The study aimed to explore the association between psychological stress-related cytokines and essential hypertension to provide the theoretical basis for the prevention and control of the essential hypertension. We sc...The study aimed to explore the association between psychological stress-related cytokines and essential hypertension to provide the theoretical basis for the prevention and control of the essential hypertension. We screened hypertension patients in six communities in Wuzhong City of Ningxia, and chose the healthy people who had lived in the same community for full 5 years as a control group. Finally, we selected 210 pairs of cases and controls randomly, including 108 pairs of Hui and 102 pairs of Han (50% male;age 35 -74). The results showed that the serum TNF alpha levels of hypertension group were higher than the control group (ρ 0.01), and the serum IFN-gamma levels were lower than the control group both in Hui and Han (ρ 0.01). Further analysis showed that the serum TNF alpha level of the Hui hypertension group was higher than the Han hypertension group (ρ 0.01), while the serum IFN-gamma level was lower than Han hypertension group (ρ 0.01). In conclusion, TNF alpha and IFN-gamma were the important related cytokines between psychological stress and hypertension, and taking effective measures to control the level of serum TNF alpha. IFN-gamma may have the vital significance in alleviating or preventing the genesis and development of essential hypertension.展开更多
目的:探讨丙种球蛋白无反应及敏感川崎病患儿血小板(PLT)、干扰素-γ(IFN-γ)、白介素-6(IL-6)表达水平的差异及临床意义。方法:选取2019年5月至2022年6月厦门大学附属中山医院收治的99例川崎病患儿,根据丙种球蛋白治疗反应性分为无反应...目的:探讨丙种球蛋白无反应及敏感川崎病患儿血小板(PLT)、干扰素-γ(IFN-γ)、白介素-6(IL-6)表达水平的差异及临床意义。方法:选取2019年5月至2022年6月厦门大学附属中山医院收治的99例川崎病患儿,根据丙种球蛋白治疗反应性分为无反应组24例和敏感组75例,比较两组基线水平及12 h、36 h PLT、IFN-γ、IL-6表达水平。采用Logistic回归分析川崎病丙种球蛋白无反应的相关影响因素,采用受试者工作特征曲线(ROC)分析PLT、IFN-γ、IL-6及联合预测川崎病丙种球蛋白无反应的价值,采用DeLong检验不同方案的预测价值,采用临床决策曲线分析法(DCA)分析PLT+IFN-γ+IL-6方案预测川崎病丙种球蛋白反应性的临床效用。结果:无反应组12 h及36 h PLT、IFN-γ、IL-6表达水平与基线水平比较,差异无统计学意义(P>0.05);敏感组12 h及36 h PLT、IFN-γ、IL-6表达水平均低于基线水平(P<0.05);无反应组基线水平及12 h、36 h PLT、IFN-γ、IL-6表达水平高于敏感组(P<0.05);基线PLT、IFN-γ、IL-6均为川崎病丙种球蛋白无反应的独立相关影响因素(P<0.05);PLT、IFN-γ、IL-6及联合的ROC曲线下面积(AUC)依次为0.818、0.767、0.712、0.915,PLT+IFN-γ+IL-6的AUC高于IFN-γ、IL-6(P<0.05),与PLT比较,差异无统计学意义(P>0.05);采用PLT+IFN-γ+IL-6方案预测川崎病丙种球蛋白无反应具有临床正向的净获益。结论:川崎病丙种球蛋白无反应和敏感患儿PLT、IFN-γ、IL-6表达水平存在显著差异,与患儿治疗反应性有关,联合检测PLT、IFN-γ、IL-6可预测丙种球蛋白治疗反应。展开更多
文摘The study aimed to explore the association between psychological stress-related cytokines and essential hypertension to provide the theoretical basis for the prevention and control of the essential hypertension. We screened hypertension patients in six communities in Wuzhong City of Ningxia, and chose the healthy people who had lived in the same community for full 5 years as a control group. Finally, we selected 210 pairs of cases and controls randomly, including 108 pairs of Hui and 102 pairs of Han (50% male;age 35 -74). The results showed that the serum TNF alpha levels of hypertension group were higher than the control group (ρ 0.01), and the serum IFN-gamma levels were lower than the control group both in Hui and Han (ρ 0.01). Further analysis showed that the serum TNF alpha level of the Hui hypertension group was higher than the Han hypertension group (ρ 0.01), while the serum IFN-gamma level was lower than Han hypertension group (ρ 0.01). In conclusion, TNF alpha and IFN-gamma were the important related cytokines between psychological stress and hypertension, and taking effective measures to control the level of serum TNF alpha. IFN-gamma may have the vital significance in alleviating or preventing the genesis and development of essential hypertension.
文摘目的:探讨丙种球蛋白无反应及敏感川崎病患儿血小板(PLT)、干扰素-γ(IFN-γ)、白介素-6(IL-6)表达水平的差异及临床意义。方法:选取2019年5月至2022年6月厦门大学附属中山医院收治的99例川崎病患儿,根据丙种球蛋白治疗反应性分为无反应组24例和敏感组75例,比较两组基线水平及12 h、36 h PLT、IFN-γ、IL-6表达水平。采用Logistic回归分析川崎病丙种球蛋白无反应的相关影响因素,采用受试者工作特征曲线(ROC)分析PLT、IFN-γ、IL-6及联合预测川崎病丙种球蛋白无反应的价值,采用DeLong检验不同方案的预测价值,采用临床决策曲线分析法(DCA)分析PLT+IFN-γ+IL-6方案预测川崎病丙种球蛋白反应性的临床效用。结果:无反应组12 h及36 h PLT、IFN-γ、IL-6表达水平与基线水平比较,差异无统计学意义(P>0.05);敏感组12 h及36 h PLT、IFN-γ、IL-6表达水平均低于基线水平(P<0.05);无反应组基线水平及12 h、36 h PLT、IFN-γ、IL-6表达水平高于敏感组(P<0.05);基线PLT、IFN-γ、IL-6均为川崎病丙种球蛋白无反应的独立相关影响因素(P<0.05);PLT、IFN-γ、IL-6及联合的ROC曲线下面积(AUC)依次为0.818、0.767、0.712、0.915,PLT+IFN-γ+IL-6的AUC高于IFN-γ、IL-6(P<0.05),与PLT比较,差异无统计学意义(P>0.05);采用PLT+IFN-γ+IL-6方案预测川崎病丙种球蛋白无反应具有临床正向的净获益。结论:川崎病丙种球蛋白无反应和敏感患儿PLT、IFN-γ、IL-6表达水平存在显著差异,与患儿治疗反应性有关,联合检测PLT、IFN-γ、IL-6可预测丙种球蛋白治疗反应。
