Malignant tumor is the second leading cause of death due to its high incidence, lack of effective treatment and poor prognosis. The evaluation of anticancer drugs used to based on NCI-60 cell line models, but the limi...Malignant tumor is the second leading cause of death due to its high incidence, lack of effective treatment and poor prognosis. The evaluation of anticancer drugs used to based on NCI-60 cell line models, but the limited heterogeneity and the divorce from clinical practice of models lead to extremely low success rate of novel anticancer drugs during clinical trials (less than 10%). In recent years, because of the high heterogeneity and human derived tumor matrix, patient-derived tumor models have been gradually applied to the preclinical evaluation of various antitumor drugs, which shows certain advantages in predicting the clinical efficacy of antitumor drugs. Optimize the drug combination through patient-derived tumor models to achieve individualized medicine has gradually become an indispensable strategy in clinical cancer therapy. The current review summarized the development of patient-derived tumor models, characterized the application, advantages and challenges of them in preclinical antitumor drug evaluation and clinical precise medicine, which will provide a scientific basis and novel insights for further basic research, drug development and clinical application.展开更多
Background:With the rapid development of the world’s technology,the connection and integration between traditional medicine and modern machine learning technology are increasingly close.In this study,we aimed to anal...Background:With the rapid development of the world’s technology,the connection and integration between traditional medicine and modern machine learning technology are increasingly close.In this study,we aimed to analyze publications on machine learning in traditional medicine by using bibliometric methods and explore global trends in the field.Methods:Relevant research on machine learning in traditional medicine extracted from the Web of Science Core Collection database.Bibliometric analysis and visualization were performed using the Bibliometrix package in R software.Global trends,source journals,authorship,and thematic keywords analysis were performed in this study.Results:From 2012 to 2022,a total of 282 publications on machine learning in traditional medicine were identified and analyzed.The average annual growth rate of the publications was 13.35%.China had the largest contribution in this field(53.9%),followed by the United States(32.6%).IEEE Access had the largest number of published articles,with a total of 15 articles.Calvin Yu-Chian Chen,Xiao-juan Hu and Jue Wang were the main researchers in this field.Shanghai University of Traditional Chinese Medicine and University of California,San Francisco were the main research institutions.Conclusion:This study provides information on research trends in machine learning in traditional medicine to better understand research hotspots and future developments in this field.According to current global trends,the number of publications in this field will gradually increase.China currently dominated the field.Applied research of machine learning techniques may be the next hot topic in this field and deserves further attention.展开更多
Background:Osteoarthritis of the knee(KOA)is a chronic degenerative disease.KOA is a growing concern due to its high incidence and the pain and other burdens it places on patients.Traditional medicine is a health care...Background:Osteoarthritis of the knee(KOA)is a chronic degenerative disease.KOA is a growing concern due to its high incidence and the pain and other burdens it places on patients.Traditional medicine is a health care model with a long history that includes nature-based treatments,psycho-psychological types of treatments,and more.Traditional medicine is also more effective in diagnosing and treating KOA,and it has never stopped researching KOA.There are no bibliometric studies analyzing articles on the traditional medical diagnosis and management of KOA.This study aimed to comprehensively analyze and analyze the general trends in the study of KOA in traditional medicine from a bibliometric perspective.Methods:All articles reporting on KOA and traditional medicine from 1 January 1990 to 01 November 2022 were obtained from the Web of Science Core.Some software such as CiteSpace,VOS Viewer and Scimago Graphica were used to analyse the publications,which included authors,citations,journals,references,countries where studies were published,institutions and research keywords.The final visualisations were produced using this data.Results:A total of 769 articles were searched.Peijian Tong was identified as the most contributing and published author in the field,and medicine was identified as the most reputable journal in the field of traditional medicine and osteoarthritis of the knee.China is a global leader in the field and a centre of collaboration in the field,with a major concentration of traditional medicine in Asia,which is consistent with the evidence that traditional medicine originated in Asia.According to the data,“osteoarthritis”,“knee osteoarthritis”,“pain”,and“knee”and“hip”were identified as hot keywords for research in this area.Conclusions:The results of this bibliometric study provide a snapshot of the current state of clinical research in the treatment of KOA in traditional medicine and are well placed to envisage future hotspots and possible trends,and may help to provide researchers with more than enough information with a view to guiding the cutting edge of research in this field and the infinite possibilities for the future.展开更多
Objective:To analyze the current status and development trend of Chinese medicine research in the field of idiopathic membranous nephropathy since 2000.Methods:The literature related to Chinese medicine for idiopathic...Objective:To analyze the current status and development trend of Chinese medicine research in the field of idiopathic membranous nephropathy since 2000.Methods:The literature related to Chinese medicine for idiopathic membranous nephropathy published in China Knowledge Network(CNKI)since 2000 was searched,and CiteSpacewas applied to visualize the publication time,authors,and keywords of the literature and to draw a visual knowledge graph.Results:372 relevant literatures were included.Author analysis showed that there were 343 authors included,and the authors with the highest number of publications published 13 articles,and the core authors accounted for 10.2%of the total number;keyword analysis showed that 15 clusters were formed after burst analysis,and 10 emergent words were formed after keyword emergence analysis.Conclusion:Chinese medicine recognizes and intervenes in idiopathic membranous nephropathy in terms of evidence type,treatment method,common prescriptions and single herbs,auxiliary examination,treatment modality,and clinical research.The development trend lies in the combination of macroscopic and microscopic,the synergy between Chinese and Western,multidisciplinary collision diagnosis and treatment,as well as the use of Chinese medicine to intervene in the disease process at an early stage,and the integration of a worldwide standardized diagnosis and treatment guideline of Chinese medicine for idiopathic membranous nephropathy.展开更多
Despite improvements in adjuvant therapies for gastric cancer in recent years, the disease is characterized by high recurrence rates and a dismal prognosis. The major improvement in the treatment of recurrent or metas...Despite improvements in adjuvant therapies for gastric cancer in recent years, the disease is characterized by high recurrence rates and a dismal prognosis. The major improvement in the treatment of recurrent or metastatic gastric cancer in recent years has been the incorporation of trastuzumab, a monoclonal antibody that inhibits human epidermal growth factor receptor 2(HER2) heterodimerization, after the demonstrated predictive value of the overexpression and/or amplification of this receptor. Beyond HER2, other genetic abnormalities have been identified, and these mutations may be targetable by tyrosine kinase inhibitors or monoclonal antibodies. The demonstration of four distinct molecular subtypes of gastric cancer by the Cancer Genome Atlas study highlight the enormous heterogeneity of the disease and its complex interplay between genetic and epigenetic alterations and provide a roadmap to implement genome-guided personalized therapy in gastric cancer. In the present review, we aim to discuss, from a clinical point of view, the genomic landscape of gastric cancer described in recent studies, the therapeutic insights derived from these findings, and the clinical trials that have been conducted and those in progress that take into account tailored therapies for gastric cancer.展开更多
Background:Considering the great heterogeneity of Hepatocellular carcinoma(HCC),more accurate prognostic models are urgently needed.This paper combined the advantages of genomics and pathomics to construct a prognosti...Background:Considering the great heterogeneity of Hepatocellular carcinoma(HCC),more accurate prognostic models are urgently needed.This paper combined the advantages of genomics and pathomics to construct a prognostic model.Methods:First,we collected data from hepatocellular carcinoma patients with complete mRNA expression profiles and clinical annotations from the TCGA database.Then,based on immune-related genes,we used random forest plots to screen prognosis-related genes and build prognostic models.Bioinformatics was used to identify biological pathways,evaluate the tumor microenvironment,and perform drug susceptibility testing.Finally,we divided the patients into different subgroups according to the gene model algorithm.Pathological models were constructed by obtaining HE-stained sections from TCGA in corresponding subgroups of patients.Results:In this study,we constructed a stable prognostic model that could predict overall survival in HCC patients.The signature consisted of six immune-related genes(BX537318.1,TMEM147,CSPG4P12,AC015908.3,CEBPZOS,and SRD5A3).We found increased levels of infiltration of immune cells in the tumor microenvironment in patients with low risk scores,indicating significant antitumor immunity and corresponding to better clinical outcomes.We then screened nine drugs that were more sensitive in the low-risk group than in the high-risk group.Finally,we addressed the complex cellular changes and phenotypic heterogeneity in the HCC microenvironment by combining genomics and pathomics analysis methods.Conclusion:Our study showed that the prognostic evaluation model of HCC based on the immune signaling pathway is feasible and provided a reference value for potential immunotherapy for HCC.展开更多
The ancient people of our country have accumulated rich experience in prevention of epidemic disease in the course of fighting the epidemic for thousands of years,and invented effective methods of external use of Chin...The ancient people of our country have accumulated rich experience in prevention of epidemic disease in the course of fighting the epidemic for thousands of years,and invented effective methods of external use of Chinese medicine for preventing epidemic,some of these methods have been still used today,in addition to ensuring the health and safety of ancient people in China.In the COVID-19 ravaged China today,all kinds of protective supplies for the general public is difficult to get,so the study of external use of Chinese medicine that preventing epidemic for modern society is still very significant and valuable.According to the characteristics of COVID-19 and the theory of combination of disease-syndrome,based on the applicability and feasibility for modern society,combed out three methods of external use of Chinese medicine,including medicine hanging,medicine smearing and medicine fumigation,and made corresponding application recommendations for hospitals,communities,families to prevent epidemic disease.展开更多
Background: Holistic thinking, which is rooted in Eastern culture, is assumed to be the core of traditional Chinese medicine (TCM). Recently, such holistic thinking has been proposed to be applicable to Western medici...Background: Holistic thinking, which is rooted in Eastern culture, is assumed to be the core of traditional Chinese medicine (TCM). Recently, such holistic thinking has been proposed to be applicable to Western medicine practices for alleviating serious side effects;however, the obscure and often ill-defined terms of TCM, such as qi, yin yang, and wuxing, pose considerable obstacles for further understanding TCM. In the present study, we explored whether and how TCM is actually related to the scientific construct of holistic thinking, to elucidate the particular cultural signature of TCM. Methods: A random sample of 101 college students majoring in TCM and 93 non-medical college students was recruited for the study. Two psychological scales—the Chinese Holistic Thinking Scale and the TCM Competence Scale were used respectively to measure the holistic thinking and participants’ ability to apply the TCM in practice. Results: We found that individuals who thought more holistically were better at applying TCM to modern medical problems. Interestingly, TCM was associated with holistic thinking in both TCM and non-medical students, suggesting that this association is intrinsic. Further exploration revealed that the association and variability facets of Eastern holistic thinking—which emphasize that the world is interconnected and ever-changing, respectively—significantly accounted for the individual differences in competence in utilizing TCM in practice. Conclusion: In short, our study provides the first empirical evidence linking TCM to the Eastern holistic thinking style, which not only deepens the understanding of TCM from a scientific perspective but also promotes dialogue between TCM and Western medicine for building safer and more effective health care systems.展开更多
National medicine nursing is a valuable resource of health industry in Yunnan Province,which provides important support for the strategy strengthening the province with traditional Chinese medicine.The development of ...National medicine nursing is a valuable resource of health industry in Yunnan Province,which provides important support for the strategy strengthening the province with traditional Chinese medicine.The development of National medicine nursing is influenced by multiple factors.Based on the development model of cultural ecosphere,this paper analysed its development trend and put forward some suggestions for promoting its development.展开更多
基金the Scientific Research Project Funding of Jianghan University(2023zd053)The Scientific Research Project Funding of Jianghan University(2021jczx-002).
文摘Malignant tumor is the second leading cause of death due to its high incidence, lack of effective treatment and poor prognosis. The evaluation of anticancer drugs used to based on NCI-60 cell line models, but the limited heterogeneity and the divorce from clinical practice of models lead to extremely low success rate of novel anticancer drugs during clinical trials (less than 10%). In recent years, because of the high heterogeneity and human derived tumor matrix, patient-derived tumor models have been gradually applied to the preclinical evaluation of various antitumor drugs, which shows certain advantages in predicting the clinical efficacy of antitumor drugs. Optimize the drug combination through patient-derived tumor models to achieve individualized medicine has gradually become an indispensable strategy in clinical cancer therapy. The current review summarized the development of patient-derived tumor models, characterized the application, advantages and challenges of them in preclinical antitumor drug evaluation and clinical precise medicine, which will provide a scientific basis and novel insights for further basic research, drug development and clinical application.
文摘Background:With the rapid development of the world’s technology,the connection and integration between traditional medicine and modern machine learning technology are increasingly close.In this study,we aimed to analyze publications on machine learning in traditional medicine by using bibliometric methods and explore global trends in the field.Methods:Relevant research on machine learning in traditional medicine extracted from the Web of Science Core Collection database.Bibliometric analysis and visualization were performed using the Bibliometrix package in R software.Global trends,source journals,authorship,and thematic keywords analysis were performed in this study.Results:From 2012 to 2022,a total of 282 publications on machine learning in traditional medicine were identified and analyzed.The average annual growth rate of the publications was 13.35%.China had the largest contribution in this field(53.9%),followed by the United States(32.6%).IEEE Access had the largest number of published articles,with a total of 15 articles.Calvin Yu-Chian Chen,Xiao-juan Hu and Jue Wang were the main researchers in this field.Shanghai University of Traditional Chinese Medicine and University of California,San Francisco were the main research institutions.Conclusion:This study provides information on research trends in machine learning in traditional medicine to better understand research hotspots and future developments in this field.According to current global trends,the number of publications in this field will gradually increase.China currently dominated the field.Applied research of machine learning techniques may be the next hot topic in this field and deserves further attention.
文摘Background:Osteoarthritis of the knee(KOA)is a chronic degenerative disease.KOA is a growing concern due to its high incidence and the pain and other burdens it places on patients.Traditional medicine is a health care model with a long history that includes nature-based treatments,psycho-psychological types of treatments,and more.Traditional medicine is also more effective in diagnosing and treating KOA,and it has never stopped researching KOA.There are no bibliometric studies analyzing articles on the traditional medical diagnosis and management of KOA.This study aimed to comprehensively analyze and analyze the general trends in the study of KOA in traditional medicine from a bibliometric perspective.Methods:All articles reporting on KOA and traditional medicine from 1 January 1990 to 01 November 2022 were obtained from the Web of Science Core.Some software such as CiteSpace,VOS Viewer and Scimago Graphica were used to analyse the publications,which included authors,citations,journals,references,countries where studies were published,institutions and research keywords.The final visualisations were produced using this data.Results:A total of 769 articles were searched.Peijian Tong was identified as the most contributing and published author in the field,and medicine was identified as the most reputable journal in the field of traditional medicine and osteoarthritis of the knee.China is a global leader in the field and a centre of collaboration in the field,with a major concentration of traditional medicine in Asia,which is consistent with the evidence that traditional medicine originated in Asia.According to the data,“osteoarthritis”,“knee osteoarthritis”,“pain”,and“knee”and“hip”were identified as hot keywords for research in this area.Conclusions:The results of this bibliometric study provide a snapshot of the current state of clinical research in the treatment of KOA in traditional medicine and are well placed to envisage future hotspots and possible trends,and may help to provide researchers with more than enough information with a view to guiding the cutting edge of research in this field and the infinite possibilities for the future.
文摘Objective:To analyze the current status and development trend of Chinese medicine research in the field of idiopathic membranous nephropathy since 2000.Methods:The literature related to Chinese medicine for idiopathic membranous nephropathy published in China Knowledge Network(CNKI)since 2000 was searched,and CiteSpacewas applied to visualize the publication time,authors,and keywords of the literature and to draw a visual knowledge graph.Results:372 relevant literatures were included.Author analysis showed that there were 343 authors included,and the authors with the highest number of publications published 13 articles,and the core authors accounted for 10.2%of the total number;keyword analysis showed that 15 clusters were formed after burst analysis,and 10 emergent words were formed after keyword emergence analysis.Conclusion:Chinese medicine recognizes and intervenes in idiopathic membranous nephropathy in terms of evidence type,treatment method,common prescriptions and single herbs,auxiliary examination,treatment modality,and clinical research.The development trend lies in the combination of macroscopic and microscopic,the synergy between Chinese and Western,multidisciplinary collision diagnosis and treatment,as well as the use of Chinese medicine to intervene in the disease process at an early stage,and the integration of a worldwide standardized diagnosis and treatment guideline of Chinese medicine for idiopathic membranous nephropathy.
基金Supported by Fundacao Waldemar Barnsley Pessoa,Brazil
文摘Despite improvements in adjuvant therapies for gastric cancer in recent years, the disease is characterized by high recurrence rates and a dismal prognosis. The major improvement in the treatment of recurrent or metastatic gastric cancer in recent years has been the incorporation of trastuzumab, a monoclonal antibody that inhibits human epidermal growth factor receptor 2(HER2) heterodimerization, after the demonstrated predictive value of the overexpression and/or amplification of this receptor. Beyond HER2, other genetic abnormalities have been identified, and these mutations may be targetable by tyrosine kinase inhibitors or monoclonal antibodies. The demonstration of four distinct molecular subtypes of gastric cancer by the Cancer Genome Atlas study highlight the enormous heterogeneity of the disease and its complex interplay between genetic and epigenetic alterations and provide a roadmap to implement genome-guided personalized therapy in gastric cancer. In the present review, we aim to discuss, from a clinical point of view, the genomic landscape of gastric cancer described in recent studies, the therapeutic insights derived from these findings, and the clinical trials that have been conducted and those in progress that take into account tailored therapies for gastric cancer.
文摘Background:Considering the great heterogeneity of Hepatocellular carcinoma(HCC),more accurate prognostic models are urgently needed.This paper combined the advantages of genomics and pathomics to construct a prognostic model.Methods:First,we collected data from hepatocellular carcinoma patients with complete mRNA expression profiles and clinical annotations from the TCGA database.Then,based on immune-related genes,we used random forest plots to screen prognosis-related genes and build prognostic models.Bioinformatics was used to identify biological pathways,evaluate the tumor microenvironment,and perform drug susceptibility testing.Finally,we divided the patients into different subgroups according to the gene model algorithm.Pathological models were constructed by obtaining HE-stained sections from TCGA in corresponding subgroups of patients.Results:In this study,we constructed a stable prognostic model that could predict overall survival in HCC patients.The signature consisted of six immune-related genes(BX537318.1,TMEM147,CSPG4P12,AC015908.3,CEBPZOS,and SRD5A3).We found increased levels of infiltration of immune cells in the tumor microenvironment in patients with low risk scores,indicating significant antitumor immunity and corresponding to better clinical outcomes.We then screened nine drugs that were more sensitive in the low-risk group than in the high-risk group.Finally,we addressed the complex cellular changes and phenotypic heterogeneity in the HCC microenvironment by combining genomics and pathomics analysis methods.Conclusion:Our study showed that the prognostic evaluation model of HCC based on the immune signaling pathway is feasible and provided a reference value for potential immunotherapy for HCC.
基金Special funding project of novel coronavirus(2019-nCoV)tackled by science and technology in Hainan Medical University(No.XGZX2020006)Key research base of philosophy and social sciences in Shanxi province,project of Shanxi health culture research center(No.JK-WH2019-Y16)
文摘The ancient people of our country have accumulated rich experience in prevention of epidemic disease in the course of fighting the epidemic for thousands of years,and invented effective methods of external use of Chinese medicine for preventing epidemic,some of these methods have been still used today,in addition to ensuring the health and safety of ancient people in China.In the COVID-19 ravaged China today,all kinds of protective supplies for the general public is difficult to get,so the study of external use of Chinese medicine that preventing epidemic for modern society is still very significant and valuable.According to the characteristics of COVID-19 and the theory of combination of disease-syndrome,based on the applicability and feasibility for modern society,combed out three methods of external use of Chinese medicine,including medicine hanging,medicine smearing and medicine fumigation,and made corresponding application recommendations for hospitals,communities,families to prevent epidemic disease.
文摘Background: Holistic thinking, which is rooted in Eastern culture, is assumed to be the core of traditional Chinese medicine (TCM). Recently, such holistic thinking has been proposed to be applicable to Western medicine practices for alleviating serious side effects;however, the obscure and often ill-defined terms of TCM, such as qi, yin yang, and wuxing, pose considerable obstacles for further understanding TCM. In the present study, we explored whether and how TCM is actually related to the scientific construct of holistic thinking, to elucidate the particular cultural signature of TCM. Methods: A random sample of 101 college students majoring in TCM and 93 non-medical college students was recruited for the study. Two psychological scales—the Chinese Holistic Thinking Scale and the TCM Competence Scale were used respectively to measure the holistic thinking and participants’ ability to apply the TCM in practice. Results: We found that individuals who thought more holistically were better at applying TCM to modern medical problems. Interestingly, TCM was associated with holistic thinking in both TCM and non-medical students, suggesting that this association is intrinsic. Further exploration revealed that the association and variability facets of Eastern holistic thinking—which emphasize that the world is interconnected and ever-changing, respectively—significantly accounted for the individual differences in competence in utilizing TCM in practice. Conclusion: In short, our study provides the first empirical evidence linking TCM to the Eastern holistic thinking style, which not only deepens the understanding of TCM from a scientific perspective but also promotes dialogue between TCM and Western medicine for building safer and more effective health care systems.
文摘National medicine nursing is a valuable resource of health industry in Yunnan Province,which provides important support for the strategy strengthening the province with traditional Chinese medicine.The development of National medicine nursing is influenced by multiple factors.Based on the development model of cultural ecosphere,this paper analysed its development trend and put forward some suggestions for promoting its development.
