Although cerebral neuroplasticity following amputation has been observed, little is understood about how network-level functional reorganization occurs in the brain following upper-limb amputation. The objective of th...Although cerebral neuroplasticity following amputation has been observed, little is understood about how network-level functional reorganization occurs in the brain following upper-limb amputation. The objective of this study was to analyze alterations in brain network functional connectivity(FC) in upper-limb amputees(ULAs). This observational study included 40 ULAs and 40 healthy control subjects;all participants underwent resting-state functional magnetic resonance imaging. Changes in intra-and inter-network FC in ULAs were quantified using independent component analysis and brain network FC analysis. We also analyzed the correlation between FC and clinical manifestations, such as pain. We identified 11 independent components using independent component analysis from all subjects. In ULAs, intra-network FC was decreased in the left precuneus(precuneus gyrus) within the dorsal attention network and left precentral(precentral gyrus) within the auditory network;but increased in the left Parietal_Inf(inferior parietal, but supramarginal and angular gyri) within the ventral sensorimotor network, right Cerebelum_Crus2(crus Ⅱ of cerebellum) and left Temporal_Mid(middle temporal gyrus) within the ventral attention network, and left Rolandic_Oper(rolandic operculum) within the auditory network. ULAs also showed decreased inter-network FCs between the dorsal sensorimotor network and ventral sensorimotor network, the dorsal sensorimotor network and right frontoparietal network, and the dorsal sensorimotor network and dorsal attention network. Correlation analyses revealed negative correlations between inter-network FC changes and residual limb pain and phantom limb pain scores, but positive correlations between inter-network FC changes and daily activity hours of stump limb. These results show that post-amputation plasticity in ULAs is not restricted to local remapping;rather, it also occurs at a network level across several cortical regions. This observation provides additional insights into the plasticity of brain networks after upper-limb amputation, and could contribute to identification of the mechanisms underlying post-amputation pain.展开更多
Distinct brain remodeling has been found after different nerve reconstruction strategies,including motor representation of the affected limb.However,differences among reconstruction strategies at the brain network lev...Distinct brain remodeling has been found after different nerve reconstruction strategies,including motor representation of the affected limb.However,differences among reconstruction strategies at the brain network level have not been elucidated.This study aimed to explore intranetwork changes related to altered peripheral neural pathways after different nerve reconstruction surgeries,including nerve repair,endto-end nerve transfer,and end-to-side nerve transfer.Sprague–Dawley rats underwent complete left brachial plexus transection and were divided into four equal groups of eight:no nerve repair,grafted nerve repair,phrenic nerve end-to-end transfer,and end-to-side transfer with a graft sutured to the anterior upper trunk.Resting-state brain functional magnetic resonance imaging was obtained 7 months after surgery.The independent component analysis algorithm was utilized to identify group-level network components of interest and extract resting-state functional connectivity values of each voxel within the component.Alterations in intra-network resting-state functional connectivity were compared among the groups.Target muscle reinnervation was assessed by behavioral observation(elbow flexion)and electromyography.The results showed that alterations in the sensorimotor and interoception networks were mostly related to changes in the peripheral neural pathway.Nerve repair was related to enhanced connectivity within the sensorimotor network,while end-to-side nerve transfer might be more beneficial for restoring control over the affected limb by the original motor representation.The thalamic-cortical pathway was enhanced within the interoception network after nerve repair and end-to-end nerve transfer.Brain areas related to cognition and emotion were enhanced after end-to-side nerve transfer.Our study revealed important brain networks related to different nerve reconstructions.These networks may be potential targets for enhancing motor recovery.展开更多
G. C. Ying, Y. Y. Meng, B. E. Sagan, and V. R. Vatter [1] found the maximum number of maximal independent sets in connected graphs which contain at most two cycles. In this paper, we give an alternative proof to deter...G. C. Ying, Y. Y. Meng, B. E. Sagan, and V. R. Vatter [1] found the maximum number of maximal independent sets in connected graphs which contain at most two cycles. In this paper, we give an alternative proof to determine the largest number of maximal independent sets among all connected graphs of order n ≥ 12, which contain at most two cycles. We also characterize the extremal graph achieving this maximum value.展开更多
Let G be a 3-connected graph with n vertices. The paper proves that if for each pair of vertices u and v of G, d(u,v)=2, has ｜N(u)∩N(v)｜≤α(α is the minimum independent set number), and then max{d(u),d(v)}≥n+12,...Let G be a 3-connected graph with n vertices. The paper proves that if for each pair of vertices u and v of G, d(u,v)=2, has ｜N(u)∩N(v)｜≤α(α is the minimum independent set number), and then max{d(u),d(v)}≥n+12, then G is a Hamilton connected graph.展开更多
Independent component analysis( ICA) has been widely applied to the monitoring of non-Gaussian processes. Despite lots of applications,there is no universally accepted criterion to select the dominant independent comp...Independent component analysis( ICA) has been widely applied to the monitoring of non-Gaussian processes. Despite lots of applications,there is no universally accepted criterion to select the dominant independent components( ICs). Moreover, how to determine the number of dominant ICs is still an open question. To further address this issue,a novel process monitoring based on IC contribution( ICC) is proposed from the perspective of information storage. Based on the ICC with each variable,the dominant ICs can be obtained and the number of dominant ICs is determined objectively. To further preserve the process information, the remaining ICs are not useless. As a result,all the ICs are regarded to be divided into dominant and residual subspaces. The monitoring models are established respectively in each subspace, and then Bayesian inference is applied to integrating monitoring results of the two subspaces. Finally, the feasibility and effectiveness of the proposed method are illustrated through a numerical example and the Tennessee Eastman process.展开更多
To cope with the constraint problem of power consumption and transmission delay in the virtual backbone of wireless sensor network, a distributed connected dominating set （CDS） algorithm with （α,β）-constraints i...To cope with the constraint problem of power consumption and transmission delay in the virtual backbone of wireless sensor network, a distributed connected dominating set （CDS） algorithm with （α,β）-constraints is proposed. Based on the （α, β）-tree concept, a new connected dominating tree with bounded transmission delay problem（CDTT） is defined and a corresponding algorithm is designed to construct a CDT-tree which can trade off limited total power and bounded transmission delay from source to destination nodes. The CDT algorithm consists of two phases： The first phase constructs a maximum independent set（MIS）in a unit disk graph model. The second phase estimates the distance and calculates the transmission power to construct a spanning tree in an undirected graph with different weights for MST and SPF, respectively. The theoretical analysis and simulation results show that the CDT algorithm gives a correct solution to the CDTF problem and forms a virtual backbone with（ α,β）-constraints balancing the requirements of power consumption and transmission delay.展开更多
基金supported by the National Natural Science Foundation of China, No.81974331(to XYZ)Shanghai Municipal Education Commission-Gaofeng Clinical Medicine Grant, No.20161429(to XYZ)
文摘Although cerebral neuroplasticity following amputation has been observed, little is understood about how network-level functional reorganization occurs in the brain following upper-limb amputation. The objective of this study was to analyze alterations in brain network functional connectivity(FC) in upper-limb amputees(ULAs). This observational study included 40 ULAs and 40 healthy control subjects;all participants underwent resting-state functional magnetic resonance imaging. Changes in intra-and inter-network FC in ULAs were quantified using independent component analysis and brain network FC analysis. We also analyzed the correlation between FC and clinical manifestations, such as pain. We identified 11 independent components using independent component analysis from all subjects. In ULAs, intra-network FC was decreased in the left precuneus(precuneus gyrus) within the dorsal attention network and left precentral(precentral gyrus) within the auditory network;but increased in the left Parietal_Inf(inferior parietal, but supramarginal and angular gyri) within the ventral sensorimotor network, right Cerebelum_Crus2(crus Ⅱ of cerebellum) and left Temporal_Mid(middle temporal gyrus) within the ventral attention network, and left Rolandic_Oper(rolandic operculum) within the auditory network. ULAs also showed decreased inter-network FCs between the dorsal sensorimotor network and ventral sensorimotor network, the dorsal sensorimotor network and right frontoparietal network, and the dorsal sensorimotor network and dorsal attention network. Correlation analyses revealed negative correlations between inter-network FC changes and residual limb pain and phantom limb pain scores, but positive correlations between inter-network FC changes and daily activity hours of stump limb. These results show that post-amputation plasticity in ULAs is not restricted to local remapping;rather, it also occurs at a network level across several cortical regions. This observation provides additional insights into the plasticity of brain networks after upper-limb amputation, and could contribute to identification of the mechanisms underlying post-amputation pain.
基金supported by the National Natural Science Foundation of China,Nos.81871836(to MZ),82172554(to XH),and 81802249(to XH),81902301(to JW)the National Key R&D Program of China,Nos.2018YFC2001600(to JX)and 2018YFC2001604(to JX)+3 种基金Shanghai Rising Star Program,No.19QA1409000(to MZ)Shanghai Municipal Commission of Health and Family Planning,No.2018YQ02(to MZ)Shanghai Youth Top Talent Development PlanShanghai“Rising Stars of Medical Talent”Youth Development Program,No.RY411.19.01.10(to XH)。
文摘Distinct brain remodeling has been found after different nerve reconstruction strategies,including motor representation of the affected limb.However,differences among reconstruction strategies at the brain network level have not been elucidated.This study aimed to explore intranetwork changes related to altered peripheral neural pathways after different nerve reconstruction surgeries,including nerve repair,endto-end nerve transfer,and end-to-side nerve transfer.Sprague–Dawley rats underwent complete left brachial plexus transection and were divided into four equal groups of eight:no nerve repair,grafted nerve repair,phrenic nerve end-to-end transfer,and end-to-side transfer with a graft sutured to the anterior upper trunk.Resting-state brain functional magnetic resonance imaging was obtained 7 months after surgery.The independent component analysis algorithm was utilized to identify group-level network components of interest and extract resting-state functional connectivity values of each voxel within the component.Alterations in intra-network resting-state functional connectivity were compared among the groups.Target muscle reinnervation was assessed by behavioral observation(elbow flexion)and electromyography.The results showed that alterations in the sensorimotor and interoception networks were mostly related to changes in the peripheral neural pathway.Nerve repair was related to enhanced connectivity within the sensorimotor network,while end-to-side nerve transfer might be more beneficial for restoring control over the affected limb by the original motor representation.The thalamic-cortical pathway was enhanced within the interoception network after nerve repair and end-to-end nerve transfer.Brain areas related to cognition and emotion were enhanced after end-to-side nerve transfer.Our study revealed important brain networks related to different nerve reconstructions.These networks may be potential targets for enhancing motor recovery.
文摘G. C. Ying, Y. Y. Meng, B. E. Sagan, and V. R. Vatter [1] found the maximum number of maximal independent sets in connected graphs which contain at most two cycles. In this paper, we give an alternative proof to determine the largest number of maximal independent sets among all connected graphs of order n ≥ 12, which contain at most two cycles. We also characterize the extremal graph achieving this maximum value.
文摘Let G be a 3-connected graph with n vertices. The paper proves that if for each pair of vertices u and v of G, d(u,v)=2, has ｜N(u)∩N(v)｜≤α(α is the minimum independent set number), and then max{d(u),d(v)}≥n+12, then G is a Hamilton connected graph.
基金National Natural Science Foundations of China(Nos.61374140,61403072,61673173)Fundamental Research Funds for the Central Universities,China(Nos.222201717006,222201714031)
文摘Independent component analysis( ICA) has been widely applied to the monitoring of non-Gaussian processes. Despite lots of applications,there is no universally accepted criterion to select the dominant independent components( ICs). Moreover, how to determine the number of dominant ICs is still an open question. To further address this issue,a novel process monitoring based on IC contribution( ICC) is proposed from the perspective of information storage. Based on the ICC with each variable,the dominant ICs can be obtained and the number of dominant ICs is determined objectively. To further preserve the process information, the remaining ICs are not useless. As a result,all the ICs are regarded to be divided into dominant and residual subspaces. The monitoring models are established respectively in each subspace, and then Bayesian inference is applied to integrating monitoring results of the two subspaces. Finally, the feasibility and effectiveness of the proposed method are illustrated through a numerical example and the Tennessee Eastman process.
基金Major Program of the National Natural Science Foundation of China (No.70533050)High Technology Research Program ofJiangsu Province(No.BG2007012)+1 种基金China Postdoctoral Science Foundation(No.20070411065)Science Foundation of China University of Mining andTechnology(No.OC080303)
文摘To cope with the constraint problem of power consumption and transmission delay in the virtual backbone of wireless sensor network, a distributed connected dominating set （CDS） algorithm with （α,β）-constraints is proposed. Based on the （α, β）-tree concept, a new connected dominating tree with bounded transmission delay problem（CDTT） is defined and a corresponding algorithm is designed to construct a CDT-tree which can trade off limited total power and bounded transmission delay from source to destination nodes. The CDT algorithm consists of two phases： The first phase constructs a maximum independent set（MIS）in a unit disk graph model. The second phase estimates the distance and calculates the transmission power to construct a spanning tree in an undirected graph with different weights for MST and SPF, respectively. The theoretical analysis and simulation results show that the CDT algorithm gives a correct solution to the CDTF problem and forms a virtual backbone with（ α,β）-constraints balancing the requirements of power consumption and transmission delay.
