Throughout the globe,diabetes mellitus（DM） is increasing in incidence with limited therapies presently available to prevent or resolve the significant complications of this disorder.DM impacts multiple organs and af...Throughout the globe,diabetes mellitus（DM） is increasing in incidence with limited therapies presently available to prevent or resolve the significant complications of this disorder.DM impacts multiple organs and affects all components of the central and peripheral nervous systems that can range from dementia to diabetic neuropathy.The mechanistic target of rapamycin（m TOR） is a promising agent for the development of novel regenerative strategies for the treatment of DM.m TOR and its related signaling pathways impact multiple metabolic parameters that include cellular metabolic homeostasis,insulin resistance,insulin secretion,stem cell proliferation and differentiation,pancreatic β-cell function,and programmed cell death with apoptosis and autophagy.m TOR is central element for the protein complexes m TOR Complex 1（m TORC1） and m TOR Complex 2（m TORC2） and is a critical component for a number of signaling pathways that involve phosphoinositide 3-kinase（PI 3-K）,protein kinase B（Akt）,AMP activated protein kinase（AMPK）,silent mating type information regulation 2 homolog 1（Saccharomyces cerevisiae）（SIRT1）,Wnt1 inducible signaling pathway protein 1（WISP1）,and growth factors.As a result,m TOR represents an exciting target to offer new clinical avenues for the treatment of DM and the complications of this disease.Future studies directed to elucidate the delicate balance m TOR holds over cellular metabolism and the impact of its broad signaling pathways should foster the translation of these targets into effective clinical regimens for DM.展开更多
The 1951 San Francisco Peace Treaty was the one and only international opportunity that would have allowed demanding for Japan’s responsibility of the colonization of Korea.However,the United States did not demand of...The 1951 San Francisco Peace Treaty was the one and only international opportunity that would have allowed demanding for Japan’s responsibility of the colonization of Korea.However,the United States did not demand of such to be done.Soon,Korea and Japan resumed their diplomatic relationship and had their first summit in 1952.After numerous negotiations,finally in 1965,the“Korea-Japan Treaty”was agreed upon.Even in this treaty,the interpretation of the colonization was different for both countries and ultimately resulted as an unresolved issue.This is because of the Japanese dependence to the San Francisco Peace Treaty.On the other hand,the League of Nations,founded in 1920,believed that the systematization of international law was vital to keeping international peace.Therefore,they put much effort in and successfully carried out the codification of international law.The“Report on the law of Treaties”which was completed in 1935,noted that the“1905 Protectorate Treaty”,which was the ultimate treaty that led to Korea being annexed by the Japanese,was one of the three treaties that had no effective standing.This decision was carried out to the International Law Commission of the United Nations in 1963 and became a Resolution after being submitted to the General Assembly in the end of the same year.Using the decisions of the League of Nations and the United Nations as evidence,this paper critically reviews the San Francisco Peace Treaty’s lack of reviewing the Japanese responsibility of the colonization of Korea.展开更多
基金supported by American Diabetes Association,American Heart Association,NIH NIEHS,NIH NIA,NIH NINDS,and NIH ARRA
文摘Throughout the globe,diabetes mellitus（DM） is increasing in incidence with limited therapies presently available to prevent or resolve the significant complications of this disorder.DM impacts multiple organs and affects all components of the central and peripheral nervous systems that can range from dementia to diabetic neuropathy.The mechanistic target of rapamycin（m TOR） is a promising agent for the development of novel regenerative strategies for the treatment of DM.m TOR and its related signaling pathways impact multiple metabolic parameters that include cellular metabolic homeostasis,insulin resistance,insulin secretion,stem cell proliferation and differentiation,pancreatic β-cell function,and programmed cell death with apoptosis and autophagy.m TOR is central element for the protein complexes m TOR Complex 1（m TORC1） and m TOR Complex 2（m TORC2） and is a critical component for a number of signaling pathways that involve phosphoinositide 3-kinase（PI 3-K）,protein kinase B（Akt）,AMP activated protein kinase（AMPK）,silent mating type information regulation 2 homolog 1（Saccharomyces cerevisiae）（SIRT1）,Wnt1 inducible signaling pathway protein 1（WISP1）,and growth factors.As a result,m TOR represents an exciting target to offer new clinical avenues for the treatment of DM and the complications of this disease.Future studies directed to elucidate the delicate balance m TOR holds over cellular metabolism and the impact of its broad signaling pathways should foster the translation of these targets into effective clinical regimens for DM.
文摘The 1951 San Francisco Peace Treaty was the one and only international opportunity that would have allowed demanding for Japan’s responsibility of the colonization of Korea.However,the United States did not demand of such to be done.Soon,Korea and Japan resumed their diplomatic relationship and had their first summit in 1952.After numerous negotiations,finally in 1965,the“Korea-Japan Treaty”was agreed upon.Even in this treaty,the interpretation of the colonization was different for both countries and ultimately resulted as an unresolved issue.This is because of the Japanese dependence to the San Francisco Peace Treaty.On the other hand,the League of Nations,founded in 1920,believed that the systematization of international law was vital to keeping international peace.Therefore,they put much effort in and successfully carried out the codification of international law.The“Report on the law of Treaties”which was completed in 1935,noted that the“1905 Protectorate Treaty”,which was the ultimate treaty that led to Korea being annexed by the Japanese,was one of the three treaties that had no effective standing.This decision was carried out to the International Law Commission of the United Nations in 1963 and became a Resolution after being submitted to the General Assembly in the end of the same year.Using the decisions of the League of Nations and the United Nations as evidence,this paper critically reviews the San Francisco Peace Treaty’s lack of reviewing the Japanese responsibility of the colonization of Korea.
