Sepsis,a highly life-threatening organ dysfunction caused by uncontrollable immune responses to infection,is a leading contributor to mortality in intensive care units.Sepsis-related deaths have been reported to accou...Sepsis,a highly life-threatening organ dysfunction caused by uncontrollable immune responses to infection,is a leading contributor to mortality in intensive care units.Sepsis-related deaths have been reported to account for 19.7%of all global deaths.However,no effective and specific therapeutic for clinical sepsis management is available due to the complex pathogenesis.Concurrently eliminating infections and restoring immune homeostasis are regarded as the core strategies to manage sepsis.Sophisticated nanoplatforms guided by supramolecular and medicinal chemistry,targeting infection and/or imbalanced immune responses,have emerged as potent tools to combat sepsis by supporting more accurate diagnosis and precision treatment.Nanoplatforms can overcome the barriers faced by clinical strategies,including delayed diagnosis,drug resistance and incapacity to manage immune disorders.Here,we present a comprehensive review highlighting the pathogenetic characteristics of sepsis and future therapeutic concepts,summarizing the progress of these well-designed nanoplatforms in sepsis management and discussing the ongoing challenges and perspectives regarding future potential therapies.Based on these state-of-the-art studies,this review will advance multidisciplinary collaboration and drive clinical translation to remedy sepsis.展开更多
This paper focuses on investigating immunological principles in designing a multi-agent security architecture for intrusion detection and response in wireless mesh networks.In this approach,the immunity-based agents m...This paper focuses on investigating immunological principles in designing a multi-agent security architecture for intrusion detection and response in wireless mesh networks.In this approach,the immunity-based agents monitor the situation in the network.These agents can take appropriate actions according to the underlying security policies.Specifically,their activities are coordinated in a hierarchical fashion while sensing,communicating,determining and generating responses.Such an agent can learn about and adapt to its environment dynamically and can detect both known and unknown intrusions.The proposed intrusion detection architecture is designed to be flexible,extendible,and adaptable so that it can perform real-time monitoring.This paper provides the conceptual view and a general framework of the proposed system.In the end,the architecture is illustrated by an example and by simulation to show it can prevent attacks efficiently.展开更多
Healthy homeostasis is a principal driving force of the dynamic equilibrium of living organisms. The dynamical basis of homeostasis is the complex and interconnected feedback mechanisms, which are fundamentally govern...Healthy homeostasis is a principal driving force of the dynamic equilibrium of living organisms. The dynamical basis of homeostasis is the complex and interconnected feedback mechanisms, which are fundamentally governed by the nervous system, mainly the balance of the sympathetic and parasympathetic controlling actions. The balancing regulation is well presented in the heart’s sinus node and can be measured by the time-domain heart-rate variation (HRV) of its frequency domain to analyze the constitutional frequencies of the variation. This last is a fluctuation that shows 1/f time fractal arrangement (f is the composing frequency). The time-fractal arrangement could depend on the structural fractal of the His-Purkinje system of the heart and personally modify the HRV. The cancers gradually destroy the homeostatic harmony, starting locally and finishing systemically. The controlling activity of vagus-nerve changes the HRV or the power density spectrum of the signal fluctuations in malignant development, presenting an appropriate control of the cancerous processes. The modified spectrum by a non-invasive radiofrequency treatment could arrest the tumor growth. An appropriate modulation could support the homeostatic control and force reconstructing of the broken complexity.展开更多
Plants have evolved a complex innate immune system that deploys two interconnected receptor layers to detect the invasion of various pathogens.Cell surface-resident pattern recognition receptors(PRRs)perceive pathogen...Plants have evolved a complex innate immune system that deploys two interconnected receptor layers to detect the invasion of various pathogens.Cell surface-resident pattern recognition receptors(PRRs)perceive pathogen-or microbeassociated molecular patterns(PAMPs/MAMPs),initiating a basal defense response called pattern-triggered immunity(PTI)(Zhou and Zhang,2020).展开更多
Tissue-resident immune cells are known to be derived from their circulating precursors and migrate to tissues for host defense.Recent studies have revealed heterogeneity in the origin and proliferation properties of m...Tissue-resident immune cells are known to be derived from their circulating precursors and migrate to tissues for host defense.Recent studies have revealed heterogeneity in the origin and proliferation properties of macrophages,which are a prototype tissue-resident immune cell.The tissue-resident macrophages can originate from embryonic and fetal sources and are selfmaintained by continuous local self-renewal.1,2 As accessory cells,tissue-resident macrophages support parenchymal cells(their‘client cells’),and their functions range from tissue development to tissue homeostasis(for example,osteoclasts,lung macrophages,microglia,splenic red-pulp macrophages,and Kupffer cells).Although macrophages are known as the major immune cell with tissue-specific functions,new frameworks integrating the functions of other immune cells with the maintenance of tissue homeostasis will be likely established in the near future.展开更多
This review discussed the relationship among copper,human,and bacteria.Copper plays an important role in human immunity.Copper can boost human immune defense reactions at recommended intake level.The content mainly fo...This review discussed the relationship among copper,human,and bacteria.Copper plays an important role in human immunity.Copper can boost human immune defense reactions at recommended intake level.The content mainly focused on copper antibacterial activity and copper antibacterial mechanisms.Conclusions stated that copper antibacterial activity is affected by copper homeostasis mechanisms in bacteria,adhesion,humidity,strain specificity,and manufacturing methods of antibacterial agents.For the preparation of particle antibacterial agents and surface antibacterial agents,this review discussed several manufacturing methods,such as sol−gel,cold spray,and biosynthesis belonging to chemical synthesis,physical synthesis,and biological synthesis,respectively.Sol−gel method contributes to the preparation of particle agents and surface agents.Cold spray technique is utilized in synthesis of surface copper agent.Biosynthesis is a novel technology which can be applied in nanoparticle agent preparation.展开更多
基金the National Key Research and Development Program of China(Grant No.2018YFC2001904).
文摘Sepsis,a highly life-threatening organ dysfunction caused by uncontrollable immune responses to infection,is a leading contributor to mortality in intensive care units.Sepsis-related deaths have been reported to account for 19.7%of all global deaths.However,no effective and specific therapeutic for clinical sepsis management is available due to the complex pathogenesis.Concurrently eliminating infections and restoring immune homeostasis are regarded as the core strategies to manage sepsis.Sophisticated nanoplatforms guided by supramolecular and medicinal chemistry,targeting infection and/or imbalanced immune responses,have emerged as potent tools to combat sepsis by supporting more accurate diagnosis and precision treatment.Nanoplatforms can overcome the barriers faced by clinical strategies,including delayed diagnosis,drug resistance and incapacity to manage immune disorders.Here,we present a comprehensive review highlighting the pathogenetic characteristics of sepsis and future therapeutic concepts,summarizing the progress of these well-designed nanoplatforms in sepsis management and discussing the ongoing challenges and perspectives regarding future potential therapies.Based on these state-of-the-art studies,this review will advance multidisciplinary collaboration and drive clinical translation to remedy sepsis.
基金supported by National Natural Science Foundation of China under Grant No.60932003National High Technical Research and Development Program of China(863 program) Grant No.2007AA01Z452,No.2009AA01Z118+1 种基金Shanghai Municipal Natural Science Foundation under Grant No.09ZR1414900National Undergraduate Innovative Test Program under Grant No.091024812
文摘This paper focuses on investigating immunological principles in designing a multi-agent security architecture for intrusion detection and response in wireless mesh networks.In this approach,the immunity-based agents monitor the situation in the network.These agents can take appropriate actions according to the underlying security policies.Specifically,their activities are coordinated in a hierarchical fashion while sensing,communicating,determining and generating responses.Such an agent can learn about and adapt to its environment dynamically and can detect both known and unknown intrusions.The proposed intrusion detection architecture is designed to be flexible,extendible,and adaptable so that it can perform real-time monitoring.This paper provides the conceptual view and a general framework of the proposed system.In the end,the architecture is illustrated by an example and by simulation to show it can prevent attacks efficiently.
文摘Healthy homeostasis is a principal driving force of the dynamic equilibrium of living organisms. The dynamical basis of homeostasis is the complex and interconnected feedback mechanisms, which are fundamentally governed by the nervous system, mainly the balance of the sympathetic and parasympathetic controlling actions. The balancing regulation is well presented in the heart’s sinus node and can be measured by the time-domain heart-rate variation (HRV) of its frequency domain to analyze the constitutional frequencies of the variation. This last is a fluctuation that shows 1/f time fractal arrangement (f is the composing frequency). The time-fractal arrangement could depend on the structural fractal of the His-Purkinje system of the heart and personally modify the HRV. The cancers gradually destroy the homeostatic harmony, starting locally and finishing systemically. The controlling activity of vagus-nerve changes the HRV or the power density spectrum of the signal fluctuations in malignant development, presenting an appropriate control of the cancerous processes. The modified spectrum by a non-invasive radiofrequency treatment could arrest the tumor growth. An appropriate modulation could support the homeostatic control and force reconstructing of the broken complexity.
基金the Taishan Scholars Program(tsqn202306306)the Key Research and Development Program of Shandong Province(2022LZGC005)+1 种基金China Postdoctoral Science Foundation(2023M732123)Shandong Postdoctoral Science Foundation(SDBX2022016).
文摘Plants have evolved a complex innate immune system that deploys two interconnected receptor layers to detect the invasion of various pathogens.Cell surface-resident pattern recognition receptors(PRRs)perceive pathogen-or microbeassociated molecular patterns(PAMPs/MAMPs),initiating a basal defense response called pattern-triggered immunity(PTI)(Zhou and Zhang,2020).
基金supported by a grant(2015-0367)from University of Ulsan.
文摘Tissue-resident immune cells are known to be derived from their circulating precursors and migrate to tissues for host defense.Recent studies have revealed heterogeneity in the origin and proliferation properties of macrophages,which are a prototype tissue-resident immune cell.The tissue-resident macrophages can originate from embryonic and fetal sources and are selfmaintained by continuous local self-renewal.1,2 As accessory cells,tissue-resident macrophages support parenchymal cells(their‘client cells’),and their functions range from tissue development to tissue homeostasis(for example,osteoclasts,lung macrophages,microglia,splenic red-pulp macrophages,and Kupffer cells).Although macrophages are known as the major immune cell with tissue-specific functions,new frameworks integrating the functions of other immune cells with the maintenance of tissue homeostasis will be likely established in the near future.
基金financial support from the fund of State Key Laboratory of Powder Metallurgy,Central South University,China
文摘This review discussed the relationship among copper,human,and bacteria.Copper plays an important role in human immunity.Copper can boost human immune defense reactions at recommended intake level.The content mainly focused on copper antibacterial activity and copper antibacterial mechanisms.Conclusions stated that copper antibacterial activity is affected by copper homeostasis mechanisms in bacteria,adhesion,humidity,strain specificity,and manufacturing methods of antibacterial agents.For the preparation of particle antibacterial agents and surface antibacterial agents,this review discussed several manufacturing methods,such as sol−gel,cold spray,and biosynthesis belonging to chemical synthesis,physical synthesis,and biological synthesis,respectively.Sol−gel method contributes to the preparation of particle agents and surface agents.Cold spray technique is utilized in synthesis of surface copper agent.Biosynthesis is a novel technology which can be applied in nanoparticle agent preparation.
