The reaction of 2-substituted imidazolinium salt with bis-Grignard reagents is reported and a new method for the synthesis of symmetric diketones from carboxylic acids and bis-Grignard reagents is provided.
Two new bis-imidazolinium salts (4a, 4b) have been synthesized as precursors of N-heterocyclic carbenes (NHCs) from the commercially available (R)-2,2′-dihydroxy-1,1′-binaphthalene. The two bis-imidazolinium salts w...Two new bis-imidazolinium salts (4a, 4b) have been synthesized as precursors of N-heterocyclic carbenes (NHCs) from the commercially available (R)-2,2′-dihydroxy-1,1′-binaphthalene. The two bis-imidazolinium salts were used as efficient precursor of NHC ancillary ligands in the palladium-catalyzed Heck reaction. Good to excellent yields and high stereoselectivities were obtained with ethyl acrylate, acrylonitrile, and acrylamide as starting materials. The structure of bis-imidazolinium salt 4b was further characterized by single crystal X-ray diffraction analysis.展开更多
基金This work was supported by the National NatUral Science Foundation of China the Provincial Natural Science Foundation of Sha
文摘The reaction of 2-substituted imidazolinium salt with bis-Grignard reagents is reported and a new method for the synthesis of symmetric diketones from carboxylic acids and bis-Grignard reagents is provided.
基金support from the National Natural Science Foundation of China (20932004, 21072093)the National Basic Research Program of China (2011CB808600)+1 种基金the Program for New Century Excellent Talents in University (NCET-07-0425)the Doctoral Fund of Ministry of Education of China (20090091110017)
文摘Two new bis-imidazolinium salts (4a, 4b) have been synthesized as precursors of N-heterocyclic carbenes (NHCs) from the commercially available (R)-2,2′-dihydroxy-1,1′-binaphthalene. The two bis-imidazolinium salts were used as efficient precursor of NHC ancillary ligands in the palladium-catalyzed Heck reaction. Good to excellent yields and high stereoselectivities were obtained with ethyl acrylate, acrylonitrile, and acrylamide as starting materials. The structure of bis-imidazolinium salt 4b was further characterized by single crystal X-ray diffraction analysis.
