laryngotracheal flap in the reconstruction of hypopharyngoesophageal defect for elderly patients is a procedure of choice.展开更多
目的研究胃镜检查时采用窄带成像(Narrow band imaging,NBI)模式是否能够比白光模式提高下咽及喉部病变的检出率。方法在我院拟行无痛胃镜检查患者中选取18岁及以上人群或既往有食管癌、鼻咽癌等病史人群,胃镜检查中均先后分别采用白光...目的研究胃镜检查时采用窄带成像(Narrow band imaging,NBI)模式是否能够比白光模式提高下咽及喉部病变的检出率。方法在我院拟行无痛胃镜检查患者中选取18岁及以上人群或既往有食管癌、鼻咽癌等病史人群,胃镜检查中均先后分别采用白光及NBI模式进行下咽及喉部的观察、记录。若进镜时无法完成上述部位观察,则待退镜时再进行相应观察、记录。最终,将白光模式与NBI模式的病变检出率进行对比。结果共入组1287例患者,其中男性761例,女性526例,共检出病变43例(检出率3.3%),其中肿瘤性病变28例(65.1%),恶性肿瘤20例(46.5%)。NBI模式检出全部43例病变,白光模式检出24例病变,统计学结果提示差异具有显著性。进一步对病变检出情况进行统计分析显示,男性及患有食管癌为下咽及喉部病变检出的危险因素。研究中未发生操作相关并发症。结论胃镜检查中采用NBI模式能够显著提高下咽及喉部病变检出率,此技术有望在食管癌高发区推广应用以促进下咽及喉部肿瘤的早诊早治。展开更多
Background: In recent years, head and neck cancers have become common worldwide, ranking sixth in incidence. In 2007, in France the incidence increased by 14,697 including 11,158 among men, which places them in fourth...Background: In recent years, head and neck cancers have become common worldwide, ranking sixth in incidence. In 2007, in France the incidence increased by 14,697 including 11,158 among men, which places them in fourth place. The same year, 32,268 patients were hospitalized for this pathology, but 95% are associated with alcohol and tobacco poisoning. Few data exist on these cancers in Africa and Senegal. In recent years, many studies have hypothesized that about 25% of head and neck cancers are associated with high-risk oncogenic human papillomaviruses (HPV) whose role in cervical cancer was already widely established. Objective: To know the prevalence and genotypes of HPV in head and neck cancers, particularly hypopharyngeal cancer. Material and method: This study was carried out on samples of biopsies of hypopharynx cancerous tissue (ulcerative-budding lesion) and healthy oropharyngeal tissue obtained from the ENT department of the Fann hospital, then sent to the Molecular Biology Unit of the Ouakam military hospital (HMO). The nucleic acids extraction was carried out using the standard method of the Zymo research kit “Quick-DNA<sup>TM</sup> Miniprep Plus kit” https://www.zymoresearch.com/. Molecular HPV detection and genotyping were performed by multiplex RT-PCR with the Seegene Anyplex<sup>TM</sup> II HPV28 kit Detection on a Biorad CFX96 automaton according to the manufacturer’s protocol for the simultaneous genotyping of 28 types of HPV including 19 at High Risk (HR) and 9 low risk (LR). Results: 156 patients were sampled, 61 Hypopharynx cancer biopsies and 95 healthy tissues. The median age of the general population was 36.5 years [12, 73];the median age of the population with hypopharyngeal cancer of 40 years. Of the general study population 24.36% (38/156) was infected with HPV. In populations with hypopharyngeal cancer, HPV prevalence was 19.67% (12/61), 17.84% (5/28) in men and 21.21% (7/33) in women. HPV6 was the most frequently encountered genotype in the cancer population. Multiple infections have also been noted in cancer patients: HPV6+HPV18, HPV6+HPV56. For patients without hypopharyngeal cancer, the HPV prevalence was 27.36% (26/95), 9.59% (7/73) in women and 89.36% (19/22) in men. Several types of HPV-HR genotypes (HPV18, HPV26, HPV69), and HPV-LR genotypes (HPV42, HPV43, HPV70, HPV6) have been detected in healthy patients but also cases of co-infections (HPV6+HPV69;HPV56+HPV44;HPV58+HPV18). Conclusion: Our results showed a higher prevalence of HPV in non-cancer patients compared to hypopharyngeal cancer patients. The genotypes (HPV 6, 18 and 56) were observed in the study population. Molecular genotyping does not show a significant involvement of HPV in hypopharyngeal cancer.展开更多
文摘BACKGROUND Hypopharyngeal lipoma is a rare disease that can lead to asphyxiation after aspiration.Sclerotic lipoma in the hypopharynx is an extremely rare histological type.Hypopharyngeal lipoma should be resected in time after diagnosis.CASE SUMMARY An 86-year-old female patient presented to our department with a long pedunculated mass protruding from her mouth.Until this time,the patient had no dyspnea,dysphagia,or throat discomfort.Physical examination showed stable vital signs and clear consciousness.The pedicel was derived from the posterior wall of the hypopharynx.The tumor was smooth,hyperemic and dark red,about 10 cm long,and 4 cm wide.In order to prevent airway obstruction,the hypopharyngeal tumor was excised in emergent operation.The pharyngeal cavity was exposed by a mouth gag during the operation.A disposable plasma knife was used to completely remove the tumor along the base of the new organism,and no active bleeding occurred.The postoperative pathological results were sclerotic lipoma.CONCLUSION Lipoma in the pharynx is relatively rare.Patients with this condition must be referred immediately to Ear-Nose-Throat specialists and complete surgical excision should be performed as soon as possible to prevent serious complications,such as airway obstruction and death.
文摘Celiac disease is a gluten-related malabsorption in small intestine occurring in genetically susceptible patients. In this disease the risk of many malignancies is increased the most important of which being non-Hodgkin lymphoma of small intestine. Other malignancies include adenocarcinoma of small intestine and squamous cell carcinoma of esophagus and melanoma. As to our knowledge so far only one case of ceJiac disease associated with hypopharyngeaJ squamous ceil car- cinoma has been reported. In this article we presented a patient suffering from celiac disease with squamous cell carcinoma of hypopharynx. She underwent chemotherapy and radiation therapy, unfortunately however she died because of progress of disease. So, in patients with celiac disease we should pay attention to various malignancies and when cases of cancers are accompanied by malabsorption we must think of celiac disease involvement.
文摘Fibrovascular polyp of the hypopharynx and esophagus, a rare, benign, intraluminal and submucosal tumor, is most commonly originated from the proximal esophagus. We discussed four cases with regurgitation, respiratory symptom or the feeling of a mass in the throat. All the patients were examined with laryngoscope under general anesthesia. A transverse cervical incision was performed in one patient and the polyps were excised under laryngoscope with CO2 laser in the other three patients. All the lesions were removed successfully. Diagnostic and therapeutic principles involved in these cases are presented and discussed. The recognition of fibrovascular polyp of the hypopharynx and esophagus as a potential cause of regurgitation is paramount. Surgical excision is recommended because of the satisfactory outcome.
文摘Reconstruction of the hypopharynx and upper esophagus after resection of advanced pyriform sinus cancer. is usually complicated and time-consuming. Laryngotracheal flap was used in hypopharyngaesophageal reconstruction for 26 elderly patients with advanced pyriform sinus cancer Pharyngocutaneous fistula developed in 5 patients and healed spontaneously without further surgery. Full diet was resumed in all the patients. The surgical technique and its advantages and disadvantages are discussed. The laryngotracheal flap in the reconstruction of hypopharyngoesophageal defect for elderly patients is a procedure of choice.
文摘目的研究胃镜检查时采用窄带成像(Narrow band imaging,NBI)模式是否能够比白光模式提高下咽及喉部病变的检出率。方法在我院拟行无痛胃镜检查患者中选取18岁及以上人群或既往有食管癌、鼻咽癌等病史人群,胃镜检查中均先后分别采用白光及NBI模式进行下咽及喉部的观察、记录。若进镜时无法完成上述部位观察,则待退镜时再进行相应观察、记录。最终,将白光模式与NBI模式的病变检出率进行对比。结果共入组1287例患者,其中男性761例,女性526例,共检出病变43例(检出率3.3%),其中肿瘤性病变28例(65.1%),恶性肿瘤20例(46.5%)。NBI模式检出全部43例病变,白光模式检出24例病变,统计学结果提示差异具有显著性。进一步对病变检出情况进行统计分析显示,男性及患有食管癌为下咽及喉部病变检出的危险因素。研究中未发生操作相关并发症。结论胃镜检查中采用NBI模式能够显著提高下咽及喉部病变检出率,此技术有望在食管癌高发区推广应用以促进下咽及喉部肿瘤的早诊早治。
文摘Background: In recent years, head and neck cancers have become common worldwide, ranking sixth in incidence. In 2007, in France the incidence increased by 14,697 including 11,158 among men, which places them in fourth place. The same year, 32,268 patients were hospitalized for this pathology, but 95% are associated with alcohol and tobacco poisoning. Few data exist on these cancers in Africa and Senegal. In recent years, many studies have hypothesized that about 25% of head and neck cancers are associated with high-risk oncogenic human papillomaviruses (HPV) whose role in cervical cancer was already widely established. Objective: To know the prevalence and genotypes of HPV in head and neck cancers, particularly hypopharyngeal cancer. Material and method: This study was carried out on samples of biopsies of hypopharynx cancerous tissue (ulcerative-budding lesion) and healthy oropharyngeal tissue obtained from the ENT department of the Fann hospital, then sent to the Molecular Biology Unit of the Ouakam military hospital (HMO). The nucleic acids extraction was carried out using the standard method of the Zymo research kit “Quick-DNA<sup>TM</sup> Miniprep Plus kit” https://www.zymoresearch.com/. Molecular HPV detection and genotyping were performed by multiplex RT-PCR with the Seegene Anyplex<sup>TM</sup> II HPV28 kit Detection on a Biorad CFX96 automaton according to the manufacturer’s protocol for the simultaneous genotyping of 28 types of HPV including 19 at High Risk (HR) and 9 low risk (LR). Results: 156 patients were sampled, 61 Hypopharynx cancer biopsies and 95 healthy tissues. The median age of the general population was 36.5 years [12, 73];the median age of the population with hypopharyngeal cancer of 40 years. Of the general study population 24.36% (38/156) was infected with HPV. In populations with hypopharyngeal cancer, HPV prevalence was 19.67% (12/61), 17.84% (5/28) in men and 21.21% (7/33) in women. HPV6 was the most frequently encountered genotype in the cancer population. Multiple infections have also been noted in cancer patients: HPV6+HPV18, HPV6+HPV56. For patients without hypopharyngeal cancer, the HPV prevalence was 27.36% (26/95), 9.59% (7/73) in women and 89.36% (19/22) in men. Several types of HPV-HR genotypes (HPV18, HPV26, HPV69), and HPV-LR genotypes (HPV42, HPV43, HPV70, HPV6) have been detected in healthy patients but also cases of co-infections (HPV6+HPV69;HPV56+HPV44;HPV58+HPV18). Conclusion: Our results showed a higher prevalence of HPV in non-cancer patients compared to hypopharyngeal cancer patients. The genotypes (HPV 6, 18 and 56) were observed in the study population. Molecular genotyping does not show a significant involvement of HPV in hypopharyngeal cancer.
