Isoflurane is a widely used inhaled anesthetic in the clinical setting. However, the mechanism underlying its effect on consciousness is under discussion. Therefore, we investigated the effect of isoflurane on the hip...Isoflurane is a widely used inhaled anesthetic in the clinical setting. However, the mechanism underlying its effect on consciousness is under discussion. Therefore, we investigated the effect of isoflurane on the hippocampus and cortex using an in vivo field recording approach. Our results showed that 1.3%, 0.8%, and 0.4% isoflurane exerted an inhibitory influence on the mouse hippocampus and cortex. Further, high frequency bands in the cortex and hippocampus showed greater suppression with increasing isoflurane concentration. Our findings suggest that in vivo field recordings can monitor the effect of isoflurane anesthesia on the mouse cortex and hippocampus.展开更多
Background Vital capacity induction and tidal breathing induction are currently administered for inhalation induction of anesthesia with sevoflurane. The aim of this study was to compare them using sevoflurane with re...Background Vital capacity induction and tidal breathing induction are currently administered for inhalation induction of anesthesia with sevoflurane. The aim of this study was to compare them using sevoflurane with respect to induction time,complications of inhalation induction, and compound A production in adult patients.Methods Fifty-one women with American Society of Anesthesiologists physical status Ⅰ-Ⅱ undergoing mammary gland tumorectomy were randomly assigned to receive either vital capacity induction or tidal breathing induction with 8% sevoflurane at 6 L/min followed by laryngeal mask airway insertion. Induction times, complications of inhalation induction,and vital signs were recorded. Inspired concentrations of compound A were assayed and sofnolime temperatures were monitored at one-minute intervals after sevoflurane administration.Results The time to loss of eyelash reflex was significantly shorter with the vital capacity induction technique than with the tidal breathing induction technique （（43.8±13.4） seconds vs. （70.8±16.4） seconds, respectively; P 〈0.01）.Cardiovascular stability was similar in both groups. The incidence of complications was significantly less with the vital capacity induction technique than with the tidal breathing induction technique （7.7% vs. 32%, respectively; P 〈0.01）.However, the mean and maximum concentrations of compound A during induction were significantly higher in the vital capacity group than those in the tidal breathing group （P 〈0.05）; compound A concentration at the beginning of anesthesia maintenance was （40.73±10.83） ppm in the vital capacity group and （29.45±7.51） ppm in tidal breathing group （P=0.019）.Conclusion For inhalation induction of anesthesia, the vital capacity induction was faster and produced fewer complications than that for tidal breathing induction, but increased compound A production in the circuit system.展开更多
文摘Isoflurane is a widely used inhaled anesthetic in the clinical setting. However, the mechanism underlying its effect on consciousness is under discussion. Therefore, we investigated the effect of isoflurane on the hippocampus and cortex using an in vivo field recording approach. Our results showed that 1.3%, 0.8%, and 0.4% isoflurane exerted an inhibitory influence on the mouse hippocampus and cortex. Further, high frequency bands in the cortex and hippocampus showed greater suppression with increasing isoflurane concentration. Our findings suggest that in vivo field recordings can monitor the effect of isoflurane anesthesia on the mouse cortex and hippocampus.
基金This work was supported by the grants from the National Natural Science Foundation of China （No. 30972839） and the Specialized Research Fund for the Doctoral Program of Higher Education （No. 20092307110005）.
文摘Background Vital capacity induction and tidal breathing induction are currently administered for inhalation induction of anesthesia with sevoflurane. The aim of this study was to compare them using sevoflurane with respect to induction time,complications of inhalation induction, and compound A production in adult patients.Methods Fifty-one women with American Society of Anesthesiologists physical status Ⅰ-Ⅱ undergoing mammary gland tumorectomy were randomly assigned to receive either vital capacity induction or tidal breathing induction with 8% sevoflurane at 6 L/min followed by laryngeal mask airway insertion. Induction times, complications of inhalation induction,and vital signs were recorded. Inspired concentrations of compound A were assayed and sofnolime temperatures were monitored at one-minute intervals after sevoflurane administration.Results The time to loss of eyelash reflex was significantly shorter with the vital capacity induction technique than with the tidal breathing induction technique （（43.8±13.4） seconds vs. （70.8±16.4） seconds, respectively; P 〈0.01）.Cardiovascular stability was similar in both groups. The incidence of complications was significantly less with the vital capacity induction technique than with the tidal breathing induction technique （7.7% vs. 32%, respectively; P 〈0.01）.However, the mean and maximum concentrations of compound A during induction were significantly higher in the vital capacity group than those in the tidal breathing group （P 〈0.05）; compound A concentration at the beginning of anesthesia maintenance was （40.73±10.83） ppm in the vital capacity group and （29.45±7.51） ppm in tidal breathing group （P=0.019）.Conclusion For inhalation induction of anesthesia, the vital capacity induction was faster and produced fewer complications than that for tidal breathing induction, but increased compound A production in the circuit system.
