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Two-dimensional particle-in-cell modeling of blow-off impulse by X-ray irradiation
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作者 Ruibo Li Jin-Long Jiao +3 位作者 Hui Luo Dezhi Zhang Dengwang Wang Kai Wang 《Nuclear Science and Techniques》 SCIE EI CAS CSCD 2024年第3期53-69,共17页
Space objects such as spacecraft or missiles may be exposed to intense X-rays in outer space,leading to severe damage.The reinforcement of these objects to reduce the damage caused by X-ray irradiation is a significan... Space objects such as spacecraft or missiles may be exposed to intense X-rays in outer space,leading to severe damage.The reinforcement of these objects to reduce the damage caused by X-ray irradiation is a significant concern.The blow-off impulse(BOI)is a crucial physical quantity for investigating material damage induced by X-ray irradiation.However,the accurate calculation of BOI is challenging,particularly for large deformations of materials with complex configurations.In this study,we develop a novel two-dimensional particle-in-cell code,Xablation2D,to calculate BOIs under far-field X-ray irradiation.This significantly reduces the dependence of the numerical simulation on the grid shape.The reliability of this code is verified by simulation results from open-source codes,and the calculated BOIs are consistent with the experimental and analytical results. 展开更多
关键词 X-ray irradiation Energy deposition Blow-off impulse Particle in cells
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Dynamic propagation velocity of a positive streamer in a 3 m air gap under lightning impulse voltage
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作者 李志伟 雷挺 +5 位作者 苏宇 姚修远 杨冰雪 刘德龙 律方成 丁玉剑 《Plasma Science and Technology》 SCIE EI CAS CSCD 2024年第4期114-121,共8页
Streamers represent an important stage in the initiation of gap discharge. In this work, we used an eight-frame intensified charge-coupled device camera to capture the streamer development process when a lightning imp... Streamers represent an important stage in the initiation of gap discharge. In this work, we used an eight-frame intensified charge-coupled device camera to capture the streamer development process when a lightning impulse voltage of 95%–100% U50% was applied in a 3 m rod–plate gap and the streamer velocity was analyzed. Analysis of the observations shows that streamer velocity can be defined by three stages: rapid velocity decline(stage 1), rapid velocity rise(stage 2)and slow velocity decline(stage 3). The effects of electrode shape, applied voltage and gap breakdown or withstanding on streamer velocity were analyzed. The electrode with a larger radius of curvature will result in a higher initial velocity, and a higher voltage amplitude will cause the streamer to propagate faster at stage 3. Gap withstanding or breakdown has no obvious effect on streamer velocity. In addition, the experimental results are compared with previous results and the statistical characteristics of the primary streamer discharge are discussed. 展开更多
关键词 lightning impulse 3 m air gap development process streamer velocity
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ON DE FINETTI'S OPTIMAL IMPULSE DIVIDEND CONTROL PROBLEM UNDER CHAPTER 11 BANKRUPTCY
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作者 王文元 明瑞星 胡亦钧 《Acta Mathematica Scientia》 SCIE CSCD 2024年第1期215-233,共19页
Motivated by recent advances made in the study of dividend control and risk management problems involving the U.S.bankruptcy code,in this paper we follow[44]to revisit the De Finetti dividend control problem under the... Motivated by recent advances made in the study of dividend control and risk management problems involving the U.S.bankruptcy code,in this paper we follow[44]to revisit the De Finetti dividend control problem under the reorganization process and the regulator's intervention documented in U.S.Chapter 11 bankruptcy.We do this by further accommodating the fixed transaction costs on dividends to imitate the real-world procedure of dividend payments.Incorporating the fixed transaction costs transforms the targeting optimal dividend problem into an impulse control problem rather than a singular control problem,and hence computations and proofs that are distinct from[44]are needed.To account for the financial stress that is due to the more subtle concept of Chapter 11 bankruptcy,the surplus process after dividends is driven by a piece-wise spectrally negative Lévy process with endogenous regime switching.Some explicit expressions of the expected net present values under a double barrier dividend strategy,new to the literature,are established in terms of scale functions.With the help of these expressions,we are able to characterize the optimal strategy among the set of admissible double barrier dividend strategies.When the tail of the Lévy measure is log-convex,this optimal double barrier dividend strategy is then verified as the optimal dividend strategy,solving our optimal impulse control problem. 展开更多
关键词 spectrally negative Lévy process Chapter 11 bankruptcy De Finetti's dividend problem double barrier strategy impulse control
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Direction finding of bistatic MIMO radar in strong impulse noise
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作者 CHEN Menghan GAO Hongyuan +2 位作者 DU Yanan CHENG Jianhua ZHANG Yuze 《Journal of Systems Engineering and Electronics》 SCIE CSCD 2024年第4期888-898,共11页
For bistatic multiple-input multiple-output(MIMO)radar,this paper presents a robust and direction finding method in strong impulse noise environment.By means of a new lower order covariance,the method is effective in ... For bistatic multiple-input multiple-output(MIMO)radar,this paper presents a robust and direction finding method in strong impulse noise environment.By means of a new lower order covariance,the method is effective in suppressing impulse noise and achieving superior direction finding performance using the maximum likelihood(ML)estimation method.A quantum equilibrium optimizer algorithm(QEOA)is devised to resolve the corresponding objective function for efficient and accurate direc-tion finding.The results of simulation reveal the capability of the presented method in success rate and root mean square error over existing direction-finding methods in different application situations,e.g.,locating coherent signal sources with very few snapshots in strong impulse noise.Other than that,the Cramér-Rao bound(CRB)under impulse noise environment has been drawn to test the capability of the presented method. 展开更多
关键词 bistatic multiple-input multiple-output(MIMO)radar impulse noise direction finding lower order covariance quan-tum equilibrium optimizer algorithm(QEOA) maximum likeli-hood estimation method Cramér-Rao bound(CRB)
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基于Impulse 7000DP对除颤监护仪的质控方法研究
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作者 孟雪圻 辛红 王鹏发 《产品可靠性报告》 2024年第6期63-64,共2页
除颤监护仪是用于临床抢救的医疗设备,凭借其疗效确切、作用快、操作简便等优势,广泛应用于各级医疗单位中。该仪器是临床上经常使用的高风险医疗设备,其释放能量的准确性直接影响到其救治效果,因此必须定期进行检测。本文按照JJF 1149... 除颤监护仪是用于临床抢救的医疗设备,凭借其疗效确切、作用快、操作简便等优势,广泛应用于各级医疗单位中。该仪器是临床上经常使用的高风险医疗设备,其释放能量的准确性直接影响到其救治效果,因此必须定期进行检测。本文按照JJF 1149—2014《心脏除颤器校准规范》中针对除颤监护仪的校准方法,使用除颤器/经皮起搏器分析仪Impulse 7000DP对除颤监护仪的质控方法展开研究。 展开更多
关键词 除颤监护仪 除颤器/经皮起搏器分析仪 impulse 7000DP 校准
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Saccades of video head impulse test in Meniere's disease and Vestibular Migraine: What can we learn from? 被引量:2
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作者 Yi Du Xingjian Liu +4 位作者 Lili Ren Yu Wang Fei Ji Weiwei Guo Ziming Wu 《Journal of Otology》 CSCD 2023年第2期79-84,共6页
Background:Saccades are often observed on video head impulse tests(vHIT)in patients with Meniere's Disease(MD)and Vestibular Migraine(VM).However,their saccadic features are not fully described.Objective:This stud... Background:Saccades are often observed on video head impulse tests(vHIT)in patients with Meniere's Disease(MD)and Vestibular Migraine(VM).However,their saccadic features are not fully described.Objective:This study aims to identify the saccades characteristics of MD and VM.Methods:75 VM patients and 103 definite unilateral MD patients were enrolled in this study.First raw saccades were exported and analyzed.The VM patients were divided into left and right based on their ears,while the MD patients were separated into affected and unaffected subgroups based on their audiograms and symptoms.Results:The MD patients have more saccades on the affected side(85%vs.69%),and saccade velocity is more consistent than the contralateral side(shown by the coefficient of variation).The saccades occurrence rates on both sides are similar in VM(77%vs.76%),as are other saccadic parameters.The MD patients have more significant inter-aural differences than the VM patients,manifested in higher velocity(p-value 0.000),earlier arriving(p-value 0.010),and more time-domain gathered(p-value 0.003)on the affected side.Conclusions:Bilateral saccades are commonly observed in MD and VM.In contrast to MD,saccades on VM are subtle,scattered,and late-arrived.Furthermore,the MD patients showed inconsistent saccadic distribution with more velocity-uniform saccades on the affected side. 展开更多
关键词 Meniere's disease Vestibular migraine SACCADES Video head impulse test Differential diagnosis
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Acoustic radiation force impulse predicts long-term outcomes in a large-scale cohort:High liver cancer,low comorbidity in hepatitis B virus 被引量:1
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作者 Jennifer Tai Adam P Harrison +7 位作者 Hui-Ming Chen Chiu-Yi Hsu Tse-Hwa Hsu Cheng-Jen Chen Wen-Juei Jeng Ming-Ling Chang Le Lu Dar-In Tai 《World Journal of Gastroenterology》 SCIE CAS 2023年第14期2188-2201,共14页
BACKGROUND Acoustic radiation force impulse(ARFI)is used to measure liver fibrosis and predict outcomes.The performance of elastography in assessment of fibrosis is poorer in hepatitis B virus(HBV)than in other etiolo... BACKGROUND Acoustic radiation force impulse(ARFI)is used to measure liver fibrosis and predict outcomes.The performance of elastography in assessment of fibrosis is poorer in hepatitis B virus(HBV)than in other etiologies of chronic liver disease.AIM To evaluate the performance of ARFI in long-term outcome prediction among different etiologies of chronic liver disease.METHODS Consecutive patients who received an ARFI study between 2011 and 2018 were enrolled.After excluding dual infection,alcoholism,autoimmune hepatitis,and others with incomplete data,this retrospective cohort were divided into hepatitis B(HBV,n=1064),hepatitis C(HCV,n=507),and non-HBV,non-HCV(NBNC,n=391)groups.The indexed cases were linked to cancer registration(1987-2020)and national mortality databases.The differences in morbidity and mortality among the groups were analyzed.RESULTS At the enrollment,the HBV group showed more males(77.5%),a higher prevalence of prediagnosed hepatocellular carcinoma(HCC),and a lower prevalence of comorbidities than the other groups(P<0.001).The HCV group was older and had a lower platelet count and higher ARFI score than the other groups(P<0.001).The NBNC group showed a higher body mass index and platelet count,a higher prevalence of pre-diagnosed non-HCC cancers(P<0.001),especially breast cancer,and a lower prevalence of cirrhosis.Male gender,ARFI score,and HBV were independent predictors of HCC.The 5-year risk of HCC was 5.9%and 9.8%for those ARFI-graded with severe fibrosis and cirrhosis.ARFI alone had an area under the receiver operating characteristic curve(AUROC)of 0.742 for prediction of HCC in 5 years.AUROC increased to 0.828 after adding etiology,gender,age,and platelet score.No difference was found in mortality rate among the groups.CONCLUSION The HBV group showed a higher prevalence of HCC but lower comorbidity that made mortality similar among the groups.Those patients with ARFI-graded severe fibrosis or cirrhosis should receive regular surveillance. 展开更多
关键词 Non-alcoholic fatty liver disease Hepatitis B Hepatocellular carcinoma Acoustic radiation force impulse MORTALITY COMORBIDITY
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Method of SLAS’s ground track manipulation based on tangential impulse thrust
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作者 LE Xinlong CAO Xibin +1 位作者 DAI Yu WU Fan 《Journal of Systems Engineering and Electronics》 SCIE EI CSCD 2023年第5期1285-1293,共9页
Satellites with altitudes below 400 km are called super low altitude satellites(SLAS),often used to achieve responsive imaging tasks.Therefore,it is important for the manipulation of its ground track.Aiming at the pro... Satellites with altitudes below 400 km are called super low altitude satellites(SLAS),often used to achieve responsive imaging tasks.Therefore,it is important for the manipulation of its ground track.Aiming at the problem of ground track manipulation of SLAS,a control method based on tangential impulse thrust is proposed.First,the equation of the longitude difference between SLAS and the target point on the target latitude is derived based on Gauss’s variational equations.On this basis,the influence of the tangential impulse thrust on the ground track’s longitude is derived.Finally,the method for ground track manipulation of SLAS under the tangential impulse thrust is proposed.The simulation results verify the effective-ness of the method,after manipulation,the satellite can visit the target point and revisit it for multiple days. 展开更多
关键词 super low altitude satellite(SLAS) ground track drift modeling ground track manipulation tangential impulse thrust
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Proper Understanding of the Nerve Impulses and the Action Potential
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作者 Salama Abdelhady 《World Journal of Neuroscience》 2023年第3期103-117,共15页
Neurologists define the transmission of nerve impulses across the membranes of the neural cells as a result of difference in the concentration of ions while they measured an electric potential, called as an action pot... Neurologists define the transmission of nerve impulses across the membranes of the neural cells as a result of difference in the concentration of ions while they measured an electric potential, called as an action potential, which allows the propagation of such nerve impulses as electrical signals. Such measurements should guide them to a logical explanation of the nerve impulses as electric charges driven by the measured action potential. However, such logical conclusion, or explanation, is ignored due to a wrong definition of the flow of electric charges as a flow of electrons that cannot pass through neural networks. According to recent studies, electric charges are properly defined as electromagnetic (EM) waves whose energy is expressed as the product of its propagating electric potential times their entropy flow which is adhered to the flow of such energy. Such definition matches the logical conclusion of the nerve impulses as electric charges, as previously explained, and defines the entropy of the neural network, measured by Ammeters, in Watt or Joule/Volt. The measured entropy represents a neurodiagnostic property of the neural networks that measures its capacity to allow the flow of energy per unit action potential. Theoretical verification of the innovative definition of nerve impulses is presented by following an advanced entropy approach. A proper review of the machine records of the stimulating electric charges, used in the diagnosis of the neural networks, and the stimulated nerve impulses or stimulated responses, represents practical verifications of the innovative definitions of the electric charges and the nerve impulses. Comparing the functioning of the thermoelectric generators and the brain neurons, such neurons are defined as thermoelectric generators of the electric nerve impulses and their propagating, or action, potential. 展开更多
关键词 Nerve impulses Action Potential Electric Charges ENTROPY Electromagnetic Waves Thermoelectric Generators
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基于Impulse C的AES加密算法的仿真与实现 被引量:1
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作者 严利民 李建东 《计算机技术与发展》 2012年第10期184-187,共4页
加解密算法在信息安全领域受到了越来越广泛的关注。文中介绍了一种利用Impulse C语言对AES加密算法进行编程的方法,并在软硬件协同设计平台上对应用程序进行了桌面仿真。通过对Application Monitor的调用,对进程间数据进行监控,有效提... 加解密算法在信息安全领域受到了越来越广泛的关注。文中介绍了一种利用Impulse C语言对AES加密算法进行编程的方法,并在软硬件协同设计平台上对应用程序进行了桌面仿真。通过对Application Monitor的调用,对进程间数据进行监控,有效提高了仿真调试的效率。最后,将应用程序转换成为Verilog代码,手工编写了测试代码,并在Modelsim中进行了RTL级仿真,得到了正确的仿真结果。文中建立了算法描述语言到硬件描述语言的翻译,对于缩短设计周期具有一定意义。 展开更多
关键词 信息安全 AES算法 impulse C Application MONITOR 硬件描述语言
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基于Impulse C的软硬件协同设计及应用 被引量:1
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作者 姚大勇 杨广文 卢琳 《辽宁工学院学报》 2007年第3期152-155,159,共5页
介绍了Impulse Accelerated Technologies公司推出的CoDeveloper硬件/软件协同开发工具,结合实例说明如何基于Impulse C库函数在CoDeveloper工具及Xilinx公司的EDK嵌入式开发环境下进行软硬件协同开发的新技术,为软、硬件工程师特别是... 介绍了Impulse Accelerated Technologies公司推出的CoDeveloper硬件/软件协同开发工具,结合实例说明如何基于Impulse C库函数在CoDeveloper工具及Xilinx公司的EDK嵌入式开发环境下进行软硬件协同开发的新技术,为软、硬件工程师特别是软件工程师开发基于FPGA的嵌入式系统提供了新的思路。 展开更多
关键词 impulse C CoDeveloper FPGA 协同设计
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IMPULSIVE DIFFERENTIAL EQUATIONS WITH GAMMA DISTRIBUTED MOMENTS OF IMPULSES AND P-MOMENT EXPONENTIAL STABILITY 被引量:1
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作者 R.AGARWAL S.HRISTOVA +1 位作者 P.KOPANOV D.O'REGAN 《Acta Mathematica Scientia》 SCIE CSCD 2017年第4期985-997,共13页
Differential tigated. We study the properties of solutions sufficient conditions for equations with impulses at random moments are set up and invescase of Gamma distributed random moments of impulses. Several are stud... Differential tigated. We study the properties of solutions sufficient conditions for equations with impulses at random moments are set up and invescase of Gamma distributed random moments of impulses. Several are studied based on properties of Gammma distributions. Some p-moment exponential stability of the solutions are given. 展开更多
关键词 impulseS Gamma distributed moments of impulses p-moment exponentialstability Lyapunov functions
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Characteristics analysis of muzzle impulse noise based on wavelet energy spectrum
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作者 赖富文 张建宇 胡桂梅 《Journal of Measurement Science and Instrumentation》 CAS CSCD 2015年第2期142-146,共5页
Because muzzle impulse noise could cause damage to or have an intluence on the operator, tiae ettecnve protecnve measures should be taken. Therefore, correct analysis of impulse noise characteristics is very significa... Because muzzle impulse noise could cause damage to or have an intluence on the operator, tiae ettecnve protecnve measures should be taken. Therefore, correct analysis of impulse noise characteristics is very significant. Considering the shortcomings of fast Fourier transform method (FFT) in analysis of muzzle impulse noise frequency characteristics, wavelet energy spectrum method is put forward. Based on specific experiment data, the frequency characteristics and spectral energy dis tribution can be obtained. The experiment results show that wavelet energy spectrum method is applicable in muzzle impulse noise characteristic analysis. 展开更多
关键词 muzzle impulse noise wavelet transform energy spectrum signal processing
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Missionary Impulses and American Isolationism and Expansionism
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作者 汪涛 《陕西师范大学学报(哲学社会科学版)》 CSSCI 北大核心 2002年第S3期220-226,共7页
Isolationism and expansionism are two themes of American diplomacy. From the beginning of the state’s history, isolationism and expansionism have manifested themselves as two policy imperatives in American diplomacy.... Isolationism and expansionism are two themes of American diplomacy. From the beginning of the state’s history, isolationism and expansionism have manifested themselves as two policy imperatives in American diplomacy. On the surface, isolationism and expansionism represent contradictory attitudes and assumptions about America’s proper relationship with the outside world: isolationism advocates diplomatic and military non-entanglement in world affairs; expansionism urges active involvement in external affairs. But in a deeper sense, both isolationism and expansionism are manifestations of American sense of mission, the belief that the US has a special role to perform for all nations in the world. Isolationism is a passive approach to accomplish that mission: it emphasizes the exemplary nature of their country. Expansionism stresses the need for active involvement to achieve that mission; thus, is an active approach to American mission. 展开更多
关键词 MISSIONARY impulseS ISOLATIONISM EXPANSIONISM AMERICAN HISTORY
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Analysis of impulse electric field effect on organic exhaust gas decomposition
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作者 Zhang Yu Jin Xin-yu +1 位作者 Jiang Xuan-zhen Wang Rui 《Journal of Environmental Sciences》 SCIE EI CAS CSCD 1999年第1期61-66,共6页
The technique of organic exhaust gas decomposition with impulse corono dischrge plasma has been investigated in this study. It has been discovered that the impulse electric field affected the decomposition efficiency ... The technique of organic exhaust gas decomposition with impulse corono dischrge plasma has been investigated in this study. It has been discovered that the impulse electric field affected the decomposition efficiency with the secondary electron emission coefficient (δ) of the corona electrode as an intermediary: when the impulse voltage power ( W ) was fixed the corona electrode material with higher δ could induce higher decomposition efficiency. In these experiments, wolfram electrode which has the highest δ has really induced the highest decomposition efficiency. 展开更多
关键词 impulse electric field power impulse corona discharge secondary electron emission coefficient organic exhaust gas decomposition.
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A Novel Starting Impulse Suppression Method for Active Power Filter Based on Slowly Rising Curve
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作者 Jianfeng Yang Yu Ding 《Energy Engineering》 EI 2021年第6期1839-1853,共15页
With the widespread application of power electronic equipment in the power grid,the harmonic problem of the power grid becomes more pronounced,reducing the efficiency of power production,transmission,and utilization,a... With the widespread application of power electronic equipment in the power grid,the harmonic problem of the power grid becomes more pronounced,reducing the efficiency of power production,transmission,and utilization,and interfering with the normal operation of the power grid.Based on the requirements of harmonic suppression and power system protection,a shunt active power filter(SAPF)is proposed as an effective harmonic suppression method.However,there are problems with impulse current and impulse voltage in the starting process of SAPF.Impulse current and impulse voltage cause the power grid and switchgear to bear greater current stress and voltage stress,which seriously affect the security and reliability of the power grid and may damage the switchgear.To effectively solve the problem of impulse current and impulse voltage,the starting process of SAPF is divided into the uncontrolled rectification stage and the transition stage.The mathematical model of the DC side of APF is established.The causes of impulse current and impulse voltage in the uncontrolled rectifier and transition phases are analyzed.By introducing voltage square,a new starting impulse suppression strategy of active power filter based on the slow rising curve is proposed,fundamentally solving the problems of impulse current and impulse voltage.Simulation results verify the effectiveness and feasibility of this method. 展开更多
关键词 Shunt active power filter starting shock impulse current impulse voltage
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基于IMPULSE C的GF(P)域椭圆加密算法的硬件加速 被引量:2
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作者 崔强强 金同标 朱勇 《计算机应用》 CSCD 北大核心 2011年第9期2385-2388,共4页
研究了大素数域上的椭圆曲线加密算法,基于IMPULSE C语言,对该算法进行编程实现;在标准射影坐标系下,对点加和倍加算法进行并行化改进,并且在编程时利用编译器特性做了进一步的并行化。通过对加密算法合理的软硬件分割,将计算量大而且... 研究了大素数域上的椭圆曲线加密算法,基于IMPULSE C语言,对该算法进行编程实现;在标准射影坐标系下,对点加和倍加算法进行并行化改进,并且在编程时利用编译器特性做了进一步的并行化。通过对加密算法合理的软硬件分割,将计算量大而且复杂的点乘运算作为硬件部分,通过现场可编程门陈列(FPGA)进行硬件加速;将加密协议的其他部分作为软件部分,在传统CPU上执行,并将硬件部分生成VHDL代码。分别进行加密算法的CoDeveloper的桌面仿真和生成的硬件VHDL代码的ISE综合仿真。最后将该加速设计在Xilinx Virtex-5 xc5vfx70tFPGA开发板上作了实现,基于FPGA的实验结果表明,P-192上点乘运算处理在133 MHz时钟下用时2.9 ms,硬件资源分配合理,与现有的手工编写的HDL代码相比,具有并行加速优势。 展开更多
关键词 椭圆曲线密码学 素数域 射影坐标系 impulse C 现场可编程门陈列
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FPGA平台上Adaboost算法的Impulse C实现 被引量:1
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作者 杨泽宏 赵峰 《信息技术》 2009年第2期98-101,共4页
Impulse C是一种与ANSIC兼容的并行性扩展集,与EDK工具结合紧密。在研究Adaboost算法流程的基础上以Impulse C为工具,实现了人脸检测的Adaboost算法在FPGA上的软硬件划分和软件模块与硬件模块的设计,并通过软件仿真验证了硬件模块的功能。
关键词 impulse C ADABOOST算法
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Characterization of focal liver masses using acoustic radiation force impulse elastography 被引量:23
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作者 Hana Park Jun Yong Park +4 位作者 Do Young Kim Sang Hoon Ahn Chae Yoon Chon Kwang-Hyub Han Seung Up Kim 《World Journal of Gastroenterology》 SCIE CAS 2013年第2期219-226,共8页
AIM:To investigate the diagnostic performance of acoustic radiation force impulse(ARFI) elastography for characterizing focal liver mass by quantifying their stiffness.METHODS:This prospective study included 62 patien... AIM:To investigate the diagnostic performance of acoustic radiation force impulse(ARFI) elastography for characterizing focal liver mass by quantifying their stiffness.METHODS:This prospective study included 62 patients with a focal liver mass that was well visualized on conventional ultrasonography performed in our institution from February 2011 to November 2011.Among them,12 patients were excluded for ARFI measurement failure due to a lesion that was smaller than the region of the interest and at an inaccessible location(deeper than 8 cm)(n = 7) or poor compliance to hold their breath as required(n = 5).Finally,50 patients with valid ARFI measurements were enrolled.If a patient had multiple liver masses,only one mass of interest was chosen.The masses were diagnosed by histological examination or clinical diagnostic criteria.During ultrasonographic evaluation,stiffness,expressed as velocity,was checked 10 times per focal liver mass and the surrounding liver parenchyma.RESULTS:After further excluding three masses that were non-diagnostic on biopsy,a total of 47 focal mass lesions were tested,including 39(83.0%) malignant masses [24 hepatocellular carcinomas(HCC),seven cholangiocellular carcinomas(CCC),and eight liver metastases] and eight(17.0%) benign masses(five hemangiomas and three focal nodular hyperplasias,FNH).Thirty-seven(74.0%) masses were confirmed by histological examination.The mean velocity was 2.48 m/s in HCCs,1.65 m/s in CCCs,2.35 m/s in metastases,1.83 m/s in hemangiomas,and 0.97 m/s in FNHs.Although considerable overlap was still noted between malignant and benign masses,significant differences in ARFI values were observed between malignant and benign masses(mean 2.31 m/s vs 1.51 m/s,P = 0.047),as well as between HCCs and benign masses(mean 2.48 m/s vs 1.51 m/s,P = 0.006).The areas under the receiver operating characteristics curves(AUROC) for discriminating the malignant masses from benign masses was 0.724(95%CI,0.566-0.883,P = 0.048),and the AUROC for discriminating HCCs from benign masses was 0.813(95%CI,0.649-0.976,P = 0.008).To maximize the sum of sensitivity and specificity,an ARFI value of 1.82 m/s was selected as the cutoff value to differentiate malignant from benign liver masses.Furthermore,the cutoff value for distinguishing HCCs from benign masses was also determined to be 1.82 m/s.The diagnostic performance of the sum of the ARFI values for focal liver masses and the surrounding liver parenchyma to differentiate liver masses improved(AUROC = 0.853;95%CI,0.745-0.960;P = 0.002 in malignant liver masses vs benign ones and AUROC = 0.948;95%CI,0.896-0.992,P < 0.001 in HCCs vs benign masses).CONCLUSION:ARFI elastography provides additional information for the differential diagnosis of liver masses.However,our results should be interpreted in clinical context,because considerable overlap in ARFI values existed among liver masses. 展开更多
关键词 Acoustic radiation force impulse FOCAL LIVER mass Hepatocellular CARCINOMA HEMANGIOMA FOCAL NODULAR HYPERPLASIA Cholangiocellular CARCINOMA LIVER metastasis
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Evaluation of acoustic radiation force impulse imaging for determination of liver stiffness using transient elastography as a reference 被引量:30
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作者 Gerald Kircheis Abdurrahman Sagir +3 位作者 Christoph Vogt Stephan vom Dahl Ralf Kubitz Dieter Hussinger 《World Journal of Gastroenterology》 SCIE CAS CSCD 2012年第10期1077-1084,共8页
AIM: To evaluate cut-off values and performance of acoustic radiation force impulse imaging (ARFI) using transient elastography [FibroScan■ (FS)] as a reference. METHODS: Six hundred and six patients were enrolled in... AIM: To evaluate cut-off values and performance of acoustic radiation force impulse imaging (ARFI) using transient elastography [FibroScan■ (FS)] as a reference. METHODS: Six hundred and six patients were enrolled in this study.All patients underwent liver stiffness measurement with FS (FS-LS) and ARFI (with shear wave velocity quantification; ARFI-SWV) and the performance of ARFI in comparison to FS was determined. Sixtyeight patients underwent liver biopsy. RESULTS: Significantly higher success rates for the determination of liver stiffness were found using ARFI as compared to FS [604/606 (99.7%) vs 482/606 (79.5%); P < 0.001]. ARFI-SWV correlated significantly with FS-LS (r = 0.920, P < 0.001). ARFI-SWV increased significantly with the stage of fibrosis (1.09 ± 0.13 m/s for patients with no significant fibrosis (FS-LS < 7.6 kPa); 1.46 ± 0.27 m/s for patients with significant liver fibrosis (7.6 < FS-LS ≤ 13.0 kPa); and 2.55 ± 0.77 m/s for patients with liver cirrhosis (FS-LS > 13.0 kPa)). ARFI-SWV cut-off values were identified for no significant fibrosis (1.29 m/s; sensitivity 91.4% and specificity 92.6%) and for liver cirrhosis (1.60 m/s; sensitivity 92.3% and specificity 96.5%). The optimal cut-off value for predicting liver fibrosis (F ≥ 2) was 1.32 m/s (sensitivity 87.0% and specificity 80.0%) and for liver cirrhosis (F4) 1.62 m/s (sensitivity 100% and specificity 85.7%), for patients who underwent liver biopsy. An excellent inter-and intraobserver reproducibility was observed for ARFI-SWV determinations. CONCLUSION: An ARFI-SWV cut-off value of 1.29 m/s seems to be optimal for patients with no significant liver fibrosis and 1.60 m/s for patients with liver cirrhosis. 展开更多
关键词 Acoustic radiation force impulse imaging ELASTOGRAPHY FIBROSCAN LIVER
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