Liver transplantation has become standard practice for treating end-stage liver disease.The success of the procedure relies on effective immunosuppressive medications to control the host's immune response.Despite ...Liver transplantation has become standard practice for treating end-stage liver disease.The success of the procedure relies on effective immunosuppressive medications to control the host's immune response.Despite the liver's inherent capacity to foster tolerance,the early post-transplant period is marked by significant immune reactivity.To ensure favorable outcomes,it is imperative to identify and manage various rejection types,encompassing T-cell-mediated,antibody-mediated,and chronic rejection.However,the approach to prescribing immunosuppressants relies heavily on clinical judgment rather than evidencebased criteria.Given that the majority of patients will require lifelong immunosuppression as the mechanisms underlying operational tolerance are still being investigated,healthcare providers must possess an understanding of immune responses,rejection mechanisms,and the pathways targeted by immunosuppressive drugs.This knowledge enables customization of treatments and improved patient care,even though a consensus on an optimal immunosuppressive regimen remains elusive.展开更多
An engineering microburst model to generate the microburst wind field for virtual flight simulation has been presented. The model is built as a finite viscosity vortex core model based on the vortex ring theory consid...An engineering microburst model to generate the microburst wind field for virtual flight simulation has been presented. The model is built as a finite viscosity vortex core model based on the vortex ring theory considering the air viscosity,and it can solve the problem of induced velocity discontinuity at the inner region near the vortex core. Moreover,the central axis velocity is obtained by turbulence free jet theory so as to avoid the singularity.The parameters in multiple-vortex-ring microburst model are determined by improved quantum genetic algorithm( QGA) based on immune and mutation operator,and the parameters optimization of the model under condition of different maximum vertical velocity are investigated. The results show that the microburst model is effective and accurate. The simulation results fit the preset value very well,and the error is controlled within 10^(- 7).展开更多
文摘Liver transplantation has become standard practice for treating end-stage liver disease.The success of the procedure relies on effective immunosuppressive medications to control the host's immune response.Despite the liver's inherent capacity to foster tolerance,the early post-transplant period is marked by significant immune reactivity.To ensure favorable outcomes,it is imperative to identify and manage various rejection types,encompassing T-cell-mediated,antibody-mediated,and chronic rejection.However,the approach to prescribing immunosuppressants relies heavily on clinical judgment rather than evidencebased criteria.Given that the majority of patients will require lifelong immunosuppression as the mechanisms underlying operational tolerance are still being investigated,healthcare providers must possess an understanding of immune responses,rejection mechanisms,and the pathways targeted by immunosuppressive drugs.This knowledge enables customization of treatments and improved patient care,even though a consensus on an optimal immunosuppressive regimen remains elusive.
基金National Natural Science Foundation of China(No.61032001)
文摘An engineering microburst model to generate the microburst wind field for virtual flight simulation has been presented. The model is built as a finite viscosity vortex core model based on the vortex ring theory considering the air viscosity,and it can solve the problem of induced velocity discontinuity at the inner region near the vortex core. Moreover,the central axis velocity is obtained by turbulence free jet theory so as to avoid the singularity.The parameters in multiple-vortex-ring microburst model are determined by improved quantum genetic algorithm( QGA) based on immune and mutation operator,and the parameters optimization of the model under condition of different maximum vertical velocity are investigated. The results show that the microburst model is effective and accurate. The simulation results fit the preset value very well,and the error is controlled within 10^(- 7).
