Background Non-infectious fever in patients with aortic dissection after endovascular aortic repair （EVAR） is very common and can cause a series of adverse effects. However, the etiology and pathophysiology of non-i...Background Non-infectious fever in patients with aortic dissection after endovascular aortic repair （EVAR） is very common and can cause a series of adverse effects. However, the etiology and pathophysiology of non-infectious postoperative fever is seldom studied. Methods According to predefined criteria, 148 patients underwent EVAR were divided into two groups： non-infectious fever group and non-fever group. Clinical data were compared between groups and multiple logistic regressions were performed to detect the risk factors of non- infectious fever. Results A total of 54.1% （80/148） EVAR patients suffered non-infectious fever. Fever （37.3- 38 ℃ ） was almost universally presented in 57.5% patients. And 37.5% of the patients had fever ranging from 38.1 to 39 ℃ and 5% of the patients had fever above 39℃. Increased levels of D-dimer, white blood cell count （WBC）, procalcitonin （PCT）, C-reactive protein （CRP）, operation time duration and the length of stents and decreased levels of hemoglobin were presented in the non-infectious fever group as compared to non-fever group （P〈0.005）. Multiple logistic regression analysis revealed that D-dimer （OR=2.533, P=0.031 ）, PCT （OR= 3.307, P=0.009）, operation time duration （OR=2.631, P=0.021 ） and the length of stents （OR=2.851, P=0.015） were independently associated with non-infective fever EVAR. Furthermore, we also found that the duration of stay in CCU （3.2±2.2 vs. 2.5±2.0）, hospital time （8.6±2.2 vs. 7.5±2.3） and hospitalization expense （131.2 ±30.8 vs. 120.6 ±25.9 thousand yuan） were significant different between the two groups. Conclusions Increased levels of D-dimer, procalcitonin concentration, operation duration and the length of stents are risk factors for non-infectious fever of EVAR, which may prolong the duration of stay in CCU and hospital, and increase the hospitalization expense.展开更多
基金supported by Projects of Guangdong Science and Technology Department(No.2015A020210064)and(No.2014A020209053)
文摘Background Non-infectious fever in patients with aortic dissection after endovascular aortic repair （EVAR） is very common and can cause a series of adverse effects. However, the etiology and pathophysiology of non-infectious postoperative fever is seldom studied. Methods According to predefined criteria, 148 patients underwent EVAR were divided into two groups： non-infectious fever group and non-fever group. Clinical data were compared between groups and multiple logistic regressions were performed to detect the risk factors of non- infectious fever. Results A total of 54.1% （80/148） EVAR patients suffered non-infectious fever. Fever （37.3- 38 ℃ ） was almost universally presented in 57.5% patients. And 37.5% of the patients had fever ranging from 38.1 to 39 ℃ and 5% of the patients had fever above 39℃. Increased levels of D-dimer, white blood cell count （WBC）, procalcitonin （PCT）, C-reactive protein （CRP）, operation time duration and the length of stents and decreased levels of hemoglobin were presented in the non-infectious fever group as compared to non-fever group （P〈0.005）. Multiple logistic regression analysis revealed that D-dimer （OR=2.533, P=0.031 ）, PCT （OR= 3.307, P=0.009）, operation time duration （OR=2.631, P=0.021 ） and the length of stents （OR=2.851, P=0.015） were independently associated with non-infective fever EVAR. Furthermore, we also found that the duration of stay in CCU （3.2±2.2 vs. 2.5±2.0）, hospital time （8.6±2.2 vs. 7.5±2.3） and hospitalization expense （131.2 ±30.8 vs. 120.6 ±25.9 thousand yuan） were significant different between the two groups. Conclusions Increased levels of D-dimer, procalcitonin concentration, operation duration and the length of stents are risk factors for non-infectious fever of EVAR, which may prolong the duration of stay in CCU and hospital, and increase the hospitalization expense.
