This study aimed to investigate the causes and managements of the fractures and migrations of the implantable venous access port catheter（IVAPC）. The fracture or migration of IVAPC occurred in 4 patients who were tr...This study aimed to investigate the causes and managements of the fractures and migrations of the implantable venous access port catheter（IVAPC）. The fracture or migration of IVAPC occurred in 4 patients who were treated between May 2012 and January 2014 in Union Hospital,Wuhan,China. The port catheter leakage was found in 2 cases during drug infusion. Catheters that dislodged to the superior vena cava and right atrium were confirmed by port angiogram. The two dislodged catheters were successfully retrieved by interventional procedures. Catheter fracture occurred in two cases during port removal. One catheter was eventually removed from the subclavian vein through right clavicle osteotomy and subclavian venotomy,and the other removed by external jugular venotomy. Flushing the port in high pressure and injury of the totally implantable venous access port（TIVP） during implantation are usually responsible for catheter displacement. Interventional retrieval procedure can be used if the catheter dislodges to the vena cava and right atrium. Catheter fracture may occur during removal if clipping syndrome occurs or the catheter is sutured very tight during implantation.展开更多
Background: Elastomeric pumps (elastic balls into which analgesics or antibiotics can be inserted) push medicines through a catheter to a nerve or blood vessel. Since elastomeric pumps are small and need no power sour...Background: Elastomeric pumps (elastic balls into which analgesics or antibiotics can be inserted) push medicines through a catheter to a nerve or blood vessel. Since elastomeric pumps are small and need no power source, they fit easily into a pocket during infusion, allowing patient mobility. Elastomeric pumps are widely used and widely studied experimentally, but they have well-known problems, such as maintaining reliable flow rates and avoiding toxicity or other peak-and-trough effects. Objectives: Our research objective is to develop a realistic theoretical model of an elastomeric pump, analyze its flow rates, determine its toxicity conditions, and otherwise improve its operation. We believe this is the first such theoretical model of an elastomeric pump consisting of an elastic, medicine-filled ball attached to a horizontal catheter. Method: Our method is to model the system as a quasi-Poiseuille flow driven by the pressure drop generated by the elastic sphere. We construct an engineering model of the pressure exerted by an elastic sphere and match it to a solution of the one-dimensional radial Navier-Stokes equation that describes flow through a horizontal, cylindrical tube. Results: Our results are that the model accurately reproduces flow rates obtained in clinical studies. We also discover that the flow rate has an unavoidable maximum, which we call the “toxicity bump”, when the radius of the sphere approaches its terminal, unstretched value—an effect that has been observed experimentally. Conclusions: We conclude that by choosing the properties of an elastomeric pump, the toxicity bump can be restricted to less than 10% of the earlier, relatively constant flow rate. Our model also produces a relation between the length of time that the analgesic fluid infuses and the physical properties of the fluid, of the elastomeric sphere and the tube, and of the blood vessel into which the analgesic infuses. From these, we conclude that elastomeric pumps can be designed, using our simple model, to control infusion times while avoiding toxicity effects.展开更多
BACKGROUND Implanted intravenous infusion port(TIAP)is mainly used for patients who need central venous infusion and poor peripheral vascular conditions.With the advantages of easy to carry,long maintenance cycle,few ...BACKGROUND Implanted intravenous infusion port(TIAP)is mainly used for patients who need central venous infusion and poor peripheral vascular conditions.With the advantages of easy to carry,long maintenance cycle,few complications and excellent quality of life,it has been widely used in the fields of malignant tumor chemotherapy,parenteral nutrition support and repeated blood collection.Implanted intravenous infusion port(IVAP)dislocation can have significant complications if not recognised and reinstated immediately.CASE SUMMARY A 24-year-old man was treated with adjuvant chemotherapy for osteosarcoma.Severe displacement of IVAP catheter was found by chest X-ray examination.The IVAP cannot be used normally.Therefore,we conducted an emergency procedure to reset the catheter through double pigtail catheters,the operation was successful and the infusion port was restored.CONCLUSION When IVAP catheter displacement cannot be reset by conventional techniques,two pigtail catheters can be successfully used instead.展开更多
目的:系统评价主动脉内球囊反搏(IABP)不同置入时机对冠心病病人行PCI术疗效的影响。方法:检索中国知网、万方、维普、中国生物医学文献服务系统、the Cochrane Library、EMbase、PubMed、MedLine、Web of Science数据库,收集IABP置入...目的:系统评价主动脉内球囊反搏(IABP)不同置入时机对冠心病病人行PCI术疗效的影响。方法:检索中国知网、万方、维普、中国生物医学文献服务系统、the Cochrane Library、EMbase、PubMed、MedLine、Web of Science数据库,收集IABP置入时机对冠心病病人行PCI术预后影响的文献,采用RevMan 5.4.1软件进行Meta分析。结果:共纳入8项研究,Meta分析结果显示,与对照组相比,试验组IABP留置时间[MD=-17.52,95%CI(-33.84,-1.20),P=0.04]和N末端B型钠尿肽前体(NT-proBNP)水平[MD=-733.85,95%CI(-1018.06,-449.64),P<0.00001]明显低于对照组,平均动脉压[MD=9.23,95%CI(7.63,10.82),P<0.00001]、平均心率[MD=3.91,95%CI(2.05,5.77),P<0.0001]和左心室射血分数[MD=3.81,95%CI(1.36,6.26),P=0.002]明显高于对照组。结论:现有证据表明,与术中、术后被动置入IABP相比,术前预防性应用IABP改善冠心病病人PCI术围术期的临床疗效更佳,且不良反应更少。展开更多
目的总结成人输液港置入与维护的最佳证据,为临床医护人员在输液港置入与维护时提供依据。方法运用PIPOST模式创建循证问题,按照“6S”证据分层模型,检索UpToDate、BMJ Best Practice、Cochrane Library、JBI循证卫生保健中心数据库、...目的总结成人输液港置入与维护的最佳证据,为临床医护人员在输液港置入与维护时提供依据。方法运用PIPOST模式创建循证问题,按照“6S”证据分层模型,检索UpToDate、BMJ Best Practice、Cochrane Library、JBI循证卫生保健中心数据库、美国国立指南库(NGC)、美国疾病预防与控制中心(CDC)、英国国家临床医学研究所指南库(NICE)、国际指南协作网(GIN)、加拿大安大略注册护士协会(RNAO)、CINAHL、EMbase、PubMed、美国静脉输液护理学会(INS)、万方、知网、维普、SinoMed、医脉通等数据库。检索时间为建库至2023年7月6日。两名接受过循证专业培训的科研人员分别对文献进行质量评价,遴选、归纳证据。结果最终纳入12篇文献,包括临床决策分析1篇,专家共识5篇,临床实践指南与证据总结各3篇。分析纳入的文献,筛选证据96条,最终整合汇总为66条证据,分别为:人员资质、适应证及禁忌证、围术期护理、PORT维护、健康教育等5个维度。结论临床医护人员应根据证据制定符合实际情况的护理策略,提高成人患者输液港置入及维护的安全。展开更多
胰腺癌是一种具有高度侵袭性的肿瘤,嗜神经生长是胰腺癌的重要生物学特点,其对神经的侵犯给患者带来极大的疼痛负担,严重影响患者生存质量和生存意志。世界卫生组织(World Health Organization,WHO)癌痛“三阶梯镇痛原则”是传统治疗癌...胰腺癌是一种具有高度侵袭性的肿瘤,嗜神经生长是胰腺癌的重要生物学特点,其对神经的侵犯给患者带来极大的疼痛负担,严重影响患者生存质量和生存意志。世界卫生组织(World Health Organization,WHO)癌痛“三阶梯镇痛原则”是传统治疗癌性疼痛的治疗方案,但由于其毒副作用明显、疗效差、易成瘾、易耐药以及医师临床用药不规范等因素,无法满足患者病情需要。近年来,随着介人技术的发展以及广泛的临床试验的开展,介入作为癌痛管理的“第四阶梯”,其治疗手段以及各种影像引导方式的发展与应用,如神经毁损术、^(125)I粒子植入术、患者自控镇痛泵技术、鞘内药物输注系统植入术等,临床疗效得到了有力证明,为癌痛患者提供了方便、安全、有效的治疗方式。展开更多
文摘This study aimed to investigate the causes and managements of the fractures and migrations of the implantable venous access port catheter（IVAPC）. The fracture or migration of IVAPC occurred in 4 patients who were treated between May 2012 and January 2014 in Union Hospital,Wuhan,China. The port catheter leakage was found in 2 cases during drug infusion. Catheters that dislodged to the superior vena cava and right atrium were confirmed by port angiogram. The two dislodged catheters were successfully retrieved by interventional procedures. Catheter fracture occurred in two cases during port removal. One catheter was eventually removed from the subclavian vein through right clavicle osteotomy and subclavian venotomy,and the other removed by external jugular venotomy. Flushing the port in high pressure and injury of the totally implantable venous access port（TIVP） during implantation are usually responsible for catheter displacement. Interventional retrieval procedure can be used if the catheter dislodges to the vena cava and right atrium. Catheter fracture may occur during removal if clipping syndrome occurs or the catheter is sutured very tight during implantation.
文摘Background: Elastomeric pumps (elastic balls into which analgesics or antibiotics can be inserted) push medicines through a catheter to a nerve or blood vessel. Since elastomeric pumps are small and need no power source, they fit easily into a pocket during infusion, allowing patient mobility. Elastomeric pumps are widely used and widely studied experimentally, but they have well-known problems, such as maintaining reliable flow rates and avoiding toxicity or other peak-and-trough effects. Objectives: Our research objective is to develop a realistic theoretical model of an elastomeric pump, analyze its flow rates, determine its toxicity conditions, and otherwise improve its operation. We believe this is the first such theoretical model of an elastomeric pump consisting of an elastic, medicine-filled ball attached to a horizontal catheter. Method: Our method is to model the system as a quasi-Poiseuille flow driven by the pressure drop generated by the elastic sphere. We construct an engineering model of the pressure exerted by an elastic sphere and match it to a solution of the one-dimensional radial Navier-Stokes equation that describes flow through a horizontal, cylindrical tube. Results: Our results are that the model accurately reproduces flow rates obtained in clinical studies. We also discover that the flow rate has an unavoidable maximum, which we call the “toxicity bump”, when the radius of the sphere approaches its terminal, unstretched value—an effect that has been observed experimentally. Conclusions: We conclude that by choosing the properties of an elastomeric pump, the toxicity bump can be restricted to less than 10% of the earlier, relatively constant flow rate. Our model also produces a relation between the length of time that the analgesic fluid infuses and the physical properties of the fluid, of the elastomeric sphere and the tube, and of the blood vessel into which the analgesic infuses. From these, we conclude that elastomeric pumps can be designed, using our simple model, to control infusion times while avoiding toxicity effects.
基金Supported by Shenzhen Key Medical Discipline Construction Fund,No.SZXK052。
文摘BACKGROUND Implanted intravenous infusion port(TIAP)is mainly used for patients who need central venous infusion and poor peripheral vascular conditions.With the advantages of easy to carry,long maintenance cycle,few complications and excellent quality of life,it has been widely used in the fields of malignant tumor chemotherapy,parenteral nutrition support and repeated blood collection.Implanted intravenous infusion port(IVAP)dislocation can have significant complications if not recognised and reinstated immediately.CASE SUMMARY A 24-year-old man was treated with adjuvant chemotherapy for osteosarcoma.Severe displacement of IVAP catheter was found by chest X-ray examination.The IVAP cannot be used normally.Therefore,we conducted an emergency procedure to reset the catheter through double pigtail catheters,the operation was successful and the infusion port was restored.CONCLUSION When IVAP catheter displacement cannot be reset by conventional techniques,two pigtail catheters can be successfully used instead.
文摘目的总结成人输液港置入与维护的最佳证据,为临床医护人员在输液港置入与维护时提供依据。方法运用PIPOST模式创建循证问题,按照“6S”证据分层模型,检索UpToDate、BMJ Best Practice、Cochrane Library、JBI循证卫生保健中心数据库、美国国立指南库(NGC)、美国疾病预防与控制中心(CDC)、英国国家临床医学研究所指南库(NICE)、国际指南协作网(GIN)、加拿大安大略注册护士协会(RNAO)、CINAHL、EMbase、PubMed、美国静脉输液护理学会(INS)、万方、知网、维普、SinoMed、医脉通等数据库。检索时间为建库至2023年7月6日。两名接受过循证专业培训的科研人员分别对文献进行质量评价,遴选、归纳证据。结果最终纳入12篇文献,包括临床决策分析1篇,专家共识5篇,临床实践指南与证据总结各3篇。分析纳入的文献,筛选证据96条,最终整合汇总为66条证据,分别为:人员资质、适应证及禁忌证、围术期护理、PORT维护、健康教育等5个维度。结论临床医护人员应根据证据制定符合实际情况的护理策略,提高成人患者输液港置入及维护的安全。
文摘胰腺癌是一种具有高度侵袭性的肿瘤,嗜神经生长是胰腺癌的重要生物学特点,其对神经的侵犯给患者带来极大的疼痛负担,严重影响患者生存质量和生存意志。世界卫生组织(World Health Organization,WHO)癌痛“三阶梯镇痛原则”是传统治疗癌性疼痛的治疗方案,但由于其毒副作用明显、疗效差、易成瘾、易耐药以及医师临床用药不规范等因素,无法满足患者病情需要。近年来,随着介人技术的发展以及广泛的临床试验的开展,介入作为癌痛管理的“第四阶梯”,其治疗手段以及各种影像引导方式的发展与应用,如神经毁损术、^(125)I粒子植入术、患者自控镇痛泵技术、鞘内药物输注系统植入术等,临床疗效得到了有力证明,为癌痛患者提供了方便、安全、有效的治疗方式。
