BACKGROUND Autoimmune atrophic gastritis(AAG)is a type of chronic gastritis that mainly affects the gastric corpus.Due to the lack of standard diagnostic criteria and overlaps with the courses of Helicobacter pylori-r...BACKGROUND Autoimmune atrophic gastritis(AAG)is a type of chronic gastritis that mainly affects the gastric corpus.Due to the lack of standard diagnostic criteria and overlaps with the courses of Helicobacter pylori-related atrophic gastritis,reports on the diagnostic strategy of AAG at an early stage are limited.CASE SUMMARY A 71-year-old woman with severe anemia was diagnosed with AAG.Endoscopic views and pathological findings showed the coexistence of normal mucosa in the gastric antrum and atrophic mucosa in the gastric fundus.Serological tests showed that anti-parietal cell antibodies and anti-intrinsic factor antibodies were both positive.Immunohistochemical results,which showed negative H^(+)-K^(+)ATPase antibody staining and positive chromogranin A(CgA)staining,confirmed the mechanism of this disease.After vitamin B12 and folic acid supplementation,the patient recovered well.CONCLUSION Successful diagnosis of AAG includes serological tests,endoscopic characteristics,and immunohistochemistry for H^(+)-K^(+)ATPase and CgA antibodies.展开更多
In this immunohistochemical study, the authors detected the expression of c-myc in ker-atinocytes ( ECK) from 30 psoriatics before and after Qingdai Compound Capsule ( QDCC) treatment and 12normal subjects for control...In this immunohistochemical study, the authors detected the expression of c-myc in ker-atinocytes ( ECK) from 30 psoriatics before and after Qingdai Compound Capsule ( QDCC) treatment and 12normal subjects for control. The results showed that the ECK of patients betore treatment was significantlyhigher than that in the normal control group, and its level was correlated with histopathological changes of af -fected skin. After treatment the ECK was normalized. It is believed that QDCC could decrease the ECK inpsoriatics and this effect was probably mediated by inhibiting c-myc expression. This study provided an ex-perimental evidence for the application of QDCC in treating psoriasis.展开更多
文摘BACKGROUND Autoimmune atrophic gastritis(AAG)is a type of chronic gastritis that mainly affects the gastric corpus.Due to the lack of standard diagnostic criteria and overlaps with the courses of Helicobacter pylori-related atrophic gastritis,reports on the diagnostic strategy of AAG at an early stage are limited.CASE SUMMARY A 71-year-old woman with severe anemia was diagnosed with AAG.Endoscopic views and pathological findings showed the coexistence of normal mucosa in the gastric antrum and atrophic mucosa in the gastric fundus.Serological tests showed that anti-parietal cell antibodies and anti-intrinsic factor antibodies were both positive.Immunohistochemical results,which showed negative H^(+)-K^(+)ATPase antibody staining and positive chromogranin A(CgA)staining,confirmed the mechanism of this disease.After vitamin B12 and folic acid supplementation,the patient recovered well.CONCLUSION Successful diagnosis of AAG includes serological tests,endoscopic characteristics,and immunohistochemistry for H^(+)-K^(+)ATPase and CgA antibodies.
文摘In this immunohistochemical study, the authors detected the expression of c-myc in ker-atinocytes ( ECK) from 30 psoriatics before and after Qingdai Compound Capsule ( QDCC) treatment and 12normal subjects for control. The results showed that the ECK of patients betore treatment was significantlyhigher than that in the normal control group, and its level was correlated with histopathological changes of af -fected skin. After treatment the ECK was normalized. It is believed that QDCC could decrease the ECK inpsoriatics and this effect was probably mediated by inhibiting c-myc expression. This study provided an ex-perimental evidence for the application of QDCC in treating psoriasis.
