Timing of Continuous Renal Replacement Therapy Initiation in Sepsis-Associated Acute Kidney Injury: A Comprehensive Review and Future Directions

This review examines the application of continuous renal replacement therapy(CRRT)in patients with sepsis-associated acute kidney injury(S-AKI),with a particular focus on the timing of CRRT initiation.This review addresses the controversy surrounding initiation timing and proposes future research directions.Through a systematic review of recent literature on CRRT for S-AKI,working principles,therapeutic mechanisms,initiation timing of CRRT,and related meta-analyses were summarized.Current studies indicate that the optimal timing for CRRT initiation in S-AKI patients remains inconclusive,with ongoing debate regarding whether early initiation significantly improves patient survival and renal function.This lack of consensus reflects the heterogeneity of the S-AKI patient population and the limitations of existing research methodologies.Future studies should focus on advancing the application of precision medicine in S-AKI and developing individualized treatment strategies by integrating multidimensional information to optimize CRRT utilization and improve patient outcomes.

Coupling effects of influence factors on probability of corrosion initiation time of reinforced concrete

The coupling model of major influence factors such state affecting the chloride diffusion process in concrete is as environmental relative humidity, load-induced crack and stress discussed. The probability distributions of the critical chloride concentration Cc, the chloride diffusion coefficient D, and the surface chloride concentration Cs were determined based on the collected natural exposure data. And the estimation of probability of corrosion initiation considering the coupling effects of influence factors is presented. It is found that the relative humidity and curing time are the most effective factors affecting the probability of corrosion initiation before and after 10 years of exposure time. At the same exposure time, the influence of load-induced crack and stress state on the probability of corrosion initiation is obvious, in which the effect of crack is the most one

Integrated Equipment Health Prognosis Considering Crack Initiation Time Uncertainty and Random Shock

With integrated equipment health prognosis, both physical models and condition monitoring data are utilized to achieve more accurate prediction of equipment remaining useful life （RUL）. In this paper, an integrated prognostics method is proposed to account for two important factors which were not considered before, the uncertainty in crack initiation time （CIT） and the shock in the degradation. Prognostics tools are used for RUL pre- diction starting from the CIT. However, there is uncertainty in CIT due to the limited capability of existing fault detection tools, and such uncertainty has not been explic- itly considered in the literature for integrated prognosis. A shock causes a sudden damage increase and creates a jump in the degradation path, which shortens the total lifetime, and it has not been considered before in the integrated prognostics framework either. In the proposed integrated prognostics method, CIT is considered as an uncertain parameter, which is updated using condition monitoring data. To deal with the sudden damage increase and reduction of total lifetime, a virtual gradual degradation path with an earlier CIT is introduced in the proposed method. In this way, the effect of shock is captured through identifying an appropriate CIT. Examples of gear prog- nostics are given to demonstrate the effectiveness of the proposed method.

Influence of Initial Value of Transient Time Step on Numerical Simulation of Blow Molding Balloon

The correlation between the initial time value of transient iterative parameters and the blowing pressure in the numerical simulation process of blowing balloon is investigated by POLYFLOW. The results show that: 1) As the blow molding pressure increases, the boundary value of the iterative time step decreases rapidly at first and then slowly. At the end of the first step of iterative calculation for each boundary value, the balloon parison is in the mold core cavity. 2) If the initial time value of transient iterative parameters is smaller than the boundary value of the iterative time step, the balloon parison is still in the mold core cavity at the end of the first iteration. However, if the iterative calculation continues, the calculation process may be interrupted when the time step is smaller than the initial time value of the transient iterative parameters, which makes the blow molding simulation of balloon unable to continue. 3) It is suggested that the initial time value of transient iterative parameters is one order of magnitude smaller than the boundary value of the iterative time step to complete smoothly the simulation of blow molding balloon.

Zircon and Apatite U-Pb Geochronology and Geochemistry of the Mafic Dykes in the Shuangxiwu Area, Northwestern Zhejiang Province: Constraints on the Initial Time of Neoproterozoic Rifting in South China

Previous studies have shown that there are some ca.770–750 Ma mafic dykes at the western segment of the Neoproterozoic Jiangnan orogen(JO),and they represent post-orogenic magmatism due to orogenic collapse(Wang

How Kieffer Density Matrix Formalism Aids Different Initial Time Steps, Leading to Lorentz Violations, and Breakup of Primordial Black Holes for GW Generation

A result from Kieffer, as outlined at the beginning of the article identifies two different candidates for initial time steps, delta t. We assert that this difference in time steps may be related to a specific early universe Lorentz Violation. The author asserts that the existence of early universe Lorentz violation in turn is assisting in a breakup of primordial black holes. And that also has a tie into Kieffer different time steps as outlined. And the wrap up is given in the final part of this document.

Analysis of Season Change in Jiyang from Meteorological Standpoint

[Objective] The aim was to analyze changing characters of four seasons in Jiyang, providing references for farming and disaster prevention in the area. [Methed] Changing characters of initial time and lasting periods of four seasons in Jiyang for 30 years were analyzed from meteorological standpoint with weather information from 1981 to 2010 observed in surface meteorological observation in Jiyang. [Result] Recent 30 years, initial time of spring and winter in Jiyang were earlier than before, especially for spring. In contrast, initial time of summer and autumn were later, especially for autumn. In addition, periods of spring and winter declined and the latter changed more significantly. Meanwhile, periods of summer and autumn extended and rate of linear trend for summer period was 0.042 hou/year. [Conclusion] The research indicated that lasting days of summer extended significantly and of spring and winter shortened under the background of global warming.

Sensitivity Analysis of Key Input Parameters in Microscopic Simulation of Congested and Uncongested Arterial Signals

This study involved investigating the sensitivity of Measures of Effectiveness （MOEs） to different simulation initialization time （7, 10, and 13 minutes）; observing the trend of variation of MOEs with increasing simulation runs; and identifying the major contributors of variation in MOEs using CORSIM and SimTraffic. The results showed that （1） the MOEs of a simulated intersection approaches were indeed sensitive to initialization times; （2） the variation within MOEs reached a steady state with increased number of simulation runs, while CORSIM required at least 50 simulation runs, SimTraffic required even higher number of runs for congested approaches; （3） lane changing and gap acceptance parameters play a major role as a source of variation of MOEs （delay/vehicle） in CORSIM and SimTraffic respectively.

Non Linear Electrodynamics Contributing to a Minimum Vacuum Energy (“Cosmological Constant”) Allowed in Early Universe Cosmology

This article poses the question of a minimum cosmological constant, i.e. vacuum energy at the start of the cosmological evolution from a near singularity. We pose this comparing formalism as given by Berry (1976) as to a small time length, and compare that in its entirety to compare this value given by Berry (1976) with a minimum time length at the start of cosmological space-time evolution. Using the methodology of Zeldovich (1972) as to a problem with electron-positron pair production we also propose another upper bound to the problem of minimum time length which may be accessible to experimental inquiry. This then makes the problem of minimum time length a way of specifying a magnetic field dependence of the cosmological constant, which has major implications to answering if quintessence, i.e. a changing cosmological vacuum energy, or a constant for the “cosmological constant” problem. Our answer is an initial value for the cosmological vacuum energy 1010 - 1020 times greater than today which suggests either Quintessence, or if still a constant, a much better value for this parameter than what is suggested by traditional field theory methods. In closing we review how our construct supports work done by Corda, as to early universe models and what the implications are, as to the choices we have made.

Shrinkage and Cracking Sensitivity of Cement Mortar Containing Fly Ash, Granulated Blast-furnace Slag and Silica Fume

A laboratory study was undertaken to investigate drying shrinkage and cracking sensitivity subjected to restrained shrinkage of mortar containing fly ash (FA), granulated blast-furnace slag (GBFS) and silica fume (SF). Six mortar mixtures including control Portland cement (PC) and FA, GBFS and SF mortar mixtures were prepared. FA replaced the cement on mass basis at the replacement ratios of 20% and 35%, GBFS replaced the cement at the replacement ratios of 40%, SF replaced the cement at the replacement ratios of 8% and the blended mixtures with 20% FA, 20% GBFS and 8% SF. Water-cementitious materials ratio and sand-cementitious materials ratio were 0.4 and 2.0 for all mixtures, respectively. The mixtures were cured at 65% relative humidity and 20℃. The drying shrinkage value, initial cracking time and cracking width of the mortar samples were measured. The results show that all the mortar mixture containing FA exhibited the decrease of drying shrinkage. Moreover, initial cracking time was markedly delayed, and the crack width of the initial crack was reduced. However, the incorporations of various ratios of GBFS and SF led to an increase of drying shrinkage, initial cracking time and cracking width as compared to control mixture.

Rapid preparation of ceramic moulds for medium-sized superalloy castings with magnesia-phosphate-bonded bauxite-mullite investments

Phosphate-bonded investments have already been widely utilized in dental restoration and micro-casting of artistic products for its outstanding rapid setting and high strength. However, the rapid setting rate of investment slurry has up to now been a barrier to extend the use of such slurry in preparation of medium-sized ceramic moulds. This paper proposes a new process of rapid fabrication of magnesia-phosphate-bonded investment ceramic moulds for medium-sized superalloy castings utilizing bauxite and mullite as refractory aggregates. In order to determine the properties of magnesia-phosphate-bonded bauxite-mullite investments (MPBBMI), a series of experiments were conducted, including modifciation of the workable time of slurry by liquid(mL)/powder(g)(L/P) ratio and addition of boric acid as retard agent and sodium tri-polyphosphate (STP) as strengthening agent, and adjustment of bauxite (g)/mullite(g)(B/M) ratio for mechanical strength. Mechanical vibration was applied to improve initial setting time and fluidity when pouring investment slurry; then an intermediate size ceramic mould for superalloy castings was manufactured by means of this rapid preparing process with MPBBMI material. The results showed that the MPBBMI slurry exhibits proper initial setting time and excellent fluidity when the L/P ratio is 0.64 and the boric acid content is 0.88wt.%. The fired specimens made from the MPBBMI material demonstrated adequate compression strength to withstand impact force of molten metal when the B/M ratio is 0.89 and the STP content is 0.92wt.%. The experimental results confirmed the feasibility of the proposed rapid fabricating process for medium-sized ceramic moulds with MPBBMI material by appropriate measures.

Simultaneously measuring initiation toughness of pure mode Ⅰ and mode Ⅱ cracks subjected to impact loads

In order to simultaneously measure the initiation toughness of pure mode Ⅰ and mode Ⅱ cracks in one specimen,a large-size double-cracked concave-convex plate(DCCP)specimen configuration was proposed.Impacting tests were implemented in the drop plate impact device.Strain gauges were employed to measure impact loads and crack initiation time.The corresponding numerical model was established by using the dynamic finite difference program AUTODYN,and the experimental-numerical method and ABAQUS code were utilized to obtain the initial fracture toughness of the crack.Using experiments and numerical research,we concluded that the DCCP specimen is suitable for measuring the initial fracture toughness of pure mode Ⅰ and mode Ⅱ cracks at the same time;the dynamic initiation toughness increases with the increase of loading rate and the crack initiation time decreases with increasing loading rate;the initiation toughness of mode Ⅱ crack is 0.5 times that of mode Ⅰ crack when subjected to the same loading rate.For the pre-crack in the vicinity of the bottom of a sample,when its length increases from 20 to 100 mm,the dynamic initiation toughness of the pure mode Ⅰ crack gradually decreases,and the longer the lower crack length is,the easier the crack would initiate,but the dynamic initiation toughness of pure mode Ⅱ crack varies little.

Preparation for Retarding and High Early Strength Concrete

The primary objective of this research was to determine optimum dosage of mixing concrete containing plasticizers and fly ash, consistent with desirable structural grade concrete properties. Factorial tests were also conducted to investigate the four main factors： water-cementing materials ratio, water content, content of superplasticizers （SP） and fly ash content. It was found that the requirement for setting time played the dominant role in shrinkage and anti-cracking, and fly ash played a critical role in workability and reducing heat of hydration but showed insignificant effects on slump, early strength and initial setting time of concrete.

The Calculation of Collision Risk on Air-Routes Based on Variable Nominal Separation

In this paper,a new method to calculate collision risk of air-routes,based on variable nominal separation,is proposed. The collision risk model of air-routes,based on the time variable and initial time interval variable,is given. Because the distance and the collision probability vary with time when the nominal relative speed between aircraft is not zero for a fixed initial time interval,the distance,the variable nominal separation,and the collision probability at any time can be expressed as functions of time and initial time interval. By the probabilistic theory,a model for calculating collision risk is acquired based on initial time interval distribution,flow rates,and the proportion of aircraft type. From the results of calculations,the collision risk can be characterized by the model when the nominal separation changes with time. As well the roles of parameters can be shown more readily.

When to start renal replacement therapy in acute kidney injury: What are we waiting for?

Acute kidney injury remains a serious condition with a high mortality risk. In the absence of any new drugs, renal replacement therapy (RRT) is the most important treatment option. Randomized controlled trials have concluded that in critically ill patients without an emergency indication for RRT, a watchful waiting strategy is safe;however, further delays in RRT did not seem to confer any benefit, rather was associated with potential harm. During this process, balancing the risks of complications due to an unnecessary intervention with the risk of not correcting a potentially life-threatening complication remains a challenge. Dynamic renal function assessment, especially dynamic assessment of renal demand-capacity matching, combined with renal biomarkers such as neutrophil gelatinase-associated lipocalin and furosemide stress test, is helpful to identify which patients and when the patients may benefit from RRT.

A Theory for the Initial Allocating of Real Time Tasks in Distributed Systems

Referring to a set of real time tasks with arriving time,executing time and deadline,this paperdiscusses the problem of polynomial time initial-allocating approximation algorithms in a distributedsystem and five new results are gained which provide a theory for the designing of initial-allocating algorithmsof real time tasks.

Constraining quantitatively the timing and process of continent-continent collision using magmatic record： Method and examples

Based on the main driving force of plate motion(the slab pull force generated by the descent of the oceanic plate in subduction zones) and the three primary mechanisms for magma generation(adding fluid, increasing temperature, and decreasing pressure), the continent-continent collisional process has been divided into three stages, including initial collision, ongoing collision, and tectonic transition. These stages are characterized by normal calc-alkaline andesitic magma(dehydration of the oceanic crust to release fluids), the migration of calc-alkaline magma toward the trench(dehydration of the oceanic crust or an increase in temperature) or small-scale crust-derived peraluminous magma(heat from intra-crustal shearing), and extensive magmatism with compositional diversity induced by slab break-off(increasing temperature and decreasing pressure), respectively.On the basis of the obtained age of slab break-off, the timing of the initial continent-continent collision can be quantitatively back-dated using the convergence rate, depth of slab break-off, and subduction angle. The spatio-temporal migration of the magmatic activity of the Gangdese Batholith, the onset of magmatic flare-up, and the increase of magma temperature at 52–51Ma documented by the volcanic rocks of the Linzizong Pana Formation were most likely the result of the break-off of the Yarlung-Zangbo Neo-Tethyan oceanic lithosphere at approximately 53 Ma. This proposed age of slab break-off suggests that the initial India-Asia collision likely occurred at approximately 55–54 Ma, which is consistent with the collision ages constrained by other abundant geological data(60–55 Ma). This magmatic method has been applied to the Bitlis orogenic belt in southern Turkey in the Arabia-Eurasia continental collision zone, yielding an age range of approximately 29–22 Ma for the initial Arabia-Asia continental collision that is close to the collision ages recently obtained by apatite fission-track dating(approximately20 Ma) and regional tectonic shortening(approximately 27 Ma). The intense folding of the Upper Cretaceous and the angular unconformity between the overlying Linzizong volcanic rocks in the southern Lhasa Terrane(90.69 Ma) are not related to the initial continental collision between India and Asia, but can be interpreted as the consequences of the strong coupling between the hot and young subducting oceanic crust immediately south of the spreading ridge and the overriding lithosphere or the subduction of the Neo-Tethys oceanic plateaux or seamounts. The tectonic event documented by the angular unconformity between the Linzizong Dianzhong Formation and the Nianbo Formation lasted approximately 3 Ma and likely marks the initial India-Asia collision. The significant deceleration of the Indian continent at approximately 51 Ma can be attributed to the disappearance of the slab pull force in the subduction zone due to the break-off of the Yarlung-Zangbo Neo-Tethyan oceanic lithosphere. The descent of the eclogitized lower crust of the northern Indian continent provides the main driving force for the current northward motion of Indian plate. The weak deformation of the lithospheric plate in the overriding plate of the India-Asia collisional zone between 60 and 40 Ma can be attributed to the high-angle subduction related to the rollback of the Yarlung-Zangbo Neo-Tethyan oceanic lithosphere after the initial India-Asia continental collision, the presence of the thick crust and high elevation on the southern margin of the Lhasa Terrane, and the decoupling between the mid-upper and lower crust and between the lower crust and lithospheric mantle of the Indian continent.

Processes of initial collision and suturing between India and Asia

The initial collision between Indian and Asian continents marked the starting point for transformation of land-sea thermal contrast,uplift of the Tibet-Himalaya orogen,and climate change in Asia.In this paper,we review the published literatures from the past 30 years in order to draw consensus on the processes of initial collision and suturing that took place between the Indian and Asian plates.Following a comparison of the different methods that have been used to constrain the initial timing of collision,we propose that the tectono-sedimentary response in the peripheral foreland basin provides the most sensitive index of this event,and that paleomagnetism presents independent evidence as an alternative,reliable,and quantitative research method.In contrast to previous studies that have suggested collision between India and Asia started in Pakistan between ca.55 Ma and50 Ma and progressively closed eastwards,more recent researches have indicated that this major event first occurred in the center of the Yarlung Tsangpo suture zone(YTSZ) between ca.65 Ma and 63 Ma and then spreading both eastwards and westwards.While continental collision is a complicated process,including the processes of deformation,sedimentation,metamorphism,and magmatism,different researchers have tended to define the nature of this event based on their own understanding,an intuitive bias that has meant that its initial timing has remained controversial for decades.Here,we recommend the use of reconstructions of each geological event within the orogenic evolution sequence as this will allow interpretation of collision timing on the basis of multidisciplinary methods.

Pre-treatment of pyridine wastewater by new cathodic–anodic-electrolysis packing

A novel cathodic–anodic-electrolysis packing（CAEP） used in the treatment of pyridine wastewater was researched, which mainly consisted of 4,4′-diamino-2,2′-disulfonic acid（DSD acid） industrial iron sludge. The physical properties and morphology of the packing were studied. The CAEP was used in a column reactor during the pretreatment of pyridine wastewater. The influence of p H, hydraulic retention time（HRT）, the air–liquid ratio（A/L）and the initial concentration of pyridine were investigated by measuring the removal of total organic carbon（TOC） and pyridine. The characterization results showed that the bulk density, grain density, water absorption percentage and specific surface area were 921 kg/m3,1086 kg/m3, 25% and 29.89 m^2/g, respectively; the removal of TOC and pyridine could reach50% and 58% at the optimal experimental conditions（p H = 3, HRT = 8 hr, A/L = 2）. Notably,the surface of the packing was renewed constantly during the running of the filter, and the handling capacity was stable after running for three months.

Investigation of radionuclide～(63)Ni(Ⅱ) sequestration mechanisms on mordenite by batch and EXAFS spectroscopy study

The sorption behavior and microscopic sequestration mechanisms of radionuclide 63Ni（II） on mordenite as a function of aging time, ionic srength, initial 63Ni（II） concentrations, solid content and coexistent electrolyte ions were investigated by the combination of batch and EXAFS techniques. Macroscopic experiment results show that the sorption of 63Ni（II） is dependent on ionic strength at pH〈7, and independent of ionic strength at pH〉7. The sorption percentage of 63Ni（II） on mordenite increases with increasing solid content, while the sorption capacity decreases as solid content increases. The presence of different electrolyte ions can enhance or inhibit the sorption of Ni（II） on mordenite in various degrees. EXAFS analysis results of the sam- ples under three different ionic strengths suggest that the retained 63Ni（II） in these samples exists in an octahedral environment with six water ligands. In the initial period of rapid uptake, the sorption of 63Ni（II） is dominated by the formation of innersphere surface complexes. As aging time increases, 63Ni（II） sequestration behavior tends to be mainly controlled by the formation of Ni phyllosilicate coprecipitates and/or Ni（OH）2（s） precipitates. Results for the second shell fit of the sample prepared at an initial 63Ni（II） concentration of 100 mg/L indicate the possible formation of Ni polynuclear surface complexes. Both the macroscopic sorption data and the molecular level evidence of 63Ni（II） surface speciation at the mordenite/water interfaces should be factored into better predictions of the mobility and bioavailability of 63Ni（II） in environment mediums.