目的:分析颅内压监测下侧脑室穿刺脑室外引流术对脑室内出血(IVH)患者的治疗效果及预后评价。方法:选取2014-01~2017-01期间内我院收治的40例脑室内出血(IVH)患者,按照治疗方式不同分为对照组(传统脑室外引流术组,简称传统手术组)、研究...目的:分析颅内压监测下侧脑室穿刺脑室外引流术对脑室内出血(IVH)患者的治疗效果及预后评价。方法:选取2014-01~2017-01期间内我院收治的40例脑室内出血(IVH)患者,按照治疗方式不同分为对照组(传统脑室外引流术组,简称传统手术组)、研究组(颅内压监测下侧脑室穿刺脑室外引流术组,简称颅内压监测组),各20例,对比疗效及预后。结果:对照组、研究组甘露醇使用量、引流管留置时间、GOS评分对比分别为1.89±0.41g/kg.d VS 0.92±0.33g/kg.d、11.93±2.02dVS 7.02±1.82d、3.01±0.42分VS 4.25±0.54分,研究组以上各项临床指标均优于对照组,对比差异有统计学意义(P<0.05);且研究组术后再出血、颅内感染、急性肾损伤发生率及死亡率均低于对照组,对比差异有统计学意义(P<0.05)。结论:予以IVH患者颅内压监测下侧脑室穿刺脑室外引流术治疗,可优化患者的临床指标,减轻神经缺损,降低并发症发生率、死亡率,预后良好。展开更多
Objectivs To evaluate the effect of phenobarbital in preventing intraventricular hemorrhage inpremature infants. Methods A randomized controlled trial for the prevention of neonatal intraventricularhemorrhage (IVH) wa...Objectivs To evaluate the effect of phenobarbital in preventing intraventricular hemorrhage inpremature infants. Methods A randomized controlled trial for the prevention of neonatal intraventricularhemorrhage (IVH) was carried out in 57 Chinese premature infants with gestation of 34 weeks. These prematureinfants were randomly assigned to prevented (23 cases) or control (34 cases) groups. Results No statisticallysignificant differences in general data between the two groups were found. It was noticed that the average Apgarscore in prevented group was lower than that in the control group. The average age at the time of the loading dosesof phenobarbital was 8.9± 8.3 (0.5～25)h (outborn babies usually delay to receive phenobarbital), and the averageduration of the maintenance dose was 5d. The mean value of serum phenobarbital level obtained on day 4 was 20.9±5.2mg/L. The results demonstrated that the incidence of IVH and severe IVH decreased significantly inprevented group (74% vs 97%, P<0.05 and 13% vs 62%, P<0.01 respectively). NO severe IVH and hydrocephaluswere develOPed in the infants with IVH grade Ⅱ in the prevented group. While 7 infants with grade Ⅱ developedgrade Ⅲ during very short period, and 2 infants had to shunt for hydrocephalus in the control group. Infants onphenobarbital had not observed any side - effects. The duration of clinical symptoms was markedly shortened in theprevented group. Conclusion The study supports the use of phenobarbital for the prevention of IVH and severeIVH in Chinese premature infants. It is suggested that phenobarbital prophylaxis should be routinely carried outin all preterm infants with gestational age 34 weeks within 6h alter birth.展开更多
文摘目的:分析颅内压监测下侧脑室穿刺脑室外引流术对脑室内出血(IVH)患者的治疗效果及预后评价。方法:选取2014-01~2017-01期间内我院收治的40例脑室内出血(IVH)患者,按照治疗方式不同分为对照组(传统脑室外引流术组,简称传统手术组)、研究组(颅内压监测下侧脑室穿刺脑室外引流术组,简称颅内压监测组),各20例,对比疗效及预后。结果:对照组、研究组甘露醇使用量、引流管留置时间、GOS评分对比分别为1.89±0.41g/kg.d VS 0.92±0.33g/kg.d、11.93±2.02dVS 7.02±1.82d、3.01±0.42分VS 4.25±0.54分,研究组以上各项临床指标均优于对照组,对比差异有统计学意义(P<0.05);且研究组术后再出血、颅内感染、急性肾损伤发生率及死亡率均低于对照组,对比差异有统计学意义(P<0.05)。结论:予以IVH患者颅内压监测下侧脑室穿刺脑室外引流术治疗,可优化患者的临床指标,减轻神经缺损,降低并发症发生率、死亡率,预后良好。
文摘Objectivs To evaluate the effect of phenobarbital in preventing intraventricular hemorrhage inpremature infants. Methods A randomized controlled trial for the prevention of neonatal intraventricularhemorrhage (IVH) was carried out in 57 Chinese premature infants with gestation of 34 weeks. These prematureinfants were randomly assigned to prevented (23 cases) or control (34 cases) groups. Results No statisticallysignificant differences in general data between the two groups were found. It was noticed that the average Apgarscore in prevented group was lower than that in the control group. The average age at the time of the loading dosesof phenobarbital was 8.9± 8.3 (0.5～25)h (outborn babies usually delay to receive phenobarbital), and the averageduration of the maintenance dose was 5d. The mean value of serum phenobarbital level obtained on day 4 was 20.9±5.2mg/L. The results demonstrated that the incidence of IVH and severe IVH decreased significantly inprevented group (74% vs 97%, P<0.05 and 13% vs 62%, P<0.01 respectively). NO severe IVH and hydrocephaluswere develOPed in the infants with IVH grade Ⅱ in the prevented group. While 7 infants with grade Ⅱ developedgrade Ⅲ during very short period, and 2 infants had to shunt for hydrocephalus in the control group. Infants onphenobarbital had not observed any side - effects. The duration of clinical symptoms was markedly shortened in theprevented group. Conclusion The study supports the use of phenobarbital for the prevention of IVH and severeIVH in Chinese premature infants. It is suggested that phenobarbital prophylaxis should be routinely carried outin all preterm infants with gestational age 34 weeks within 6h alter birth.
