Changes of bone mineral density, bone metabolism indices and cell factors in patients with hyperthyroidism

Objective:To observe the changes of bone mineral density, bone metabolism indices and cell factor in patients with hyperthyroidismMethods:A total of 116 cases of hyperthyroidism patients from June 2015 to June 2016 in our hospital were selected. as the object of observation group. Then, 120 cases of healthy people were selected as the object of control group. Thyroid function indexes (TT3, TT4, FT3, FT4, TSH), bone mineral density (BMD), bone metabolism indexes (PTH, BGP, PINP) and cell factors (IL-2, IL-6) in both groups were detected and compared.Results:TT3, TT4, FT3, FT4, TSH in control group were (1.40±0.81) nmol/L, (94.36±32.10) nmol/L, (5.04±1.18) pmol/L, (15.37±4.60) pmol/L, (2.55±1.21) mU/L. TT3, TT4, FT3, FT4, TSH in observation group were (5.48±2.36) nmol/L, (405.55±71.48) nmol/L, (16.27±5.14) pmol/L, (46.83±12.66) pmol/L, (0.04±0.01) mU/L. TT3, TT4, FT3, FT4 in the observation group were higher than that in control group obviously. TSH in the observation group was lower than that in observation group obviously. The difference between two groups was considered statistically significant. BMD, PTH in observation group were (0.62±0.08) g/m2, (26.25±9.16) pg/mL, which were obviously lower than BMD (1.23±0.11) g/m2, PTH (37.13±8.05) pg/mL in control group. The difference between two groups was considered statistically significant. BGP, PINP in observation group were (14.51±6.25) ng/mL, (223.63±10.38) μg/L, which were obviously higher than BGP (5.97±1.98) ng/mL, PINP (33.18±6.15) μg/L in control group. The difference between two groups was considered statistically significant. IL-2 in observation group was (1.60±0.51) ng/L, which was obviously lower than IL-2 (4.72±1.29) ng/L, in control group. IL-6 in observation group was (1.98±0.34) pg/L, which was obviously higher than IL-6, (1.50±0.23) pg/L, in control group. The difference between two groups was considered statistically significant.Conclusion:Bone mineral density in patients with hyperthyroidism decreased and bone metabolism in patients with hyperthyroidism was active. The significant changes of IL-2, IL-6 also can be seen. In the clinical ,We should enhance the detection of these indexes, so as to take measures to prevent and cure the complications such as osteoporosis.

公检法三机关分工、配合、制约原则质疑

公检法三机关分工、配合、制约的原则是特定历史条件下的产物,在当时的历史条件下有其合理因素,但不能否认这一原则背离了诉讼的基本原理,也与现代刑事司法价值观不符,已不适应作为基本原则在刑事诉讼中的规定。应重塑公检法三机关的关系,构建一体化的检警关系格局,实行起诉书一本主义,提高犯罪嫌疑人、被告人诉讼地位,扩大辩护律师的刑事诉讼中的参与范围。