Sequential intraventricular injection of tigecycline and polymyxin B in the treatment of intracranial Acinetobacter baumannii infection after trauma: a case report and review of the literature

Background:Intracranial infection after craniotomy is one of the most serious postoperative complications,especially multidrug-resistant(MDR)or extensively drug-resistant(XDR)bacterial meningitis,and strongly affects the prognosis of patients.Current treatment experience regarding these infections is scarce.Case presentation:We report a case of severe intracranial infection of XDR Acinetobacter baumannii(A.baumannii)that was treated by intravenous(IV)injection,sequential intraventricular(IVT)injection of tigecycline and polymyxin B,and other anti-infective drugs.Good results were obtained,and the patient was eventually discharged from the hospital.This case is characterized by intracranial infection.Conclusions:The polymyxin B IV+IVT pathway is an ideal treatment strategy for XDR A.baumannii.The tigecycline IVT pathway is also a safe treatment option.

Sepsis after Administering an Intramuscular Iron Injection in the Arm of an Elder Patient with Multiple Comorbidities: A Case Report

Background: Skin reactions and musculoskeletal injuries caused by intramuscular injection are an increased risk for skin and soft tissue infections and may culminate in sepsis. Objective: To describe the history of an elderly patient who developed a lesion in her right arm after home administration of intramuscular iron injection in this arm and its outcome. Methods: This is a case report of a patient who participated in a study in an intensive care unit. Results: This study describes a 65-year-old patient with multiple comorbidities who was admitted to the hospital complaining of pain for two months and difficulty in moving her right shoulder associated with skin and soft tissue infections in her right arm after intramuscular iron administration by a relative for the treatment of multifactorial anemia and refractory melena. The patient worsened her general condition and was transferred to the intensive care unit. Despite the therapy instituted, the patient developed sepsis of cutaneous origin, multiple organ dysfunction, and death. Conclusions: The administration of intramuscular medication requires the participation of qualified professionals, such as nurses, mainly within the scope of the Brazilian public health system which commonly comprises patients in a context of vulnerability.

The clinical efficacy of percutaneous ethanol-lipiodol injection(PEI)combined with high-intensity focused ultrasound(HIFU)for small hepatocellularcarcinoma in special or high-risk locations

Objective The objective of this study was to explore the short-term effects and postoperative complications of ultrasound-guided percutaneous ethanol-lipiodol injection(PEI)combined with high-intensity focused ultrasound(HIFU)for the treatment of small hepatocellular carcinoma in a special or high-risk location.Methods Forty patients with small liver cancer in a special or high-risk location were randomly divided into two groups:20 patients were treated with PEI combined with HIFU(P+H group),and 20 patients were treated with HIFU alone(H group).There were no significant differences in average age,liver function,tumor location,tumor number,or tumor size between the two groups(P>0.05).Results Significant differences were observed in ablation parameters between the two groups(P<0.05).Under the same power,ablation rates of the P+H group were significantly higher than those in the H group,and postoperative complications in the P+H group were significantly lower than those in the H group(P<0.05).Conclusion The combination of PEI and HIFU has better clinical value than HIFU alone for small-cell liver cancer in special or high-risk locations.

Qingkailing injection for the treatment of acute upper respiratory infection in children: a systematic review and meta-analysis

Objective:To systematically evaluate the clinical efficacy and safety of Qingkailing (QKL) injection for pediatric acute upper respiratory infection (AURI).Methods:We searched for randomized controlled trials (RCTs) of pediatric AURI treated by QKL and western medicine (WM) in the China National Knowledge Infrastructure Database,China Science and Technology Journal Database,Wanfang,Chinese Biomedical Literature Database,PubMed and Cochrane Library from inception to August,2016.Two reviewers independently retrieved the RCTs and extracted information.The Cochrane Collaboration Risk of Bias Assessment Tool was used to evaluate the methodological quality of RCTs.The data were meta-analyzed by RevMan 5.3 software.Results:Ultimately,21 RCTs that involved 2364 participants were included,and the quality of RCTs was generally poor.According to the meta-analysis,the combined use of QKL and WM for treating AURI can be effective,with a higher total effective rate,less defervescence time and less recovery time of tonsil and throat inflammation.Twenty-five adverse drug reactions (ADRs) were reported in three RCTs,but there were no serious ADRs.Conclusion:The combination of QKL and WM for treating pediatric AURI can result in better effects,but no definitive conclusions can be made regarding its safety.More rigorous RCTs are needed to support the clinical application of QKL.

Clinical Analysis of Lumbar Pool Drainage Combined with Antibiotics in the Treatment of Intracranial Infection

Objective: To explore the clinical effect of lumbar pool drainage combined with antibiotics in the treatment of patients with intracranial infections, and to provide a reference basis for clinical treatment. Methods: To collect and select patients admitted to the First People’s Hospital of Jingzhou City for craniotomy from January 2016 to June 2022, the infected were 20 cases, and continuous drainage of the lumbar pool was used under the premise of systemic application of sensitive antibiotics. Results: Twenty cases in this group were discharged cured. Conclusion: Lumbar pool placement drainage combined with systemic application of antibiotics for intracranial infection is a safe and effective treatment method.

Tanreqing injection auxiliary in the treatment of heart failure with pulmonary infection:A systematic review

Objective:To systematically evaluate the clinical efficacy and safety of Tanreqing injection in the treatment of heart failure complicated with pulmonary infection.Methods:The database of CNKI,SinoMed,VIP full text database,Wanfang database,Cochrance Library,Web of Science and PubMed were searched.The retrieval time was from the inception to August 2021.Clinical randomized controlled trial of Tanreqing injection in the treatment of heart failure complicated with pulmonary infection was collected,and two researchers independently screened the document data.Meta-analysis was performed using RevMan 5.4.1 software.Results:A total of 10 documents were included,including 862 cases of heart failure complicated with pulmonary infection,including 431 cases in the test group,and 431 cases in the control group.The Meta analysis showed that compared to the control group,the test group increased clinical efficiency[OR=4.56,95%CI(2.79,7.52),P<0.00001],reduced the value of C-reactive protein[MD=-7.55,95%CI(-11.40,-3.69),P=0.0001],reduced the time required to correct heart failure[OR=-4.04,95%CI(-4.59,-3.49),P<0.00001],reduced the number of days of the average hospitalization[MD=-4.78,95%CI(-6.67,-2.89),P<0.00001],and there were no statistically significant differences in the incidence of adverse reactions.Conclusion:Tanreqing injection,as an auxiliary treatment for heart failure complicated with pulmonary infection,has significantly effective effect on improving efficiency.Tanreqing injection has a certain advantage in reducing C-creative protein values,shortening the time of correcting heart failure,and reducing the number of days of the average hospitalization,and the adverse reactions are smaller.However,the overall quality of the included studies is low,and more high-quality randomized controlled trials are needed to increase the evidence-based basis.

Meta-analysis of the comparison between reduning injection and ribavirin injection for acute upper respiratory tract infection in children

Objective:To systematically evaluate the effectiveness and safety of reduning injection in acute upper respiratory tract infection of children.Methods:Use computer to search PubMed,the Cochrane Library,EMBASE,Web of Science,China National Knowledge Infrastructure(CNKI),Wanfang Database,Weipu database(VIP)and China Biomedical studies Service System(CBM)for randomized controlled trials(RCT)of acute upper respiratory tract infection in children,and the retrieval time is from their establishment to May,2022.After two researchers independently screened the studies,extracted data and evaluated the risk bias of studies,RevMan5.3 software was used to perform meta-analysis.Results:10 studies in total were included,involving 1466 patients.Results of the meta-analysis:total effective rate[RR=1.12,95%CI(1.07,1.16),P<0.00001],cure time[MD=-1.51,95%CI(-1.71,-1.32),P<0.00001],antipyretic time[MD=-1.32,95%CI(-1.72,-0.92),P<0.00001],disappearing time of nasal obstruction and nose running[MD=-1.04,95%CI(-1.45,-0.62),P<0.00001],disappearing time of cough[MD=-1.35,95%CI(-1.58,-1.13),P<0.00001],disappearing time of throat congestion[MD=-1.36,95%CI(-1.68,-1.03),P<0.00001],disappearing time of sore throat[MD=-1.55,95%CI(-1.74,-1.35),P<0.00001],the incidence of adverse reactions[RR=0.34,95%CI(0.20,0.57),P<0.0001].The differences between two groups in total effective rate,cure time,antipyretic time,disappearing time of nasal obstruction and nose running,disappearing time of cough,disappearing time of throat congestion,disappearing time of sore throat and the incidence of adverse reactions are all statistically significant(P<0.05).The sensitivity analysis demonstrates that three outcomes(total effective rate,cure time and disappearing time of sore throat)have unstable results,while others having stable results.Conclusion:Reduning injection is more effective than ribavirin injection in clinical,and it is better than ribavirin injection at relieving fever,nasal obstruction and nose running,cough and throat congestion.In addition,it’s safer in clinical than ribavirin injection.

Understanding the effects of intramuscular injection and feed withdrawal on Salmonella Typhimurium shedding and gut microbiota in pullets

Background:Gut microbiota plays a key role in health,immunity,digestion,and production in layers.Factors such as environment,diet,diseases,stress,and flock management significantly affect gut microbiota;however,it is not known how potential stressors such as intramuscular injections or feed withdrawal alter the composition of gut microbiota that result in increased the shedding level of foodborne pathogens.In the current study,the effects of intramuscular corticosterone injection and feed withdrawal were evaluated to understand their role in Salmonella Typhimurium shedding and changes in the composition of gut microbiota in layers.Results:Salmonella shedding was observed for 8 weeks post-infection.There was a significant increase in Salmonella Typhimurium count after intramuscular injection and feed withdrawal.The Salmonella infected and the negative control groups showed significant differences in the abundance of different genera in gut microbiota at week 1 and up to week 7 post infection.The infected group showed a significant reduction in alpha diversity of gut microbiota.Firmicutes reduced significantly(P<0.05)after intramuscular injection,while the feed withdrawal groups did not cause any significant changes in Proteobacteria-Firmicutes ratio.Furthermore,intramuscular injection resulted in a significant change in alpha diversity of gut microbiota.Conclusions:Exposure of chicks to relatively low dose of Salmonella Typhimurium can lead to persistent shedding in pullets.The Salmonella Typhimurium infection disrupted the gut microbiota composition immediately after infection.The potential stress of intramuscular injection and feed withdrawal significantly increased the Salmonella Typhimurium count in faeces.The intramuscular injection also resulted in a significant alteration of the Proteobacteria-Firmicutes ratio,which could increase the risk of dysbiosis.

Mycobacterium abscessus infection after facial injection of argireline:A case report

BACKGROUND The incidence of infection with Mycobacterium abscessus(M.abscessus)has increased in recent years.This increase is partly associated with invasive cosmetic procedures.CASE SUMMARY The purpose of this case summary is to increase clinicians'awareness of M.abscessus infection and reduce mycobacterial infection caused by cosmetic procedures.We report the case of a 45-year-old woman who received acetyl hexapeptide-8(argireline)injections in the forehead and temples,and erythema,nodules,and abscesses appeared at the injection sites after one week.The pus specimens were examined by microbiological culture and confirmed to be positive for M.abscessus.Clarithromycin 500 mg twice daily and moxifloxacin 400 mg once daily were administered for 5 mo and the lesions gradually subsided.CONCLUSION We report here for the first time a case of infection with M.abscessus after argireline injection.This condition is easily misdiagnosed as a common bacterial infection.Microbiological examinations are helpful for diagnosis and standardized cosmetic procedures can prevent infection with M.abscessus.

Subcutaneous infection caused by Mycobacterium abscessus following cosmetic injections of botulinum toxin:A case report

BACKGROUND In recent years,the cosmetic intervention related infections caused by nontuberculous mycobacteria(NTM)are increasing as the informal cosmetic treatments are performed.However,many dermatologists are inexperienced in the diagnosis and management of similar cases.Here we report a case of subcutaneous infection caused by Mycobacterium abscessus(M.abscessus)following cosmetic injections of botulinum toxin.CASE SUMMARY A 53-year-old woman presented with multiple abscesses and nodules on her forehead and both temporal sites for half a month after cosmetic injections of botulinum toxin.Her lesions did not show any alleviation after 2-wk prescription of antibiotics.Laboratory examinations indicated that she had no sign of immunodeficiency and the whole body of computed tomography did not find any systemic infection or diseases.The pathology of skin tissue showed inflammatory cell infiltration with the negative results of Periodic acid Schiff(PAS)and Acidfast staining and the culture yielded no microbiome.Afterwards,the puncture on abscess was performed and M.abscessus was successfully isolated.The pathogen was identified by acid-fast staining and DNA sequencing.The patient was treated with the strategy of clarithromycin,ofloxacin,and amikacin according to the result of drug sensitivity test and got complete remission of the lesions.CONCLUSION The case presents the whole process of diagnosis and management of NTM infection after cosmetic intervention and highlights the diagnostic thoughts.In a word,the mycobacterium infection should be aware in patients after cosmetic performance.

Plasma density transition-based electron injection in laser wake field acceleration driven by a flying focus laser

By using a high-intensity flying focus laser,the dephasingless[Phys.Rev.Lett.124134802(2020)]or phase-locked[Nat.Photon.14475(2020)]laser wakefield acceleration(LWFA)can be realized,which may overcome issues of laser diffraction,pump depletion,and electron dephasing which are always suffered in usual LWFA.The scheme thus has the potentiality to accelerate electrons to Te V energy in a single acceleration stage.However,the controlled electron injection has not been self-consistently included in such schemes.Only external injection was suggested in previous theoretical studies,which requires other accelerators and is relatively difficulty to operate.Here,we numerically study the actively controlled density transition injection in phase-locked LWFA to get appropriate density profiles for amount of electron injection.The study shows that compared with LWFA driven by lasers with fixed focus,a larger plasma density gradient is necessary.Electrons experience both transverse and longitudinal loss during acceleration due to the superluminal group velocity of the driver and the variation of the wakefield structure.Furthermore,the periodic deformation and fracture of the flying focus laser in the high-density plasma plateau make the final injected charge also depend on the beginning position of the density downramp.Our studies show a possible way for amount of electron injection in LWFA driven by flying focus lasers.

聚焦解决护理模式对乳腺癌患者术后感染预防及自我护理能力的影响

目的:探讨聚焦解决护理模式在预防乳腺癌患者术后感染,提高其自我护理能力方面的应用效果,为临床护理提供依据。方法:回顾性分析2020年10月—2022年1月河南省襄城县人民医院接受治疗的137例乳腺癌患者的病历资料,采用随机数表法将患者分为常规组69例和聚焦组68例。常规组术后采用常规护理干预,聚焦组采用聚焦解决护理模式干预。比较两组患者自我护理能力、血清炎性因子水平、血流变化指标、患肢活动能力。结果:护理后,聚焦组患者自我护理能力各维度评分均明显高于常规组,差异有统计学意义(t=3.430、5.112、3.529,P<0.05)。护理后,聚焦组患者血清炎性因子水平均明显低于常规组,差异有统计学意义(t=3.377、2.688、4.990,P<0.05)。护理后,聚焦组患者红细胞压积、全血黏度和血浆黏度均明显低于常规组,差异有统计学意义(t=3.377、2.688、4.692,P<0.05)。护理后,聚焦组患者患肢前后伸展、前后旋转、患肢洗漱、患肢拿物及抓举物品评分均明显高于常规组,差异有统计学意义(t=24.078、32.434、28.327、29.166、20.112,P<0.05)。结论:乳腺癌患者术后应用聚焦解决护理模式干预,能够提升患者的自我护理意识,增强自我护理技巧和能力,降低炎性因子水平,改善血流动力及血液循环,提高患肢活动能力,促进手术切口愈合。

鞘内注射美罗培南对丙戊酸钠血药浓度的影响

一例特重型颅脑损伤的患者术后出现颅内感染,使用美罗培南抗感染效果良好,但患者随后出现继发性癫痫,先后使用左乙拉西坦、地西泮、苯巴比妥后效果不佳,在征求家属同意的基础上,临床药师探索性地给予鞘内注射美罗培南并鼻饲丙戊酸钠的方法,同时监测感染控制情况、癫痫症状及丙戊酸钠血药浓度,患者感染控制较好,丙戊酸钠血药浓度未见明显下降,癫痫未再发作。

美罗培南不同给药途径治疗颅脑损伤术后颅内感染患者的效果及对预后的影响

目的 分析美罗培南不同给药途径治疗颅脑损伤术后颅内感染患者的效果及对预后的影响。方法 选取2020年1月至2023年12月收治的90例颅脑损伤术后颅内感染患者为研究对象,根据美罗培南不同给药途径将其分为常规组(23例,常规静脉滴注)和观察组(67例,常规静脉滴注+脑室内注射)。比较两组的治疗效果。结果 观察组的治疗总有效率高于常规组(P<0.05)。观察组的脑室外引流管留置时长、静脉用药时长短于常规组(P<0.05)。治疗后,观察组的C反应蛋白(CRP)、白细胞介素-6(IL-6)、白细胞介素-34(IL-34)、降钙素原(PCT)水平及白细胞计数(WBC)低于常规组(P<0.05)。治疗后,观察组的CD4^(+)、CD4^(+)/CD8^(+)高于常规组,CD8^(+)低于常规组,差异具有统计学意义(P<0.05)。两组的不良反应总发生率无显著差异(P>0.05)。结论美罗培南常规静脉滴注+脑室内注射给药途径治疗颅脑损伤术后颅内感染患者可取得理想效果与预后保障。

基于行为改变理论的远程指导结合聚焦解决模式对幽门螺杆菌感染性胃炎患者自我管理能力及疾病控制的影响

目的研究基于行为改变理论的远程指导结合聚焦解决模式对幽门螺杆菌(Hp)感染性胃炎患者自我管理能力及疾病控制的影响。方法选取2019年6月至2021年6月收治的486例Hp感染性胃炎患者为研究对象,以随机数字表法将其分为对照组与观察组,各243例。对照组采用聚焦解决模式,观察组在对照组基础上加施基于行为改变理论的远程指导。比较两组的干预效果。结果干预后,观察组的自我护理能力测定量表(ESCA)评分高于对照组(P<0.05)。干预后,观察组的医学应对方式问卷(MCMQ)中面对评分高于对照组,回避、屈服评分低于对照组(P<0.05)。观察组的Hp转阴率、治愈率均高于对照组(P<0.05)。干预后,观察组的胃泌素(GAS)、胃动素(MTL)水平高于对照组(P<0.05)。结论基于行为改变理论的远程指导结合聚焦解决模式不仅能够提高Hp感染性胃炎患者的自我管理能力,还能改变疾病应对方式,加强疾病控制,值得推广。

聚乙二醇干扰素治疗慢性乙型肝炎过程中继发重度骨髓抑制并呼吸道鲍曼不动杆菌感染、腹腔积液1例

本文介绍了我院收治的1例聚乙二醇干扰素治疗慢性乙型肝炎过程中继发重度骨髓抑制并鲍曼不动杆菌感染、腹腔积液患者,描述并讨论分析其临床特点、实验室检查结果及诊治过程。

腹腔注射攻毒建立蜱媒脑炎病毒感染BALB/c小鼠模型

目的通过腹腔注射攻毒途径建立蜱媒脑炎病毒(TBEV)感染BALB/c小鼠模型,观察小鼠的感染症状和病毒在小鼠体内的复制特征。方法将6周龄雌性BALB/c小鼠随机分为未感染病毒对照组、1×10^(3)空斑形成单位(PFU)TBEV感染组(以每只小鼠1×10^(3)PFU的攻毒剂量经腹腔注射感染小鼠)、1×10^(4)PFU TBEV感染组(以每只小鼠1×10^(4)PFU的攻毒剂量经腹腔注射感染小鼠),观察小鼠的感染症状、体重变化与生存情况。通过H-E染色观察小鼠脑、脾的病理改变,采用免疫组织化学染色检测小鼠脑、脾中TBEV蛋白的表达,采用空斑试验检测小鼠脑、脾中TBEV滴度的动态变化。结果1×10^(4)PFU TBEV感染组小鼠于感染后第6天出现弓背、后肢瘫痪等感染症状,1×10^(3)PFU TBEV感染组小鼠于感染后第7天出现上述症状。与未感染病毒对照组小鼠相比,1×10^(4)PFU TBEV感染组小鼠从第5天、1×10^(3)PFU TBEV感染组小鼠从第6天开始体重明显降低,差异有统计学意义(P<0.05)。1×10^(4)PFU TBEV感染组小鼠第7天开始死亡、第8天全部死亡,1×10^(3)PFU TBEV感染组小鼠第7天开始死亡、第9天全部死亡。H-E染色结果显示,TBEV感染后第5天、第7天小鼠大脑皮质仅出现少量神经元核固缩、深染,未观察到炎症细胞浸润;TBEV感染后第5天小鼠脾红髓轻度淤血、多见中性粒细胞,第7天中性粒细胞数量增多。免疫组织化学染色结果显示,TBEV感染后第5天小鼠脑与脾少量表达TBEV蛋白,第7天TBEV蛋白表达量增加。1×10^(3)PFU TBEV感染第7天,小鼠脑内TBEV滴度高达(1.3±0.6)×10^(5)PFU/mL,而脾中TBEV滴度为(1.3±0.6)×10^(3)PFU/mL。结论经腹腔注射攻毒成功建立了TBEV感染BALB/c小鼠模型,TBEV可在小鼠体内增殖并具致病性。

替加环素和头孢他啶阿维巴坦钠鞘内注射治疗神经介入术后颅内感染的效果及对脑脊液NSE Ang-Ⅱ和MDA的影响

目的探讨替加环素和头孢他啶阿维巴坦钠鞘内注射治疗神经介入术后颅内感染患者的效果及对脑脊液神经特异性烯醇化酶(NSE)、血管紧张素Ⅱ(Ang-Ⅱ)、丙二醛(MDA)的影响。方法选取山东第一医科大学附属人民医院2019-01—2021-06经替加环素鞘内注射治疗的神经介入术后颅内感染患者20例为A组,2022-01—2023-06经头孢他啶阿维巴坦钠鞘内注射治疗的神经介入术后颅内感染患者44例为B组。比较2组患者脑脊液NSE、Ang-Ⅱ、MDA水平,血清炎症指标[白细胞计数(WBC)、C反应蛋白(CRP)、降钙素元(PCT)、外周血中性粒细胞比例(NEU%)],临床有效率,细菌清除情况及不良反应。结果2组患者脑脊液NSE、Ang-Ⅱ、MDA水平比较差异无统计学意义(P>0.05)。2组患者血清CRP、PCT、WBC及NEU%比较差异无统计学意义(P>0.05)。2组临床有效率比较差异无统计学意义(P>0.05)。2组细菌清除率、细菌再感染率及细菌替换率比较差异无统计学意义(P>0.05)。2组患者不良反应发生率比较差异无统计学意义(P>0.05)。结论头孢他啶阿维巴坦钠与替加环素鞘内注射治疗神经介入术后颅内感染均能显著消除脑脊液病原菌,降低炎症因子水平,改善神经损伤,临床有效率较高。临床可对耐药性较强的患者进行头孢他啶阿维巴坦钠鞘内注射治疗。

痰热清注射液雾化吸入联合左氧氟沙星治疗高龄呼吸道感染患者的临床研究

目的:探讨痰热清注射液雾化吸入联合左氧氟沙星治疗高龄呼吸道感染患者的临床疗效及安全性分析。方法:选取2022年6月~2023年6月期间某院收治的104例呼吸道感染患者作为研究对象,按照随机数字表法分为对照组和观察组,每组52例。两组患者均接受氧气支持、祛痰止咳、纠正水电解质紊乱等常规治疗。对照组患者给予盐酸左氧氟沙星注射液治疗;观察组患者在对照组基础上给予痰热清注射液雾化吸入。两组均持续治疗1周。比较两组患者血清炎症因子[γ干扰素(IFN-γ)、白介素-4(IL-4)、白介素-5(IL-5)、肿瘤坏死因子-α(TNF-α)]、急性蛋白标志物[血清淀粉样蛋白A(SAA)、C反应蛋白(CRP)]和不良反应发生情况。结果:治疗后,两组患者血清IFN-γ、IL-4、IL-5、TNF-α水平均降低(P<0.05),且观察组低于对照组(P<0.05);两组患者血清SAA、CRP水平均降低(P<0.05),且观察组低于对照组(P<0.05);观察组患者恶心呕吐、食欲减退、注射部位发红及皮疹不良反应总发生率(5.77%)低于对照组(15.38%,P<0.05)。结论:在常规治疗的基础上,痰热清注射液雾化吸入联合左氧氟沙星治疗呼吸道感染,可有效减轻患者炎症反应,降低急性蛋白标志物水平,且未增加不良反应的发生风险。

鞘内注射万古霉素治疗脑出血患者术后颅内感染的疗效评价

目的分析鞘内注射万古霉素治疗脑出血患者术后颅内感染与美罗培南的效果差异。方法回顾分析2021年3月至2023年1月山西省晋中市第一人民医院收治的60例小骨窗脑内血肿清除术后颅内感染患者的临床资料。根据患者所接受的治疗方案不同分为研究组与对照组,每组各30例,研究组给予万古霉素输注+鞘内注射,对照组给予美罗培南输注+鞘内注射。比较2组治疗后的临床疗效、脑脊液葡萄糖、颅内压、体温及感染相关因子水平。结果研究组临床有效率97%,高于对照组73%,差异有统计学意义(χ^(2)=4.706,P=0.030);治疗前,研究组的脑脊液葡萄糖、颅内压及体温与对照组比较差异无统计学意义(P均>0.05);2组白细胞计数(WBC)、C反应蛋白(CRP)、白细胞介素(IL)-6、肿瘤坏死因子(TNF)-α比较差异无统计学意义(P均>0.05)。治疗后,2组脑脊液葡萄糖均升高,且研究组高于对照组(P<0.001)。2组治疗后颅内压(P=0.041)和体温(P=0.017)均降低,且研究组低于对照组;2组治疗后WBC(P<0.001)、CRP(P=0.017)、IL-6(P<0.001)、TNF-α(P=0.011)均降低,研究组低于对照组,差异有统计学意义。结论对脑出血术后颅内感染患者给予万古霉素+鞘内注射能有效控制感染,对临床工作具有一定指导价值。