A型流感病毒(influenza A virus,IAV)是一种呼吸道病原体,可诱导宿主发生炎症反应,促进炎症细胞聚集,释放大量趋化因子、细胞因子以及转录因子等炎症因子,引起宿主过度炎症,导致细胞死亡和组织损伤。IAV编码的多种蛋白质可通过不同的机...A型流感病毒(influenza A virus,IAV)是一种呼吸道病原体,可诱导宿主发生炎症反应,促进炎症细胞聚集,释放大量趋化因子、细胞因子以及转录因子等炎症因子,引起宿主过度炎症,导致细胞死亡和组织损伤。IAV编码的多种蛋白质可通过不同的机制参与宿主炎症反应,大大增加IAV感染的发病率和死亡率。越来越多的研究表明,免疫调节策略可以在不影响宿主抵抗感染的情况下改善疾病预后。本文综述了IAV引发炎症反应的最新进展,以便为临床治疗IAV提供新思路。展开更多
Background From late May 2009, sporadic imported cases of novel influenza A （HIN1） were continuously confirmed in Shanghai, but there were few reports on its clinical presentation in China. The aim of the study was ...Background From late May 2009, sporadic imported cases of novel influenza A （HIN1） were continuously confirmed in Shanghai, but there were few reports on its clinical presentation in China. The aim of the study was to investigate the demographic and clinical features of the laboratory-confirmed cases and the treatment with oseltamivir. Method We performed a retrospective study in the Shanghai Public Health Clinical Center （SHAPHC）, reviewing the medical records of the laboratory-confirmed patients derived from June 10 to July 20, 2009. Results A total of 156 cases were enrolled, of whom 152 had a history of recent travel. The mean age was 22.6 years and 89 cases （57.1%） were males. The most common symptoms were fever, cough, and sore throat, with children more likely to run a temperature above 38.5℃ than adults. The mean leucocyte count was 5.4×10^9/L, the mean neutrophil count 3.2×10^9/L and the mean lymphocyte count 1.4×10^9/L. Other findings included a normal range or elevated level of C-reactive protein （CRP） and glutamic-pyruvic transaminase and a normal or decreased level of prealbumin; the levels of prealbumin and CRP were significantly lower in the children than in the adults. Fifty-two patients had abnormal chest CT results, with small unilateral or bilateral pulmonary infiltrates, axillary and mediastinal lymphadenopathy and local pleural thickening, while no cases showed symptoms of hypoxia. All the patients received oseltamivir and recovered without complications, but the duration of fever and virus shedding were significantly longer in the children than in the adults. Conclusions Travel-related circulation may be an important reason for the H1N1 epidemic in the non-epidemic areas, and the virus caused mild respiratory symptoms. The infection in children was more severe in terms of prealbumin levels, temperature, the duration of fever and virus shedding. Oseltamivir was effective for H1N1, but more effective in the adults than in the children.展开更多
为探讨中医中药抗乙型肝炎病毒的最佳方法,我们用自拟的抗病毒Ⅰ号方及辨证中药治疗慢性乙肝85例,分析了不同组方对乙肝病毒(HBV)复制指标的影响及其临床意义.1材料和方法1.1材料本组85例均为 HBeAg 和(或)HBV DNA 阳性的慢性肝炎患者,...为探讨中医中药抗乙型肝炎病毒的最佳方法,我们用自拟的抗病毒Ⅰ号方及辨证中药治疗慢性乙肝85例,分析了不同组方对乙肝病毒(HBV)复制指标的影响及其临床意义.1材料和方法1.1材料本组85例均为 HBeAg 和(或)HBV DNA 阳性的慢性肝炎患者,其中男68例,女17例,年龄14岁～60岁,平均34岁±11岁.平均病程3.95 a.临床诊断根据北京第五次全国传染病寄生虫病学术会议制定的《病毒性肝炎防治方案(试行)中的慢性肝炎诊断标准.85例均为慢性乙型肝炎。展开更多
文摘A型流感病毒(influenza A virus,IAV)是一种呼吸道病原体,可诱导宿主发生炎症反应,促进炎症细胞聚集,释放大量趋化因子、细胞因子以及转录因子等炎症因子,引起宿主过度炎症,导致细胞死亡和组织损伤。IAV编码的多种蛋白质可通过不同的机制参与宿主炎症反应,大大增加IAV感染的发病率和死亡率。越来越多的研究表明,免疫调节策略可以在不影响宿主抵抗感染的情况下改善疾病预后。本文综述了IAV引发炎症反应的最新进展,以便为临床治疗IAV提供新思路。
文摘Background From late May 2009, sporadic imported cases of novel influenza A （HIN1） were continuously confirmed in Shanghai, but there were few reports on its clinical presentation in China. The aim of the study was to investigate the demographic and clinical features of the laboratory-confirmed cases and the treatment with oseltamivir. Method We performed a retrospective study in the Shanghai Public Health Clinical Center （SHAPHC）, reviewing the medical records of the laboratory-confirmed patients derived from June 10 to July 20, 2009. Results A total of 156 cases were enrolled, of whom 152 had a history of recent travel. The mean age was 22.6 years and 89 cases （57.1%） were males. The most common symptoms were fever, cough, and sore throat, with children more likely to run a temperature above 38.5℃ than adults. The mean leucocyte count was 5.4×10^9/L, the mean neutrophil count 3.2×10^9/L and the mean lymphocyte count 1.4×10^9/L. Other findings included a normal range or elevated level of C-reactive protein （CRP） and glutamic-pyruvic transaminase and a normal or decreased level of prealbumin; the levels of prealbumin and CRP were significantly lower in the children than in the adults. Fifty-two patients had abnormal chest CT results, with small unilateral or bilateral pulmonary infiltrates, axillary and mediastinal lymphadenopathy and local pleural thickening, while no cases showed symptoms of hypoxia. All the patients received oseltamivir and recovered without complications, but the duration of fever and virus shedding were significantly longer in the children than in the adults. Conclusions Travel-related circulation may be an important reason for the H1N1 epidemic in the non-epidemic areas, and the virus caused mild respiratory symptoms. The infection in children was more severe in terms of prealbumin levels, temperature, the duration of fever and virus shedding. Oseltamivir was effective for H1N1, but more effective in the adults than in the children.
