Three groups of dynamic triaxial tests were performed for saturated Nanjing fine sand subjected to uniform cyclic loading. The tested curves of the excess pore water pressure （EPWP） ratio variation with the ratio of...Three groups of dynamic triaxial tests were performed for saturated Nanjing fine sand subjected to uniform cyclic loading. The tested curves of the excess pore water pressure （EPWP） ratio variation with the ratio of the number of cycles are provided. The concept of the EPWP increment ratio is introduced and two new concepts of the effective dynamic shear stress ratio and the log decrement of effective stress are defined. It is found that the development of the EPWP increment ratio can be divided into three stages： descending, stable and ascending. Furthermore, at the stable and ascending stages, a satisfactory linear relationship is obtained between the accumulative EPWP increment ratio and natural logarithm of the effective dynamic shear stress ratio. Accordingly, the EPWP increment ratio at the number of cycles N has been deduced that is proportional to the log decrement of effective stress at the cycle number N-l, but is independent of the cyclic stress amplitude. Based on the analysis, a new EPWP increment model for saturated Nanjing fine sand is developed from tested data fitting, which provides a better prediction of the curves of EPWP generation, the number of cycles required for initial liquefaction and the liquefaction resistance.展开更多
Objective: Zoledronic acid (ZOL) is a nitrogen-containing bisphosphonate that induces osteoclast apoptosis and inhibits bone resorption. Adding ZOL to neoadjuvant chemotherapy has been shown to have potential anticanc...Objective: Zoledronic acid (ZOL) is a nitrogen-containing bisphosphonate that induces osteoclast apoptosis and inhibits bone resorption. Adding ZOL to neoadjuvant chemotherapy has been shown to have potential anticancer benefits in women with HER2-negative breast cancer. The objective of the present study was to investigate ZOL’s cost-effectiveness from the perspective of health care payers in Japan. Methods: A Markov model was developed to evaluate the costs and effectiveness associated with ZOL + chemotherapy (CTZ) and chemotherapy (CT) alone over a 10-year time horizon. Monthly transition probabilities were estimated according to JONIE1 (Japan Organization of Neoadjuvant Innovative Expert) Study data and an extrapolated Weibull model. Health outcomes were measured in quality-adjusted life years (QALYs). Costs were calculated using year-2018 Japanese yen (JPY) (1.00 US dollars (USD) = 110.4 JPY). Model robustness was addressed through one-way and probabilistic sensitivity analysis. The costs and QALYs were discounted at a rate of 2% per year. Results: In the base case, the use of CTZ was associated with a gain of 3.94 QALYs. The incremental cost per QALY of the CTZ gain was 681,056.1 JPY (6168.99 USD) per QALY. Conclusion: It is convincing that neoadjuvant CTZ for patients with breast cancer would be expected to have statistically significant clinical efficacy. Addition of ZOL to CT might be a cost-effective option compared with CT alone.展开更多
The spatial pattern of paulownia witches＇ broom was investigated using an Iwao＇s （m^＊-m） model in Shaanxi Province, China. Iwao＇s （m^＊-m） model revealed that spatial pattern of paulownia witches＇ broom exhib...The spatial pattern of paulownia witches＇ broom was investigated using an Iwao＇s （m^＊-m） model in Shaanxi Province, China. Iwao＇s （m^＊-m） model revealed that spatial pattern of paulownia witches＇ broom exhibited a uniform distribution in sample plots. In this model, characteristics of contagiousness coefficient （a） justified the probability of infection by virus-transmission vectors. For tree age less than six, susceptible individuals were aggregated as clusters in the plots and then mutually repelled over age. A preliminary survey of stand volume show that from age five to six, stand volumes of disease grade II showed excessive vegetative growth and returned to normal level between ages ten and 11. Loss rate of volume increment with disease grade II decreased, and then returned to raising trend both at grades III and IV. This phenomenon is possibly caused by an over-compensation effect and by environmental factors. The redundancy of growth hormones in branches, shoots, leaves, buds and roots increased the stem volume of entire trees.展开更多
Since the reform and opening up in 1978, the improving efficiency of resource allocation, particularly the flow and migration of agricultural workforce to non-agricultural sectors, has contributed greatly to China'...Since the reform and opening up in 1978, the improving efficiency of resource allocation, particularly the flow and migration of agricultural workforce to non-agricultural sectors, has contributed greatly to China's economic growth. However, scholars have seldom carried out continuous empirical study on the extent of such contribution mainly due to limited methods for the calculation of labor allocation effect. This paper employs the incremental analysis method of index to separate labor allocation effect from economic growth in order to conduct an analysis on such effect under the framework of economic growth. Using this approach, this paper has calculated the labor allocation effect during various periods of time in China between 1978 and 2014 and the results indicate that the flow and migration of labor constituted the major source of China's economic growth during the periods between 1978 and 1987, between 1992 and 1998 and between 2003 and 2014 and still have great potentials in the coming decade. After 2025, the labor allocation effect will diminish and is likely to become a factor that hinders economic growth.展开更多
In view of the problems in the selection of alternatives which are mutually exclusive and the criticism against the increment principle, this article reveals the cause of the mistake and demonstrates that only the inc...In view of the problems in the selection of alternatives which are mutually exclusive and the criticism against the increment principle, this article reveals the cause of the mistake and demonstrates that only the increment principle and the incremental analysis method is the principle and method that we should follow and adopt in schematizing the economic policy-making.展开更多
In the study on functional low-carbon ergonomic validity in buildings,ergonomic validity is different from resource validity which is easy for quantitative analysis. To eliminate the complexity and uncertainty impacts...In the study on functional low-carbon ergonomic validity in buildings,ergonomic validity is different from resource validity which is easy for quantitative analysis. To eliminate the complexity and uncertainty impacts of human factors on quantitative study,it proposes a method of building a parameter of ergonomic validity—multi-effect time by using cardiotachometer to record heart rate change,being used to evaluate the functional low-carbon ergonomic validity targeting at the ontological characteristics of kitchen. This method is used to determine the physical consumption intensity( multi-effect) through heart rate incremental relation based on the principles of physiology and ergonomics,and to confirm the ergonomic validity of environmental factors by the time to complete standard work as well as multi-effect quantitative analysis. The test results show that,under the kitchen operating conditions,the multi-effect( ME) can properly reflect the real-time status of the operator and is easily operated; the parameters obtained are not significantly related to the physiological status of the operator,and multi-effect time( MT) is sensitive to the physical consumption brought about to the operator due to kitchen environmental factors; thus,it can be taken as an objective index,which is simple and easy to operate in residential kitchen functional low-carbon evaluation.展开更多
During the installation of a pipe pile,the soil around the pile will be squeezed out. This paper deals with this squeezing effect of open-ended pipe piles using the cylindrical cavity expansion theory. The characteris...During the installation of a pipe pile,the soil around the pile will be squeezed out. This paper deals with this squeezing effect of open-ended pipe piles using the cylindrical cavity expansion theory. The characteristics of soil with different tension and compression moduli and dilation are involved by applying the elastic theory with different moduli and logarithmic strain. The closed-form solutions of the radius of the plastic region,the displacement of the boundary between the plastic region and the elastic region and the expansion pressure on the external surface of the pipe piles are obtained. When obtaining these solutions,the soil plug in the open-ended pipe pile is considered by employing an incremental filling ratio to quantify the degree of soil plugging. Moreover,the effects of the ratio of tension and compression moduli,angle of dilation and incremental filling ratio on the radius of the plastic region and the expansion pressure on the external surface of the pipe pile are investigated. The parametric analyses show that it is necessary and important to consider the difference between the tension modulus and compression modulus,dilation angle and incremental filling ratio for studying the squeezing effect of open-ended pipe pile installation. It is concluded that the analytical solutions presented in this paper are suitable for studying the squeezing effect of open-ended pipe piles.展开更多
基金Key Research Project of National Natural Science Foundation of China Under Grant No.90715018National Basic Research Program of China Under Grant No.2007CB714200the Special Fund for the Commonweal Industry of China Under Grant No.200808022
文摘Three groups of dynamic triaxial tests were performed for saturated Nanjing fine sand subjected to uniform cyclic loading. The tested curves of the excess pore water pressure （EPWP） ratio variation with the ratio of the number of cycles are provided. The concept of the EPWP increment ratio is introduced and two new concepts of the effective dynamic shear stress ratio and the log decrement of effective stress are defined. It is found that the development of the EPWP increment ratio can be divided into three stages： descending, stable and ascending. Furthermore, at the stable and ascending stages, a satisfactory linear relationship is obtained between the accumulative EPWP increment ratio and natural logarithm of the effective dynamic shear stress ratio. Accordingly, the EPWP increment ratio at the number of cycles N has been deduced that is proportional to the log decrement of effective stress at the cycle number N-l, but is independent of the cyclic stress amplitude. Based on the analysis, a new EPWP increment model for saturated Nanjing fine sand is developed from tested data fitting, which provides a better prediction of the curves of EPWP generation, the number of cycles required for initial liquefaction and the liquefaction resistance.
文摘Objective: Zoledronic acid (ZOL) is a nitrogen-containing bisphosphonate that induces osteoclast apoptosis and inhibits bone resorption. Adding ZOL to neoadjuvant chemotherapy has been shown to have potential anticancer benefits in women with HER2-negative breast cancer. The objective of the present study was to investigate ZOL’s cost-effectiveness from the perspective of health care payers in Japan. Methods: A Markov model was developed to evaluate the costs and effectiveness associated with ZOL + chemotherapy (CTZ) and chemotherapy (CT) alone over a 10-year time horizon. Monthly transition probabilities were estimated according to JONIE1 (Japan Organization of Neoadjuvant Innovative Expert) Study data and an extrapolated Weibull model. Health outcomes were measured in quality-adjusted life years (QALYs). Costs were calculated using year-2018 Japanese yen (JPY) (1.00 US dollars (USD) = 110.4 JPY). Model robustness was addressed through one-way and probabilistic sensitivity analysis. The costs and QALYs were discounted at a rate of 2% per year. Results: In the base case, the use of CTZ was associated with a gain of 3.94 QALYs. The incremental cost per QALY of the CTZ gain was 681,056.1 JPY (6168.99 USD) per QALY. Conclusion: It is convincing that neoadjuvant CTZ for patients with breast cancer would be expected to have statistically significant clinical efficacy. Addition of ZOL to CT might be a cost-effective option compared with CT alone.
文摘The spatial pattern of paulownia witches＇ broom was investigated using an Iwao＇s （m^＊-m） model in Shaanxi Province, China. Iwao＇s （m^＊-m） model revealed that spatial pattern of paulownia witches＇ broom exhibited a uniform distribution in sample plots. In this model, characteristics of contagiousness coefficient （a） justified the probability of infection by virus-transmission vectors. For tree age less than six, susceptible individuals were aggregated as clusters in the plots and then mutually repelled over age. A preliminary survey of stand volume show that from age five to six, stand volumes of disease grade II showed excessive vegetative growth and returned to normal level between ages ten and 11. Loss rate of volume increment with disease grade II decreased, and then returned to raising trend both at grades III and IV. This phenomenon is possibly caused by an over-compensation effect and by environmental factors. The redundancy of growth hormones in branches, shoots, leaves, buds and roots increased the stem volume of entire trees.
文摘Since the reform and opening up in 1978, the improving efficiency of resource allocation, particularly the flow and migration of agricultural workforce to non-agricultural sectors, has contributed greatly to China's economic growth. However, scholars have seldom carried out continuous empirical study on the extent of such contribution mainly due to limited methods for the calculation of labor allocation effect. This paper employs the incremental analysis method of index to separate labor allocation effect from economic growth in order to conduct an analysis on such effect under the framework of economic growth. Using this approach, this paper has calculated the labor allocation effect during various periods of time in China between 1978 and 2014 and the results indicate that the flow and migration of labor constituted the major source of China's economic growth during the periods between 1978 and 1987, between 1992 and 1998 and between 2003 and 2014 and still have great potentials in the coming decade. After 2025, the labor allocation effect will diminish and is likely to become a factor that hinders economic growth.
文摘In view of the problems in the selection of alternatives which are mutually exclusive and the criticism against the increment principle, this article reveals the cause of the mistake and demonstrates that only the increment principle and the incremental analysis method is the principle and method that we should follow and adopt in schematizing the economic policy-making.
基金Sponsored by the "Twelfth Five-year" National Science and Technology Supoort Programe(Grant No.2011BAJ05B02-03)
文摘In the study on functional low-carbon ergonomic validity in buildings,ergonomic validity is different from resource validity which is easy for quantitative analysis. To eliminate the complexity and uncertainty impacts of human factors on quantitative study,it proposes a method of building a parameter of ergonomic validity—multi-effect time by using cardiotachometer to record heart rate change,being used to evaluate the functional low-carbon ergonomic validity targeting at the ontological characteristics of kitchen. This method is used to determine the physical consumption intensity( multi-effect) through heart rate incremental relation based on the principles of physiology and ergonomics,and to confirm the ergonomic validity of environmental factors by the time to complete standard work as well as multi-effect quantitative analysis. The test results show that,under the kitchen operating conditions,the multi-effect( ME) can properly reflect the real-time status of the operator and is easily operated; the parameters obtained are not significantly related to the physiological status of the operator,and multi-effect time( MT) is sensitive to the physical consumption brought about to the operator due to kitchen environmental factors; thus,it can be taken as an objective index,which is simple and easy to operate in residential kitchen functional low-carbon evaluation.
文摘During the installation of a pipe pile,the soil around the pile will be squeezed out. This paper deals with this squeezing effect of open-ended pipe piles using the cylindrical cavity expansion theory. The characteristics of soil with different tension and compression moduli and dilation are involved by applying the elastic theory with different moduli and logarithmic strain. The closed-form solutions of the radius of the plastic region,the displacement of the boundary between the plastic region and the elastic region and the expansion pressure on the external surface of the pipe piles are obtained. When obtaining these solutions,the soil plug in the open-ended pipe pile is considered by employing an incremental filling ratio to quantify the degree of soil plugging. Moreover,the effects of the ratio of tension and compression moduli,angle of dilation and incremental filling ratio on the radius of the plastic region and the expansion pressure on the external surface of the pipe pile are investigated. The parametric analyses show that it is necessary and important to consider the difference between the tension modulus and compression modulus,dilation angle and incremental filling ratio for studying the squeezing effect of open-ended pipe pile installation. It is concluded that the analytical solutions presented in this paper are suitable for studying the squeezing effect of open-ended pipe piles.
