介绍一种可用APB总线配置的I3C控制器IP的设计与验证,I3C(Improved Inter Integrated Circuit),即改进的I2C,是一种新型的串行通信模块,同样是用于SoC设计中的外围IP模块。与I2C相比,它支持新的通信模式、更高的通信速度(高达12.5 MHz)...介绍一种可用APB总线配置的I3C控制器IP的设计与验证,I3C(Improved Inter Integrated Circuit),即改进的I2C,是一种新型的串行通信模块,同样是用于SoC设计中的外围IP模块。与I2C相比,它支持新的通信模式、更高的通信速度(高达12.5 MHz)、动态地址分配,并带有内置中断(IBI)。这些特性使得I3C与I2C相比优势明显,未来大规模地普及和商用也是大势所趋。首先介绍I3C协议的基本原理和优势,然后详细描述I3C控制器的设计架构和功能模块,在设计完成后,对I3C控制器进行了功能验证并展示其验证结果,证明了所提出方法的有效性和可靠性。展开更多
Cruciferous vegetables belong to the plant family that has flowers with four equal-sized petals in the pattern of a crucifer cross.These vegetables are an abundant source of dietary phytochemicals,including glucosinol...Cruciferous vegetables belong to the plant family that has flowers with four equal-sized petals in the pattern of a crucifer cross.These vegetables are an abundant source of dietary phytochemicals,including glucosinolates and their hydrolysis products such as indole-3-carbinol（I3C） and 3,3＇-diindolylmethane（DIM）.By 2013,the total number of natural glucosinolates that have been documented is estimated to be 132.Recently,cruciferous vegetable intake has garnered great interest for its multiple health benefits such as anticancer,antiviral infections,human sex hormone regulation,and its therapeutic and preventive effects on prostate cancer and high grade prostatic intraepithelial neoplasia（HGPIN）.DIM is a hydrolysis product of glucosinolates and has been used in various trials.This review is to provide an insight into the latest developments of DIM in treating or preventing both prostate cancer and HGPIN.展开更多
Obtaining phase information for the solution of macromolecular structures is a bottleneck in X-ray crystallography. Anomalous dispersion was recognized as a powerful tool for phasing macromolecular structures. It was ...Obtaining phase information for the solution of macromolecular structures is a bottleneck in X-ray crystallography. Anomalous dispersion was recognized as a powerful tool for phasing macromolecular structures. It was used mainly to supplement the isomorphous replacement or to locate the anomalous scatterer itself. The first step in solving macromolecular structures by SAD (single-wavelength anomalous diffraction) is the location of the anomalous scatterers. The SAD method for experimental phasing has evolved substantially in the recent years. A phasing tool, 5-amino-2,4,6- triiodoisophthalic acid (I3C—magic triangle), was incorporated into three proteins, lysozyme, glucose isomerase and thermolysin using quick-soaking and co-crystallization method in order to understand the binding of metal ion with proteins. The high quality of the diffraction data, the use of chromium anode X-ray radiation and the required amount of anomalous signal enabled way for successful structure determination and automated model building. An analysis and/or comparison of the sulfur and iodine anomalous signals at the Cr Kα wavelength are discussed.展开更多
The irradiation stability of polystyrene (PS) was studied by 13C and 1H NMR spectra, Nuclear Overhauser Relaxation (NOE) and 13C NMR spin-lattice relaxation time (T1). The results indicate that 13C and 1H NMR chemical...The irradiation stability of polystyrene (PS) was studied by 13C and 1H NMR spectra, Nuclear Overhauser Relaxation (NOE) and 13C NMR spin-lattice relaxation time (T1). The results indicate that 13C and 1H NMR chemical shifts, NOE and T1 were almost invariant with the increase of irradiation dose. This shows that polystyrene is particularly stable within 2.5 kGy doses and the mechanism of its stability is discussed.展开更多
<sup>13</sup>C NMR is a widely used NMR technique. But for some samples, such as polymerand biological macromolecule, it is very difficult to assign their <sup>13</sup>C spectra sinee the peaks...<sup>13</sup>C NMR is a widely used NMR technique. But for some samples, such as polymerand biological macromolecule, it is very difficult to assign their <sup>13</sup>C spectra sinee the peaksof these spectra are often seriously overlapping. In solution, a number of techniques areavailable fbr simplifying the complex spectra, such as ’distortionless enhaneement展开更多
Low hip bone mineral density(BMD)is an important index for osteoporosis and is associated with hip fracture,which leads to more cases of disability and mortality than all other kinds of fractures(Kanis et al.,2007).BM...Low hip bone mineral density(BMD)is an important index for osteoporosis and is associated with hip fracture,which leads to more cases of disability and mortality than all other kinds of fractures(Kanis et al.,2007).BMD’s heritability is more than 60%(Arden et al.,1996).A number of candidate loci for BMD have been previously identified by Genome Wide Association Studies(GWAS)(Xiong et al.,2009;Karasik et al.,2010;Zhang et al.,2013).Nevertheless,many significant signals based on GWAS are展开更多
文摘介绍一种可用APB总线配置的I3C控制器IP的设计与验证,I3C(Improved Inter Integrated Circuit),即改进的I2C,是一种新型的串行通信模块,同样是用于SoC设计中的外围IP模块。与I2C相比,它支持新的通信模式、更高的通信速度(高达12.5 MHz)、动态地址分配,并带有内置中断(IBI)。这些特性使得I3C与I2C相比优势明显,未来大规模地普及和商用也是大势所趋。首先介绍I3C协议的基本原理和优势,然后详细描述I3C控制器的设计架构和功能模块,在设计完成后,对I3C控制器进行了功能验证并展示其验证结果,证明了所提出方法的有效性和可靠性。
文摘Cruciferous vegetables belong to the plant family that has flowers with four equal-sized petals in the pattern of a crucifer cross.These vegetables are an abundant source of dietary phytochemicals,including glucosinolates and their hydrolysis products such as indole-3-carbinol（I3C） and 3,3＇-diindolylmethane（DIM）.By 2013,the total number of natural glucosinolates that have been documented is estimated to be 132.Recently,cruciferous vegetable intake has garnered great interest for its multiple health benefits such as anticancer,antiviral infections,human sex hormone regulation,and its therapeutic and preventive effects on prostate cancer and high grade prostatic intraepithelial neoplasia（HGPIN）.DIM is a hydrolysis product of glucosinolates and has been used in various trials.This review is to provide an insight into the latest developments of DIM in treating or preventing both prostate cancer and HGPIN.
文摘Obtaining phase information for the solution of macromolecular structures is a bottleneck in X-ray crystallography. Anomalous dispersion was recognized as a powerful tool for phasing macromolecular structures. It was used mainly to supplement the isomorphous replacement or to locate the anomalous scatterer itself. The first step in solving macromolecular structures by SAD (single-wavelength anomalous diffraction) is the location of the anomalous scatterers. The SAD method for experimental phasing has evolved substantially in the recent years. A phasing tool, 5-amino-2,4,6- triiodoisophthalic acid (I3C—magic triangle), was incorporated into three proteins, lysozyme, glucose isomerase and thermolysin using quick-soaking and co-crystallization method in order to understand the binding of metal ion with proteins. The high quality of the diffraction data, the use of chromium anode X-ray radiation and the required amount of anomalous signal enabled way for successful structure determination and automated model building. An analysis and/or comparison of the sulfur and iodine anomalous signals at the Cr Kα wavelength are discussed.
基金Supported by the Doctor Foundation of Xinjiang University
文摘The irradiation stability of polystyrene (PS) was studied by 13C and 1H NMR spectra, Nuclear Overhauser Relaxation (NOE) and 13C NMR spin-lattice relaxation time (T1). The results indicate that 13C and 1H NMR chemical shifts, NOE and T1 were almost invariant with the increase of irradiation dose. This shows that polystyrene is particularly stable within 2.5 kGy doses and the mechanism of its stability is discussed.
基金Project supported by the National Natural Science Foundation of Chinathe Third World Academy Grant 93-023 RG/CHE/AS.
文摘<sup>13</sup>C NMR is a widely used NMR technique. But for some samples, such as polymerand biological macromolecule, it is very difficult to assign their <sup>13</sup>C spectra sinee the peaksof these spectra are often seriously overlapping. In solution, a number of techniques areavailable fbr simplifying the complex spectra, such as ’distortionless enhaneement
基金partially supported by or benefited from grants from NIH (P50AR055081,R01AG026564,R01AR050496,R01AR059781,D43TW009107,P20GM109036,R01GM109068,R01MH104680,R01MH107354,R01AR057049,and R03TW008221)
文摘Low hip bone mineral density(BMD)is an important index for osteoporosis and is associated with hip fracture,which leads to more cases of disability and mortality than all other kinds of fractures(Kanis et al.,2007).BMD’s heritability is more than 60%(Arden et al.,1996).A number of candidate loci for BMD have been previously identified by Genome Wide Association Studies(GWAS)(Xiong et al.,2009;Karasik et al.,2010;Zhang et al.,2013).Nevertheless,many significant signals based on GWAS are
