Study on the inclusion interactions of berberine hydrochloride and cucurbit[7] by spectrofluorimetry

The inclusion interaction between berberine hydrochloride （BRH） and cucurbit[7] （CB[7]） has been studied by spectrofluorimetry. The result showed that CB[7] interaction with BRH to form a stable inclusion complex with an association constant of 9.57 × 10^4 L/mol and the fluorescence intensity of the complex was enhanced in 17 times higher than that of the studied drug itself. Based on the significant enhancement of fluorescence intensity of BRH in inclusion complex, a spetrofluorimetric method with high sensitivity and selectivity was developed for the determination of BRH in aqueous solution. The linear range of the method was 3.2- 2 × 10^3 ng/mL with a detection limit of 1.1 ng/mL. The proposed procedure could be applied successfully to determination of BRH remained in pharmaceutical dosage forms, spiked human plasma and urine with satisfactory results.

Inclusion Property and Molecular Modeling of Calix[4]arene Derivatives

The inclusion properties of two calix[4]arene derivatives 5,11,17,23 tetra tert butyl 25, 27 bis (isopropyl carbamoyl methoxy) 26,28 diundecenyloxy calix[4]arene (C[4]A) and 25,27 dibutoxy 5,11,17,23 tetra tert butyl 26,28 diundecenyloxy calix[4]arene (C[4]B) were studied by gas chromatographic method. It was found that C[4]A could form inclusion complexes with benzene, toluene, methanol and ethanol while C[4]B could only form inclusion complex with methanol, which might be due to the different conformations of C[4]A and C[4]B. Molecular modeling showed that CH/π and OH/π interactions played important roles in the forming of inclusion complexes.

Host-guest interactions based supramolecular complexes self-assemblies for amplified chemodynamic therapy with H_(2)O_(2) elevation and GSH consumption properties

Although endogenous H_(2)O_(2) is overexpressed in tumor tissue,the amount of endogenous H_(2)O_(2) is still insufficient for chemodynamic therapy(CDT).In addition,the abundant cellular glutathione(GSH)could also consume·OH for reduced CDT.Thus,the elevation of H_(2)O_(2) and the consumption of GSH in tumor tissue are essential for the increased·OH yield and amplified CDT efficacy.In this paper,hostguest interactions based supramolecular complexes self-assemblies(SCSAs)were fabricated by incorporating cinnamaldehyde(CA)and PEG-modified cyclodextrin host units(m PEG-CD-CA)with ferrocene-(phenylboronic acid pinacol ester)conjugates(Fc-BE)on the basis of CD-induced host-guest interactions.After being internalized by cancer cells,CA can be released from SCSAs through the p H-responsive acetal linkage,elevating the H2O2level by activating NADPH oxidase.Then,Fc can catalyze the H_(2)O_(2) to higher cytotoxic hydroxyl radicals(·OH).Moreover,quinone methide(QM)can be produced through H_(2)O_(2)-induced aryl boronic ester rearrangement and further consume the antioxidant GSH.In vitro and in vivo experiments demonstrate that SCSAs can be provided as potential amplified CDT nanoagents.

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