Clinical outcomes of Angio Jet pharmacomechanical thrombectomy versus catheter-directed thrombolysis for the treatment of filter-related caval thrombosis

BACKGROUND The inferior vena cava filter is utilized worldwide to intercept thrombi and to reduce the risk of fatal pulmonary embolism(PE).However,filter-related thrombosis is a complication of filter implantation.Endovascular methods such as AngioJet rheolytic thrombectomy(ART)and catheter-directed thrombolysis(CDT)can treat filter-related caval thrombosis,but the clinical outcomes of both treatment modalities have not been determined.AIM To compare the treatment outcomes of AngioJet rheolytic thrombectomy vs catheter-directed thrombolysis in patients with filter-related caval thrombosis.METHODS In this single-center retrospective study,65 patients(34 males and 31 females;mean age:59.0±13.43 years)with intrafilter and inferior vena cava thrombosis were enrolled between January 2021 and August 2022.These patients were assigned to either the AngioJet group(n=44)or the CDT group(n=21).Clinical data and imaging information were collected.Evaluation measures included thrombus clearance rate,periprocedural complications,urokinase dosage,incidence of PE,limb circumference difference,length of stay,and filter removal rate.RESULTS Technical success rates were 100%in the AngioJet and CDT groups.In the AngioJet group,grade II and grade III thrombus clearance was achieved in 26(59.09%)and 14(31.82%)patients,respectively.In the CDT group,grade II and grade III thrombus clearance was accomplished in 11(52.38%)patients and 8(38.10%)patients,respectively(P>0.05).The peridiameter difference of the thigh was significantly reduced in patients from both groups after treatment(P<0.05).The median dosage of urokinase was 0.08(0.02,0.25)million U in the AngioJet group and 1.50(1.17,1.83)million U in the CDT group(P<0.05).Minor bleeding was shown in 4(19.05%)patients in the CDT group,and when it was compared with that in the AngioJet group,the difference was statistically significant(P<0.05).No major bleeding occurred.Seven(15.91%)patients in the AngioJet group had hemoglobinuria and 1(4.76%)patient in the CDT group had bacteremia.There were 8(18.18%)patients with PE in the AngioJet group and 4(19.05%)patients in the CDT group before the intervention(P>0.05).Computed tomography angiopulmonography(CTA)showed that PE was resolved after the intervention.New PE occurred in 4(9.09%)patients in the AngioJet group and in 2(9.52%)patients in the CDT group after theintervention(P>0.05).These cases of PE were asymptomatic.The mean length of stay was longer in the CDT group(11.67±5.34 d)than in the AngioJet group(10.64±3.52 d)(P<0.05).The filter was successfully retrieved in the first phase in 10(47.62%)patients in the CDT group and in 15(34.09%)patients in the AngioJet group(P>0.05).Cumulative removal was accomplished in 17(80.95%)out of 21 patients in the CDT group and in 42(95.45%)out of 44 patients in the ART group(P>0.05).The median indwelling time for patients with successful retrieval was 16(13139)d in the CDT group and 59(12231)d in the ART group(P>0.05).CONCLUSION Compared with catheter-directed thrombolysis,AngioJet rheolytic thrombectomy can achieve similar thrombus clearance effects,improve the filter retrieval rate,reduce the urokinase dosage and lower the risk of bleeding events in patients with filter-related caval thrombosis.

Manual aspiration thrombectomy for acute and subacute inferior vena cava thrombosis and lower extremity deep venous thrombosis

Deep vein thrombosis(DVT), which can lead to pulmonary embolism(PE), is a major contributor to the global disease burden and is the third most common cardiovascular pathology after coronary artery disease and stroke. Venous thromboembolic disease, which encompasses the disease entities of DVT and PE, affects up to 10 million cases every year and represents a serious and potentially life-threatening condition. Standard anticoagulation therapy alone is ineffective at promoting deep venous system thrombus removal. Many patients develop postthrombotic syndrome(PTS) despite being on adequate anticoagulation therapy. Aggressive therapy for rapid thrombus removal is important to prevent the development of PTS. Besides impeding the onset of PTS, rapid clearance of the thrombus is also required in the treatment of phlegmasia cerulea dolens, an uncommon but life-threatening complication of acute DVT that can lead to arterial insufficiency, compartment syndrome, venous gangrene, and limb amputation. Manual aspiration thrombectomy(MAT) can provide rapid and effective therapy that could be compared to the open surgical thrombectomy approach with minimal risk of morbidity, mortality, or recurrence after surgery. Though many devices have been developed to date for pharmacomechanical thrombolysis, the cost of the treatment using these devices is very expensive. MAT is simple to perform, easy to learn, inexpensive, and rapid. This review will outline and dissect several studies and case reports, sourced from the Pub Med database, on the subject of the use of MAT in treating inferior vena cava thrombosis and lower extremity DVT, including in patients with compression of the iliac vein and phlegmasia cerulea dolens.

Deep vein thrombosis in patient with left-sided inferior vena cava draining into the hemiazygos vein: A case report

BACKGROUND Abnormalities of the inferior vena cava(IVC)are uncommon,and in many cases they are asymptomatic.Even so,it is vital that clinicians be aware of such anomalies prior to surgery in affected individuals.In the present report,we describe a rare anatomical variation of the IVC.CASE SUMMARY A 66-year-old male was admitted to the hospital due to deep vein thrombosis of the right lower extremity.Upon contrast-enhanced computed tomography imaging,we found that this patient presented with a case of left-sided IVC draining into the hemiazygos vein,while his hepatic vein was directly draining into the atrium.CONCLUSION Cases of left-sided IVC can increase patient susceptibility to thromboembolism owing to the resultant changes in blood flow and/or associated vascular compression.

High Inferior Vena Cava Thrombosis in a 16-year-old Postpartum Patient:A Case Report

Postpartum inferior vena cava (IVC) thrombosis is a rare,but potentially life-threatening disorder.Here we reported one case of the youngest woman to date who presented with massive IVC thrombus extending from deep veins of the right leg to the level of the 11th thoracic vertebra,associated with asymptomatic pulmonary embolism.

Surgery for hepatocellular carcinoma with tumor thrombosis in inferior vena cava: A case report

BACKGROUND Hepatocellular carcinoma(HCC)accompanied by a tumor thrombus is very common.However,the treatment strategy is controversial and varies by the location of the thrombus.CASE SUMMARY We report herein a case of HCC with a tumor thrombus in the suprahepatic inferior vena cava(IVC),which was successfully treated by hepatectomy combined with thrombectomy following sorafenib chemotherapy.A 47-year-old woman with chronic hepatitis was diagnosed with HCC.Computed tomography and magnetic resonance imaging showed that the tumor lesion was located in the right half of the liver,and a tumor thrombus was detected in the suprahepatic IVC near the right atrium.After multi-departmental discussion and patient informed consent,right major hepatectomy and total removal of the tumor thrombus were successfully performed under cardiopulmonary bypass.There were no serious complications after surgery.Following sorafenib treatment,no recurrence has been detected so far(11 mo later).CONCLUSION Surgical treatment followed by adjuvant sorafenib therapy might be an acceptable choice for HCC patients with tumor thrombosis in the IVC.

Pediatric Pancreatic Lymphadenitis Tuberculosis Causing Inferior Vena Cava Thrombosis in Syria

Background: Pancreatic tuberculosis (TB) is very rare, mostly due to the antibacterial effects of the pancreatic enzymes. The association of thrombosis and tuberculosis has been reported but that of inferior vena cava (IVC) thrombosis and pancreatic tuberculosis is extremely rare and has only been reported once. Case presentation: A case of pancreatic Tuberculosis and IVC thrombosis presented with constitutional symptoms. Ultrasonography and computerized tomography showed a lesion in the head of the pancreas and a large lymph mass. Magnetic resonance imaging (MRI) of (IVC) showed thrombosis in the IVC. Histological examination revealed necrotizing granulomas after a laparotomy. The patient received antituberculosis chemotherapy and low molecular weight heparin. Conclusion: Pancreatic TB is a challenge to diagnose especially in Resource-poor countries, which might lead to delay in treatment and worse complications.

A Case Report and a Descriptive Retrospective Study of Cases of Inferior Vena Cava Thrombosis Diagnosed over a 10-Year Period in a Third Level Hospital

Inferior vena cava thrombosis is an under-recognized entity associated with significant morbidity and mortality. This is the reason why, although the diagnosis is challenging, a high index of suspicion is required. Regarding this condition, we present the case of a 63-year-old man who had repeatedly visited the emergency room suffering from abdominal and back pain and painful lower limb edema. After several tests, including magnetic resonance imaging (MRI), he was diagnosed to have agenesis of left renal vein and inferior vena cava thrombosis, from hypercoagulable state secondary to Antiphospholipid Syndrome. He had anticoagulation treatment with low-molecular-weight heparin with good subsequent evolution. This study sets out a descriptive retrospective study of fifty cases of inferior vena cava thrombosis diagnosed in a third-level hospital in the north of Spain over a ten-year period (2010-2018). The aim of this article is to identify the epidemiology, predisposing factors and symptoms that characterize this entity, in order to be able to achieve an early diagnosis that allows us to initiate immediate treatment, minimizing acute and chronic complications of this disease.

Comparative outcomes of Inferior Vena Cava filters placed at bedside using digital radiography versus conventional fluoroscopy

Purpose:To retrospectively assess the outcomes of Inferior Vena Cava(IVC)filters placed in critically ill patients in the ICU at bedside using digital radiograph(DR)guidance with previous cross-sectional imaging for planning,compared to IVC filters placed by conventional fluoroscopy(CF).Method and materials:The cohort consisted of 129 IVC filter placements;48 placed at bedside and 81 placed conventionally from July 2015 to September 2016.Patient demographics,indication,radiation exposures,access site,procedural duration,dwell time,and complications were identified by the EMR.IVC Filter positioning with measurements of tip to renal vein distance and lateral filter tilt were performed when cavograms or post placement CTs were available for review.Statistical analysis was performed using Stata IC 11.2.Results:Technical success of the procedure was 100% in both groups.Procedural duration was longer at the bedside lasting 14.5+/-10.2 versus 6.7+/-6.0 min(p<0.0001).The bedside DR group had a median radiation exposure of 25 mGy(15-35)and the CF group had mean radiation exposure of 256.94 mGy+/-158.6.There was no significant difference in distance of IVC tip to renal vein(p=0.31),mispositioning(p=0.59),degree of filter tilt(p=0.33),or rate of complications(p=0.65)between the two groups.Conclusion:IVCF placement at the bedside using DR is comparable to CF with no statistical difference in outcomes based on IVCF positioning,degree of lateral tilt or removal issues.It decreased radiation dose,but with overall increased procedural time.

Fracture Rate and Serious Complications of Vena Cava Filters

Purpose: To retrospectively evaluate the prevalence of fracture and fragment embolization of inferior vena cava (IVC) filters. Methods: Electronic medical records and imaging studies of all Kaiser Permanente patients who received IVC filters from August 2000 until August 2010 were retrospectively reviewed for filter complications. Results: 283 patients received an IVC filter during the study period. 143 patients were deceased, while 140 are living. Among deceased patients, the average age at the time of death was 69.8 ± 15.3 [range: 24.7 - 99.2] years;55.9% were men;the mean implantation-to-image time was 13.6 ± 20.6 [range: 0 - 92.4] months, and there were no reported major complications attributable to filter migration or fracture at a mean of 16.8 ± 24.8 [range: 0 - 119.6] months following implantation. One of 14 (7.1%) G2 filters perforated the aorta, which already had a stent graft in place. Among those patients still living, the average age was 67.3 ± 15.2 [range: 15.2 - 97.3] years, 47.1% were men, the mean implantation-to-image time was 33.3 ± 36.5 [range: 0.1-141.7] months, and there were no reported major complications at a mean of 35.3 ± 36.5 [range: 0 - 141.7] months following implantation. Three of 60 (5.0%) Trapease filters were found to have at least 1 strut fracture. There were no cases of filter migration or fragment embolization. The overall fracture rate of all filters with an implantation-to-image-time greater than two years (mean implantation-to-image time 4.7 ± 2.7 [range: 2.0 - 11.8] years) was 3 of 67 (4.5%). Bard G2 and G2X filters had a 0% fracture and embolization rate at a mean of 19.0 ± 16.6 [range: 0.07 - 49.5] months after implantation. Conclusions: IVC filters, regardless of type, have a low prevalence of fracture and we found no cases of fragment embolization.

Fatal thrombotic complications of hepatic cystic compression of the inferior vena: A case report

Of 5% of patients who develop liver cysts, only 10-15%of them come for medical attention, typically because of dull right upper quadrant pain, abdominal bloating or early satiety. We treated a 77-year-old female with a rare complication of inferior vena cava thrombosis. The patient expired due to septic shock and multiple organ failure.

Treatment of deep vein thrombosis (DVT) around renal vein

Objective To study and evaluate the treatment of the deep vein thrombosis(DVT) around the renal vein(DVT involving the renal vein and it's surrounding,shortly as DVTAR in our study)by two-positioned filter for catheter thrombectomy assisted with a Fogarty balloon.Methods We retrospectivly analysed seven cases of DVTAR and by comparison to elicit the respective effect different methods in DVT treatment.The methods used were:1.direct thrombectomy 2.thrombectomy facillitated by blocking of blood flow with a balloon 3.direct thrombolysis via Peripheral vein and 4.thrombectomy with simultaneous placement of a two-positioned filter with a Fogarty balloon and followed by intubation thrombolysis.Result Segmental pulmonary embolism(PE)or thrombosis in vena cava were still observed by CT angiography(CTA)or venography in those cases treated with the first three methods.As for the 3 cases where two-positioned filter for catheter thrombectomy with Fogarty balloon was used,neither pulmonary embolism during and after the operation nor thrombosis in the inferior vena cava was observed.Conclusion For DVTAR,thrombectomy with simultaneous placement of a two-positioned filter with a Fogarty balloon and followed by intubation thrombolysis can be regarded as safe and effective.

分期递增式球囊扩张术治疗布加综合征合并下腔静脉血栓的临床疗效及安全性分析

目的探讨分期递增式球囊扩张术治疗布加综合征(BCS)合并下腔静脉血栓的临床疗效及安全性。方法62例BCS合并下腔静脉血栓患者,均使用分期递增式球囊扩张术进行治疗。分析治疗结果(小球囊预开通成功率、血栓溶解率、并发症发生情况及死亡情况);比较手术前后实验室指标[白细胞计数(WBC)、红细胞计数(RBC)、血红蛋白(Hb)、白蛋白(ALB)、血小板计数(PLT)、谷丙转氨酶(ALT)、谷草转氨酶(AST)、碱性磷酸酶(ALP)、直接胆红素(DBil)、总胆固醇(TC)、高密度脂蛋白胆固醇(HDL-C)]。结果62例患者中,小球囊预开通成功率为61例(98.39%),有1例因下腔静脉长段闭塞而反复扩张无法开通;其中,新鲜血栓25例,均行经导管溶栓后清除,其余为陈旧性血栓,在1个月内完全溶解率为93.44%(57/61);所有患者围术期均未发生无症状性肺栓塞、死亡病例。患者术后PLT(131.65±37.02)×10^(9)/L、HDL-C(1.15±0.21)mmol/L均高于术前的(108.94±46.36)×10^(9)/L、(0.93±0.28)mmol/L,ALP(88.19±40.63)U/L、DBil(21.02±7.59)μmol/L均低于术前的(111.57±57.48)U/L、(24.89±9.98)μmol/L(P<0.05);手术前后WBC、RBC、Hb、ALB、ALT、AST、TC水平相比无明显差异(P>0.05)。结论在BCS合并下腔静脉血栓患者的治疗中,分期递增式球囊扩张术的临床疗效显著,手术成功率及血栓溶解率高,并发症发生率低,能有效调节PLT、HDL-C等水平,对改善预后有积极意义。

循环旁路技术在肾癌合并下腔静脉癌栓外科治疗中的应用进展

肾细胞癌(renal cell carcinoma,RCC)合并MayoⅢ~Ⅳ级下腔静脉癌栓的外科治疗难度极高,切除此类癌栓常需阻断肝门血管和下腔静脉。体外循环(cardiopulmonary bypass,CPB)和深低温停循环(deep hypothermic circulatory arrest,DHCA)等循环旁路技术能够建立新的循环通路以维持机体循环系统的正常运转,保护机体重要器官,从而保证手术的安全性。使用CPB和DHCA可能出现出血、神经系统功能障碍等并发症,其应用存在一定局限性。本文对以CPB和DHCA为代表的循环旁路技术在肾癌合并下腔静脉癌栓外科治疗中的应用进展进行综述,并讨论其并发症和应对策略。

不同入路放置下腔静脉滤器的效果分析

目的 探讨经颈静脉和经股静脉不同入路置入下腔静脉滤器(Inferior vena cava filter,IVCF)的效果差异。方法 选取我院收治的股静脉穿刺置管后发生急性髂股静脉血栓形成且单纯行IVCF置入术后资料完整患者66例,按IVCF置入的不同入路将以上患者分为经颈静脉入路组和经股静脉入路组,比较两组在出血、IVCF倾斜、排尿困难、腰背疼痛、舒适度、满意度、睡眠质量等方面的效果差异。结果 经颈静脉入路组排尿困难发生率低于经股静脉入路组,差异有统计学意义(P<0.05)。经颈静脉入路组腰背疼痛评分和睡眠质量平均评分均低于经股静脉入路组,差异有统计学意义(P<0.05),舒适度、满意度评分均高于经股静脉入路组,差异有统计学意义(P<0.05)。结论 经颈静脉穿刺IVCF置入可以降低患者术后排尿困难以及腰背疼痛的情况发生,患者具有较高的舒适度、满意度以及睡眠质量。

股静脉途径夹角预测锥形下腔静脉滤器倾斜研究

目的了解髂总静脉与下腔静脉夹角、髂总静脉与髂外静脉夹角与锥形下腔静脉滤器(IVCF)置入时倾斜之间的关系,为临床IVCF置入手术入路选择、IVCF类型选择提供参考。方法回顾性分析2019年1月—2021年9月本院介入科收治的86例行锥形IVCF置入术患者的临床资料,根据术中DSA影像资料,采用ROC分析髂总静脉与下腔静脉之间夹角、髂总静脉与髂外静脉之间夹角以及两者结合对IVCF置入后倾斜的预测价值。结果右股静脉入路,髂总静脉与下腔静脉夹角预测IVCF置入后不倾斜(滤器倾斜角度小于5°)的AUC(0.630)大于髂总静脉与髂外静脉夹角(0.554)、两者结合(0.609)。髂总静脉与下腔静脉角度最佳截断值156.5°;左股静脉入路,髂总静脉与下腔静脉夹角预测IVCF置入后不倾斜AUC(0.908)大于髂总静脉与髂外静脉夹角(0.689)、两者结合(0.852)。髂总静脉与下腔静脉夹角最佳截断值135°。结论IVCF置入时,经左股静脉入路,造影后髂总静脉与下腔静脉角度小于135°或经右股静脉入路,造影后髂总静脉与下腔静脉角度小于156.5°,锥形滤器发生倾斜可能性大,建议选择其他入路或者选择其他类型IVCF。

下腔静脉滤器置入联合重组人尿激酶原经导管接触溶栓治疗急性下肢深静脉血栓形成的临床效果

目的探讨下腔静脉滤器(IVCF)置入联合重组人尿激酶原(rhPro-UK)经导管接触性溶栓(CDT)治疗急性下肢深静脉血栓形成(DVT)的临床效果。方法选取2019年6月至2021年12月本院收治的100例急性下肢DVT患者作为研究对象,随机将其分为对照组与观察组,每组50例。对照组实施rhPro-UK经CDT治疗,观察组实施rhPro-UK经CDT+IVCF置入治疗。比较两组的治疗效果。结果观察组的临床治疗总有效率显著高于对照组(P<0.05)。观察组的治疗时长、住院时间短于对照组,尿激酶原用量、残余狭窄处病灶数量均显著少于对照组(P<0.05)。治疗后,观察组的凝血酶原时间(PT)、活化部分凝血酶时间(APTT)长于对照组,纤维蛋白原(Fig)水平低于对照组(P<0.05)。治疗后,观察组的大腿周径差、小腿周径差、静脉通畅评分均显著低于对照组(P<0.05)。观察组的并发症总发生率低于对照组(P<0.05)。结论IVCF置入+CDT方案可显著提升急性下肢DVT患者临床治疗效果,有助于降低栓塞、出血风险,缩短治疗时间,具有显著临床应用价值。

下肢深静脉血栓患者下腔静脉滤器置入术后发生静脉不畅的影响因素

目的:探讨下肢深静脉血栓(DVT)患者下腔静脉滤器(IVCF)置入术后发生静脉不畅的影响因素。方法:回顾性分析2020年3月至2022年4月该院收治的70例下肢DVT患者的临床资料,患者均行IVCF置入术治疗,术后3个月复查,根据静脉通畅程度将其分为静脉通畅组32例和静脉不畅组38例。收集患者的临床资料,采用单因素和多因素Logistic回归分析下肢DVT患者IVCF置入术后发生静脉不畅的影响因素。结果:两组性别、年龄、体质量指数、DVT分期、D-二聚体水平比较,差异均无统计学意义(P>0.05);静脉不畅组合并糖尿病、高血压占比和白细胞计数(WBC)、血小板计数(PLT)、纤维蛋白原(FIB)水平均高于静脉通畅组,差异有统计学意义(P<0.05);Logistic回归分析结果显示,合并糖尿病、高血压和WBC、PLT、FIB水平升高均为下肢DVT患者IVCF置入术后发生静脉不畅的危险因素(P<0.05)。结论:合并糖尿病、高血压和WBC、PLT、FIB水平升高均为下肢DVT患者IVCF置入术后发生静脉不畅的危险因素,临床可针对上述危险因素实施针对性干预措施,以改善预后。

经皮机械吸栓联合导管接触性溶栓治疗急性期下腔静脉滤器相关血栓的疗效分析

目的探讨经皮机械吸栓(percutaneous mechanical thrombectomy,PMT)联合导管接触性溶栓(catheter-directed thrombolysis,CDT)治疗急性期下腔静脉滤器相关血栓的疗效与安全性。方法回顾性分析2018~2021年河北省人民医院收治的21例急性期下腔静脉滤器相关血栓患者的临床资料,根据治疗方法不同分为PMT+CDT组(12例)和CDT组(9例),比较两组溶栓时间、尿激酶用量、滤器回收成功率以及治疗前后下腔静脉滤器血栓和血红蛋白的变化。结果PMT+CDT组的溶栓时间、尿激酶用量均低于CDT组,差异有统计学意义(P<0.05)。PMT+CDT组术中吸栓平均出血量为(71.50±13.47)ml。两组治疗后下腔静脉血栓较治疗前均缩小(P<0.05);治疗后PMT+CDT组下腔静脉血栓小于CDT组,差异有统计学意义(P<0.05)。两组治疗前后的血红蛋白比较差异均无统计学意义(P<0.05)。PMT+CDT组患者均成功回收滤器,滤器回收率为100%;CDT组有5例患者成功回收滤器,滤器回收率为55.6%,两组比较差异有统计学意义(P=0.021)。两组均无严重并发症发生。结论PMT联合CDT是治疗急性期下腔静脉滤器相关血栓安全有效的方法,有助于缩短溶栓时间,减少溶栓药物用量,提高滤器回收率。

鹅颈式抓捕器配合可调弯鞘回收下腔静脉滤器的临床效果观察

目的观察鹅颈式抓捕器配合可调弯鞘回收下腔静脉滤器(IVCF)的临床效果。方法收集2021年3月至2022年4月于安徽医科大学合肥第三临床学院(合肥市第三人民医院影像中心)行IVCF取出术的25例下肢深静脉血栓形成(DVT)患者的临床资料,将采用滤器回收套件回收滤器的患者作为对照组(n=12),将采用鹅颈式抓捕器配合可调弯鞘回收滤器的患者作为观察组(n=13)。比较两组患者的手术成功率、手术时间、手术费用及并发症发生情况。结果两组患者均成功取出滤器,手术成功率均为100%。观察组患者的手术时间短于对照组患者,手术费用低于对照组患者,差异均有统计学意义(P﹤0.05)。两组患者术后并发症总发生率比较,差异无统计学意义(P﹥0.05)。结论鹅颈式抓捕器配合可调弯鞘回收IVCF是一种安全、方便、快捷的手术方式,不但能够快速、有效地完成回收,而且节省治疗费用,值得临床推广应用。

体外膜肺氧合支持期间合并下腔静脉血栓1例

体外膜肺氧合(ECMO)是一种行之有效的心肺支持手段,可为常规治疗无法逆转的危重患者提供临时的心肺支持。患者因暴发性心肌炎入住滨州医学院附属医院重症医学科,因存在血流动力学紊乱且符合ECMO支持指征,给予静脉-动脉体外膜肺氧合(VA-ECMO)支持治疗。撤除ECMO引流管后发现下腔静脉血栓形成,经多学科会诊,治疗上在充分抗凝及放置下腔静脉滤器后,给予尿激酶溶栓治疗,4 d后患者下腔静脉血栓消失。ECMO辅助下下腔静脉血栓并不多见,多经抗凝治疗后逐渐消失。该例患者在放置下腔静脉滤器后果断给予溶栓药物尿激酶静脉治疗,短期内复查血栓消失,提高了治疗效率。