Objective:To investigate the effects of electricity on the expression of procalcitonin(CGRP)and serotonin(5-HT)in serum and colon in rats with constipation-type irritable bowel syndrome(IBS-C).Methods:50 rats were ran...Objective:To investigate the effects of electricity on the expression of procalcitonin(CGRP)and serotonin(5-HT)in serum and colon in rats with constipation-type irritable bowel syndrome(IBS-C).Methods:50 rats were randomly divided into three groups:normal control group,model group,electroacupuncture group with four single points(tianshu electroacupuncture group,Colonic acupuncture group,Quchi electroacupuncture group,Shangjuxu acupoint group,and bilateral acupoint alternating between left and right),and non-meridian non-acupoint group(non-meridian non-acupoint group on both hip of electroacupuncture rats).The IBS-C model was replicated in the other three groups,except the normal control group,using the cold-fear-starvation synthesis method.After successful replication of the model,the four electroacupuncture single-point group and the non-acupoint group began electroacupuncture treatment once a day for 3 consecutive days.The visceral sensitivity and the expression of CGRP and 5-HT in serum and colon were observed.Results:Compared with the normal control group,the minimum volume threshold of abdominal retractile reflex(AWR)in the model group decreased(P<0.05),and the expressions of 5-HT and CGRP in serum and colon increased(P<0.05).Compared with the model group,AWR minimum volume threshold was increased in the electroacupuncture group with four single acupuncture points(P<0.05),the expression of 5-ht and CGRP in serum and colon was significantly decreased(P<0.05),and there was no significant change in each indicator in the non-acupuncture point group(P>0.05).Conclusion:Electroacupuncture combined with four single points can effectively improve the visceral sensitivity of IBS-C rats and regulate the levels of 5-HT and CGRP in serum and colon of rats,thus providing experimental basis for the clinical treatment of IBS-C.展开更多
目的:采用循证医学方法分析针刺治疗便秘型肠易激综合征(IBS-C)的经络取穴规律,为临床提供方案。方法:应用计算机检索截止至7月1日的文献,按照Cochrane系统文献质量评价的方法筛选随机对照研究方法文献,穴位出现采用频数和频率进行描述...目的:采用循证医学方法分析针刺治疗便秘型肠易激综合征(IBS-C)的经络取穴规律,为临床提供方案。方法:应用计算机检索截止至7月1日的文献,按照Cochrane系统文献质量评价的方法筛选随机对照研究方法文献,穴位出现采用频数和频率进行描述,运用SPSS26.0进行统计分析。结果:共有十二篇符合纳入标准的研究;十四经筛选统计总共出现19个穴位(前8个穴位依次为:足三里、天枢、上巨虚、三阴交、太冲、印堂、百会、中脘),分属11条经脉(足阳明胃经 > 任脉 > 足太阴脾经、督脉 > 足厥阴肝经、手少阳三焦经、手厥阴心包经、手阳明大肠经、足太阳膀胱经、手少阴心经、足少阳胆经)。结论:肠易激综合征便秘型针刺治疗穴位多选用募穴、下合穴、交会穴,常选用足阳明胃经、督脉、任脉、足太阴脾经、足厥阴肝经。Objective: To analyze the rule of meridian point selection in the treatment of constipated irritable bowel syndrome (IBS-C) by evidence-based medicine, and to provide clinical scheme. Methods: The literatures up to July 1 were searched by computer, and the literatures of randomized controlled studies were screened according to Cochrane systematic literature quality evaluation. The frequency of acupuncture points were described, and SPSS26.0 was used for statistical analysis. Results: A total of 12 studies met the inclusion criteria;After 14 screening, a total of 19 acupoints were found (the first 8 acupoints were: Zusanli, Tianshu, Shangjuxu, Sanyinjiao, Taichong, Yintang, Baihui, Zhongwan) belonging to 11 meridians (Zyangming Stomach Channel > Ren channel > Taiyin Spleen Channel, Du Channel > Jueyin Liver channel, Shaoyang Sanjiao Channel, Jueyin myocardium Channel, Yangming large intestine channel, Yang Sun Heart Channel, Shaoyang gallbladder channel). Conclusion: Mu point, Xiaihe point and Conifing point are the main acupuncture points for irritable bowel syndrome. The stomach channel, Du vein, Ren vein, Taiyin spleen channel and Jueyin liver channel of foot Yangming are often selected.展开更多
Objective To observe the effects of bowls-unblocking and mind-regulating acupuncture therapy on constipation,anxiety,depression and serum neuropeptide Y(NPY)content for the patients with constipation-predominant irrit...Objective To observe the effects of bowls-unblocking and mind-regulating acupuncture therapy on constipation,anxiety,depression and serum neuropeptide Y(NPY)content for the patients with constipation-predominant irritable bowel syndrome(IBS-C).Methods Forty-two IBS-C patients were randomly assigned either into a bowls-unblocking and mind-regulating acupuncture group(acupuncture group)or a mosapride citrate group(medication group)with 21 cases in each group.During the treatment,one patient in the medication group was excluded and 20 patients were included in final statistical analysis;while 21 patients completed the trial in the acupuncture group.Before treatment,after treatment and in follow-up(1 month after the whole treatment),the scores of the Cleveland clinical constipation scoring system(CCS),the self-rating anxiety scale(SAS),and the self-rating depression scale(SDS)were assessed in both groups.The changes in NPY content were compared before and after treatment.Results①Total score of CCS:after treatment,the total score in the acupuncture group and the medication group were(4.76±2.10)points and(5.60±1.88)points,respectively,which were significantly lower than those before treatment in both groups(both P<0.05);and the difference in the score was not significant for the between-group comparison(P>0.05).In the follow-up,the total scores were(4.19±1.69)points in the acupuncture group,and was(6.35±2.06)points in the medication group.The score in the medication group was higher than that after treatment in the same group(P<0.05),but there was no significant difference between acupuncture group and the medication group(P>0.05).②SAS score:after treatment,the SAS scores were(50.24±2.19)points and(53.45±2.46)points in the acupuncture group and the medication group,respectively,which was lower than that before treatment in the two groups(both P<0.05);and the difference in the score was significant between two groups(P<0.05).In the follow-up,the scores were(51.95±2.27)points and(54.55±1.67)points in the acupuncture group and the medication group,respectively;which was lower than that before treatment in the two groups(both P<0.05),and the difference in the score was significant between two groups(P<0.05).③SDS score:after treatment,the SDS scores were(50.71±2.70)points and(53.15±2.25)points in the acupuncture group and the medication group,respectively,which was significantly lower than that before treatment in the two groups(both P<0.05);and the difference in the score was significant between the two group(P<0.05).In the follow-up,the score of the acupuncture group was(52.57±3.72)points and it was(56.60±2.42)points in the medication group,which was significantly lower than that before treatment in the two groups(both P<0.05);and the difference in the score was significant between the two groups(P<0.05).④Comparison of serum NPY content:after treatment,the serum NPY content of the acupuncture group and the medication group were(7.08±3.02)mmol/L and(9.89±3.82)mmol/L,respectively,which was significantly lower than that before treatment within each group(both P<0.05).The difference was significant between the two groups(P<0.05).⑤Effective rate:after treatment,the total effective rate was 95.24%in the acupuncture group and 90.00%in the medication group,without statistically significant difference(P>0.05).Conclusions bowls-unblocking and mind-regulating acupuncture therapy relieved the defecation-related symptoms,anxiety,and depression in IBS-C patients;and it was more effective on abdominal pain compared with mosapride citrate.Acupuncture therapy also had some long-term effect,which may be related to its regulatory effect on the serum NPY content.展开更多
基金National natural science foundation of China(No.81904294)Key natural science research project of Anhui(No.KJ2018A0297)。
文摘Objective:To investigate the effects of electricity on the expression of procalcitonin(CGRP)and serotonin(5-HT)in serum and colon in rats with constipation-type irritable bowel syndrome(IBS-C).Methods:50 rats were randomly divided into three groups:normal control group,model group,electroacupuncture group with four single points(tianshu electroacupuncture group,Colonic acupuncture group,Quchi electroacupuncture group,Shangjuxu acupoint group,and bilateral acupoint alternating between left and right),and non-meridian non-acupoint group(non-meridian non-acupoint group on both hip of electroacupuncture rats).The IBS-C model was replicated in the other three groups,except the normal control group,using the cold-fear-starvation synthesis method.After successful replication of the model,the four electroacupuncture single-point group and the non-acupoint group began electroacupuncture treatment once a day for 3 consecutive days.The visceral sensitivity and the expression of CGRP and 5-HT in serum and colon were observed.Results:Compared with the normal control group,the minimum volume threshold of abdominal retractile reflex(AWR)in the model group decreased(P<0.05),and the expressions of 5-HT and CGRP in serum and colon increased(P<0.05).Compared with the model group,AWR minimum volume threshold was increased in the electroacupuncture group with four single acupuncture points(P<0.05),the expression of 5-ht and CGRP in serum and colon was significantly decreased(P<0.05),and there was no significant change in each indicator in the non-acupuncture point group(P>0.05).Conclusion:Electroacupuncture combined with four single points can effectively improve the visceral sensitivity of IBS-C rats and regulate the levels of 5-HT and CGRP in serum and colon of rats,thus providing experimental basis for the clinical treatment of IBS-C.
文摘目的:采用循证医学方法分析针刺治疗便秘型肠易激综合征(IBS-C)的经络取穴规律,为临床提供方案。方法:应用计算机检索截止至7月1日的文献,按照Cochrane系统文献质量评价的方法筛选随机对照研究方法文献,穴位出现采用频数和频率进行描述,运用SPSS26.0进行统计分析。结果:共有十二篇符合纳入标准的研究;十四经筛选统计总共出现19个穴位(前8个穴位依次为:足三里、天枢、上巨虚、三阴交、太冲、印堂、百会、中脘),分属11条经脉(足阳明胃经 > 任脉 > 足太阴脾经、督脉 > 足厥阴肝经、手少阳三焦经、手厥阴心包经、手阳明大肠经、足太阳膀胱经、手少阴心经、足少阳胆经)。结论:肠易激综合征便秘型针刺治疗穴位多选用募穴、下合穴、交会穴,常选用足阳明胃经、督脉、任脉、足太阴脾经、足厥阴肝经。Objective: To analyze the rule of meridian point selection in the treatment of constipated irritable bowel syndrome (IBS-C) by evidence-based medicine, and to provide clinical scheme. Methods: The literatures up to July 1 were searched by computer, and the literatures of randomized controlled studies were screened according to Cochrane systematic literature quality evaluation. The frequency of acupuncture points were described, and SPSS26.0 was used for statistical analysis. Results: A total of 12 studies met the inclusion criteria;After 14 screening, a total of 19 acupoints were found (the first 8 acupoints were: Zusanli, Tianshu, Shangjuxu, Sanyinjiao, Taichong, Yintang, Baihui, Zhongwan) belonging to 11 meridians (Zyangming Stomach Channel > Ren channel > Taiyin Spleen Channel, Du Channel > Jueyin Liver channel, Shaoyang Sanjiao Channel, Jueyin myocardium Channel, Yangming large intestine channel, Yang Sun Heart Channel, Shaoyang gallbladder channel). Conclusion: Mu point, Xiaihe point and Conifing point are the main acupuncture points for irritable bowel syndrome. The stomach channel, Du vein, Ren vein, Taiyin spleen channel and Jueyin liver channel of foot Yangming are often selected.
基金Supported by Graduate Education Innovation Project of Guizhou Province:YJSCXJH(2018)075Major special project of Guiyang College of Traditional Chinese Medicine:[2017]5735-34。
文摘Objective To observe the effects of bowls-unblocking and mind-regulating acupuncture therapy on constipation,anxiety,depression and serum neuropeptide Y(NPY)content for the patients with constipation-predominant irritable bowel syndrome(IBS-C).Methods Forty-two IBS-C patients were randomly assigned either into a bowls-unblocking and mind-regulating acupuncture group(acupuncture group)or a mosapride citrate group(medication group)with 21 cases in each group.During the treatment,one patient in the medication group was excluded and 20 patients were included in final statistical analysis;while 21 patients completed the trial in the acupuncture group.Before treatment,after treatment and in follow-up(1 month after the whole treatment),the scores of the Cleveland clinical constipation scoring system(CCS),the self-rating anxiety scale(SAS),and the self-rating depression scale(SDS)were assessed in both groups.The changes in NPY content were compared before and after treatment.Results①Total score of CCS:after treatment,the total score in the acupuncture group and the medication group were(4.76±2.10)points and(5.60±1.88)points,respectively,which were significantly lower than those before treatment in both groups(both P<0.05);and the difference in the score was not significant for the between-group comparison(P>0.05).In the follow-up,the total scores were(4.19±1.69)points in the acupuncture group,and was(6.35±2.06)points in the medication group.The score in the medication group was higher than that after treatment in the same group(P<0.05),but there was no significant difference between acupuncture group and the medication group(P>0.05).②SAS score:after treatment,the SAS scores were(50.24±2.19)points and(53.45±2.46)points in the acupuncture group and the medication group,respectively,which was lower than that before treatment in the two groups(both P<0.05);and the difference in the score was significant between two groups(P<0.05).In the follow-up,the scores were(51.95±2.27)points and(54.55±1.67)points in the acupuncture group and the medication group,respectively;which was lower than that before treatment in the two groups(both P<0.05),and the difference in the score was significant between two groups(P<0.05).③SDS score:after treatment,the SDS scores were(50.71±2.70)points and(53.15±2.25)points in the acupuncture group and the medication group,respectively,which was significantly lower than that before treatment in the two groups(both P<0.05);and the difference in the score was significant between the two group(P<0.05).In the follow-up,the score of the acupuncture group was(52.57±3.72)points and it was(56.60±2.42)points in the medication group,which was significantly lower than that before treatment in the two groups(both P<0.05);and the difference in the score was significant between the two groups(P<0.05).④Comparison of serum NPY content:after treatment,the serum NPY content of the acupuncture group and the medication group were(7.08±3.02)mmol/L and(9.89±3.82)mmol/L,respectively,which was significantly lower than that before treatment within each group(both P<0.05).The difference was significant between the two groups(P<0.05).⑤Effective rate:after treatment,the total effective rate was 95.24%in the acupuncture group and 90.00%in the medication group,without statistically significant difference(P>0.05).Conclusions bowls-unblocking and mind-regulating acupuncture therapy relieved the defecation-related symptoms,anxiety,and depression in IBS-C patients;and it was more effective on abdominal pain compared with mosapride citrate.Acupuncture therapy also had some long-term effect,which may be related to its regulatory effect on the serum NPY content.
