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ERK1/2和Akt通路对控制性低压后处理兔缺血/再灌注损伤脊髓线粒体功能的影响 被引量:1
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作者 艾春雨 江晓菁 +1 位作者 马虹 王俊科 《中国药理学通报》 CAS CSCD 北大核心 2012年第8期1084-1087,共4页
目的研究PI3K/Akt和ERK1/2通路对控制性低压后处理兔缺血/再灌注损伤脊髓线粒体功能的影响。方法30只日本大耳白兔随机分为5组(n=6):假手术组(Sham)、缺血/再灌注组(I/R),控制性低压后处理组(Post),控制性低压后处理+PD98059组(Post+PD... 目的研究PI3K/Akt和ERK1/2通路对控制性低压后处理兔缺血/再灌注损伤脊髓线粒体功能的影响。方法30只日本大耳白兔随机分为5组(n=6):假手术组(Sham)、缺血/再灌注组(I/R),控制性低压后处理组(Post),控制性低压后处理+PD98059组(Post+PD)、控制性低压后处理+LY294002组(Post+LY)组。除Sham组外,其余各组分别于肾动脉下水平阻断腹主动脉25 min。Post组:再灌注开始10 min采用控制性低灌注压后处理法球囊部分排空,将腹主动脉远端血压控制在5.99~7.32 kPa,10min后球囊完全开放。Post+PD组、Post+LY组:同Post组,并分别于腹主动脉开放前1 min鞘内注射ERK抑制剂PD98059(3μg,20μl)、PI3K/AKT抑制剂LY294002(10μg,20μl)。再灌注24 h后将实验动物处死,取脊髓组织用Western blot技术测定Caspase-3、胞质Cytochrome C蛋白表达;电镜观察线粒体结构。结果与I/R组比较,Post组Caspase-3和胞质Cytochrome C蛋白表达明显减少,线粒体结构破坏减轻。ERK抑制剂PD98059和PI3K/Akt抑制剂LY294002减弱了Post的作用。结论控制性低压后处理对缺血/再灌注损伤脊髓线粒体功能有保护作用,其机制可能与激活PI3K/Akt和ERK1/2通路有关。 展开更多
关键词 控制性低压 缺血/再灌注损伤 缺血后处理 脊髓 AKT ErK 线粒体
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利用双线性变换和R-H准则判定LSI系统的稳定性
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作者 陈绍荣 何健 +1 位作者 陈柏良 薛在阳 《通信技术》 2019年第6期1365-1369,共5页
离散时间系统稳定性最初是采用行为定义给出的,即有界激励引起有界响应,亦即所谓的BIBO稳定条件。线性移不变(LSI)离散时间系统稳定性的时域判据,是系统的单位冲激响应满足绝对可和条件;LSI离散时间因果系统稳定性的时域判据,是系统的... 离散时间系统稳定性最初是采用行为定义给出的,即有界激励引起有界响应,亦即所谓的BIBO稳定条件。线性移不变(LSI)离散时间系统稳定性的时域判据,是系统的单位冲激响应满足绝对可和条件;LSI离散时间因果系统稳定性的时域判据,是系统的单位冲激响应为因果序列,且满足绝对可和条件。在z域,LSI离散时间因果系统的稳定性可利用Jury准则进行判定。因此,介绍了Jury准则,给出了基于双线性变换和R-H准则来判定LSI离散时间因果系统稳定性的方法,间接解决了Jury准则遗留的问题。 展开更多
关键词 LSI离散时间系统 稳定性判据 jury准则 双线性变换 r-H准则
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Seed and Wasp Production in the Mutualism of Figs and Fig Wasps 被引量:1
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作者 YaoJin-yan ZhaoNan-xian +3 位作者 ChenYi-zhu JiaXiao-cheng DengYuan YuHui 《Forestry Studies in China》 CAS 2005年第1期25-28,共4页
Figs (Moracea: Ficus) and fig wasps (Hymenoptera: Chlocloids: Agaonideae) depend on each other to complete their reproduction. Monoecious fig species and their pollinating wasps are in conflict over the use of fig ov... Figs (Moracea: Ficus) and fig wasps (Hymenoptera: Chlocloids: Agaonideae) depend on each other to complete their reproduction. Monoecious fig species and their pollinating wasps are in conflict over the use of fig ovaries which can either produce one seed or one wasp. From observation on Ficus virens Ait., we showed that female flowers with outer layer of ovaries (near to the wall of syconium) had no significant difference from that with inner and interval layer of ovaries (near to the syconium cavity), in which most seeds and wasps were produced. This meant that fig tree provided the same potential resource for seed and wasps production. Observation indicated that there was usually only one foundress in syconium at female flower phase and no com- petition pollinators. Measurement of the style length of female flowers and the ovipositor of pollinators indicated that most ovaries could be reached by pollinator’s ovipositor. However, at the male flower phase, production of seeds was significantly more than that of wasps including non-pollinating wasps but there was no significant difference between seed and pollinating wasp production when without non-pollinating wasps produced. This result indicated that non-pollinating wasps competed ovaries not with seeds but with pollinating wasps for ovipositing. Bagged experiment showed that the sampling fig species was not self-sterile which was important for figs and wasps to survive bad season. Seed production in self-pollinated figs was not significantly different from total wasps in- cluding non-pollinating ones. This might be related with the weaker competition among wasps since bagged figs were not easy to reach by wasps from outside. 展开更多
关键词 FICUS Ficus wasp mutualism conflicts seed and wasp production Seed and Wasp Production in the Mutualism of Figs and Fig Wasps Yao Jin-yan1 2 Zhao Nan-xian1 Chen Yi-zhu1* Jia Xiao-cheng1 2 Deng Yuan1 2 Yu Hui1 2 1South China Botanical Garden Chinese Academy of Sciences Guangzhou 510650 P. r. China 2Graduate School of the Chinese Academy of Sciences Beijing 100039 P. r. China ABSTrACT Figs (Moracea: Ficus) and fig wasps (Hymenoptera: Chlocloids: Agaonideae) depend on each other to complete their reproduction. Monoecious fig species and their pollinating wasps are in conflict over the use of fig ovaries which can either produce one seed or one wasp. From observation on Ficus virens Ait. we showed that female flowers with outer layer of ovaries (near to the wall of syconium) had no significant difference from that with inner and interval layer of ovaries (near to the syconium cavity) in which most seeds and wasps were produced. This meant that fig tree provided the same potential resource for seed and wasps production. Observation indicated that there was usually only one foundress in syconium at female flower phase and no com- petition pollinators. Measurement of the style length of female flowers and the ovipositor of pollinators indicated that most ovaries could be reached by pollinator’s ovipositor. However at the male flower phase production of seeds was significantly more than that of wasps including non-pollinating wasps but there was no significant difference between seed and pollinating wasp production when without non-pollinating wasps produced. This result indicated that non-pollinating wasps competed ovaries not with seeds but with pollinating wasps for ovipositing. Bagged experiment showed that the sampling fig species was not self-sterile which was important for figs and wasps to survive bad season. Seed production in self-pollinated figs was not significantly different from total wasps in- cluding non-pollinating
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