Presents the conception of concurrent engineering employed for CAD/CAM of injection moulds by closely combining the management science with the manufacturing techniques with the cost of processing, material cost, etc ...Presents the conception of concurrent engineering employed for CAD/CAM of injection moulds by closely combining the management science with the manufacturing techniques with the cost of processing, material cost, etc taken into consideration from the conceptural design to delivery of products and concludes with the results of analyses that the cost of finished plastic parts is lower, the production efficiency is higher while energy is saved.展开更多
A diffraction-limited storage ring with a multi-bend achromat lattice suffers from a small dynamic aperture for conventional off-axis injection.Thus,a longitudinal on-axis injection scheme based on a new type of crab ...A diffraction-limited storage ring with a multi-bend achromat lattice suffers from a small dynamic aperture for conventional off-axis injection.Thus,a longitudinal on-axis injection scheme based on a new type of crab cavity is proposed in this paper.Particle tracking simulations were performed to study the disturbance of the stored beam and the motion of the injected beam during the injection process.The possibility of multi-bunch injections was discussed.In addition,the effect of the long-range wake field induced by the stored beam was analyzed.A C-band standing-wave crab cavity was designed and produced as requested,and its field distribution was measured.The corresponding results are consistent with the simulation results.展开更多
In this work, the characteristics of the photonic crystal tunneling injection quantum dot vertical cavity surface emitting lasers(Ph C-TIQD-VCSEL) are studied through analyzing a modified modulation transfer functio...In this work, the characteristics of the photonic crystal tunneling injection quantum dot vertical cavity surface emitting lasers(Ph C-TIQD-VCSEL) are studied through analyzing a modified modulation transfer function. The function is based on the rate equations describing the carrier dynamics at different energy levels of dot and injector well. Although the frequency modulation response component associated with carrier dynamics in wetting layer(WL) and at excited state(ES) levels of dots limits the total bandwidth in conventional QD-VCSEL, our study shows that it can be compensated for by electron tunneling from the injector well into the dot in TIQD structure. Carrier back tunneling time is one of the most important parameters, and by increment of that, the bias current dependence of the total bandwidth will be insignificant. It is proved that at high bias current, the limitation of the WL-ES level plays an important role in reducing the total bandwidth and results in rollovers on 3-d B bandwidth-I curves. In such a way, for smaller air hole diameter of photonic crystal, the effect of this reduction is stronger.展开更多
Injection molding is a complicated production technique for the manufacturing of polymer products. During injection molding, it's hard to predict molding quality; the injection molding parameters, such as mold temper...Injection molding is a complicated production technique for the manufacturing of polymer products. During injection molding, it's hard to predict molding quality; the injection molding parameters, such as mold temperature, melt temperature, packing pressure and packing time, affect the final properties of product. The cavity pressure is a significant key factor. Residual stress and injection molding weight are significantly affected by the cavity pressure. This study created an approach to predict weight of injection-molded by real-time online cavity pressure monitoring. This study uses a 6-inch with thickness lmm light guide panel and the largest area beneath the pressure curve of time as well as the maximum pressure as its characteristic. The upper and lower limits of the control are set to +2 standard deviations, and GUI (Graphical User Interface)-based LabVIEW software is used to perform calculation and analysis of the pressure curve. The results of the experiment show that the online internal cavity pressure monitoring system can effectively monitor the quality of the molded products. In 500 injection molding cycle tests, its error rate was less than 8%, whereas the deviation in mass of the molded products selected through the system's filtering process was successfully controlled to be within ±4%.展开更多
Longitudinal injection is a promising on-axis injection scheme for diffraction-limited storage rings. In the latest version of the Hefei advanced light source (HALS), both the dynamic aperture and momentum aperture ha...Longitudinal injection is a promising on-axis injection scheme for diffraction-limited storage rings. In the latest version of the Hefei advanced light source (HALS), both the dynamic aperture and momentum aperture have been optimized. A longitudinal injection scheme was investigated on the HALS using a doublefrequency radio frequency system. To evaluate the injection performance, various errors were considered. A series of tracking simulations were conducted, and the injection efficiency was obtained under different error levels.展开更多
Objective: To explore the vision-related quality of life ( VRQL) before and after the injection of antiangiogenic drug into the vitreous cavity of patients with wet age-related macular degeneration ( AMD) . Methods: T...Objective: To explore the vision-related quality of life ( VRQL) before and after the injection of antiangiogenic drug into the vitreous cavity of patients with wet age-related macular degeneration ( AMD) . Methods: The 2000 edition of the Visual Functioning Questionnaire 25 that was issued by the Na-tional Eye Institute was applied, and the VRQL evaluation was conducted on the initially diagnosed patients with wet-AMD before and after the injection of ranibizumab into the vitreous cavity. Results: Among the wet-AMD patients, patients with better distance visual acuity before the in-travitreal injection had a lower VFQ-25 score. After the vitreous cavity injection, the VFQ-25 questionnaire score was related to patient care and education from the doctors and nurses; specific-ally, the better the nursing, the higher the score. Conclusions: Before the vitreous cavity injection, the degree of distance visual acuity is an im-portant factor affecting the VRQL of wet-AMD patients. In addition, patient care and education from the doctors and nurses toward patients during the pre-, intra-and post-operation of the intrav-itreal injection are also important factors affecting the VRQL.展开更多
The injection of a self-avoiding flexible polymer into a spherical cavity under a driving force is studied by using Langevin dynamics simulation.For given polymer length(N)and driving force(f),the polymer can be compl...The injection of a self-avoiding flexible polymer into a spherical cavity under a driving force is studied by using Langevin dynamics simulation.For given polymer length(N)and driving force(f),the polymer can be completely injected into the cavity only when the radius of the cavity is larger than a transition radius(ReC).The dependence of ReC on N and f can be described by a scaling relation ReC∝N ^(1/3) f−δ.The value ofδchanges from 4/15 in the small f region to 1/6 in the moderate f region due to the screening of the excluded-volume interaction between monomers.We find the complete injection time(τ)decreases monotonously with increasing the cavity radius or decreasing the polymer length.The simulation results are in good agreement with the theoretical predictions from the free energy analysis and a simple kinetic model.展开更多
BACKGROUND Intramuscular corticosteroid injection may cause adverse effects such as dermal and/or subcutaneous atrophy,alopecia,hypopigmentation,and hyperpigmentation.Although cutaneous atrophy can spontaneously resol...BACKGROUND Intramuscular corticosteroid injection may cause adverse effects such as dermal and/or subcutaneous atrophy,alopecia,hypopigmentation,and hyperpigmentation.Although cutaneous atrophy can spontaneously resolve,several treatment options have been suggested for this condition.CASE SUMMARY In this paper,we report a case of corticosteroid injection induced lipoatrophy treated with autologous whole blood(AWB)injection,as the condition had been unresponsive to fractional laser therapy.A 29-year-old female patient visited the dermatology clinic complaining of skin depression on her right buttock area,which had appeared six months earlier.There had been only subtle improvement at the margins after fractional CO2 laser treatment;therefore,after obtaining informed consent from the patient,AWB treatment was initiated.One month after the first AWB injection,the size and depth of the lesion had noticeably improved,and a slight improvement was also observed in discoloration.CONCLUSION Close observation is the initial treatment of choice for steroid induced skin atrophy;however,for patients in need of immediate cosmetic improvement,AWB injection may be a safe and cost-effective alternative.展开更多
It has been found that the static pressure distribution along the axial direction of liquid kerosene is lower than that of the gaseous kerosene under the same flow condition and overall equivalent ratio from previous ...It has been found that the static pressure distribution along the axial direction of liquid kerosene is lower than that of the gaseous kerosene under the same flow condition and overall equivalent ratio from previous studies.To further investigate this phenomenon,a compressible two-phase parallel simulation method is utilized to analyze the mixing and combustion characteristics of gaseous and liquid kerosene jets in a cavity-based supersonic combustor.The numerical results are consistent with the experiments and demonstrate that gaseous injection leads to a cavity shear layer that dives deeper into the cavity,forming two recirculation zones in the front and rear of the cavity.In contrast,the cavity shear layer is closer to the mainstream during liquid injection,and only a large recirculation zone is formed in the rear of the cavity.As a result of the cavity shear layer and the recirculating flow,the fuel vapor of gaseous injection accumulates in the front of the cavity,while for the liquid injection,the fuel vapor disperses in the cavity,cavity shear layer,and the region above,and the rear of the cavity has a higher fuel vapor concentration than the front.This unique fuel distribution causes the combustion area to be concentrated in the cavity during the gaseous injection but dispersed inside and downstream of the cavity during the liquid injection.As a result,forming a thermal throat under the same conditions is more challenging during liquid injection,and the generated static pressure distribution is lower than that during the gaseous injection.展开更多
Dear Editor,Treating psoriatic arthritis(PsA)is always difficult.Systemic treatments can be administered either orally or through intramuscular and intra-articular injection,including conventional synthetics,biologics...Dear Editor,Treating psoriatic arthritis(PsA)is always difficult.Systemic treatments can be administered either orally or through intramuscular and intra-articular injection,including conventional synthetics,biologics and targeted synthetic disease-modifying antirheumatic drugs[1].The alternatives,topical external therapies,are not effective on joint lesions due to drug permeability issues.Drugs injected into the articular cavity are also unsuitable for small peripheral joint lesions,the most common manifestations of PsA.The limited treatment options for PsA present a challenge.展开更多
To validate the design rationality of the power coupler for the RFQ cavity and minimize cavity contamination,we designed a low-loss offline conditioning cavity and conducted high-power testing.This offline cavity feat...To validate the design rationality of the power coupler for the RFQ cavity and minimize cavity contamination,we designed a low-loss offline conditioning cavity and conducted high-power testing.This offline cavity features two coupling ports and two tuners,operating at a frequency of 162.5 MHz with a tuning range of 3.2 MHz.Adjusting the installation angle of the coupling ring and the insertion depth of the tuner helps minimize cavity losses.We performed electromagnetic structural and multiphysics simulations,revealing a minimal theoretical power loss of 4.3%.However,when the cavity frequency varied by110 kHz,theoretical power losses increased to10%,necessitating constant tuner adjustments during conditioning.Multiphysics simulations indicated that increased cavity temperature did not affect frequency variation.Upon completion of the offline high-power conditioning platform,we measured the transmission performance,revealing a power loss of 6.3%,exceeding the theoretical calculation.Conditioning utilized efficient automatic range scanning and standing wave resonant methods.To fully condition the power coupler,a 15°phase difference between two standing wave points in the condition-ing system was necessary.Notably,the maximum continuous wave power surpassed 20 kW,exceeding the expected target.展开更多
Finesse is a critical parameter for describing the characteristics of an optical enhancement cavity(OEC). This paper first presents a review of finesse measurement techniques, including a comparative analysis of the a...Finesse is a critical parameter for describing the characteristics of an optical enhancement cavity(OEC). This paper first presents a review of finesse measurement techniques, including a comparative analysis of the advantages, disadvantages, and potential limitations of several main methods from both theoretical and practical perspectives. A variant of the existing method called the free spectral range(FSR) modulation method is proposed and compared with three other finesse measurement methods, i.e., the fast-switching cavity ring-down(CRD) method, the rapidly swept-frequency(SF) CRD method, and the ringing effect method. A high-power OEC platform with a high finesse of approximately 16000 is built and measured with the four methods. The performance of these methods is compared, and the results show that the FSR modulation method and the fast-switching CRD method are more suitable and accurate than the other two methods for high-finesse OEC measurements. The CRD method and the ringing effect method can be implemented in open loop using simple equipment and are easy to perform. Additionally, recommendations for selecting finesse measurement methods under different conditions are proposed, which benefit the development of OEC and its applications.展开更多
The design of three-dimensional printing based conformal cooling channels(CCCs)in injection molding holds great significance.Compared to CCCs,conformal cooling(CC)cavity solutions show promise in delivering enhanced c...The design of three-dimensional printing based conformal cooling channels(CCCs)in injection molding holds great significance.Compared to CCCs,conformal cooling(CC)cavity solutions show promise in delivering enhanced cooling performance for plastic products,although they have been underexplored.In this research,CC cavity is designed within the mold geometry,reinforced by body-centered cubic(BCC)lattice structures to enhance mechanical strength.Three distinct BCC lattice variations have been integrated into the CC cavity:the BCC structure,BCC with cubes,and BCC with pillars.The thermal performances of the BCC lattice-added CC cavity are assessed numerically after experimental validation.To provide feasible solutions from viewpoints of thermal performances,various BCC lattice structure thicknesses are analyzed in the range of 0.8–1.2mm.Thermal simulation outcomes reveal that thicker lattice structures enhance mechanical strength but simultaneously lead to an increase in cooling time.Upon examining all the proposed CC cavity solutions supported by BCC,the cooling times range from 2.2 to 4 s,resulting in a reduction of 38.6%to 66.1%when compared to conventional straightdrilled channels.In contrast to CCCs,CC cavities have the potential to decrease the maximum temperature nonuniformity from 8.5 to 6 K.Nevertheless,the presence of lattice structures in CC cavity solutions results in an elevated pressure drop,reaching 2.8MPa,whereas the results for CCCs remain below2.1MPa.展开更多
Self-injection locking has emerged as a crucial technique for coherent optical sources,spanning from narrow linewidth lasers to the generation of localized microcombs.This technique involves key components,namely a la...Self-injection locking has emerged as a crucial technique for coherent optical sources,spanning from narrow linewidth lasers to the generation of localized microcombs.This technique involves key components,namely a laser diode and a high-quality cavity that induces narrow-band reflection back into the laser diode.However,in prior studies,the reflection mainly relied on the random intracavity Rayleigh backscattering,rendering it unpredictable and unsuitable for large-scale production and wide-band operation.In this work,we present a simple approach to achieve reliable intracavity reflection for self-injection locking to address this challenge by introducing a Sagnac loop into the cavity.This method guarantees robust reflection for every resonance within a wide operational band without compromising the quality factor or adding complexity to the fabrication process.As a proof of concept,we showcase the robust generation of narrow linewidth lasers and localized microcombs locked to different resonances within a normal-dispersion microcavity.Furthermore,the existence and generation of localized patterns in a normal-dispersion cavity with broadband forward–backward field coupling is first proved,as far as we know,both in simulation and in experiment.Our research offers a transformative approach to self-injection locking and holds great potential for large-scale production.展开更多
Asphaltene deposition is a significant problem during gas injection processes,as it can block the porous medium,the wellbore,and the involved facilities,significantly impacting reservoir productivity and ultimate oil re...Asphaltene deposition is a significant problem during gas injection processes,as it can block the porous medium,the wellbore,and the involved facilities,significantly impacting reservoir productivity and ultimate oil recovery.Only a few studies have investigated the numerical modeling of this potential effect in porous media.This study focuses on asphaltene deposition due to natural gas and CO_(2) injection.Predictions of the effect of gas injection on asphaltene deposition behavior have been made using a 3D numerical simulation model.The results indicate that the injection of natural gas exacerbates asphaltene deposition,leading to a significant reduction in permeability near the injection well and throughout the reservoir.This reduction in permeability strongly affects the ability of gas toflow through the reservoir,resulting in an improvement of the displacement front.The displacement effi-ciency of the injection gas process increases by up to 1.40%when gas is injected at 5500 psi,compared to the scenario where the asphaltene model is not considered.CO_(2) injection leads to a miscible process with crude oil,extracting light and intermediate components,which intensifies asphaltene precipitation and increases the viscosity of the remaining crude oil,ultimately reducing the recovery rate.展开更多
Large cavity structures are widely employed in aerospace engineering, such as thin-walled cylinders, blades andwings. Enhancing performance of aerial vehicles while reducing manufacturing costs and fuel consumptionhas...Large cavity structures are widely employed in aerospace engineering, such as thin-walled cylinders, blades andwings. Enhancing performance of aerial vehicles while reducing manufacturing costs and fuel consumptionhas become a focal point for contemporary researchers. Therefore, this paper aims to investigate the topologyoptimization of large cavity structures as a means to enhance their performance, safety, and efficiency. By usingthe variable density method, lightweight design is achieved without compromising structural strength. Theoptimization model considers both concentrated and distributed loads, and utilizes techniques like sensitivityfiltering and projection to obtain a robust optimized configuration. The mechanical properties are checked bycomparing the stress distribution and displacement of the unoptimized and optimized structures under the sameload. The results confirm that the optimized structures exhibit improved mechanical properties, thus offering keyinsights for engineering lightweight, high-strength large cavity structures.展开更多
The paper proposes a biomass cross-upgrading process that combines hydrothermal carbonization and pyrolysis to produce high-quality blast furnace injection fuel.The results showed that after upgrading,the volatile con...The paper proposes a biomass cross-upgrading process that combines hydrothermal carbonization and pyrolysis to produce high-quality blast furnace injection fuel.The results showed that after upgrading,the volatile content of biochar ranged from 16.19%to 45.35%,and the alkali metal content,ash content,and specific surface area were significantly reduced.The optimal route for biochar pro-duction is hydrothermal carbonization-pyrolysis(P-HC),resulting in biochar with a higher calorific value,C=C structure,and increased graphitization degree.The apparent activation energy(E)of the sample ranges from 199.1 to 324.8 kJ/mol,with P-HC having an E of 277.8 kJ/mol,lower than that of raw biomass,primary biochar,and anthracite.This makes P-HC more suitable for blast furnace injection fuel.Additionally,the paper proposes a path for P-HC injection in blast furnaces and calculates potential environmental benefits.P-HC of-fers the highest potential for carbon emission reduction,capable of reducing emissions by 96.04 kg/t when replacing 40wt%coal injec-tion.展开更多
High-resolution multi-color printing relies upon pixelated optical nanostructures,which is crucial to promote color display by producing nonbleaching colors,yet requires simplicity in fabrication and dynamic switching...High-resolution multi-color printing relies upon pixelated optical nanostructures,which is crucial to promote color display by producing nonbleaching colors,yet requires simplicity in fabrication and dynamic switching.Antimony trisulfide(Sb_(2)S_(3))is a newly rising chalcogenide material that possesses prompt and significant transition of its optical characteristics in the visible region between amorphous and crystalline phases,which holds the key to color-varying devices.Herein,we proposed a dynamically switchable color printing method using Sb_(2)S_(3)-based stepwise pixelated Fabry-Pérot(FP)cavities with various cavity lengths.The device was fabricated by employing a direct laser patterning that is a less timeconsuming,more approachable,and low-cost technique.As switching the state of Sb_(2)S_(3) between amorphous and crystalline,the multi-color of stepwise pixelated FP cavities can be actively changed.The color variation is due to the profound change in the refractive index of Sb_(2)S_(3) over the visible spectrum during its phase transition.Moreover,we directly fabricated sub-50 nm nano-grating on ultrathin Sb_(2)S_(3) laminate via microsphere 800-nm femtosecond laser irradiation in far field.The minimum feature size can be further decreased down to~45 nm(λ/17)by varying the thickness of Sb_(2)S_(3) film.Ultrafast switchable Sb_(2)S_(3) photonic devices can take one step toward the next generation of inkless erasable papers or displays and enable information encryption,camouflaging surfaces,anticounterfeiting,etc.Importantly,our work explores the prospects of rapid and rewritable fabrication of periodic structures with nano-scale resolution and can serve as a guideline for further development of chalcogenide-based photonics components.展开更多
Future 6G communications are envisioned to enable a large catalogue of pioneering applications.These will range from networked Cyber-Physical Systems to edge computing devices,establishing real-time feedback control l...Future 6G communications are envisioned to enable a large catalogue of pioneering applications.These will range from networked Cyber-Physical Systems to edge computing devices,establishing real-time feedback control loops critical for managing Industry 5.0 deployments,digital agriculture systems,and essential infrastructures.The provision of extensive machine-type communications through 6G will render many of these innovative systems autonomous and unsupervised.While full automation will enhance industrial efficiency significantly,it concurrently introduces new cyber risks and vulnerabilities.In particular,unattended systems are highly susceptible to trust issues:malicious nodes and false information can be easily introduced into control loops.Additionally,Denialof-Service attacks can be executed by inundating the network with valueless noise.Current anomaly detection schemes require the entire transformation of the control software to integrate new steps and can only mitigate anomalies that conform to predefined mathematical models.Solutions based on an exhaustive data collection to detect anomalies are precise but extremely slow.Standard models,with their limited understanding of mobile networks,can achieve precision rates no higher than 75%.Therefore,more general and transversal protection mechanisms are needed to detect malicious behaviors transparently.This paper introduces a probabilistic trust model and control algorithm designed to address this gap.The model determines the probability of any node to be trustworthy.Communication channels are pruned for those nodes whose probability is below a given threshold.The trust control algorithmcomprises three primary phases,which feed themodel with three different probabilities,which are weighted and combined.Initially,anomalous nodes are identified using Gaussian mixture models and clustering technologies.Next,traffic patterns are studied using digital Bessel functions and the functional scalar product.Finally,the information coherence and content are analyzed.The noise content and abnormal information sequences are detected using a Volterra filter and a bank of Finite Impulse Response filters.An experimental validation based on simulation tools and environments was carried out.Results show the proposed solution can successfully detect up to 92%of malicious data injection attacks.展开更多
文摘Presents the conception of concurrent engineering employed for CAD/CAM of injection moulds by closely combining the management science with the manufacturing techniques with the cost of processing, material cost, etc taken into consideration from the conceptural design to delivery of products and concludes with the results of analyses that the cost of finished plastic parts is lower, the production efficiency is higher while energy is saved.
基金the National Natural Science Foundation of China(Nos.11975298 and 12175292).
文摘A diffraction-limited storage ring with a multi-bend achromat lattice suffers from a small dynamic aperture for conventional off-axis injection.Thus,a longitudinal on-axis injection scheme based on a new type of crab cavity is proposed in this paper.Particle tracking simulations were performed to study the disturbance of the stored beam and the motion of the injected beam during the injection process.The possibility of multi-bunch injections was discussed.In addition,the effect of the long-range wake field induced by the stored beam was analyzed.A C-band standing-wave crab cavity was designed and produced as requested,and its field distribution was measured.The corresponding results are consistent with the simulation results.
文摘In this work, the characteristics of the photonic crystal tunneling injection quantum dot vertical cavity surface emitting lasers(Ph C-TIQD-VCSEL) are studied through analyzing a modified modulation transfer function. The function is based on the rate equations describing the carrier dynamics at different energy levels of dot and injector well. Although the frequency modulation response component associated with carrier dynamics in wetting layer(WL) and at excited state(ES) levels of dots limits the total bandwidth in conventional QD-VCSEL, our study shows that it can be compensated for by electron tunneling from the injector well into the dot in TIQD structure. Carrier back tunneling time is one of the most important parameters, and by increment of that, the bias current dependence of the total bandwidth will be insignificant. It is proved that at high bias current, the limitation of the WL-ES level plays an important role in reducing the total bandwidth and results in rollovers on 3-d B bandwidth-I curves. In such a way, for smaller air hole diameter of photonic crystal, the effect of this reduction is stronger.
文摘Injection molding is a complicated production technique for the manufacturing of polymer products. During injection molding, it's hard to predict molding quality; the injection molding parameters, such as mold temperature, melt temperature, packing pressure and packing time, affect the final properties of product. The cavity pressure is a significant key factor. Residual stress and injection molding weight are significantly affected by the cavity pressure. This study created an approach to predict weight of injection-molded by real-time online cavity pressure monitoring. This study uses a 6-inch with thickness lmm light guide panel and the largest area beneath the pressure curve of time as well as the maximum pressure as its characteristic. The upper and lower limits of the control are set to +2 standard deviations, and GUI (Graphical User Interface)-based LabVIEW software is used to perform calculation and analysis of the pressure curve. The results of the experiment show that the online internal cavity pressure monitoring system can effectively monitor the quality of the molded products. In 500 injection molding cycle tests, its error rate was less than 8%, whereas the deviation in mass of the molded products selected through the system's filtering process was successfully controlled to be within ±4%.
基金supported by the National Key R&D Program of China(No.2016YFA0402002)
文摘Longitudinal injection is a promising on-axis injection scheme for diffraction-limited storage rings. In the latest version of the Hefei advanced light source (HALS), both the dynamic aperture and momentum aperture have been optimized. A longitudinal injection scheme was investigated on the HALS using a doublefrequency radio frequency system. To evaluate the injection performance, various errors were considered. A series of tracking simulations were conducted, and the injection efficiency was obtained under different error levels.
基金supported by National Natural Science Fund Project(No.81470029)Science and Technology Commission of Shanghai Natural fund Project(No.11JC410602)
文摘Objective: To explore the vision-related quality of life ( VRQL) before and after the injection of antiangiogenic drug into the vitreous cavity of patients with wet age-related macular degeneration ( AMD) . Methods: The 2000 edition of the Visual Functioning Questionnaire 25 that was issued by the Na-tional Eye Institute was applied, and the VRQL evaluation was conducted on the initially diagnosed patients with wet-AMD before and after the injection of ranibizumab into the vitreous cavity. Results: Among the wet-AMD patients, patients with better distance visual acuity before the in-travitreal injection had a lower VFQ-25 score. After the vitreous cavity injection, the VFQ-25 questionnaire score was related to patient care and education from the doctors and nurses; specific-ally, the better the nursing, the higher the score. Conclusions: Before the vitreous cavity injection, the degree of distance visual acuity is an im-portant factor affecting the VRQL of wet-AMD patients. In addition, patient care and education from the doctors and nurses toward patients during the pre-, intra-and post-operation of the intrav-itreal injection are also important factors affecting the VRQL.
基金supported by the Natural Science Foundation of Zhejiang Province,China(Grant No.LY20A040004)the National Natural Science Foundation of China(Grant Nos.11604232 and 11974305)。
文摘The injection of a self-avoiding flexible polymer into a spherical cavity under a driving force is studied by using Langevin dynamics simulation.For given polymer length(N)and driving force(f),the polymer can be completely injected into the cavity only when the radius of the cavity is larger than a transition radius(ReC).The dependence of ReC on N and f can be described by a scaling relation ReC∝N ^(1/3) f−δ.The value ofδchanges from 4/15 in the small f region to 1/6 in the moderate f region due to the screening of the excluded-volume interaction between monomers.We find the complete injection time(τ)decreases monotonously with increasing the cavity radius or decreasing the polymer length.The simulation results are in good agreement with the theoretical predictions from the free energy analysis and a simple kinetic model.
基金Supported by The New Faculty Research Grant of Pusan National University,2023The Research Grant of the Chungbuk National University in 2023.
文摘BACKGROUND Intramuscular corticosteroid injection may cause adverse effects such as dermal and/or subcutaneous atrophy,alopecia,hypopigmentation,and hyperpigmentation.Although cutaneous atrophy can spontaneously resolve,several treatment options have been suggested for this condition.CASE SUMMARY In this paper,we report a case of corticosteroid injection induced lipoatrophy treated with autologous whole blood(AWB)injection,as the condition had been unresponsive to fractional laser therapy.A 29-year-old female patient visited the dermatology clinic complaining of skin depression on her right buttock area,which had appeared six months earlier.There had been only subtle improvement at the margins after fractional CO2 laser treatment;therefore,after obtaining informed consent from the patient,AWB treatment was initiated.One month after the first AWB injection,the size and depth of the lesion had noticeably improved,and a slight improvement was also observed in discoloration.CONCLUSION Close observation is the initial treatment of choice for steroid induced skin atrophy;however,for patients in need of immediate cosmetic improvement,AWB injection may be a safe and cost-effective alternative.
基金supported by the National Natural Science Foundation of China (Nos.92252206,11925207,T2221002 and 12102472)。
文摘It has been found that the static pressure distribution along the axial direction of liquid kerosene is lower than that of the gaseous kerosene under the same flow condition and overall equivalent ratio from previous studies.To further investigate this phenomenon,a compressible two-phase parallel simulation method is utilized to analyze the mixing and combustion characteristics of gaseous and liquid kerosene jets in a cavity-based supersonic combustor.The numerical results are consistent with the experiments and demonstrate that gaseous injection leads to a cavity shear layer that dives deeper into the cavity,forming two recirculation zones in the front and rear of the cavity.In contrast,the cavity shear layer is closer to the mainstream during liquid injection,and only a large recirculation zone is formed in the rear of the cavity.As a result of the cavity shear layer and the recirculating flow,the fuel vapor of gaseous injection accumulates in the front of the cavity,while for the liquid injection,the fuel vapor disperses in the cavity,cavity shear layer,and the region above,and the rear of the cavity has a higher fuel vapor concentration than the front.This unique fuel distribution causes the combustion area to be concentrated in the cavity during the gaseous injection but dispersed inside and downstream of the cavity during the liquid injection.As a result,forming a thermal throat under the same conditions is more challenging during liquid injection,and the generated static pressure distribution is lower than that during the gaseous injection.
基金supported by the National Natural Science Foundation of China(Grant No.82073439).
文摘Dear Editor,Treating psoriatic arthritis(PsA)is always difficult.Systemic treatments can be administered either orally or through intramuscular and intra-articular injection,including conventional synthetics,biologics and targeted synthetic disease-modifying antirheumatic drugs[1].The alternatives,topical external therapies,are not effective on joint lesions due to drug permeability issues.Drugs injected into the articular cavity are also unsuitable for small peripheral joint lesions,the most common manifestations of PsA.The limited treatment options for PsA present a challenge.
基金supported by the Chinese initiative accelerator driven subcritical system and the hundred talents plan of the Chinese Academy of Sciences(No.E129841Y).
文摘To validate the design rationality of the power coupler for the RFQ cavity and minimize cavity contamination,we designed a low-loss offline conditioning cavity and conducted high-power testing.This offline cavity features two coupling ports and two tuners,operating at a frequency of 162.5 MHz with a tuning range of 3.2 MHz.Adjusting the installation angle of the coupling ring and the insertion depth of the tuner helps minimize cavity losses.We performed electromagnetic structural and multiphysics simulations,revealing a minimal theoretical power loss of 4.3%.However,when the cavity frequency varied by110 kHz,theoretical power losses increased to10%,necessitating constant tuner adjustments during conditioning.Multiphysics simulations indicated that increased cavity temperature did not affect frequency variation.Upon completion of the offline high-power conditioning platform,we measured the transmission performance,revealing a power loss of 6.3%,exceeding the theoretical calculation.Conditioning utilized efficient automatic range scanning and standing wave resonant methods.To fully condition the power coupler,a 15°phase difference between two standing wave points in the condition-ing system was necessary.Notably,the maximum continuous wave power surpassed 20 kW,exceeding the expected target.
基金Project supported by National Key Research and Development Program of China (Grant No.2022YFA1603403)。
文摘Finesse is a critical parameter for describing the characteristics of an optical enhancement cavity(OEC). This paper first presents a review of finesse measurement techniques, including a comparative analysis of the advantages, disadvantages, and potential limitations of several main methods from both theoretical and practical perspectives. A variant of the existing method called the free spectral range(FSR) modulation method is proposed and compared with three other finesse measurement methods, i.e., the fast-switching cavity ring-down(CRD) method, the rapidly swept-frequency(SF) CRD method, and the ringing effect method. A high-power OEC platform with a high finesse of approximately 16000 is built and measured with the four methods. The performance of these methods is compared, and the results show that the FSR modulation method and the fast-switching CRD method are more suitable and accurate than the other two methods for high-finesse OEC measurements. The CRD method and the ringing effect method can be implemented in open loop using simple equipment and are easy to perform. Additionally, recommendations for selecting finesse measurement methods under different conditions are proposed, which benefit the development of OEC and its applications.
文摘The design of three-dimensional printing based conformal cooling channels(CCCs)in injection molding holds great significance.Compared to CCCs,conformal cooling(CC)cavity solutions show promise in delivering enhanced cooling performance for plastic products,although they have been underexplored.In this research,CC cavity is designed within the mold geometry,reinforced by body-centered cubic(BCC)lattice structures to enhance mechanical strength.Three distinct BCC lattice variations have been integrated into the CC cavity:the BCC structure,BCC with cubes,and BCC with pillars.The thermal performances of the BCC lattice-added CC cavity are assessed numerically after experimental validation.To provide feasible solutions from viewpoints of thermal performances,various BCC lattice structure thicknesses are analyzed in the range of 0.8–1.2mm.Thermal simulation outcomes reveal that thicker lattice structures enhance mechanical strength but simultaneously lead to an increase in cooling time.Upon examining all the proposed CC cavity solutions supported by BCC,the cooling times range from 2.2 to 4 s,resulting in a reduction of 38.6%to 66.1%when compared to conventional straightdrilled channels.In contrast to CCCs,CC cavities have the potential to decrease the maximum temperature nonuniformity from 8.5 to 6 K.Nevertheless,the presence of lattice structures in CC cavity solutions results in an elevated pressure drop,reaching 2.8MPa,whereas the results for CCCs remain below2.1MPa.
基金National Key Research and Development Program of China(2021YFB2800400)National Natural Science Foundation of China(12204021,62105008,62235002,62235003,62322501,8200908114)+3 种基金Beijing Municipal Science and Technology Commission(Z221100006722003)Natural Science Foundation of Beijing Municipality(Z210004)Nantong Municipal Science and Technology Bureau(JB2022008,JC22022050)China Postdoctoral Science Foundation(2021T140004)。
文摘Self-injection locking has emerged as a crucial technique for coherent optical sources,spanning from narrow linewidth lasers to the generation of localized microcombs.This technique involves key components,namely a laser diode and a high-quality cavity that induces narrow-band reflection back into the laser diode.However,in prior studies,the reflection mainly relied on the random intracavity Rayleigh backscattering,rendering it unpredictable and unsuitable for large-scale production and wide-band operation.In this work,we present a simple approach to achieve reliable intracavity reflection for self-injection locking to address this challenge by introducing a Sagnac loop into the cavity.This method guarantees robust reflection for every resonance within a wide operational band without compromising the quality factor or adding complexity to the fabrication process.As a proof of concept,we showcase the robust generation of narrow linewidth lasers and localized microcombs locked to different resonances within a normal-dispersion microcavity.Furthermore,the existence and generation of localized patterns in a normal-dispersion cavity with broadband forward–backward field coupling is first proved,as far as we know,both in simulation and in experiment.Our research offers a transformative approach to self-injection locking and holds great potential for large-scale production.
基金funded by CNOOC Production Research Project(CCL2022SZPS0076).
文摘Asphaltene deposition is a significant problem during gas injection processes,as it can block the porous medium,the wellbore,and the involved facilities,significantly impacting reservoir productivity and ultimate oil recovery.Only a few studies have investigated the numerical modeling of this potential effect in porous media.This study focuses on asphaltene deposition due to natural gas and CO_(2) injection.Predictions of the effect of gas injection on asphaltene deposition behavior have been made using a 3D numerical simulation model.The results indicate that the injection of natural gas exacerbates asphaltene deposition,leading to a significant reduction in permeability near the injection well and throughout the reservoir.This reduction in permeability strongly affects the ability of gas toflow through the reservoir,resulting in an improvement of the displacement front.The displacement effi-ciency of the injection gas process increases by up to 1.40%when gas is injected at 5500 psi,compared to the scenario where the asphaltene model is not considered.CO_(2) injection leads to a miscible process with crude oil,extracting light and intermediate components,which intensifies asphaltene precipitation and increases the viscosity of the remaining crude oil,ultimately reducing the recovery rate.
基金the National Natural Science Foundation of China and the Natural Science Foundation of Jiangsu Province.It was also supported in part by Young Elite Scientists Sponsorship Program by CAST.
文摘Large cavity structures are widely employed in aerospace engineering, such as thin-walled cylinders, blades andwings. Enhancing performance of aerial vehicles while reducing manufacturing costs and fuel consumptionhas become a focal point for contemporary researchers. Therefore, this paper aims to investigate the topologyoptimization of large cavity structures as a means to enhance their performance, safety, and efficiency. By usingthe variable density method, lightweight design is achieved without compromising structural strength. Theoptimization model considers both concentrated and distributed loads, and utilizes techniques like sensitivityfiltering and projection to obtain a robust optimized configuration. The mechanical properties are checked bycomparing the stress distribution and displacement of the unoptimized and optimized structures under the sameload. The results confirm that the optimized structures exhibit improved mechanical properties, thus offering keyinsights for engineering lightweight, high-strength large cavity structures.
基金the National Key R&D Program of China(No.2022YFE0208100)the National Natural Science Foundation of China(No.5274316)+1 种基金the Key Research and Development Plan of Anhui Province,China(No.202210700037)the Major Science and Technology Project of Xinjiang Uygur Autonomous Region,China(No.2022A01003).
文摘The paper proposes a biomass cross-upgrading process that combines hydrothermal carbonization and pyrolysis to produce high-quality blast furnace injection fuel.The results showed that after upgrading,the volatile content of biochar ranged from 16.19%to 45.35%,and the alkali metal content,ash content,and specific surface area were significantly reduced.The optimal route for biochar pro-duction is hydrothermal carbonization-pyrolysis(P-HC),resulting in biochar with a higher calorific value,C=C structure,and increased graphitization degree.The apparent activation energy(E)of the sample ranges from 199.1 to 324.8 kJ/mol,with P-HC having an E of 277.8 kJ/mol,lower than that of raw biomass,primary biochar,and anthracite.This makes P-HC more suitable for blast furnace injection fuel.Additionally,the paper proposes a path for P-HC injection in blast furnaces and calculates potential environmental benefits.P-HC of-fers the highest potential for carbon emission reduction,capable of reducing emissions by 96.04 kg/t when replacing 40wt%coal injec-tion.
基金support from the National Key Research and Development Program of China (2020YFA0714504,2019YFA0709100).
文摘High-resolution multi-color printing relies upon pixelated optical nanostructures,which is crucial to promote color display by producing nonbleaching colors,yet requires simplicity in fabrication and dynamic switching.Antimony trisulfide(Sb_(2)S_(3))is a newly rising chalcogenide material that possesses prompt and significant transition of its optical characteristics in the visible region between amorphous and crystalline phases,which holds the key to color-varying devices.Herein,we proposed a dynamically switchable color printing method using Sb_(2)S_(3)-based stepwise pixelated Fabry-Pérot(FP)cavities with various cavity lengths.The device was fabricated by employing a direct laser patterning that is a less timeconsuming,more approachable,and low-cost technique.As switching the state of Sb_(2)S_(3) between amorphous and crystalline,the multi-color of stepwise pixelated FP cavities can be actively changed.The color variation is due to the profound change in the refractive index of Sb_(2)S_(3) over the visible spectrum during its phase transition.Moreover,we directly fabricated sub-50 nm nano-grating on ultrathin Sb_(2)S_(3) laminate via microsphere 800-nm femtosecond laser irradiation in far field.The minimum feature size can be further decreased down to~45 nm(λ/17)by varying the thickness of Sb_(2)S_(3) film.Ultrafast switchable Sb_(2)S_(3) photonic devices can take one step toward the next generation of inkless erasable papers or displays and enable information encryption,camouflaging surfaces,anticounterfeiting,etc.Importantly,our work explores the prospects of rapid and rewritable fabrication of periodic structures with nano-scale resolution and can serve as a guideline for further development of chalcogenide-based photonics components.
基金funding by Comunidad de Madrid within the framework of the Multiannual Agreement with Universidad Politécnica de Madrid to encourage research by young doctors(PRINCE project).
文摘Future 6G communications are envisioned to enable a large catalogue of pioneering applications.These will range from networked Cyber-Physical Systems to edge computing devices,establishing real-time feedback control loops critical for managing Industry 5.0 deployments,digital agriculture systems,and essential infrastructures.The provision of extensive machine-type communications through 6G will render many of these innovative systems autonomous and unsupervised.While full automation will enhance industrial efficiency significantly,it concurrently introduces new cyber risks and vulnerabilities.In particular,unattended systems are highly susceptible to trust issues:malicious nodes and false information can be easily introduced into control loops.Additionally,Denialof-Service attacks can be executed by inundating the network with valueless noise.Current anomaly detection schemes require the entire transformation of the control software to integrate new steps and can only mitigate anomalies that conform to predefined mathematical models.Solutions based on an exhaustive data collection to detect anomalies are precise but extremely slow.Standard models,with their limited understanding of mobile networks,can achieve precision rates no higher than 75%.Therefore,more general and transversal protection mechanisms are needed to detect malicious behaviors transparently.This paper introduces a probabilistic trust model and control algorithm designed to address this gap.The model determines the probability of any node to be trustworthy.Communication channels are pruned for those nodes whose probability is below a given threshold.The trust control algorithmcomprises three primary phases,which feed themodel with three different probabilities,which are weighted and combined.Initially,anomalous nodes are identified using Gaussian mixture models and clustering technologies.Next,traffic patterns are studied using digital Bessel functions and the functional scalar product.Finally,the information coherence and content are analyzed.The noise content and abnormal information sequences are detected using a Volterra filter and a bank of Finite Impulse Response filters.An experimental validation based on simulation tools and environments was carried out.Results show the proposed solution can successfully detect up to 92%of malicious data injection attacks.