基于负二项稀疏算子和推广的负二项稀疏算子的INAR(1)模型的比较

本文利用条件极大似然估计的方法比较利用预设新息分布法基于推广的负二项稀疏算子INAR(1)模型和负二项稀疏算子的INAR(1)模型的参数估计情况。通过对取不同新息项分布的两个模型分别进行数值模拟,并对两个模型数值模拟的结果进行对比来直观地表明由于基于负二项稀疏算子的INAR(1)模型在x=0点时概率质量不存在进而模型的所有边际分布不存在,从而证明利用预设新息分布法基于负二项稀疏算子的INAR(1)模型不存在,也表明推广的负二项稀疏算子在利用预设新息分布法构建INAR(1)模型中的必要性。

SIL1 improves cognitive impairment in APP23/PS45 mice by regulating amyloid precursor protein processing and Aβ generation

SIL1,an endoplasmic reticulum(ER)-resident protein,is reported to play a protective role in Alzheimer’s disease(AD).However,the effect of SIL1 on amyloid precursor protein(APP)processing remains unclear.In this study,the role of SIL1 in APP processing was explored both in vitro and in vivo.In the in vitro experiment,SIL1 was either overexpressed or knocked down in cells stably expressing the human Swedish mutant APP695.In the in vivo experiment,AAV-SIL1-EGFP or AAV-EGFP was microinjected into APP23/PS45 mice and their wild-type littermates.Western blotting(WB),immunohistochemistry,RNA sequencing(RNA-seq),and behavioral experiments were performed to evaluate the relevant parameters.Results indicated that SIL1 expression decreased in APP23/PS45 mice.Overexpression of SIL1 significantly decreased the protein levels of APP,presenilin-1(PS1),and C-terminal fragments(CTFs)of APP in vivo and in vitro.Conversely,knockdown of SIL1 increased the protein levels of APP,β-site APP cleavage enzyme 1(BACE1),PS1,and CTFs,as well as APP mRNA expression in 2EB2 cells.Furthermore,SIL1 overexpression reduced the number of senile plaques in APP23/PS45 mice.Importantly,Y-maze and Morris Water maze tests demonstrated that SIL1 overexpression improved cognitive impairment in APP23/PS45 mice.These findings indicate that SIL1 improves cognitive impairment in APP23/PS45 mice by inhibiting APP amyloidogenic processing and suggest that SIL1 is a potential therapeutic target for AD by modulating APP processing.

TLC Identification and Extraction Process of Rubiasin-1-methyl Ether from Yao Medicine Chuanlianzhu

[Objectives]To establish a thin-layer chromatography(TLC)method for the determination of rubiadin-1-methyl ether in Yao Medicine Chuanlianzhu(Damnacanthus giganteus).[Methods]A silica gel G thin-layer plate was adopted for TLC.Petroleum ether(60-90℃)-chloroform-methanol-water(7:15:3:1)was used as the developing solvent and inspected under ultraviolet lamp(365 nm).The content was determined by Inertsil ODS-3 C 18 column(4.60 mm×250 mm,5μm),mobile phase:acetonitrile-0.2%phosphoric acid gradient elution,detection wavelength 277 nm,flow rate 1.0 mL/min,column temperature 30℃,injection volume 10μL.[Results]The spots of 10 Chuanlianzhu samples from different origins showed the same color at the same position as the control,and the spots were clear and specific.The injection volume of rubiadin-1-methyl ether showed a good linear relationship in the range of 2.90-145μg(R=0.9996).The average recovery rate of rubiadin-1-methyl ether in the low,medium and high dose groups of Yao Medicine Chuanlianzhu was 98.72%,and RSD=1.78%.[Conclusions]This method can effectively identify Yao Medicine Chuanlianzhu medicinal materials and accurately determine the content of rubiadin-1-methyl ether in the medicinal materials.It provides a scientific basis for the development and utilization of Yao Medicine Chuanlianzhu medicinal resources.

Preliminary Announcement for the 1st Pacific Rim International Conference on Advanced Materials and Processing(PRICM-1)

The Joint Conference Organizing Committee of The Chinese Society of Metals(CSM),The Japan Insti-tute of Metals(JIM),The Korean Institute of Metals(KIM)and The Minerals,Metals & Materials Society(TMS)announces The First Pacific Rim International Conference on Advanced Materials and Processing(PRICM-1)which will be held in Hangzhou,China,in the last week of June,1992 lasting about four days.It is agreed that the PRICM-1 will be organized by The Chinese Society of Metals.

INAR(1)模型参数的Bayes估计

利用Bayes方法研究INAR(1)模型的参数估计,给出了模型参数的Bayes估计因子,并通过数值模拟将Bayes估计与Yule-Walker估计、条件最小二乘估计、条件极大似然估计进行比较.结果表明,Bayes估计方法在一定情形下优于其他方法.

Dynamic recrystallization of Ti-6Al-2Zr-1Mo-1V in β forging process

The dynamic recrystallization（DRX） behavior of Ti-6Al-2Zr-1Mo-1V alloy was investigated at deformation temperature of 1000-1100 °C and strain rate of 10-3-1.0 s-1 by using compression test.The results show that discontinuous dynamic recrystallization（DDRX） is the predominant recrystallization mechanism at temperature higher than 1050 °C and strain rate lower than 0.01 s-1.Meanwhile,continuous dynamic recrystallization is the main mechanism observed at temperature below 1050 °C and strain rate above 0.01 s-1,mixed with a few DDRX grains.In addition,decreasing strain rate and increasing deformation temperature are found to facilitate the progress of DRX and refinement of grains in the Ti alloy in β forging process.

Influence of pretreatment process on structure, morphology and electrochemical properties of Li[Ni_(1/3)Co_(1/3)Mn_(1/3)]O_2 cathode material

The layered Li[Ni1/3Mn1/3Co1/3]O2 was separately synthesized by pretreatment process of ball mill method and solution phase route, using [Ni1/3Co1/3Mn1/3]3O4 and lithium hydroxide as raw materials. The physical and electrochemical behaviors of Li[Ni1/3Mn1/3Co1/3]O2 were characterized by X-ray diffraction （XRD）, scanning electron microscopy （SEM）, field emission scanning electron microscopy （FESEM） and electrochemical charge/discharge cycling tests. The results show that the difference in pretreatment process results in the difference in compound Li[Ni1/3Co1/3Mn1/3]O2 structure, morphology and the electrochemical characteristics. The Li[Ni1/3Mn1/3Co1/3]O2 prepared by solution phase route maintains the uniform spherical morphology of the [Ni1/3Co1/3Mn1/3]3O4, and it exhibits a higher capacity retention and better rate capability than that prepared by ball mill method. The initial discharge capacity of this sample reaches 178 mA-h/g and the capacity retention after 50 cycles is 98.7% at a current density of 20 mA/g. Moreover, it delivers high discharge capacity of 135 mA-h/g at a current density of 1 000 mA/g.

新集矿区深部1煤层底板奥灰岩溶突水危险性评价

奥灰岩溶裂隙含水层是影响华北型煤矿深部开采的重要水害,在水-岩相互作用下奥灰含水层易导致煤层底板突水。为进一步认识奥灰岩溶突水问题,文章以新集矿区深部1煤层开采为例,利用矿区近些年最新积累的奥灰钻孔资料,选取断层强度指数、断层交叉点与尖灭点、含水层水压、富水性、隔水层等效厚度、脆塑比7个因素作为奥灰岩溶突水的主控因素,并结合层次分析法(analytic hierarchy process,AHP)确定各主控因素影响权重。运用地理信息系统(geographic information system,GIS)空间分析功能建立各主控因素专题图,通过对专题栅格图归一化处理,将各主控因素按照权重进行空间复合叠加,最终获得1煤层底板奥灰岩溶突水危险性评价分区结果。将评价结果与突水系数法计算结果对比分析可知,基于GIS的煤层底板突水危险性评价方法更符合矿区实际地质情况,可以为矿区深部煤层开采与水害防治工作提供参考依据。

玉米新品种华纬1号的选育及栽培技术要点

为促进玉米新品种华纬1号的推广应用,介绍了该品种的亲本来源及杂交种选育过程、植株生物学特性、产量表现及配套栽培技术。华纬1号是黑龙江省农业科学院玉米研究所和吉林宏兴高科农业有限公司于2015年以自交系J1136为母本、自交系J0866为父本杂交育成的玉米新品种,2023年通过黑龙江省农作物品种审定委员会审定(审定编号为黑审玉2023004)。2021-2022年区域试验平均产量为12 423.2 kg·hm^(-2),较对照品种先玉696增产7.8%;2022生产试验平均产量为12 622.6 kg·hm^(-2),较对照品种先玉696增产7.5%,该品种具有早发优势强、性状整齐、耐旱性好、亲本繁殖制种简单等优点。

彰显龙岩CB-1烟叶清甜蜜甜香型风格密集烘烤工艺研究

研究龙岩地区‘翠碧一号’的密集烘烤工艺,为彰显其清甜蜜甜香型风格提供参考。为彰显‘翠碧一号’烟叶清甜蜜甜香型风格,以福建龙岩烟区栽种‘翠碧一号’下、中、上部的适熟烟叶为实验材料,设置3种烘烤工艺,采用“背靠背”编烟方式编竿装烟,对烤后烟叶分别按下、中、上部进行分级,然后进行鉴定,统计外观、化学成分及感官质量等信息。结果显示,‘翠碧一号’(CB-1)品种烟叶下部烟宜采用T3(高温/高低高湿)烘烤工艺,关键烘烤阶段干/湿球温度为:变黄期38~40/37~38℃、凋萎期42/36℃、变筋期46/36℃、干片期50~54/38~39℃、干筋期60~65/40~42℃,中、上部烟叶宜采用T1(高温/高湿)烘烤工艺,关键烘烤阶段干/湿球温度为:变黄期38~40/37~38℃、凋萎期42/38℃、变筋期46/38℃、干片期50~54/39~40℃、干筋期60~65/40~42℃。该研究为彰显‘翠碧一号’香型的密集烘烤工艺提供技术参考。

Poisson INAR(1)过程的质量控制

为解决在实际生产中,过程数据并不总能满足彼此独立的假设前提,从而使得一些控制图不再适用于具有相关性的过程的问题,以免在监控过程中出现大量的虚假警报.论文采用取整法研究一阶自回归泊松计数过程模型,首先将一阶自回归模型与泊松计数过程结合起来,然后对原有的模型就行修正,在新模型的基础上重新构造了c控制图和残差控制图的控制限,以使得这两种控制图能够适应新的模型.研究结果表明:两种控制图都只是在一定的情况下使用,研究结论对于研究具有相关性的统计过程有着重要的推进作用.

Optimizing Control of Bio-dissimilation Process of Glycerol to 1,3-Propanedlol

An iterative optimization strategy is proposed and applied to the steady state optimizing control of the bio-dissimilation process of glycerol to 1,3-propanediol in the presence of model-plant mismatch and input constraints. The scheme is based on the Augmented Integrated System Optimization and Parameter Estimation （AI- SOPE） technique, but a linearization of some performance function in the modified model-based optimization problem of AISOPE is introduced to overcome the difficulty of determining an appropriate penalty parameter. When carrying out the iterative optimization, the penalty coefficient is set to a larger value at the current iteration than at the previous iteration, which can promote the evolution rate of the iterative optimization. Simulation studies illustrate the potential ofthe approach presented for the optimizing control of the bioTdissimilation process of glycerol to 1,3-propanediol. The effects of measurement noise, measured and unmeasured disturbances on the proposed algorithm are also investigated.

基于推广的负二项稀疏算子的随机系数INAR(1)模型及其应用

基于推广的负二项稀疏算子构建带有随机系数的一元INAR(1)模型,推导了该模型的概率统计性质,采用最小二乘估计法进行参数估计并进行了数值模拟。最后给出一个实例应用,并将该模型与其他模型进行对比研究,结果显示带有随机系数的基于推广的负二项稀疏算子的一元INAR(1)模型更适用于实际数据。

LncRNA DPP10-AS1 promotes malignant processes through epigenetically activating its cognate gene DPP10 and predicts poor prognosis in lung cancer patients

Objective:The purpose of this study was to explore the function and gene expression regulation of the newly identified lnc RNA DPP10-AS1 in lung cancer,and its potential value as a prognostic biomarker.Methods:q RT-PCR and Western blot were conducted to detect the expression of DDP10-AS1 and DPP10 in lung cancer cell lines and tissues.The effects of DDP10-AS1 on DPP10 expression,cell growth,invasion,apoptosis,and in vivo tumor growth were investigated in lung cancer cells by Western blot,rescue experiments,colony formation,flow cytometry,and xenograft animal experiments.Results:The novel antisense lnc RNA DPP10-AS1 was found to be highly expressed in cancer tissues(P<0.0001),and its upregulation predicted poor prognosis in patients with lung cancer(P=0.0025).Notably,DPP10-AS1 promoted lung cancer cell growth,colony formation,and cell cycle progression,and repressed apoptosis in lung cancer cells by upregulating DPP10 expression.Additionally,DPP10-AS1 facilitated lung tumor growth via upregulation of DPP10 protein in a xenograft mouse model.Importantly,DPP10-AS1 positively regulated DPP10 gene expression,and both were coordinately upregulated in lung cancer tissues.Mechanically,DPP10-AS1 was found to associate with DPP10 m RNA but did not enhance DPP10 m RNA stability.Hypomethylation of DPP10-AS1 and DPP10 contributed to their coordinate upregulation in lung cancer.Conclusions:These findings indicated that the upregulation of the antisense lnc RNA DPP10-AS1 promotes lung cancer malignant processes and facilitates tumorigenesis by epigenetically regulating its cognate sense gene DPP10.DPP10-AS1 may serve as a candidate prognostic biomarker and a potential therapeutic target in lung cancer.

观察值驱动的广义INAR(1)过程的经验似然推断

整值时间序列分析作为时间序列分析的重要组成部分,被广泛地应用于社会生活的各个领域。文章提出了一类观察值驱动的广义INAR(l)过程,推导了该模型的概率统计性质,并利用经验似然的方法研究了该模型的参数估计问题,给出了模型参数的极大经验似然估计量及其渐近分布。通过一系列的仿真实验,验证了经验似然方法的有效性。最后利用所提出的模型拟合了一组犯罪数据。

干酪乳杆菌LK-1的发酵特性及其在菠萝果汁中的应用

为利用干酪乳杆菌制备发酵菠萝果汁饮品,本研究对干酪乳杆菌LK-1(Lactobacillus casei LK-1,L. casei LK-1)的生长曲线、产酸、耐酸和耐糖等特性进行研究分析,并以活菌数和总酸为指标,通过单因素实验及响应面法考察L. casei LK-1发酵菠萝果汁的最佳条件。结果表明,L. casei LK-1在pH5~7和0%~10%质量分数葡萄糖环境下,具备良好的生长繁殖能力;在酸性(pH3)和高糖(40%质量分数葡萄糖)环境中培养3 h,其存活率分别为76%和71%;在MRS培养基中培养48 h,产酸量为5.35 g/kg,产酸能力良好,适用于果汁的发酵。L. casei LK-1发酵菠萝果汁的最佳条件为:初始pH6.8,发酵温度37℃,接种量1%(v/v),发酵时间30 h,此条件下制备的发酵菠萝果汁饮品活菌数为8.99±0.04 lg CFU/mL,总酸含量为7.16±0.26 g/kg,且色泽鲜亮,酸甜适口,风味较好,为L. casei LK-1在发酵食品中的进一步应用提供了理论和技术依据。

Optimization of processing parameters for preparation of Al-3Ti-1B grain refiner

Al-3Ti-1B master alloys were prepared at different processing parameters by the reaction of halide salts,and the grain refining response of Al-7Si alloy was investigated with Al-3Ti-B master alloy.The microstructure of master alloy and its grain refining effect on Al-7Si alloy were investigated by means of OM,XRD and SEM.Experimental results show that,the size of Al3Ti particles presented in Al-3Ti-1B master alloys increases with the increase of reaction temperature and decreases with the increase of cooling rate.The grain refining efficiency of Al-3Ti-1B master alloy on Al-7Si alloy is mainly attributed to heterogeneous nucleation of Al3Ti particles,and the morphology ofα(Al)changes from coarse dendritic to fine equiaxed.As a result,Al-3Ti-1B master alloy is prepared by permanent mold,and holding at 800 ℃for 30min,which has better grain refining performance on Al-7Si alloy.

Reducing Efficiencies of the Commonly Used Heat Treatment Methods and Fermentation Processes on Aflatoxin M1 in Naturally Contaminated Fresh Cow Milk

The reducing efficiencies of the commonly used heat treatment methods and fermentation processes on aflatoxin M1 (AFM1) in Nigeria were investigated. Seventy samples of fresh cow milk from both conventional and traditional dairy cattle herds were collected and analyzed for the determination of AFM1 using Cobra-cell incorporated high performance liquid chromatography. Of these analyzed samples, 56 (80.0%) tested positive for AFM1 out of which 3 milk samples with high AFM1 concentrations were selectively pooled and subjected to varied conditions of heat treatments and fermentation processes using both indigenized and exotic strains of lactic acid bacteria (Lactobacillus bulgaricus + Streptococcus thermophilus and L. rhamnosus and L. plantarum) as starter cultures respectively. Both processes used either singly or combined, demonstrated high degrees of reducing effects on AFM1 levels. Sterilization of the milk at 121?C and 80?C under the same condition of time (15 - 20) min showed significant reduction of up to 58.8% (p 0.05) in the level of AFM1 when compared with the initial mean AFM1 concentration of the untreated fresh milk. The situation was however different around the boiling temperature of 100?C at which point the level of AFM1 reduction was found to be inconsistent. The indigenized combined strains showed some slight margins of AFM1 reduction in the proportions of (20.5, 30.8 and 43.9)% over and above that of the exotic strains (17.4, 30.0 and 41.1)% in 12 h, 48 h and 72 h of fermentation respectively. Generally, fermentation alone showed lower reduction of AFM1 in milk from 24.5% to 43.9% compared with the reducing activities of (35.4 to 58.8)% when heat-treated milk samples were subsequently subjected to varied fermentation conditions.

龙川县米贝村1^(#)泥石流灾害特征与运动过程

受区域气流影响,广东省龙川县在2019年6月10—13日出现持续强降雨天气,累计降雨量超过260 mm,从而引起全县发生大量滑坡、泥石流灾害。以米贝村1^(#)泥石流为研究对象,在野外调查认识基础上,结合Fluent数值分析对这类低山丘陵区的小型泥石流灾害运动特征展开研究。研究发现:米贝村1^(#)泥石流受沟床粗糙度、纵坡降、流向等因素影响,其流速具有动态变化特征,总体表现为先增大再减小的发展趋势,泥石流物质的变化对其运动速度有一定影响。在整个过程中最大流速可达9.77 m/s,平均速度为3.31 m/s,与实际调查结果相符。研究成果不仅可直接为米贝村重在区灾后工程防治提供指导,对于东南沿海相似地区的降雨型滑坡-泥石流灾害的研究具有借鉴作用。

基于经验似然方法的BINAR(1)过程参数的置信域

考虑将经验似然(EL)方法应用于二维一阶整数值自回归(BINAR(1))过程.先利用该过程条件最小二乘(CLS)估计量的渐近正态性建立经验似然比(ELR)统计量,并寻找其极限分布,以构造参数的置信域,解决参数的假设检验问题;然后通过数值模拟对比由EL方法和正态逼近(NA)法计算的参数置信域的覆盖率.