Objective:To investigate the relationship betweenp16INK4a and primary hepatocellular carcinoma (HCC),especially hepatitis B-related HCC. Methods: p16INK4a andits protein in HCC were analyzed with PCR-SSCP and theimmun...Objective:To investigate the relationship betweenp16INK4a and primary hepatocellular carcinoma (HCC),especially hepatitis B-related HCC. Methods: p16INK4a andits protein in HCC were analyzed with PCR-SSCP and theimmunohistochemistry methods respectively. Results: Thepositive incidence of p16INK4 protein expressing in HCC waslower than that of normal liver tissue (P<0.05), and theabsence of p16INK4 protein was associated with HCCmetastasis (P<0.05). The low frequency of mutation ofp16INK4 exonl and exon2 upstream fragment was found inHCC. Conclusion: Absence of p16INK4 protein in HCC wasnot associated with HBV-infection.展开更多
文摘Objective:To investigate the relationship betweenp16INK4a and primary hepatocellular carcinoma (HCC),especially hepatitis B-related HCC. Methods: p16INK4a andits protein in HCC were analyzed with PCR-SSCP and theimmunohistochemistry methods respectively. Results: Thepositive incidence of p16INK4 protein expressing in HCC waslower than that of normal liver tissue (P<0.05), and theabsence of p16INK4 protein was associated with HCCmetastasis (P<0.05). The low frequency of mutation ofp16INK4 exonl and exon2 upstream fragment was found inHCC. Conclusion: Absence of p16INK4 protein in HCC wasnot associated with HBV-infection.
